73
Views
8
CrossRef citations to date
0
Altmetric
Molecular Responses to Non-Ionizing Radiation

Radiofrequency radiation does not significantly affect ornithine decarboxylase activity, proliferation, or caspase-3 activity of fibroblasts in different physiological conditions

, , &
Pages 727-733 | Received 12 Feb 2008, Accepted 25 Jun 2008, Published online: 03 Jul 2009

References

  • Auvinen M, Paasinen A, Andersson L C, Hölttä E. Ornithine decarboxylase activity is critical for cell transformation. Nature 1992; 360: 355–358
  • Azadniv M, Klinge C M, Gelein R, Carstensen E L, Cox C, Brayman A A, Miller M W. A test of the hypothesis that a 60-Hz magnetic field affects ornithine decarboxylase activity in mouse L929 cells in vitro. Biochemical and Biophysical Research Communications 1995; 214: 627–631
  • Byus C V, Kartun K, Pieper S, Adey W R. Increased ornithine decarboxylase activity in cultured cells exposed to low energy modulated microwave fields and phorbol ester tumor promoters. Cancer Research 1988; 48: 4222–4226
  • Capri M, Scarcella E, Bianchi E, Fumelli C, Mesirca P, Agostini C, Remondini D, Schuderer J, Kuster N, Franceschi C, Bersani F. 1800 MHz radiofrequency (mobile phones, different global system for mobile communication modulations) does not affect apoptosis and heat shock protein 70 level in peripheral blood mononuclear cells from young and old donors. International Journal of Radiation Biology 2004a; 80: 389–397
  • Capri M, Scarcella E, Fumelli C, Bianchi E, Salvioli S, Mesirca P, Agostini C, Antolini A, Schiavoni A, Castellani G, Bersani F, Franceschi C. In vitro exposure of human lymphocytes to 900 MHz CW and GSM modulated radiofrequency: Studies of proliferation, apoptosis and mitochondrial membrane potential. Radiation Research 2004b; 162: 211–218
  • Caraglia M, Marra M, Mancinelli F, D'Ambrosio G, Massa R, Giordano A, Budillon A, Abbruzzese A, Bismuto E. Electromagnetic fields at mobile phone frequency induce apoptosis and inactivation of the multi-chaperone complex in human epidermoid cancer cells. Journal of Cellular Physiology 2005; 204: 539–548
  • Chauhan V, Mariampillai A, Kutzner B C, Wilkins R C, Ferrarotto C, Bellier P V, Marro L, Gajda G B, Lemay E, Thansandote A, McNamee J P. Evaluating the biological effects of intermittent 1.9 GHz pulse-modulated radiofrequency fields in a series of human-derived cell lines. Radiation Research 2007; 167: 87–93
  • Cleary S F, Du Z, Cao G, Liu L M, McCrady C. Effect of isothermal radiofrequency radiation on cytolytic T lymphocytes. The FASEB Journal 1996; 10: 913–919
  • Cleary S F, Liu L M, Merchant R E. Glioma proliferation modulated in vitro by isothermal radiofrequency radiation exposure. Radiation Research 1990a; 121: 38–45
  • Cleary S F, Liu L M, Merchant R E. In vitro lymphocyte proliferation induced by radio-frequency electromagnetic radiation under isothermal conditions. Bioelectromagnetics 1990b; 11: 47–56
  • Desta A B, Owen R D, Cress L W. Non-thermal exposure to radiofrequency energy from digital wireless phones does not affect ornithine decarboxylase activity in L929 cells. Radiation Research 2003; 160: 488–491
  • Gurisik E, Warton K, Martin D K, Valenzuela S M. An in vitro study of the effects of exposure to a GSM signal in two human cell lines: Monocytic U937 and neuroblastoma SK-N-SH. Cell Biology International 2006; 30: 793–799
  • Hirose H, Sakuma N, Kaji N, Suhara T, Sekijima M, Nojima T, Miyakoshi J. Phosphorylation and gene expression of p53 are not affected in human cells exposed to 2.1425 GHz band CW or W-CDMA modulated radiation allocated to mobile radio base stations. Bioelectromagnetics 2006; 27: 494–504
  • Hook G J, Spitz D R, Sim J E, Higashikubo R, Baty J D, Moros E G, Roti Roti J L. Evaluation of parameters of oxidative stress after in vitro exposure to FMCW- and CDMA-modulated radiofrequency radiation fields. Radiation Research 2004a; 162: 497–504
  • Hook G J, Zhang P, Lagroye I, Li L, Higashikubo R, Moros E G, Straube W L, Pickard W F, Baty J D, Roti Roti J L. Measurement of DNA damage and apoptosis in molt-4 cells after in vitro exposure to radiofrequency radiation. Radiation Research 2004b; 161: 193–200
  • Höytö A, Juutilainen J, Naarala J. Ornithine decarboxylase activity is affected in primary astrocytes but not in secondary cell lines exposed to 872 MHz RF radiation. International Journal of Radiation Biology 2007a; 83: 367–374
  • Höytö A, Juutilainen J, Naarala J. Ornithine decarboxylase activity of L929 cells after exposure to continuous wave or 50 Hz modulated radiofrequency radiation – a replication study. Bioelectromagnetics 2007b; 28: 501–508
  • Höytö A, Sihvonen A-P, Alhonen L, Juutilainen J, Naarala J. Modest increase in temperature affects ODC activity in L929 cells: Low-level radiofrequency radiation does not. Radiation and Environmental Biophysics 2006; 45: 231–235
  • Joubert V, Bourthoumieu S, Leveque P, Yardin C. Apoptosis is induced by radiofrequency fields through the caspase-independent mitochondrial pathway in cortical neurons. Radiation Research 2008; 169: 38–45
  • Joubert V, Leveque P, Cueille M, Bourthoumieu S, Yardin C. No apoptosis is induced in rat cortical neurons exposed to GSM phone fields. Bioelectromagnetics 2007; 28: 115–121
  • Joubert V, Leveque P, Rametti A, Collin A, Bourthoumieu S, Yardin C. Microwave exposure of neuronal cells in vitro: Study of apoptosis. International Journal of Radiation Biology 2006; 82: 267–275
  • Krause D, Mullins J M, Penafiel L M, Meister R, Nardone R M. Microwave exposure alters the expression of 2-5A-dependent RNase. Radiation Research 1991; 127: 164–170
  • Kwee S, Raskmark P. Changes in cell proliferation due to environmantal non-ionizing radiation 2. Microwave radiation. Bioelectrochemistry and Bioenergetics 1998; 44: 251–255
  • Lantow M, Viergutz T, Weiss D G, Simko M. Comparative study of cell cycle kinetics and induction of apoptosis or necrosis after exposure of human mono mac 6 cells to radiofrequency radiation. Radiation Research 2006; 166: 539–543
  • Litovitz T A, Krause D, Penafiel M, Elson E C, Mullins J M. The role of coherence time in the effect of microwaves on ornithine decarboxylase activity. Bioelectromagnetics 1993; 14: 395–403
  • Litovitz T A, Penafiel L M, Farrel J M, Krause D, Meister R, Mullins J M. Bioeffects induced by exposure to microwaves are mitigated by superposition of ELF noise. Bioelectromagnetics 1997; 18: 422–430
  • Lixia S, Yao K, Kaijun W, Deqiang L, Huajun H, Xiangwei G, Baohong W, Wei Z, Jianling L, Wei W. Effects of 1.8 GHz radiofrequency field on DNA damage and expression of heat shock protein 70 in human lens epithelial cells. Mutation Research 2006; 602: 135–142
  • Marinelli F, La Sala D, Cicciotti G, Cattini L, Trimarchi C, Putti S, Zamparelli A, Giuliani L, Tomassetti G, Cinti C. Exposure to 900 MHz Electromagnetic field induces an unbalance between pro-apoptotic and pro-survival signals in T-lymphoblastoid leukemia CCRF-CEM cells. Journal of Cellular Physiology 2004; 198: 324–332
  • Markkanen A, Penttinen P, Naarala J, Pelkonen J, Sihvonen A P, Juutilainen J. Apoptosis induced by ultraviolet radiation is enhanced by amplitude modulated radiofrequency radiation in mutant yeast cells. Bioelectromagnetics 2004; 25: 127–133
  • Merola P, Marino C, Lovisolo G A, Pinto R, Laconi C, Negroni A. Proliferation and apoptosis in a neuroblastoma cell line exposed to 900 MHz modulated radiofrequency field. Bioelectromagnetics 2006; 27: 164–171
  • Nicholson D W, Thornberry N A. Caspases: killer proteases. Trends in Biochemical Sciences 1997; 22: 299–306
  • Nikolova T, Czyz J, Rolletschek A, Blyszczuk P, Fuchs J, Jovtchev G, Schuderer J, Kuster N, Wobus A M. Electromagnetic fields affect transcript levels of apoptosis-related genes in embryonic stem cell-derived neural progenitor cells. The FASEB Journal 2005; 19: 1686–1688
  • O'Brien T G, Diamond L. Ornithine decarboxylase induction and DNA synthesis in hamster embryo cell cultures treated with tumor-promoting phorbol diesters. Cancer Research 1977; 37: 3895–3900
  • Peinnequin A, Piriou A, Mathieu J, Dabouis V, Sebbah C, Malabiau R, Debouzy J C. Non-thermal effects of continuous 2.45 GHz microwaves on fas-induced apoptosis in human jurkat T-cell line. Bioelectrochemistry 2000; 51: 157–161
  • Penafiel L M, Litovitz T, Krause D, Desta A, Mullins J M. Role of modulation on the effect of microwaves on ornithine decarboxylase activity in L929 cells. Bioelectromagnetics 1997; 18: 132–141
  • Port M, Abend M, Romer B, Van Beuningen D. Influence of high-frequency electromagnetic fields on different modes of cell death and gene expression. International Journal of Radiation Biology 2003; 79: 701–708
  • Sanchez S, Milochau A, Ruffie G, Poulletier de Gannes F, Lagroye I, Haro E, Surleve-Bazeille J E, Billaudel B, Lassegues M, Veyret B. Human skin cell stress response to GSM-900 mobile phone signals. In vitro study on isolated primary cells and reconstructed epidermis. FEBS Journal 2006; 273: 5491–5507
  • Scarfi M R, Fresegna A M, Villani P, Pinto R, Marino C, Sarti M, Altavista P, Sannino A, Lovisolo G A. Exposure to radiofrequency radiation (900 MHz, GSM signal) does not affect micronucleus frequency and cell proliferation in human peripheral blood lymphocytes: An interlaboratory study. Radiation Research 2006; 165: 655–663
  • Stagg R B, Thomas W J, Jones R A, Adey W R. DNA synthesis and cell proliferation in C6 glioma and primary glial cells exposed to an 836.55 MHz modulated radiofrequency field. Bioelectromagnetics 1997; 18: 230–236
  • Thomas T, Thomas T J. Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications. Cellular and Molecular Life Sciences 2001; 58: 244–258
  • Takashima Y, Hirose H, Koyama S, Suzuki Y, Taki M, Miyakoshi J. Effects of continuous and intermittent exposure to RF fields with a wide range of SARs on cell growth, survival, and cell cycle distribution. Bioelectromagnetics 2006; 27: 392–400
  • Velizarov S, Raskmark P, Kwee S. The effects of radiofrequency fields on cell proliferation are non-thermal. Bioelectrochemistry and Bioenergetics 1999; 48: 177–180
  • Vijayalaxmi N Mohan, Meltz M L, Wittler M A. Proliferation and cytogenetic studies in human blood lymphocytes exposed in vitro to 2450 MHz radiofrequency radiation. International Journal of Radiation Biology 1997; 72: 751–757

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.