Lessons learned from an unstable genomic landscape

References

• Chang WP, Little JB. 1991. Delayed reproductive death in X-irradiated Chinese hamster ovary cells. Int J Radiat Biol. 60:483–496.
   PubMed Web of Science ®Google Scholar
• Chang WP, Little JB. 1992a. Evidence that DNA double-strand breaks initiate the phenotype of delayed reproductive death in Chinese hamster ovary cells. Radiat Res. 131:53–59.
   PubMed Web of Science ®Google Scholar
• Chang WP, Little JB. 1992b. Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving X-irradiation: association with delayed reproductive death phenotype. Mutat Res. 270:191–199.
   PubMed Web of Science ®Google Scholar
• Clutton SM, Townsend KMS, Walker C, Ansell JD, Wright EG. 1996. Radiation-induced genomic instability and persisting oxidative stress in primary bone marrow cultures. Carcinogenesis. 17:1633–1639.
   PubMed Web of Science ®Google Scholar
• Dayal D, Martin SM, Limoli CL, Spitz DR. 2008. Hydrogen peroxide mediates the radiation-induced mutator phenotype in mammalian cells. Biochem J. 413:185–191.
   PubMed Web of Science ®Google Scholar
• Dayal D, Martin SM, Owens KM, Aykin-Burns N, Zhu Y, Boominathan A, Pain D, Limoli CL, Goswami PC, Domann FE, et al. 2009. Mitochondrial complex II dysfunction can contribute significantly to genomic instability after exposure to ionizing radiation. Radiat Res. 172:737–745.
   PubMed Web of Science ®Google Scholar
• Hong M, Xu A, Zhou H, Wu L, Randers-Pehrson G, Santella RM, Yu Z, Hei TK. 2010. Mechanism of genotoxicity induced by targeted cytoplasmic irradiation. Br J Cancer. 103:1263–1268.
   PubMed Web of Science ®Google Scholar
• Hu B, Grabham P, Nie J, Balajee AS, Zhou H, Hei TK, Geard CR. 2012. Intrachromosomal changes and genomic instability in site-specific microbeam-irradiated and bystander human-hamster hybrid cells. Radiat Res. 177:25–34.
   PubMed Web of Science ®Google Scholar
• Huang L, Grim S, Smith LE, Kim PM, Nickoloff JA, Goloubeva OG, Morgan WF. 2004. Ionizing radiation induces delayed hyperrecombination in mammalian cells. Mol Cell Biol. 24:5060–5068.
   PubMed Web of Science ®Google Scholar
• Kadhim MA, Lorimore SA, Hepburn MD, Goodhead DT, Buckle VJ, Wright EG. 1994. Alpha-particle-induced chromosomal instability in human bone marrow cells. Lancet. 344:987–988.
   PubMed Web of Science ®Google Scholar
• Kadhim MA, Lorimore SA, Townsend KMS, Goodhead DT, Buckle VJ, Wright EG. 1995. Radiation-induced genomic instability: delayed cytogenetic aberrations and apoptosis in primary human bone marrow cells. Int J Radiat Biol. 67:287–293.
   PubMed Web of Science ®Google Scholar
• Kadhim MA, Macdonald DA, Goodhead DT, Lorimore SA, Marsden SJ, Wright EG. 1992. Transmission of chromosomal instability after plutonium alpha-particle irradiation. Nature. 355:738–740.
   PubMed Web of Science ®Google Scholar
• Leach JK, Van Tuyle G, Lin PS, Schmidt-Ullrich R, Mikkelsen RB. 2001. Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen/nitrogen. Cancer Res. 61:3894–3901.
   PubMed Web of Science ®Google Scholar
• Limoli C, Giedzinski E. 2003. Induction of chromosomal instability by chronic oxidative stress. Neoplasia. 5:339–346.
   PubMed Web of Science ®Google Scholar
• Limoli C, Giedzinski E, Morgan W, Swarts S, Jones G, Hyun W. 2003. Persistent oxidative stress in chromosomally unstable cells. Cancer Res. 63:3107–3111.
   PubMed Web of Science ®Google Scholar
• Limoli CL, Corcoran JJ, Milligan JR, Ward JF, Morgan WF. 1999. Critical target and dose and dose-rate responses for the induction of chromosomal instability by ionizing radiation. Radiat Res. 151:677–685.
   PubMed Web of Science ®Google Scholar
• Limoli CL, Hartmann A, Shephard L, Yang CR, Boothman DA, Bartholomew J, Morgan WF. 1998. Apoptosis, reproductive failure, and oxidative stress in Chinese hamster ovary cells with compromised genomic integrity. Cancer Res. 58:3712–3718.
   PubMed Web of Science ®Google Scholar
• Limoli CL, Kaplan MI, Corcoran J, Meyers M, Boothman DA, Morgan WF. 1997a. Chromosomal instability and its relationship to other end points of genomic instability. Cancer Res. 57:5557–5563.
   PubMed Web of Science ®Google Scholar
• Limoli CL, Kaplan MI, Giedzinski E, Morgan WF. 2001. Attenuation of radiation-induced genomic instability by free radical scavengers and cellular proliferation. Free Radic Biol Med. 31:10–19.
   PubMed Web of Science ®Google Scholar
• Limoli CL, Kaplan MI, Phillips JW, Adair GM, Morgan WF. 1997b. Differential induction of chromosomal instability by DNA strand-breaking agents. Cancer Res. 57:4048–4056.
   PubMed Web of Science ®Google Scholar
• Limoli CL, Ponnaita B, Corcoran JJ, Giedzinski E, Kaplan MI, Hartmann A, Morgan WF. 2000. Genomic instability induced by high and low LET ionizing radiation. Adv Space Res. 25:2107–2117.
   PubMed Web of Science ®Google Scholar
• Lorimore SA, Kadhim MA, Pocock DA, Papworth D, Stevens DL, Goodhead DT, Wright EG. 1998. Chromosomal instability in the descendants of unirradiated surviving cells after alpha-particle irradiation. Proc Natl Acad Sci USA. 95:5730–5733.
   PubMed Web of Science ®Google Scholar
• Marder BA, Morgan WF. 1993. Delayed chromosomal instability induced by DNA damage. Mol Cell Biol. 13:6667–6677.
   PubMed Web of Science ®Google Scholar
• Morgan WF. 2003a. Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro. Radiat Res. 159:567–580.
   PubMed Web of Science ®Google Scholar
• Morgan WF. 2003b. Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects. Radiat Res. 159:581–596.
   PubMed Web of Science ®Google Scholar
• Morgan WF. 2011. Communicating non-targeted effects of ionizing radiation to achieve adaptive homeostasis in tissues. Curr Mol Pharmacol. 4:135–140.
   PubMedGoogle Scholar
• Morgan WF, Day JP, Kaplan MI, McGhee EM, Limoli CL. 1996. Genomic instability induced by ionizing radiation. Radiat Res. 146:247–258.
   PubMed Web of Science ®Google Scholar
• Morgan WF, Hartmann A, Limoli CL, Nagar S, Ponnaiya B. 2002. Bystander effects in radiation-induced genomic instability. Mutat Res. 504:91–100.
   PubMed Web of Science ®Google Scholar
• Morgan WF, Sowa MB. 2007. Non-targeted bystander effects induced by ionizing radiation. Mutat Res. 616:159–164.
   PubMed Web of Science ®Google Scholar
• Morgan WF, Sowa MB. 2009. Non-targeted effects of ionizing radiation: implications for risk assessment and the radiation dose response profile. Health Phys. 97:426–432.
   PubMed Web of Science ®Google Scholar
• Morgan WF, Sowa MB. 2015. Non-targeted effects induced by ionizing radiation: mechanisms and potential impact on radiation induced health effects. Cancer Lett. 356:17–21.
   PubMed Web of Science ®Google Scholar
• Morgan WF, Winegar RA. 1990. The use of restriction endonucleases to study the mechanisms of chromosome damage. In: Chromosomal aberrations: basic and applied aspects. Berlin: Springer-Verlag; pp. 70–78.
   Google Scholar
• Mothersill C, Seymour C. 1987. The influence of lethal mutations on the quantification of radiation transformation frequencies. Int J Radiat Biol Relat Stud Phys Chem Med. 51:723–729.
   PubMed Web of Science ®Google Scholar
• Owens KM, Aykin-Burns N, Dayal D, Coleman MC, Domann FE, Spitz DR. 2012. Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-.) and H2O2. Free Radic Biol Med. 52:160–166.
   PubMed Web of Science ®Google Scholar
• Phillips JW, Morgan WF. 1994. Illegitimate recombination induced by DNA double-strand breaks in a mammalian chromosome. Mol Cell Biol. 14:5794–5803.
   PubMed Web of Science ®Google Scholar
• Seymour CB, Mothersill C, Alper T. 1986. High yields of lethal mutations in somatic mammalian cells that survive ionizing radiation. Int J Radiat Biol Relat Stud Phys Chem Med. 50:167–179.
   PubMed Web of Science ®Google Scholar
• Thomas SN, Waters KM, Morgan WF, Yang AJ, Baulch JE. 2012. Quantitative proteomic analysis of mitochondrial proteins reveals prosurvival mechanisms in the perpetuation of radiation-induced genomic instability. Free Radic Biol Med. 53:618–628.
   PubMed Web of Science ®Google Scholar
• Winegar RA, Phillips JW, Youngblom JH, Morgan WF. 1989. Cell electroporation is a highly efficient method for introducing restriction endonucleases into cells. Mutat Res. 225:49–53.
   PubMed Web of Science ®Google Scholar
• Zhang B, Davidson MM, Zhou H, Wang C, Walker WF, Hei TK. 2013. Cytoplasmic irradiation results in mitochondrial dysfunction and DRP1-dependent mitochondrial fission. Cancer Res. 73:6700–6710.
   PubMed Web of Science ®Google Scholar