371
Views
67
CrossRef citations to date
0
Altmetric
Bone Marrow Radioprotection by Genistein

Genistein induces radioprotection by hematopoietic stem cell quiescence

, PhD, , , &
Pages 713-726 | Received 12 Feb 2008, Accepted 25 Jun 2008, Published online: 03 Jul 2009

References

  • Arai F, Suda T. Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche. Annals of the New York Academy of Sciences 2007; 1106: 41–53
  • Banker D E, Groudine M, Willman C L, Norwood T, Appelbaum F R. Cell cycle perturbations in acute myeloid leukemia samples following in vitro exposures to therapeutic agents. Leukemia Research 1998; 22: 221–239
  • Bertoncello I, Kriegler A B, Woodcock D M, Williams B, Barber L, Nilsson S K. Haematopoietic radioprotection by Cremophor EL: A polyethoxylated castor oil. International Journal of Radiation Biology 1995; 67: 57–64
  • Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown J P, Sedivy J M, Kinzler K W, Vogelstein B. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998; 282: 1497–1501
  • Calvi L M, Adams G B, Weibrecht K W, Weber J M, Olson D P, Knight M C, Martin R P, Schipani E, Divieti P, Bringhurst F R, Milner L A, Kronenberg H M, Scadden D T. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 2003; 425: 841–846
  • Cheng T, Rodrigues N, Shen H, Yang Y, Dombkowski D, Sykes M, Scadden D T. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 2000; 287: 1804–1808
  • Cheshier S H, Morrison S J, Liao X, Weissman I L. In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells. Proceedings of the National Academy of Sciences USA 1999; 96: 3120–3125
  • Davis T A, Clarke T K, Mog S R, Landauer M R. Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survival. International Journal of Radiation Biology 2007; 83: 141–151
  • Day R M, Kupper-Barshishat M, Mog S R, McCart E A, Prasanna P GS, Davis T A, Landauer M R. Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation. Journal of Radiation Research 2008; 49: 361–372
  • Hanahan D, Weinberg R A. The hallmarks of cancer. Cell 2000; 100: 57–70
  • Harper J W, Adami G R, Wei N, Keyomarsi K, Elledge S J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993; 75: 805–816
  • Harrison D E, Lerner C P. Most primitive hematopoietic stem cells are stimulated to cycle rapidly after treatment with 5-fluorouracil. Blood 1991; 78: 1237–1240
  • Hermann R M, Fest J, Christiansen H, Hille A, Rave-Frank M, Nitsche M, Grundker C, Viereck V, Jarry H, Schmidberger H. Radiosensitization dependent on p53 function in bronchial carcinoma cells by the isoflavone genistein and estradiol in vitro. Strahlentherapie und Onkologie 2007; 183: 195–202
  • Hillman G G, Forman J D, Kucuk O, Yudelev M, Maughan R L, Rubio J, Layer A, Tekyi-Mensah S, Abrams J, Sarkar F H. Genistein potentiates the radiation effect on prostate carcinoma cells. Clinical Cancer Research 2001; 7: 382–390
  • Hillman G G, Wang Y, Che M, Raffoul J J, Yudelev M, Kucuk O, Sarkar F H. Progression of renal cell carcinoma is inhibited by genistein and radiation in an orthotopic model. BMC Cancer 2007; 7: 4
  • Hodgson G S, Bradley T R, Radley J M. The organization of hemopoietic tissue as inferred from the effects of 5-fluorouracil. Experimental Hematology 1982; 10: 26–35
  • Jetmore A, Plett P A, Tong X, Wolber F M, Breese R, Abonour R, Orschell-Traycoff C M, Srour E F. Homing efficiency, cell cycle kinetics, and survival of quiescent and cycling human CD34(+) cells transplanted into conditioned NOD/SCID recipients. Blood 2002; 99: 1585–1593
  • Landauer M R, Castro C A, Benson K A, Hogan J B, Weiss J F. Radioprotective and locomotor responses of mice treated with nimodipine alone and in combination with WR-151327. Journal of Applied Toxicology 2001; 21: 25–31
  • Landauer M R, Srinivasan V, Seed T M. Genistein treatment protects mice from ionizing radiation injury. Journal of Applied Toxicology 2003; 23: 379–385
  • Li Z, Li J, Mo B, Hu C, Liu H, Qi H, Wang X, Xu J. Genistein induces G(2)/M cell cycle arrest via stable activation of ERK1/2 pathway in MDA-MB-231 breast cancer cells. Cell Biology and Toxicology 2008, in press
  • Matsukawa Y, Marui N, Sakai T, Satomi Y, Yoshida M, Matsumoto K, Nishino H, Aoike A. Genistein arrests cell cycle progression at G2-M. Cancer Research 1993; 53: 1328–1331
  • Mauch P, Constine L, Greenberger J, Knospe W, Sullivan J, Liesveld J L, Deeg H J. Hematopoietic stem cell compartment: Acute and late effects of radiation therapy and chemotherapy. International Journal of Radiation Oncology, Biology, Physics 1995; 31: 1319–1339
  • McPherson C. Reduction of Psuedomonas aeruginosa and coliform bacteria in mouse drinking water following treatment with hyrdochloric acid and chlorine. Laboratory Animal Care 1963; 13: 737–744
  • Mohammad R M, Al-Katib A, Aboukameel A, Doerge D R, Sarkar F, Kucuk O. Genistein sensitizes diffuse large cell lymphoma to CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy. Molecular Cancer Therapeutics 2003; 2: 1361–1368
  • Moos W S, LeVan H, Mason H C. Radioprotective effects of dimethyl sulfoxide vapor on mice. Experientia 1967; 23: 923
  • Morrison S J, Weissman I L. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity 1994; 1: 661–673
  • Orschell-Traycoff C M, Hiatt K, Dagher R N, Rice S, Yoder M C, Srour E F. Homing and engraftment potential of Sca-1(+)Lin(−) cells fractionated on the basis of adhesion molecule expression and position in cell cycle. Blood 2000; 96: 1380–1387
  • Papazisis K T, Zambouli D, Kimoundri O T, Papadakis E S, Vala V, Geromichalos G D, Voyatzi S, Markala D, Destouni E, Boutis L, Kortsaris A H. Protein tyrosine kinase inhibitor, genistein, enhances apoptosis and cell cycle arrest in K562 cells treated with gamma-irradiation. Cancer Letters 2000; 160: 107–113
  • Passegue E, Wagers A J, Giuriato S, Anderson W C, Weissman I L. Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. The Journal of Experimental Medicine 2005; 202: 1599–1611
  • Pawlik T M, Keyomarsi K. Role of cell cycle in mediating sensitivity to radiotherapy. Journal of Radiation Oncology, Biology, Physics 2004; 59: 928–942
  • Raffoul J J, Wang Y, Kucuk O, Forman J D, Sarkar F H, Hillman G G. Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest. BMC Cancer 2006; 6: 107
  • Rosen E M, Fan S, Rockwell S, Goldberg I D. The molecular and cellular basis of radiosensitivity: Implications for understanding how normal tissues and tumors respond to therapeutic radiation. Cancer Investigation 1999; 17: 56–72
  • Shaeffer J, Schellenberg K A. Polyethylene glycol as a protector against head and neck irradiation. Journal of Radiation Oncology, Biology, Physics 1984; 10: 2329–2333
  • Srour E F, Jetmore A, Wolber F M, Plett P A, Abonour R, Yoder M C, Orschell-Traycoff C M. Homing, cell cycle kinetics and fate of transplanted hematopoietic stem cells. Leukemia 2001; 15: 1681–1684
  • Steinman R A. Cell cycle regulators and hematopoiesis. Oncogene 2002; 21: 3403–3413
  • Stott F J, Bates S, James M C, McConnell B B, Starborg M, Brookes S, Palmero I, Ryan K, Hara E, Vousden K H, Peters G. The alternative product from the human Cdkn2a locus, p14(Arf), participates in a regulatory feedback loop with p53 and Mdm2. EMBO Journal 1998; 17: 5001–5014
  • Tamulevicius P, Wang M, Iliakis G. Homology-directed repair is required for the development of radioresistance during S phase: Interplay between double-strand break repair and checkpoint response. Radiation Research 2007; 167: 1–11
  • Tanaka T, Halicka H D, Traganos F, Darzynkiewicz Z. Phosphorylation of histone H2AX on ser 139 and activation of ATM during oxidative burst in phorbol ester-treated human leukocytes. Cell Cycle 2006; 5: 2671–2675
  • Tanaka T, Kajstura M, Halicka H D, Traganos F, Darzynkiewicz Z. Constitutive histone H2AX phosphorylation and ATM activation are strongly amplified during mitogenic stimulation of lymphocytes. Cell Proliferation 2007; 40: 1–13
  • Traganos F, Ardelt B, Halko N, Bruno S, Darzynkiewicz Z. Effects of genistein on the growth and cell cycle progression of normal human lymphocytes and human leukemic Molt-4 and HL-60 cells. Cancer Research 1992; 52: 6200–6208
  • Valachovicova T, Slivova V, Sliva D. Cellular and physiological effects of soy flavonoids. Mini Reviews in Medicinal Chemistry 2004; 4: 881–887
  • Walkley C R, Fero M L, Chien W M, Purton L E, McArthur G A. Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells. Nature Cell Biology 2005; 7: 172–178
  • Wang Y, Schulte B A, Zhou D. Hematopoietic stem cell senescence and long-term bone marrow injury. Cell Cycle 2006; 5: 35–38
  • Wlodarski P, Wasik M, Ratajczak M Z, Sevignani C, Hoser G, Kawiak J, Gewirtz A M, Calabretta B, Skorski T. Role of p53 in hematopoietic recovery after cytotoxic treatment. Blood 1998; 91: 2998–3006
  • Yang L, Bryder D, Adolfsson J, Nygren J, Mansson R, Sigvardsson M, Jacobsen S E. Identification of Lin(−)Sca1(+)kit(+)CD34(+)Flt3(−) short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients. Blood 2005; 105: 2717–2723
  • Yashar C M, Spanos W J, Taylor D D, Gercel-Taylor C. Potentiation of the radiation effect with genistein in cervical cancer cells. Gynecologic Oncology 2005; 99: 199–205
  • Yellayi S, Naaz A, Szewczykowski M A, Sato T, Woods J A, Chang J, Segre M, Allred C D, Helferich W G, Cooke P S. The phytoestrogen genistein induces thymic and immune changes: A human health concern?. Proceedings of the National Academy of Sciences USA 2002; 99: 7616–7621
  • Yousefi S, Green D R, Blaser K, Simon H U. Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils. Proceedings of the National Academy of Sciences USA 1994; 91: 10868–10872
  • Zinberg N, Kohn A. Dimethyl sulfoxide protection of bone marrow cells of mice against X-ray damage. Israeli Journal of Medical Science 1971; 7: 713–718

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.