P53 oncosuppressor influences selection of genomic imbalances in response to ionizing radiations in human osteosarcoma cell line SAOS-2

References

• Achanta G, Sasaki R, Feng L, Carew J S, Lu W, Pelicano H, Keating M J, Huang P. Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gamma. The EMBO Journal 2005; 24: 3482–3492
   PubMed Web of Science ®Google Scholar
• Albright N. Computer programs for the analysis of cellular survival data. Radiation Research 1987; 112: 331–340
   PubMed Web of Science ®Google Scholar
• Bache M, Dunst J, Wurl P, Frode D, Meye A, Schmidt H, Rath F W, Taubert H. G2/M checkpoint is p53-dependent and independent after irradiation in five human sarcoma cell lines. Anticancer Research 1999; 19: 1827–1832
   PubMed Web of Science ®Google Scholar
• Brusa G, Zuffa E, Hattinger C M, Serra M, Remondini D, Castellani G, Righi S, C. Campielli S, Pileri S, Zinzani P L, Gabriele A, Mancini M, Corrado P, Barbieri E, Santucci M A. Genomic imbalances associated with secondary acute leukemias in Hodgkin lymphoma. Oncology Reports 2007; 18: 1427–1434
   PubMed Web of Science ®Google Scholar
• Biswas G, Guha M, Avadhani N G. Mitochondria-to-nucleus stress signaling in mammalian cells: nature of nuclear gene targets, transcription regulation, and induced resistance to apoptosis. Gene 2005; 354: 132–139
   PubMed Web of Science ®Google Scholar
• Chen D, Yu Z, Zhu Z, Lopez C D. The p53 pathway promotes efficient mitochondrial DNA base excision repair in colorectal cancer cells. Cancer Research 2006; 66: 3485–3494
   PubMed Web of Science ®Google Scholar
• Cortopassi G A, Arnheim N. Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Research 1990; 18: 6927–6933
   PubMed Web of Science ®Google Scholar
• Dahm-Daphi J, Hubbe P, Horvath F, El-Awadi R A, Bouffard K E, Powell S N, Willers H. Nonhomologous end-joining of site-specific but not of radiation-induced DNA double-strand breaks is reduced in the presence of wild-type p53. Oncogene 2005; 24: 1663–1672
   PubMed Web of Science ®Google Scholar
• de Souza-Pinto N C, Harris C C, Bohr V A. P53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria. Oncogene 2004; 23: 6559–6568
   Google Scholar
• Gatz S A, Wiesmuller L. p53 in recombination and repair. Cell Death and Differentiation 2006; 13: 1003–1016
   PubMed Web of Science ®Google Scholar
• Hanawalt P C. Subpathways of nucleotide excision repair and their regulation. Oncogene 2002; 21: 8949–8956
   PubMed Web of Science ®Google Scholar
• Hattinger C M, Reverter-Branchat G, Remondini D, Castellani G, Benini S, Pasello M, Manara M C, Scotlandi K, Picci P, Serra M. Genomic imbalances associated with methotrexate resistance in human osteosarcoma cell lines detected by comparative genomic hybridization-based techniques. European Journal of Cell Biology 2003; 82: 483–493
   PubMed Web of Science ®Google Scholar
• Hellwinkel O J, Muller J, Pollmann A, Kabisch H. Osteosarcoma cell lines display variable individual reactions on wildtype p53 and Rb tumour-suppressor transgenes. Journal of Gene Medicine 2005; 7: 407–419
   PubMed Web of Science ®Google Scholar
• Huo J X, Metz S A, Li G D. P53-independent induction of p21 (waf1/cip1) contributes to the activation of caspases in GTP-depletion-induced apoptosis of insulin-secreting cells. Cell Death and Differentiation 2004; 11: 99–109
   PubMed Web of Science ®Google Scholar
• Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 1999; 283: 1321–1325
   PubMed Web of Science ®Google Scholar
• Khanna K K, Jackson S P. DNA double-strand breaks: Signaling, repair and the cancer connection. Nature Genetics 2001; 27: 247–254
   PubMed Web of Science ®Google Scholar
• Lavin M F, Gueven N. The complexity of p53 stabilization and activation. Cell Death and Differentiation 2006; 13: 941–950
   PubMed Web of Science ®Google Scholar
• Lengner C J, Steinman H A, Gagnon J, Smith T W, Henderson J E, Kream B E, Stein G S, Lian J B, Jones S N. Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling. The Journal of Cell Biology 2006; 172: 909–921
   PubMed Web of Science ®Google Scholar
• Lorimore S A, Wright E G. Radiation-induced genomic instability and bystander effects: Related inflammatory-type responses to radiation-induced stress and injury? A review. International Journal of Radiation Biology 2003; 79: 15–25
   PubMed Web of Science ®Google Scholar
• Man T K, Lu X Y, Jaeweon K, Perlaki L, Harris C P, Shah S, Ladanyi M, Gorlick R, Lau C C, Rao P H. Genome-wide array comparative genomic hybridization analysis reveals distinct amplifications in osteosarcoma. BMC Cancer 2004; 4: 45
   PubMed Web of Science ®Google Scholar
• Mancini M, Brusa G, Zuffa E, Corrado P, Martinelli G, Grafone T, Barbieri E, Santucci M A. Persistent Cdk2 inactivation drives growth arrest of BCR-ABL-expressing cells in response to dual inhibitor of SRC and ABL kinases SKI606. Leukaemia Research 2007; 31: 979–987
   PubMed Web of Science ®Google Scholar
• Mao J H, Li J, Jiang T, Li Q, Wu D, Perez-Losada J, DelRosario R, Peterson L, Balmain A, Cai W W. Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice. Oncogene 2005; 24: 7924–7934
   PubMed Web of Science ®Google Scholar
• Marina N, Gebhardt M, Teot L, Gotlick R. Biology and therapeutic advances for pediatric osteosarcoma. Oncologist 2004; 9: 422–441
   PubMed Web of Science ®Google Scholar
• Okaichi K, Wang L H, Ihara M, Okumura Y. Sensitivity to ionizing radiation in Saos-2 cells transfected with mutant p53 genes depends on the mutation position. Journal of Radiation Research 1998; 39: 111–118
   PubMed Web of Science ®Google Scholar
• Overholtzer M, Rao P H, Favis R, Lu X Y, Elowitz M B, Barany F, Ladanyi M, Gorlick R, Levine A J. The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability. Proceedings of the National Academy of Sciences of the United States of America 2003; 100: 11547–11552
   PubMed Web of Science ®Google Scholar
• Ozaki T, Schaefer K L, Wai D, Buerger H, Flege S, Lindner N, Kevric M, Diallo R, Bankfalvi A, Poremba C. Genetic imbalances revealed by comparative genomic hybridization in osteosarcomas. International Journal of Cancer 2002; 102: 355–365
   PubMed Web of Science ®Google Scholar
• Pelicano H, Feng L, Zhou Y, Carew J S, Hileman E O, Plunkett W, Keating M J, Huang P. Inhibition of mitochondrial respiration: A novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism. Journal of Biological Chemistry 2003; 278: 37832–37839
   PubMed Web of Science ®Google Scholar
• Prithivirajsingh S, Story M D, Bergh S A, Geara F B, Ang K K, Ismail S M, Stevens C W, Buchholz T A, Brock E A. Accumulation of the common mitochondrial DNA deletion induced by ionizing radiation. FEBS Letters 2004; 571: 227–232
   PubMed Web of Science ®Google Scholar
• Soddu S, Blandino G, Citro G, Scardigli R, Piaggio G, Ferber A, Calabretta B, Sacchi A. Wild-type p53 gene expression induces granulocytic differentiation of HL-60 cells. Blood 1994; 83: 2230–2237
   PubMed Web of Science ®Google Scholar
• Squire J A, Pei J, Marrano P, Beheshti B, Bayani J, Lim G, Moldovan L, Zielenska M. High-resolution mapping of amplifications and deletions in pediatric osteosarcoma by use of CGH analysis of cDNA microarrays. Genes Chromosomes and Cancer 2003; 38: 215–225
   PubMed Web of Science ®Google Scholar
• Stock C, Kager L, Fink F M, Gadner H, Ambros P F. Chromosomal regions involved in the pathogenesis of osteosarcomas. Genes Chromosomes and Cancer 2000; 28: 329–336
   PubMed Web of Science ®Google Scholar
• Stuart J A, Hashiguchi K, Wilson 3rd D M, Copeland W C, Souza-Pinto N C, Bohr V A. DNA base excision repair activities and pathway function in mitochondrial and cellular lysates from cells lacking mitochondrial DNA. Nucleic Acids Research 2004; 32: 2181–2192
   PubMed Web of Science ®Google Scholar
• Suzuki K, Mori I, Nakayama Y, Miyakoda M, Kodama S, Watanabe M. Radiation-induced senescence-like growth arrest requires TP53 function but not telomere shortening. Radiation Research 2001; 155: 248–253
   PubMed Web of Science ®Google Scholar
• Suzuki K, Ojima M, Kodama S, Watanabe M. Radiation-induced DNA damage and delayed induced genomic instability. Oncogene 2003; 22: 6988–6993
   PubMed Web of Science ®Google Scholar
• Szak S T, Mays D, Pietenpol J A. Kinetics of p53 binding to promoter sites in vivo. Molecular and Cellular Biology 2001; 21: 3375–3386
   PubMed Web of Science ®Google Scholar
• Tarkkanen M, Elomaa I, Blomqvist C, Kivioja A H, Kellokumpu-Lehtinen P, Bohling T, Valle J, Knuutila S. DNA sequence copy number increase at 8q: A potential new prognostic marker in high-grade osteosarcoma. International Journal of Cancer 1999; 84: 114–121
   PubMed Web of Science ®Google Scholar
• Ternovoi V V, Curiel D T, Smith B F, Siegal G P. Adenovirus-mediated p53 tumor suppressor gene therapy of osteosarcoma. Laboratory Investigation 2006; 86: 748–766
   PubMed Web of Science ®Google Scholar
• Yakes F M, Van Houten B. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proceedings of the National Academy of Sciences of the United States of America 1997; 94: 514–519
   PubMed Web of Science ®Google Scholar
• Zhou J, Ahn J, Wilson S H, Prives C. A role for p53 in base excision repair. The EMBO Journal 2001; 20: 914–923
   PubMed Web of Science ®Google Scholar
• Zielenska M, Bayani J, Pandita A, Toledo S, Marrano P, Andrade J, Petrilli A, Thorner P, Sorensen P, Squire J A. Comparative genomic hybridization analysis identifies gains of 1p35 approximately p36 and chromosome 19 in osteosarcoma. Cancer Genetics and Cytogenetics 2001; 130: 14–21
   PubMed Web of Science ®Google Scholar