256
Views
6
CrossRef citations to date
0
Altmetric
Original Article

Whole body proton irradiation causes acute damage to bone marrow hematopoietic progenitor and stem cells in mice

, , , , , , , , , & ORCID Icon show all
Pages 1312-1320 | Received 29 Jan 2017, Accepted 01 Jul 2017, Published online: 07 Aug 2017

References

  • Cengel KA, Diffenderfer ES, Avery S, Kennedy AR, McDonough J. 2010. Using electron beam radiation to simulate the dose distribution for whole body solar particle event proton exposure. Radiat Environ Biophys. 49:715–721.
  • Chambers KA, Harrington NP, Ross WM, Filion LG. 1998. Relative alterations in blood mononuclear cell populations reflect radiation injury in mice. Cytometry. 31:45–52.
  • Chang J, Feng W, Wang Y, Luo Y, Allen AR, Koturbash I, Turner J, Stewart B, Raber J, Hauer-Jensen M, et al. 2015. Whole-body proton irradiation causes long-term damage to hematopoietic stem cells in mice. Radiat Res. 183:240–248.
  • Chang J, Luo Y, Wang Y, Pathak R, Sridharan V, Jones T, Mao XW, Nelson G, Boerma M, Hauer-Jensen M, et al. 2016. Low doses of oxygen ion irradiation cause acute damage to hematopoietic cells in mice. PLoS ONE. 11:e0158097.
  • Chen C, Liu Y, Liu R, Ikenoue T, Guan KL, Zheng P. 2008. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med. 205:2397–2408.
  • Dorr H, Meineke V. 2011. Acute radiation syndrome caused by accidental radiation exposure – therapeutic principles. BMC Med. 9:126.
  • Doulatov S, Notta F, Laurenti E, Dick JE. 2012. Hematopoiesis: a human perspective. Cell Stem Cell. 10:120–136.
  • Gridley DS, Rizvi A, Luo-Owen X, Makinde AY, Coutrakon GB, Koss P, Slater JM, Pecaut MJ. 2008. Variable hematopoietic responses to acute photons, protons and simulated solar particle event protons. In Vivo. 22:159–169.
  • Harrington NP, Chambers KA, Ross WM, Filion LG. 1997. Radiation damage and immune suppression in splenic mononuclear cell populations. Clin Exp Immunol. 107:417–424.
  • Li H, Wang Y, Pazhanisamy SK, Shao L, Batinic-Haberle I, Meng A, Zhou D. 2011. Mn(iii) meso-tetrakis-(n-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression. Free Radic Biol Med. 51:30–37.
  • Luo-Owen X, Pecaut MJ, Rizvi A, Gridley DS. 2012. Low-dose total-body γ irradiation modulates immune response to acute proton radiation. Radiat Res. 177:251–264.
  • Maks CJ, Wan XS, Ware JH, Romero-Weaver AL, Sanzari JK, Wilson JM, Rightnar S, Wroe AJ, Koss P, Gridley DS, et al. 2011. Analysis of white blood cell counts in mice after gamma- or proton-radiation exposure. Radiat Res. 176:170.
  • Nelson GA. 2016. Space radiation and human exposures, a primer. Radiat Res. 185:349–358.
  • Sanzari JK, Cengel KA, Wan XS, Rusek A, Kennedy AR. 2014. Acute hematological effects in mice exposed to the expected doses, dose-rates, and energies of solar particle event-like proton radiation. Life Sci Space Res (Amst). 2: 86–91.
  • Sanzari JK, Romero-Weaver AL, James G, Krigsfeld G, Lin L, Diffenderfer ES, Kennedy AR. 2013. Leukocyte activity is altered in a ground based murine model of microgravity and proton radiation exposure. PLoS One. 8:e71757.
  • Schuringa JJ, Vellenga E. 2010. Role of the polycomb group gene bmi1 in normal and leukemic hematopoietic stem and progenitor cells. Curr Opin Hematol. 17:294–299.
  • Shao L, Luo Y, Zhou D. 2014. Hematopoietic stem cell injury induced by ionizing radiation. Antioxid Redox Signal. 20:1447–1462.
  • Shao L, Sun Y, Zhang Z, Feng W, Gao Y, Cai Z, Wang ZZ, Look AT, Wu WS. 2010. Deletion of proapoptotic puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation. Blood. 115:4707–4714.
  • Townsend LW. 2005. Implications of the space radiation environment for human exploration in deep space. Radiat Prot Dosimetry. 115:44–50.
  • Wang Y, Liu L, Pazhanisamy SK, Li H, Meng A, Zhou D. 2010. Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells. Free Radic Biol Med. 48: 348–356.
  • Wang Y, Schulte BA, LaRue AC, Ogawa M, Zhou D. 2006. Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood. 107:358–366.
  • Yu H, Shen H, Yuan Y, XuFeng R, Hu X, Garrison SP, Zhang L, Yu J, Zambetti GP, Cheng T. 2010. Deletion of puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation. Blood. 115:3472–3480.
  • Zhang H, Zhai Z, Wang Y, Zhang J, Wu H, Li C, Li D, Lu L, Wang X, Chang J, et al. 2013. Resveratrol ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice. Free Radic Biol Med. 54:40–50.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.