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Original

Analysis of γ-rays induced chromosome aberrations: A fingerprint evaluation with a combination of pan-centromeric and pan-telomeric probes

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Pages 869-875 | Received 07 Apr 2006, Accepted 28 Aug 2006, Published online: 03 Jul 2009

References

  • Anderson R M, Marsden S J, Paice S J, Bristow A E, Kadhim M A, Griffin C S, Goodhead D T. Transmissible and nontransmissible complex chromosome aberrations characterized by three-color and mFISH define a biomarker of exposure to high-LET alpha particles. Radiation Research 2003; 159: 40–48
  • Bauchinger M, Schmid E. Is there reliable experimental evidence for a chromosomal “fingerprint” of exposure to densely ionizing radiation?. Radiation Research 1997; 147: 506–510
  • Bauchinger M, Schmid E. LET dependence of yield ratios of radiation-induced intra- and interchromosomal aberrations in human lymphocytes. International Journal of Radiation Biology 1998; 74: 17–25
  • Boei J J, Vermeulen S, Fomina J, Natarajan A T. Detection of incomplete exchanges and interstitial fragments in X-irradiated human lymphocytes using a telomeric PNA probe. International Journal of Radiation Biology 1998; 73: 599–603
  • Boei J J, Vermeulen S, Natarajan A T. Analysis of radiation-induced chromosomal aberrations using telomeric and centromeric PNA probes. International Journal of Radiation Biology 2000; 76: 163–167
  • Boei J J, Vermeulen S, Mullenders L H, Natarajan A T. Impact of radiation quality on the spectrum of induced chromosome exchange aberrations. International Journal of Radiation Biology 2001; 77: 847–857
  • Brenner D J, Sachs R K. Chromosomal “fingerprints” of prior exposure to densely ionizing radiation. Radiation Research 1994; 140: 134–142
  • Brenner D J, Okladnikova N, Hande P, Burak L, Geard C R, Azizova T. Biomarkers specific to densely-ionising (high LET) radiations. Radiation Protection Dosimetry 2001; 97: 69–73
  • Chudoba I, Plesch A, Lorch T, Lemke J, Claussen U, Senger G. High resolution multicolor-banding: A new technique for refined FISH analysis of human chromosomes. Cytogenetics Cell Genetics 1999; 84: 156–160
  • Deng W, Morrison D P, Gale K L, Lucas J N. A comparative study on potential cytogenetic fingerprints for radiation LET in human lymphocytes. International Journal of Radiation Biology 2000; 76: 1589–1598
  • Edwards A A, Lindholm C, Darroudi F, Stephan G, Romm H, Barquinero J F, Barrios L, Caballín M R, Roy L, Whitehouse C A, Tawn E J, Moquet J, Lloyd D C, Voisin P. Review of translocations detected by FISH for retrospective biological dosimetry applications. Radiation Protection Dosimetry 2005; 113: 396–402
  • Fomina J, Darroudi F, Boei J J, Natarajan A T. Discrimination between complete and incomplete chromosome exchanges in X-irradiated human lymphocytes using FISH with pan-centromeric and chromosome specific DNA probes in combination with telomeric PNA probe. International Journal of Radiation Biology 2000; 76: 807–813
  • Fomina J, Darroudi F, Boei J J, Natarajan A T. Accurate detection of true incomplete exchanges in human lymphocytes exposed to neutron radiation using chromosome painting in combination with a telomeric PNA probe. International Journal of Radiation Biology 2001; 77: 1175–1183
  • Goodhead D T, Thacker J, Cox R. Effects of radiations of different qualities on cells: Molecular mechanisms of damage and repair. International Journal of Radiation Biology 1993; 63: 543–556
  • Hande M P, Azizova T V, Geard C R, Burak L E, Mitchell C R, Khokhryakov V F, Vasilenko E K, Brenner D J. Past exposure to densely ionizing radiation leaves a unique permanent signature in the genome. American Journal of Human Genetics 2003; 72: 1162–1170
  • Hande M P, Azizova T V, Burak L E, Khokhryakov V F, Geard C R, Brenner D J. Complex chromosome aberrations persist in individuals many years after occupational exposure to densely ionizing radiation: An mFISH study. Genes Chromosomes Cancer 2005; 44: 1–9
  • Hlatky L R, Sachs R K, Hahnfeldt P. The ratio of dicentrics to centric rings produced in human lymphocytes by acute low-LET radiation. Radiation Research 1992; 129: 304–308
  • International Atomic Energy Agency (IAEA). Chromosomal aberrations analysis for dose-assessment. IAEA, Vienna 1986, Technical reports series no. 260
  • Jenner T J, Delara C M, O'Neill P, Stevens D L. Induction and rejoining of DNA double-strand breaks in V79-4 mammalian cells following gamma- and alpha-irradiation. International Journal of Radiation Biology 1993; 64: 265–273
  • Kodama Y, Nakano M, Ohtaki K, Dongchamp R, Awa A A, Nakamura N. Estimation of minimal size of translocated chromosome segments detectable by fluorescence in situ hybridization. International Journal of Radiation Biology 1997; 71: 35–39
  • Kodama Y, Ohtaki K, Awa A A, Nakano M, Itoh M, Nakamura N. The F value for chromosome aberrations in atomic bomb survivors does not provide evidence for a primary contribution of neutrons to the dose in Hiroshima. Radiation Research 1999; 152: 558–562
  • Lansdorp P M, Verwoerd N P, van de Rijke F M, Dragowska V, Little M T, Dirks R W, Raap A K, Tanke H J. Heterogeneity in telomere length of human chromosomes. Human Molecular Genetics 1996; 5: 685–691
  • Lindholm C, Romm H, Stephan G, Schmid E, Moquet J, Edwards A A. Intercomparison of translocation and dicentric frequencies between laboratories in a follow-up of the radiological accident in Estonia. International Journal of Radiation Biology 2002; 78: 883–890
  • Lucas J N, Awa A, Straume T, Poggensee M, Kodama Y, Nakano M, Ohtaki K, Weier H U, Pinkel D, Gray J, Littlefield G. Rapid translocation frequency analysis in man decades after exposure to ionizing radiation. International Journal of Radiation Biology 1992; 62: 53–63
  • Lucas J N. Cytogenetic signature for ionizing radiation. International Journal of Radiation Biology 1998; 73: 15–20
  • Lucas J N, Deng W, Oram S W, Hill F S, Durante M, George K, Wu H, Owens C L, Yang T. Theoretical and experimental tests of a chromosomal fingerprint for densely ionizing radiation based on F ratios calculated from stable and unstable chromosome aberrations. Radiation Research 1999; 151: 85–91
  • Lloyd D C, Edwards A A, Prosser J S. Chromosome aberrations induced in human lymphocytes by in vitro acute X and gamma radiation. Radiation Protection Dosimetry 1986; 15: 83–88
  • Mestres M, Caballin M R, Schmid E, Stephan G, Sachs R, Barrios L, Barquinero J F. Analysis of alpha-particle induced chromosome aberrations in human lymphocytes, using pan-centromeric and pan-telomeric probes. International Journal of Radiation Biology 2004; 80: 737–744
  • Mitchell C R, Azizova T V, Hande M P, Burak L E, Tsakok J M, Khokhryakov V F, Geard C R, Brenner D J. Stable intrachromosomal biomarkers of past exposure to densely ionizing radiation in several chromosomes of exposed individuals. Radiation Research 2004; 162: 257–263
  • Natarajan A T, Balajee A S, Boei J J, Darroudi F, Dominguez I, Hande M P, Meijers M, Slijepcevic P, Vermeulen S, Xiao Y. Mechanisms of induction of chromosomal aberrations and their detection by fluorescence in situ hybridization. Mutation Research 1996; 372: 247–258
  • Rao C R, Chakravarti I M. Some small sample tests of significance for a Poisson distribution. Biometrics 1956; 12: 264–282
  • Sasaki M S, Takatsuji T, Ejima Y. The F value cannot be ruled out as a chromosomal fingerprint of radiation quality. Radiation Research 1998; 150: 253–258
  • Sachs R K, Brenner D J, Chen A M, Hahnfeldt P, Hlatky L R. Intra-arm and interarm chromosome intrachanges: Tools for probing the geometry and dynamics of chromatin. Radiation Research 1997; 148: 330–340
  • Savage J R, Simpson P J. FISH “painting” patterns resulting from complex exchanges. Mutation Research 1994; 312: 51–60
  • Speicher M R, Gwyn Ballard S, Ward D C. Karyotyping human chromosomes by combinatorial multi-fluor FISH. Nature Genetics 1996; 12: 368–375
  • Stephens J C, Cavanaugh M L, Gradie M I, Mador M L, Kidd K K. Mapping the human genome: Current status. Science 1990; 250: 237–244
  • Wu H, Durante M, Sachs R K, Yang T C. Centric rings, acentric rings and excess acentric fragments based on a random-walk interphase chromosome model. International Journal of Radiation Biology 1997; 71: 487–496
  • Wu H, George K, Yang T C. Estimate of true incomplete exchanges using fluorescence in situ hybridization with telomere probes. International Journal of Radiation Biology 1998; 73: 521–527
  • Wu H, George K, Yang T C. Estimate of the frequency of true incomplete exchanges in human lymphocytes exposed to 1 GeV/u Fe ions in vitro. International Journal of Radiation Biology 1999; 75: 593–599
  • Wu H, George K, Willingham V, Kawata T, Cucinotta F A. Comparison of F ratios generated from interphase and metaphase chromosome damage induced by high doses of low- and high-LET radiation. Radiation Research 2001; 155: 57–62
  • Wu H, Durante M, Furusawa Y, George K, Kawata T, Cucinotta F A. M-FISH analysis of chromosome aberrations in human fibroblasts exposed to energetic iron ions in vitro. Advances in Space Research 2003; 31: 1537–1542

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