Upregulating DAB2IP expression via EGR-1 inhibition, a new approach for overcoming fractionated-irradiation-induced cross-tolerance to ionizing radiation and mitomycin C in tumor cells

References

• Ahmed MM. 2004. Regulation of radiation-induced apoptosis by early growth response-1 gene in solid tumors. Curr Cancer Drug Targets. 4:43–52.
   PubMed Web of Science ®Google Scholar
• Alili L, Diekmann J, Giesen M, Holtkotter O, Brenneisen P. 2014. A drug-induced accelerated senescence (DIAS) is a possibility to study aging in time lapse. Age. 36:1329–1343.
   Web of Science ®Google Scholar
• Brand TM, Iida M, Luthar N, Starr MM, Huppert EJ, Wheeler DL. 2013. Nuclear EGFR as a molecular target in cancer. Radiother Oncol. 108:370–377.
   PubMed Web of Science ®Google Scholar
• Burris HA. 2013. Overcoming acquired resistance to anticancer therapy: focus on the PI3K/AKT/mTOR pathway. Cancer Chemother Pharmacol. 71:829–842.
   PubMed Web of Science ®Google Scholar
• Deorukhkar A, Krishnan S. 2010. Targeting inflammatory pathways for tumor radiosensitization. Biochem Pharmacol. 80:1904–1914.
   PubMed Web of Science ®Google Scholar
• Di Minin G, Bellazzo A, Dal Ferro M, Chiaruttini G, Nuzzo S, Bicciato S, Piazza S, Rami D, Bulla R, Sommaggio R, et al. 2014. Mutant p53 reprograms TNF signaling in cancer cells through interaction with the tumor suppressor DAB2IP. Mol Cell. 56:617–629.
   PubMed Web of Science ®Google Scholar
• Fan QW, Weiss WA. 2010. Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance. Curr Top Microbiol Immunol. 347:279–296.
   PubMed Web of Science ®Google Scholar
• Gospodinov A, Popova S, Vassileva I, Anachkova B. 2012. The inhibitor of histone deacetylases sodium butyrate enhances the cytotoxicity of mitomycin C. Mol Cancer Ther. 11:2116–2126.
   PubMed Web of Science ®Google Scholar
• Hallahan DE, Dunphy E, Virudachalam S, Sukhatme VP, Kufe DW, Weichselbaum RR. 1995. C-jun and Egr-1 participate in DNA synthesis and cell survival in response to ionizing radiation exposure. J Biol Chem. 270:30303–30309.
   PubMed Web of Science ®Google Scholar
• Hann SS, Tang Q, Zheng F, Zhao S, Chen J, Wang Z. 2014. Repression of phosphoinositide-dependent protein kinase 1 expression by ciglitazone via Egr-1 represents a new approach for inhibition of lung cancer cell growth. Mol Cancer. 13:149.
   PubMed Web of Science ®Google Scholar
• Ikushima T. 1989. Radio-adaptive response: characterization of a cytogenetic repair induced by low-level ionizing radiation in cultured Chinese hamster cells. Mutat Res. 227:241–246.
   PubMed Web of Science ®Google Scholar
• Kong Z, Xie D, Boike T, Raghavan P, Burma S, Chen DJ, Habib AA, Chakraborty A, Hsieh JT, Saha D. 2010a. Downregulation of human DAB2IP gene expression in prostate cancer cells results in resistance to ionizing radiation. Cancer Res. 70:2829–2839.
   PubMed Web of Science ®Google Scholar
• Kong Z, Raghavan P, Xie D, Boike T, Burma S, Chen D, Chakraborty A, Hsieh J-T, Saha D. 2010b. Epothilone B confers radiation dose enhancement in DAB2IP gene knock-down radioresistant prostate cancer cells. Int J Radiat Oncol Biol Phys. 78:1210–1218.
   PubMed Web of Science ®Google Scholar
• Lu C, Meng QY. 1994. Studies on the induction of cross-resistance by low dose radiation or by low concentrations of chemicals. Biomed Environ Sci. 7:241–247.
   PubMedGoogle Scholar
• Sauer L, Gitenay D, Vo C, Baron VT. 2010. Mutant p53 initiates a feedback loop that involves Egr-1/EGF receptor/ERK in prostate cancer cells. Oncogene. 29:2628–2637.
   PubMed Web of Science ®Google Scholar
• Shen YJ, Kong ZL, Wan FN, Wang HK, Bian XJ, Gan HL, Wang CF, Ye DW. 2014. Downregulation of DAB2IP results in cell proliferation and invasion and contributes to unfavorable outcomes in bladder cancer. Cancer Sci. 105:704–712.
   PubMed Web of Science ®Google Scholar
• Shimura T. 2011. Acquired radioresistance of cancer and the AKT/GSK3β/cyclin D1 overexpression cycle. J Radiat Res. 52:539–544.
   PubMed Web of Science ®Google Scholar
• Shimura T, Kakuda S, Ochiai Y, Kuwahara Y, Takai Y, Fukumoto M. 2011. Targeting the AKT/GSK3β/Cyclin D1/Cdk4 survival signaling pathway for eradication of tumor radioresistance acquired by fractionated radiotherapy. Int J Radiat Oncol Biol Phys. 80:540–548.
   PubMed Web of Science ®Google Scholar
• Tsai YS, Lai CL, Lai CH, Chang KH, Wu K, Tseng SF, Fazli L, Gleave M, Xiao G, Gandee L, Sharifi N, Moro L, Tzai TS, Hsieh JT. 2014. The role of homeostatic regulation between tumor suppressor DAB2IP and oncogenic Skp2 in prostate cancer growth. Oncotarget. 5:6425–6436.
   PubMed Web of Science ®Google Scholar
• Wu K, Wang B, Chen Y, Zhou J, Huang J, Hui K, Zeng J, Zhu J, Zhang K, Li L, Guo P, Wang X, Hsieh JT, He D, Fan J. 2015. DAB2IP regulates the chemoresistance to pirarubicin and tumor recurrence of non-muscle invasive bladder cancer through STAT3/Twist1/P-glycoprotein signaling. Cell Signal. 27:2515–2523.
   PubMed Web of Science ®Google Scholar
• Wu K, Xie D, Zou Y, Zhang T, Pong RC, Xiao G, Fazli L, Gleave M, He D, Boothman DA, Hsieh JT. 2013. The mechanism of DAB2IP in chemoresistance of prostate cancer cells. Clin Cancer Res. 19:4740–4749.
   PubMed Web of Science ®Google Scholar
• Yang SZ, Eltoum IA, Abdulkadir SA. 2006. Enhanced EGR1 activity promotes the growth of prostate cancer cells in an androgen-depleted environment. J Cell Biochem. 97:1292–1299.
   PubMed Web of Science ®Google Scholar
• Yun EJ, Baek ST, Xie D, Tseng SF, Dobin T, Hernandez E, Zhou J, Zhang L, Yang J, Sun H, et al. 2015. DAB2IP regulates cancer stem cell phenotypes through modulating stem cell factor receptor and ZEB1. Oncogene. 34:2741–2752.
   PubMed Web of Science ®Google Scholar
• Zhang H, Zhang R, Luo Y, D’Alessio A, Pober JS, Min W. 2004. AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation. J Biol Chem. 279:44955–44965.
   PubMed Web of Science ®Google Scholar
• Zhang T, Shen Y, Chen Y, Hsieh J-T, Kong Z. 2015. The ATM inhibitor KU55933 sensitizes radioresistant bladder cancer cells with DAB2IP gene defect. Int J Radiat Biol. 91:368–378.
   PubMed Web of Science ®Google Scholar