678
Views
57
CrossRef citations to date
0
Altmetric
50th Anniversary Review

Response of heterogeneous ribonuclear proteins (hnRNP) to ionising radiation and their involvement in DNA damage repair

, , & , PhD
Pages 643-655 | Received 19 Sep 2008, Accepted 21 Apr 2009, Published online: 13 Aug 2009

References

  • Abraham R T. PI 3-kinase related kinases: ‘Big’ players in stress-induced signaling pathways. DNA Repair 2004; 3: 883–887
  • Barenco M, Tomescu D, Brewer D, Callard R, Stark J, Hubank M. Ranked prediction of p53 targets using hidden variable dynamic modeling. Genome Biology 2006; 7: R25
  • Barker S, Weinfeld M, Sheng J, Li L, Murray D. Identification of mammalian proteins cross-linked to DNA by ionising radiation. Journal of Biological Chemistry 2005; 280: 33826–33838
  • Beals C R, Sheridan C M, Turck C W, Gardner P, Crabtree G R. Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science 1997; 275: 1930–1934
  • Berggren M, Gallegos A, Gasdaska J R, Gasdaska P Y, Warneke J, Powis G. Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia. Anticancer Research 1996; 16: 3459–3466
  • Beyer A L, Christensen M E, Walker B W, Lestourgeon W M. Identification and characterisation of the packaging proteins of core 40S hnRNP particles. Cell 1977; 11: 127–138
  • Bomsstyk K, Van Seuningen I, Susuki H, Denisenko O, Ostrowski J. Diverse molecular interactions of the hnRNP K protein. FEBS Letters 1997; 403: 113–115
  • Bullock A N, Fersht A R. Rescuing the function of mutant p 53. Nature Reviews Cancer 2001; 1: 68–76
  • Burd C G, Swanson M S, Gorlach M, Dreyfuss G. Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: A diversity of RNA binding proteins is generated by small peptide inserts. Proceedings of the National Academy of Sciences of the USA 1989; 86: 9788–9792
  • Caceres J F, Stamm S, Helfman D M, Krainer A R. Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science 1994; 265: 1706–1709
  • Calvio C, Neubauer G, Mann M, Lamond A I. Identification of hnRNP P2 as TLS/FUS using electrospray mass spectrometry. RNA 1995; 1: 724–733
  • Crosat A, Aman P, Mandahl N, Ron D. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature 1993; 363: 640–644
  • Dai J M, Sun D C, Lin R X, Yang J, Lou S, Wang S Q. Microarray analysis of differentially expressed genes in mouse bone marrow tissues after ionising radiation. International Journal of Radiation Biology 2006; 82: 511–521
  • Dallaire F, Dupuis S, Fiset S, Chabot B. Heterogeneous nuclear ribonucleoprotein A1 and UP1 protect mammalian telomeric repeats and modulate telomere replication in vitro. Journal of Biological Chemistry 2000; 275: 14509–14516
  • Delattre O, Sucman J, Plougastel B, Desmase C, Melot T, Peter M, Kovar H, Joubert I, De Jong P, Rouleau G. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature 1992; 359: 162–165
  • Denko N, Schindler C, Koong A, Laderoute K, Green C, Giaccia A. Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment. Clinical Cancer Research 2000; 6: 480–487
  • Dreyfuss G, Kim V N, Kataoka N. Messenger-RNA-binding proteins and the messages they carry. Nature Reviews Molecular Cell Biology 2002; 3: 195–205
  • Dreyfuss G, Matunis M J, Pihol-Roma S. hnRNP proteins and the biogenesis of mNA. Annual Review of Biochemistry 1993; 62: 289–321
  • Edick M J, Cheng C, Yang W, Cheok M, Wilkinson M R, Pei D, Evans W E, Kun L E, Pui C H, Relling M V. Lymphoid gene expression as a predictor of risk of secondary brain tumors. Genes Chromosomes and Cancer 2005; 42: 107–116
  • Efeyan A, Serrano M. p53: Guardian of the genome and policeman of the oncogenes. Cell Cycle 2007; 6: 1006–1010
  • Fanning E, Klimovich V, Nager A R. A dynamic model for replication protein A (RPA) function in DNA processing pathways. Nucleic Acids Research 2006; 34: 4126
  • Fiset S, Chabot B. hnRNP A1 may interact simultaneously with telomeric DNA and the human telomerase RNA in vitro. Nucleic Acids Research 2001; 29: 2268–2275
  • Ford L P, Suh J M, Wright W E, Shay J W. Heterogeneous nuclear ribonucleoproteins C1 and C2 associate with the RNA component of human telomerase. Molecular and Cellular Biology 2000; 20: 9084–9091
  • Fornace A J, Alamo I, Hollander M C. DNA damage-inducible transcripts in mammalian cells. Proceedings of the National Academy of Sciences of the USA 1988; 85: 8800–8804
  • Funasaka Y, Ichihashi M. The effect of ultraviolet B induced adult T cell leukemia-derived factor/thioredoxin (ADF/TRX) on survival and growth of human melanocytes. Pigment Cell Research 1997; 10: 68–73
  • Gamble S C, Dunn M J, Wheeler C H, Joiner M C, Adu-Poku A, Arrand J E. Expression of proteins coincident with inducible radioprotection in human lung epithelial cells. Cancer Research 2000; 60: 2146–2151
  • Goto Y, Sueoka E, Chiba H, Fujiki H. Significance of heterogeneous nuclear ribonucleoprotein B1 as a new early detection marker for oral squamous cell carcinoma. Japanese Journal of Cancer Research 1999; 90: 1358–1363
  • Grogan T M, Fenoglio-Prieser C, Seheb R, Bellamy W, Frutiger Y, Vela E, Stemmerman G, Macdonald J, Richter L, Gallegos A. Thioredoxin, a putative oncogene product, is overexpressed in gastric carcinoma and associated with increased proliferation and increased cell survival. Human Pathology 2000; 31: 475–481
  • Guil S, Long J C, Cáceres J F. hnRNP A1 Relocalisation to the stress granules reflects a role in the stress response. Molecular and Cellular Biology 2006; 26: 5744–5758
  • Hamasaki M, Kamma H, Wu W, Kaneko S, Fujiwara M, Satoh H, Haraoka S, Kikuchi M, Shirakusa T. Expression of hnRNP B1 in four major histological types of lung cancers. Anticancer Research 2001; 21: 979–984
  • Henning W, Stürsbecher H W. Homologous recombination and cell cycle checkpoints: Rad51 in tumour progression and therapy resistance. Toxicology 2003; 193: 91–109
  • Iwanaga K, Sueoka N, Sato A, Hayashi S, Sueoka E. Heterogeneous nuclear ribonucleoprotein B1 protein impairs DNA repair mediated through the inhibition of DNA-dependent protein kinase activity. Biochemical and Biophysical Research Communications 2005; 333: 888–895
  • Jen K Y, Cheung V G. Transcriptional response of lymphoblastoid cells to ionising radiation. Genome Research 2003; 13: 2092–2100
  • Kamma H, Horiguchi H, Wan L, Matsui M, Fujiwara M, Fujimoto M, Yasawa T, Dreyfuss G. Molecular characterisation of the hnRNP A2/B1 proteins: Tissue-specific expression and novel isoforms. Experimental Cell Research 1999; 246: 399–411
  • Khodarev N N, Park J O, Yu J, Gupta N, Nodsenski E, Roisman B, Weichselbaum R R. Dose-dependent and independent temporal patterns of gene responses to ionising radiation in normal and tumor cells and tumor xenografts. Proceedings of the National Academy of Sciences of the USA 2001; 98: 12665–12670
  • Kiledjian M, Dreyfuss G. Primary structure and binding activity of the hnRNP U protein: Binding RNA through RGG box. EMBO Journal 1992; 11: 2655–2664
  • Kim L, Kimmel A R. GSK3, a master switch regulating cell-fate specification and tumorigenesis. Current Opinion Genetic Development 2000; 10: 508–514
  • Klimek-Tomcsak K, Wyrwics L S, Jain S, Bomsstyk K, Ostrowski J. Characterisation of hnRNP K protein-RNA interactions. Journal of Molecular Biology 2004; 342: 1131–1141
  • Krecic A M, Swanson M S. hnRNP complexes: Composition, structure, and function. Current Opinion Cell Biology 1999; 11: 363–371
  • Kuroda M, Sok J, Webb L, Baechtold H, Urano F, Yin Y, Chung P, De Rooij D G, Akhmedov A, Ashley T. Male sterility and enhanced radiation sensitivity in TLS−/−mice. EMBO Journal 2000; 19: 453–462
  • Labranche H, Dupuis S, Ben-David Y, Bani M R, Wellinger R J, Chabot B. Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase. Nature Genetics 1998; 19: 199–202
  • Lane D P. p 53, guardian of the genome. Nature 1992; 358: 15–16
  • Lécuyer E, Yoshida H, Parthasarathy N, Alm C, Babak T, Cerovina T, Hughes T R, Tomancak P, Krause H M. Global analysis of mRNA localisation reveals a prominent role in organising cellular architecture and function. Cell 2007; 131: 174–187
  • Lee S Y, Park J H, Kim S, Park E J, Yun Y, Kwon J. A proteomics approach for the identification of nucleophosmin and heterogeneous nuclear ribonucleoprotein C1/C2 as chromatin-binding proteins in response to DNA double-strand breaks. Biochemistry Journal 2005; 388: 7–15
  • Lin S, Lim S, Viani M A, Sapp M, Lim M S. Down-regulation of telomerase activity in malignant lymphomas by radiation and chemotherapeutic agents. American Journal of Pathology 2001; 159: 711–719
  • Ljungman M. The transcription stress response. Cell Cycle 2007; 6: 2252–2257
  • Matsuyama S, Goto Y, Sueoka N, Ohkura Y, Tanaka Y, Nakachi K, Sueoka E. Heterogeneous nuclear ribonucleoprotein B1 expressed in esophageal squamous cell carcinomas as a new biomarker for diagnosis. Cancer Science 2000; 91: 658–663
  • Mattick J S. Challenging the dogma: The hidden layer of non-protein-coding RNAs in complex organisms. BioEssays 2003; 25: 930–939
  • Mayeda A, Krainer A R. Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell 1992; 68: 365–375
  • Moumen A, Masterson P, O'Connor M J, Jackson S P. hnRNP K: An HDM2 target and transcriptional coactivator of p53 in response to DNA damage. Cell 2005; 123: 1065–1078
  • Nishiyama H, Itoh K, Kaneko Y, Kishishita M, Yoshida O, Fujita J. A Glycine-rich RNA-binding protein mediating cold-inducible suppression of mammalian cell growth. Journal of Cell Biology 1997; 137: 899–908
  • Pino I, Pio R, Toledo G, Sabalegui N, Vicent S, Rey N, Losano M D, Torre W, Garcia-Foncillas J, Montuenga L M. Altered patterns of expression of members of the heterogeneous nuclear ribonucleoprotein (hnRNP) family in lung cancer. Lung Cancer 2003; 41: 131–143
  • Pinol-Roma S, Dreyfuss G. Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm. Nature 1992; 355: 730–732
  • Rabbitts T H, Forster A, Larson R, Nathan P. Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t (12; 16) in malignant liposarcoma. Nature Genetics 1993; 4: 175–180
  • Rundhaug J E, Hawkins K A, Pavone A, Gaddis S, Kil H, Klein R D, Berton T R, Mccauley E, Johnson D G, Lubet R A. SAGE profiling of UV-induced mouse skin squamous cell carcinomas, comparison with acute UV irradiation effects. Molecular Carcinogenesis 2005; 42: 40–52
  • San Filippo J, Sung P, Klein H. Mechanism of eukaryotic homologous recombination. Annual Review of Biochemistry 77:229–257. 2008
  • Sheikh M S, Carrier F, Papathanasiou M A, Hollander M C, Shan Q, Yu K, Fornace A J. Identification of several human homologs of hamster DNA damage-inducible transcripts cloning and characterisation of a novel UV-inducible cDNA that codes for a putative RNA-binding protein. Journal of Biological Chemistry 1997; 272: 26720–26726
  • Sheikh M S, Fornace A J, Jr. Regulation of translation initiation following stress. Oncogene 1999; 18: 6121–6128
  • Shiloh Y, Andegeko Y, Tsarfaty I. In search of drug treatment for genetic defects in the DNA damage response: The example of ataxia-telangiectasia. Seminal Cancer Biology 2004; 14: 295–305
  • Shyu A B, Wilkinson M F. The double lives of shuttling mRNA binding proteins. Cell 2000; 102: 135–138
  • Sonoda E, Hochegger H, Saberi A, Taniguchi Y, Takeda S. Differential usage of non-homologous end-joining and homologous recombination in double strand break repair. DNA Repair 2006; 5: 1021–1029
  • Sueoka E, Goto Y, Sueoka N, Kai Y, Kosu T, Fujiki H. Heterogeneous nuclear ribonucleoprotein B1 as a new marker of early detection for human lung cancers. Cancer Research 1999; 59: 1404–1407
  • Sueoka E, Sueoka N, Goto Y, Matsuyama S, Nishimura H, Sato M, Fujimura S, Chiba H, Fujiki H. Heterogeneous nuclear ribonucleoprotein B1 as early cancer biomarker for occult cancer of human lungs and bronchial dysplasia. Cancer Research 2001; 61: 1896–1902
  • Takao J, Ariisumi K, Dougherty I I, Crus P D. Genomic scale analysis of the human keratinocyte response to broad-band ultraviolet-B irradiation. Photodermatology Photoimmunology and Photomedicine 2002; 18: 5–13
  • Van Der Houven Van Oordt W, Dias-Meco M T, Losano J, Krainer A R, Moscat J, Caceres J F. The MKK3/6-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation. Journal of Cell Biology 2000; 149: 307–316
  • Ward J F. DNA damage produced by ionising radiation in mammalian cells: Identities, mechanisms of formation, and reparability. Progress in Nucleic Acid Research and Molecular Biology 1988; 35: 95–125
  • Waterhouse N, Kumar S, Song Q, Strike P, Sparrow L, Dreyfuss G, Alnemri E S, Litwack G, Lavin M, Watters D. Heteronuclear ribonucleoproteins C1 and C2, components of the spliceosome, are specific targets of Interleukin 1 beta-converting ensyme-like proteases in apoptosis. Journal of Biological Chemistry 1996; 271: 29335–29341
  • Weinstock D M, Richardson C A, Elliott B, Jasin M. Modeling oncogenic translocations: Distinct roles for double-strand break repair pathways in translocation formation in mammalian cells. DNA Repair 2006; 5: 1065–1074
  • Weinstock G M. ENCODE: More genomic empowerment. Genome Research 2007; 17: 667–668
  • Weller G R, Brandt V L, Roth D B. Doing more with less in bacterial DNA repair. Nature Structural & Molecular Biology 2004; 11: 1158–1159
  • Yang C, Carrier F. The UV-inducible RNA-binding protein A18 (A18 hnRNP) plays a protective role in the genotoxic stress response. Journal of Biological Chemistry 2001; 276: 47277–47284
  • Yang R, Weber D J, Carrier F. Post-transcriptional regulation of thioredoxin by the stress inducible heterogenous ribonucleoprotein A18. Nucleic Acids Research 2006; 34: 1224
  • Yang X, Bani M, Lu S, Rowan S, Ben-David Y, Chabot B. The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5′ splice site selection in vivo. Proceedings of the National Academy of Sciences of the USA 1994; 91: 6924–6928
  • Yim E K, Lee K H, Kim C J, Park J S. Analysis of differential protein expression by cisplatin treatment in cervical carcinoma cells. International Journal of Gynecological Cancer 2006; 16: 690–697
  • Yokomiso A, Ono M, Nanri H, Makino Y, Ohga T, Wada M, Okamoto T, Yodoi J, Kuwano M, Kohno K. Cellular levels of thioredoxin associated with drug sensitivity to cisplatin, mitomycin C, doxorubicin, and etoposide. Cancer Research 1995; 55: 4293–4296
  • Shang S, Schlott B, Görlach M, Grosse F, Journals O. DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner. Nucleic Acids Research 2004; 32: 1–10

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.