122
Views
20
CrossRef citations to date
0
Altmetric
Original

DNA damage in cultured skin microvascular endothelial cells exposed to gamma rays and treated by the combination pentoxifylline and α-tocopherol

, &
Pages 309-321 | Received 12 Dec 2005, Accepted 29 Mar 2006, Published online: 03 Jul 2009

References

  • Adamson I Y, Bowden D H. Endothelial injury and repair in radiation-induced pulmonary fibrosis. American Journal of Pathology 1983; 112: 224–230
  • Akudugu J M, Slabbert J P, Serafin A, Bohm L. Frequency of radiation-induced micronuclei in neuronal cells does not correlate with clonogenic survival. Radiation Research 2000; 153(5 Pt 1)62–67
  • Amirkhosravi A, Meyer T, Warnes G, Amaya M, Malik Z, Biggerstaff J P, Siddiqui F A, Sherman P, Francis J L. Pentoxifylline inhibits hypoxia-induced upregulation of tumor cell tissue factor and vascular endothelial growth factor. Thrombosis and Haemostasis 1998; 80: 598–602
  • Archambeau J O, Pezner R, Wasserman T. Pathophysiology of irradiated skin and breast. International Journal of Radiation Oncology & Biology & Physics 1995; 31: 1171–1185
  • Aygenc E, Celikkanat S, Kaymakci M, Aksaray F, Ozdem C. Prophylactic effect of pentoxifylline on radiotherapy complications: A clinical study. Otolaryngology and Head and Neck Surgery 2004; 130: 351–356
  • Binder A B, Serafin A M, Bohm L J. Abrogation of G(2)/M phase block enhances the cytotoxicity of daunorubicin, melphalan and cisplatin in TP53 mutant human tumor cells. Radiation Research 2000; 154: 640–649
  • Binder A B, Theron T, Donninger H, Parker M, Bohm L. Radiosensitization and DNA repair inhibition by pentoxifylline in NIH3T3 p53 transfectants. International Journal of Radiation Biology 2002; 78: 991–1000
  • Bohm L, Roos W P, Serafin A M. Inhibition of DNA repair by Pentoxifylline and related methylxanthine derivatives. Toxicology 2003; 193: 153–160
  • Bozsakyova E, Chalupa I, Sebova L, Slamenova D. Chromosomal aberrations, sister chromatid exchanges and micronuclei induced by pentoxifylline in in vitro cultivated Chinese hamster cells (V79) and human blood lymphocytes. Mutation Research 2001; 497: 63–70
  • Burkitt M J. A critical overview of the chemistry of copper-dependent low density lipoprotein oxidation: roles of lipid hydroperoxides, alpha-tocopherol, thiols, and of. Biochemistry and Biophysics 2001; 394: 117–135
  • Chiao T B, Lee A J. Role of pentoxifylline and vitamin E in attenuation of radiation-induced fibrosis. The Annals of Pharmacotherapy 2005; 39: 516–522
  • Delanian S, Baillet F, Huart J, Lefaix J L, Maulard C, Housset M. Successful treatment of radiation-induced fibrosis using liposomal Cu/Zn superoxide dismutase: Clinical trial. Radiotherapy and Oncology 1994; 32: 12–20
  • Delanian S, Balla-Mekias S, Lefaix J L. Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol. Journal of Clinical Oncology 1999; 17: 3283–3290
  • Delanian S, Lefaix J L. Complete healing of severe osteoradionecrosis with treatment combining pentoxifylline, tocopherol and clodronate. British Journal of Radiology 2002; 75: 467–469
  • Delanian S, Porcher R, Balla-Mekias S, Lefaix J L. Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis. Journal of Clinical Oncology 2003; 21: 2545–2550
  • Dion M W, Hussey D H, Osborne J W. The effect of pentoxifylline on early and late radiation injury following fractionated irradiation in C3H mice. International Journal of Radiation Oncology & Biology & Physics 1989; 17: 101–107
  • Dion M W, Hussey D H, Doornbos J F, Vigliotti A P, Wen B C, Anderson B. Preliminary results of a pilot study of pentoxifylline in the treatment of late radiation soft tissue necrosis. International Journal of Radiation Oncology & Biology & Physics 1990; 19: 401–407
  • Dubray B, Delanian S, Lefaix J L. [Late effects of mammary radiotherapy on skin and subcutaneous tissues.]. Cancer/Radiotherapie 1997; 1: 744–752
  • Ehrly A M, Schroeder W. Oxygen pressure values in the ischemic muscle tissue of patients with chronic occlusive arterial disease. Advances in Experimental Medicine and Biology 1977; 94: 401–405
  • Ehrly A M. The effect of pentoxifylline on the deformability of erythrocytes and on the muscular oxygen pressure in patients with chronic arterial disease. Journal of Medicine 1979; 10: 331–338
  • Eley K W, Benedict S H, Chung T D, Kavanagh B D, Broaddus W C, Schmidt-Ullrich R K, Lin P S. The effects of pentoxifylline on the survival of human glioma cells with continuous and intermittent stereotactic radiosurgery irradiation. International Journal of Radiation Oncology & Biology & Physics 2002; 54: 542–550
  • Freitas J P, Filipe P, Guerra Rodrigo F. [Potential antioxidative effects of pentoxifylline.]. Comptes Rendus des Sceances de la Societe de Biologie et de ses Filiales 1995; 189: 401–405
  • Hill R P, Rodemann H P, Hendry J H, Roberts S A, Anscher M S. Normal tissue radiobiology: From the laboratory to the clinic. International Journal of Radiation Oncology & Biology & Physics 2001; 49: 353–365
  • Horvath B, Marton Z, Halmosi R, Alexy T, Szapary L, Vekasi J, Biro Z, Habon T, Kesmarky G, Toth K. In vitro antioxidant properties of pentoxifylline, piracetam, and vinpocetine. Clinical Neuropharmacology 2002; 25: 37–42
  • Iliakis G. The role of DNA double strand breaks in ionizing radiation-induced killing of eukaryotic cells. BioEssays 1991; 13: 641–648
  • Koh W J, Stelzer K J, Peterson L M, Staker B L, Ward W F, Russell K J, Griffin T W. Effect of pentoxifylline on radiation-induced lung and skin toxicity in rats. International Journal of Radiation Oncology & Biology & Physics 1995; 31: 71–77
  • Kumar B, Jha M N, Cole W C, Bedford J S, Prasad K N. D-alpha-tocopheryl succinate (vitamin E) enhances radiation-induced chromosomal damage levels in human cancer cells, but reduces it in normal cells. Journal of the American College of Nutrition 2002; 21: 339–343
  • Laurent C, Pouget J P, Voisin P. Modulation of DNA damage by pentoxifylline and alpha-tocopherol in skin fibroblasts exposed to Gamma rays. Radiation Research 2005; 164: 63–72
  • Law M P. Radiation-induced vascular injury and its relation to late effects in normal tissues. Advances in Radiation Biology 1981; 9: 37
  • LeBel C P, Ischiropoulos H, Bondy S C. Evaluation of the probe 2′,7′-dichlorofluorescein as an indicator of reactive oxygen species formation and oxidative stress. Chemical Research in Toxicology 1992; 5: 227–231
  • Lefaix J L, Delanian S, Leplat J J, Tricaud Y, Martin M, Nimrod A, Baillet F, Daburon F. Successful treatment of radiation-induced fibrosis using Cu/Zn-SOD and Mn-SOD: An experimental study. International Journal of Radiation Oncology & Biology & Physics 1996; 35: 305–312
  • Lefaix J L, Delanian S, Vozenin M C, Leplat J J, Tricaud Y, Martin M. Striking regression of subcutaneous fibrosis induced by high doses of gamma rays using a combination of pentoxifylline and alpha-tocopherol: An experimental study. International Journal of Radiation Oncology & Biology & Physics 1999; 43: 839–847
  • Letur-Konirsch H, Guis F, Delanian S. Uterine restoration by radiation sequelae regression with combined pentoxifylline-tocopherol: A phase II study. Fertility and Sterility 2002; 77: 1219–1126
  • Lorke D E, Wenzel S, Siebert K, Zywietz F. Microvascular and tumor cell alterations during continuous hyperfractionated irradiation: An electron microscopic investigation on the rat R1H rhabdomyosarcoma. International Journal of Radiation Oncology & Biology & Physics 1999; 44: 895–904
  • Ozturk B, Egehan I, Atavci S, Kitapci M. Pentoxifylline in prevention of radiation-induced lung toxicity in patients with breast and lung cancer: A double-blind randomized trial. International Journal of Radiation Oncology & Biology & Physics 2004; 58: 213–219
  • Peter R U, Gottlober P. Management of cutanetous radiation injuries: Diagnostic and therapeutic principles of the cutaneous radiation syndrome. Military Medicine 2002; 167: 110–112
  • Phillips T L. An ultrastructural study of the development of radiation injury in the lung. Radiology 1966; 87: 49–54
  • Pouget J P, Douki T, Richard M J, Cadet J. DNA damage induced in cells by gamma and UVA radiation as measured by HPLC/GC-MS and HPLC-EC and Comet assay. Chemical Research in Toxicology 2000; 13: 541–549
  • Rimbach G, Minihane A M, Majewicz J, Fischer A, Pallauf J, Virgli F, Weinberg P D. Regulation of cell signalling by vitamin E. The Proceedings of the Nutrition Society 2002; 61: 415–425
  • Robbins M E, Zhao W. Chronic oxidative stress and radiation-induced late normal tissue injury: a review. International Journal of Radiation Biology 2004; 80: 251–259
  • Rube C E, Wilfert F, Uthe D, Schmid K W, Knoop R, Willich N, Schuck A, Rube C. Modulation of radiation-induced tumour necrosis factor alpha (TNF-alpha) expression in the lung tissue by pentoxifylline. Radiotherapy and Oncology 2002; 64: 177–187
  • Rubin P, Casarett G W. Clinical radiation pathology as applied to curative radiotherapy. Cancer 1968; 22: 767–778
  • Russell K J, Wiens L W, Demers G W, Galloway D A, Le T, Rice G C, Bianco J A, Singer J W, Groudine M. Preferential radiosensitization of G1 checkpoint-deficient cells by methylxanthines. International Journal of Radiation Oncology & Biology & Physics 1996; 36: 1099–1106
  • Sarkaria J N, Eshleman J S. ATM as a target for novel radiosensitizers. Seminars in Radiation Oncology 2001; 11: 316–327
  • Strunz A M, Peschke P, Waldeck W, Ehemann V, Kissel M, Debus J. Preferential radiosensitization in p53-mutated human tumour cell lines by pentoxifylline-mediated disruption of the G2/M checkpoint control. International Journal of Radiation Biology 2002; 78: 721–732
  • Sweetman S F, Strain J J, McKelvey-Martin V J. Effect of antioxidant vitamin supplementation on DNA damage and repair in human lymphoblastoid cells. Nutrition and Cancer 1997; 27: 122–130
  • Theron T, Binder A, Verheye-Dua F, Bohm L. The role of G2-block abrogation, DNA double-strand break repair and apoptosis in the radiosensitization of melanoma and squamous cell carcinoma cell lines by pentoxifylline. International Journal of Radiation Biology 2000; 76: 1197–1208
  • Ts'ao C H, Ward W F, Port C D. Radiation injury in rat lung. III. Plasminogen activator and fibrinolytic inhibitor activities. Radiation Research 1983; 96: 301–308
  • Wang H, Wang M, Wang H, Bocker W, Iliakis G. Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors. Journal of Cellular Physiology 2005; 202: 492–502
  • Ward W F, Kim Y T, Molteni A, Ts'ao C, Hinz J M. Pentoxifylline does not spare acute radiation reactions in rat lung and skin. Radiation Research 1992; 129: 107–111
  • Weiss J F, Landauer M R. Protection against ionizing radiation by antioxidant nutrients and phytochemicals. Toxicology 2003; 189: 1–20
  • Yoshida Y, Niki E, Noguchi N. Comparative study on the action of tocopherols and tocotrienols as antioxidant: chemical and physical effects. Chemistry and Physics of Lipids 2003; 123: 63–75
  • Zywietz F, Hahn L S, Lierse W. Ultrastructural studies on tumor capillaries of a rat rhabdomyosarcoma during fractionated radiotherapy. Acta Anatomica 1994; 150: 80–85
  • Zywietz F, Bohm L, Sagowski C, Kehrl W. Pentoxifylline enhances tumor oxygenation and radiosensitivity in rat rhabdomyosarcomas during continuous hyperfractionated irradiation. Strahlenterapie und Onkologie 2004; 180: 306–314

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.