143
Views
3
CrossRef citations to date
0
Altmetric
Flt3-1 and Bone Marrow Stromal Cells

Bone marrow stromal cells spontaneously produce Flt3-ligand: Influence of ionizing radiations and cytokine stimulation

, PhD, IRSN, DRPH/SRBE, LRTOX, , , , , & show all
Pages 659-667 | Received 29 Aug 2007, Accepted 27 Feb 2008, Published online: 03 Jul 2009

References

  • Bertho J M, Demarquay C, Frick J, Joubert C, Arenales S, Jacquet N, Aigueperse J, Gorin N C, Gourmelon P. Level of Flt3-ligand in plasma: A possible new bio-indicator for radiation-induced aplasia. International Journal of Radiation Biology 2001; 77: 703–712
  • Chamberlain G, Fox J, Ashton B, Middleton J. Mesenchymal stem cells: Their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 2007; 25: 2739–2749
  • Chiang C S, McBride W H. Radiation enhances tumor necrosis factor α production by murine brain cells. Brain Research 1991; 566: 265–269
  • Chklovskaia E, Jansen W, Nissen C, Lyman S D, Rahner C, Landmann L, Wodnar-Filipowicz A. Mechanism of flt3 ligand expression in bone marrow failure: Translocation from intracellular stores to the surface of T lymphocytes after chemotherapy-induced suppression of hematopoiesis. Blood 1999; 93: 2595–2604
  • Chklovskaia E, Nissen C, Landmann L, Rahner C, Pfister O, Wodnar-Filipowicz A. Cell-surface trafficking and release of flt3 ligand from T lymphocytes is induced by common cytokine receptor γ-chain signalling and inhibited by cyclosporine A. Blood 2001; 97: 1027–1034
  • Dainiak N. Hematologic consequences of exposure to ionizing radiation. Experimental Hematology 2002; 30: 513–528
  • Dutreix J, Girinski T, Cosset J M, Bernard A, Pico J, Baume D, Bayle C, Benk V. Blood cell kinetics and total body irradiation. Radiotherapy & Oncology 1987; 9: 119–129
  • Fichelson S. The FLT3/FLK2 ligand: Structure, functions and prospects. European Cytokine Network 1998; 9: 7–22
  • Geddis A E, Linden H M, Kaushansky K. Thrombopoietin: A pan-hematopoietic cytokine. Cytokine and Growth Factor Review 2002; 13: 61–73
  • Hannum C, Culpepper J, Campbell D, McClanahan T, Zurawski S, Bazan J F, Kastelein R, Hudak S, Wagner J, Mattson J, Luh J, Duda G, Martina N, Peterson D, Menon S, Shanafelt A, Muench M, Kelner G, Namikawa R, Rennick D, Roncarolo M G, Zlotnik A, Rosnet O, Dubreuil P, Birnbaum D, Lee F. Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variants RNAs. Nature 1994; 368: 643–648
  • Huchet A, Belkacemi Y, Frick J, Prat M, Muresan-Kloos I, Altan D, Chapel A, Gorin N C, Gourmelon P, Bertho J M. Plasma Flt3 ligand concentration correlated with radiation-induced bone marrow damage during local fractionated radiotherapy. International Journal of Radiation Oncology, Biology, Physics 2003; 57: 508–515
  • Lisovsky M, Braun S E, Ge Y, Takahira H, Lu L, Savchenko V G, Lyman S D, Broxmeyer H E. Flt3-ligand production by human bone marrow stromal cells. Leukemia 1996; 10: 1012–1018
  • Louagie H, Van Eijkeren M, Philippe J, Thierens H, De Ridder L. Changes in peripheral blood lymphocyte subsets in patients undergoing radiotherapy. International Journal of Radiation Biology 1999; 75: 767–771
  • Lyman S D, James L, Johnson L, Brasel K, deVries P, Escobar S S, Downey H, Splett R R, Beckmann M P, McKenna H J. Cloning of the human homolog of the murine flt3 ligand: A growth factor for early hematopoietic progenitor cells. Blood 1994; 83: 2795–2801
  • Lyman S D, Seaberg M, Hanna R, Zappone J D, Brasel K, Abkowitz J L, Prchal J T, Schultz J C, Shahidi N T. Plasma/serum levels of flt3 ligand are low in normal individuals and highly elevated in patients with fanconi anemia and acquired aplastic anemia. Blood 1995; 86: 4091–4096
  • Maraskovsky E, Brasel K, Teepe M, Roux E R, Lyman S D, Shortman K, McKenna H J. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: Multiple dendritic cell populations identified. Journal of Experimental Medicine 1996; 184: 1953–1962
  • Matthews W, Jordan C T, Wiegand G W, Pardoll D, Lemischka I R. A receptor tyrosine kinase specific to hematopoietic stem cell and progenitor cell-enriched populations. Cell 1991; 65: 1143–1152
  • McClanahan T, Culpepper J, Campbell D, Wagner J, Franz-Bacon K, Mattson J, Tsai S, Luh J, Guimaraes M J, Mattei M G, Rosnet O, Birnbaum D, Hannum C H. Biochemical and genetic characterization of multiple splice variants of the flt3 ligand. Blood 1996; 88: 3371–3382
  • Müller K, Meineke V. Radiation-induced alterations in cytokine production by skin cells. Experimental Hematology 2007; 35: 96–104
  • Pittenger M F, Mackay A M, Beck S C, Jaiswal R K, Douglas R, Mosca J D, Moorman M A, Simonetti D W, Craig S, Marshak D R. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284: 143–147
  • Prat M, Demarquay C, Frick J, Thierry D, Gorin N C, Bertho J M. Radiation-induced increase in plasma Flt3 ligand concentration in mice: Evidence for the implication of several cell types. Radiation Research 2005; 163: 408–417
  • Prat M, Frick J, Laporte J P, Thierry D, Gorin N C, Bertho J M. Kinetics of plasma flt3 lignad concentration in hematopoietic stem cell transplanted patients. Leukemia & Lymphoma 2006; 47: 77–80
  • Rusten L S, Lyman S D, Veiby O P, Jacobsen S EW. The Flt3 ligand is a direct and potent stimulator of the growth of primitive and committed human CD34+ bone marrow progenitor cells in vitro. Blood 1996; 87: 1317–1325
  • Sherman M L, Datta R, Hallahan D E, Weichselbaum R R, Kufe D W. Regulation of tumor necrosis factor gene expression by ionizing radiation in human myeloid leukemia cells and peripheral blood monocytes. Journal of Clinical Investigation 1991; 87: 1794–1797
  • Solanilla A, Grosset C, Duchez P, Legembre P, Pitard V, Dupouy M, Belloc F, Viallard J F, Reiffers J, Boiron J M, Coulombel L, Ripoche J. Flt3-ligand induces adhesion of haematopoietic progenitor cells via a very late antigen (VLA)- 4- and VLA-5-dependent mechanism. British Journal of Haematology 2003; 120: 782–786
  • Solanilla A, Grosset C, Lemercier C, Dupouy M, Mahon F X, Schweitzer K, Reiffers J, Weksler B, Ripoche J. Expression of flt3 ligand by the endothelial cell. Leukemia 2000; 14: 153–162
  • Taichman R S. Blood and bone: Two tissues whose fates are intertwined to create the hematopoietic stem-cell niche. Blood 2005; 105: 2631–2639
  • Takeuchi Y, Fukumoto S, Matsumoto T. Relationship between actions of transforming growth factor (TGF)-β and cell surface expression of its receptors in clonal osteoblastic cells. Journal of Cellular Physiology 1995; 163: 315–321
  • Wodnar-Filipowicz A, Lyman S D, Gratwohl A, Tichelli A, Speck B, Nissen C. Flt3 ligand level reflects hematopoietic progenitor cell function in aplastic anemia and chemotherapy-induced bone marrow aplasia. Blood 1996; 88: 4493–4499

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.