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Original Articles

Efficacy of delayed administration of sargramostim up to 120 hours post exposure in a nonhuman primate total body radiation model

Pages S100-S116 | Received 11 Jun 2019, Accepted 18 Sep 2019, Published online: 22 Sep 2020

References

  • Adegoke AA, Stenstrom TA, Okoh AI. 2017. Stenotrophomonas maltophilia as an emerging ubiquitous pathogen: looking beyond contemporary antibiotic therapy. Front Microbiol. 8:2276.
  • Amgen Inc. 2018. Neupogen (filgrastim) – US prescribing information. [accessed 2019 Oct 2]. https://www.pi.amgen.com/∼/media/amgen/repositorysites/pi-amgen-com/neupogen/neupogen_pi_hcp_english.pdf
  • Amgen Inc. 2019. Neulasta (pegfilgrastim) – US prescribing information. [accessed 2019 Oct 2]. https://www.pi.amgen.com/∼/media/amgen/repositorysites/pi-amgen-com/neulasta/neulasta_pi_hcp_english.pdf
  • Basu S, Hodgson G, Katz M, Dunn AR. 2002. Evaluation of role of G-CSF in the production, survival, and release of neutrophils from bone marrow into circulation. Blood 100(3):854–861.
  • Booth C, Tudor G, Tudor J, Katz BP, MacVittie TJ. 2012. Acute gastrointestinal syndrome in high-dose irradiated mice. Health Phys. 103(4):383–399.
  • Brook I, Walker RI, MacVittie TJ. 1988. Effect of antimicrobial therapy on bowel flora and bacterial infection in irradiated mice. Int J Radiat Biol Relat Stud Phys Chem Med. 53(5):709–716.
  • Clayton J, Danzeisen J, Trent A, Murphy T, Johnson T. 2014. Longitudinal characterization of Escherichia coli in healthy captive non-human primates. Front Vet Sci. 1:24.
  • Clayton NP, Charpentier E, LaCasse ER, Khan-Malek RC, Keutzer JM. 2016. Sargramostim accelerates leukocyte recovery and improves mortality rate at day 60 in a non-human primate model of hematopoietic acute radiation syndrome when administered 48 h after total body irradiation. Blood 128:2512.
  • Conway T, Krogfelt KA, Cohen PS. 2004. The life of commensal Escherichia coli in the mammalian intestine. EcoSal Plus. 1(1). https://doi.org/https://doi.org/10.1128/ecosalplus.8.3.1.2
  • Dainiak N. 2002. Hematologic consequences of exposure to ionizing radiation. Exp Hematol. 30(6):513–528.
  • Dainiak N, Waselenko JK, Armitage JO, MacVittie TJ, Farese AM. 2003. The hematologist and radiation casualties. Hematology Am Soc Hematol Educ Program. 2003(1):473–496.
  • Denapaite D, Rieger M, Kondgen S, Bruckner R, Ochigava I, Kappeler P, Matz-Rensing K, Leendertz F, Hakenbeck R. 2016. Highly variable Streptococcus oralis strains are common among Viridans Streptococci isolated from primates. mSphere 1(2):pii: e00041-15.
  • DiCarlo AL, Maher C, Hick JL, Hanfling D, Dainiak N, Chao N, Bader JL, Coleman CN, Weinstock DM. 2011. Radiation injury after a nuclear detonation: medical consequences and the need for scarce resources allocation. Disaster Med Public Health Prep. 5(S1):S32–S44.
  • Dorr H, Meineke V. 2011. Acute radiation syndrome caused by accidental radiation exposure – therapeutic principles. BMC Med. 9:126.
  • Farese AM, Brown CR, Smith CP, Gibbs AM, Katz BP, Johnson CS, Prado KL, MacVittie TJ. 2014. The ability of filgrastim to mitigate mortality following LD50/60 total-body irradiation is administration time-dependent. Health Phys. 106(1):39–47.
  • Farese AM, Cohen MV, Katz BP, Smith CP, Gibbs A, Cohen DM, MacVittie TJ. 2013. Filgrastim improves survival in lethally irradiated nonhuman primates. Radiat Res. 179(1):89–100.
  • Farese AM, Cohen MV, Stead RB, Jackson W, MacVittie TJ. 2012. Pegfilgrastim administered in an abbreviated schedule, significantly improved neutrophil recovery after high-dose radiation-induced myelosuppression in rhesus macaques. Radiat Res. 178(5):403–413.
  • Farese AM, Williams DE, Seiler FR, MacVittie TJ. 1993. Combination protocols of cytokine therapy with interleukin-3 and granulocyte-macrophage colony-stimulating factor in a primate model of radiation-induced marrow aplasia. Blood 82(10):3012–3018.
  • Gafter-Gvili A, Fraser A, Paul M, Leibovici L. 2005. Meta-analysis: antibiotic prophylaxis reduces mortality in neutropenic patients. Ann Intern Med. 142(12_Part_1):979–995.
  • Ganz T, Nemeth E. 2009. Iron sequestration and anemia of inflammation. Semin Hematol. 46(4):387–393.
  • Gianni AM, Bregni M, Siena S, Villa S, Sciorelli GA, Ravagnani F, Pellegris G, Bonadonna G. 1989. Rapid and complete hemopoietic reconstitution following combined transplantation of autologous blood and bone marrow cells. A changing role for high dose chemo-radiotherapy? Hematol Oncol. 7(2):139–148.
  • Gluzman-Poltorak Z, Vainstein V, Basile LA. 2014. Recombinant interleukin-12, but not granulocyte-colony stimulating factor, improves survival in lethally irradiated nonhuman primates in the absence of supportive care: evidence for the development of a frontline radiation medical countermeasure. Am J Hematol. 89(9):868–873.
  • Goans RE, Holloway EC, Berger ME, Ricks RC. 1997. Early dose assessment following severe radiation accidents. Health Phys. 72(4):513–518.
  • Hamada S, Slade HD. 1980. Biology, immunology, and cariogenicity of Streptococcus mutans. Microbiol Rev. 44(2):331–384.
  • Hankey KG, Farese AM, Blaauw EC, Gibbs AM, Smith CP, Katz BP, Tong Y, Prado KL, MacVittie TJ. 2015. Pegfilgrastim improves survival of lethally irradiated nonhuman primates. Radiat Res. 183(6):643–655.
  • Inoue T, Hirabayashi Y, Mitsui H, Sasaki H, Cronkite EP, Bullis JE, Jr., Bond VP, Yoshida K. 1995. Survival of spleen colony-forming units (CFU-S) of irradiated bone marrow cells in mice: evidence for the existence of a radioresistant subfraction. Exp Hematol. 23(12):1296–1300.
  • Kuhn V, Diederich L, Keller TCS, Kramer CM, Lückstädt W, Panknin C, Suvorava T, Isakson BE, Kelm M, Cortese-Krott MM. 2017. Red blood cell function and dysfunction: redox regulation, nitric oxide metabolism, anemia. Antioxid Redox Signal. 26(13):718–742.
  • Kumar KS, Srinivasan V, Toles RE, Miner VL, Jackson WE, Seed TM. 2002. High-dose antibiotic therapy is superior to a 3-drug combination of prostanoids and lipid A derivative in protecting irradiated canines. J Radiat Res. 43(4):361–370.
  • Laterveer L, Zijlmans JM, Liehl E, Willemze R, Fibbe WE. 1996. Accelerated platelet reconstitution following transplantation of bone marrow cells derived from IL-6-treated donor mice. Ann Hematol. 73(5):239–245.
  • Lebreton F, Willems RJL, Gilmore MS. 2014. Enterococcus diversity, origins in nature, and gut colonization. In: Gilmore MS, Clewell DB, Ike Y, editors. Enterococci: from commensals to leading causes of drug resistant infection. Boston: Massachusetts Eye and Ear Infirmary.
  • MacVittie TJ, Bennett AW, Farese AM, Taylor-Howell C, Smith CP, Gibbs AM, Prado K, Jackson W. 3rd. 2015. The effect of radiation dose and variation in neupogen(R) initiation schedule on the mitigation of myelosuppression during the concomitant GI-ARS and H-ARS in a nonhuman primate model of high-dose exposure with marrow sparing. Health Phys. 109(5):427–439.
  • Mason KL, Stepien TA, Blum JE, Holt JF, Labbe NH, Rush JS, Raffa KF, Handelsman J. 2011. From commensal to pathogen: translocation of Enterococcus faecalis from the midgut to the hemocoel of Manduca sexta. MBio 2(3):e00065–00011.
  • Mehta HM, Malandra M, Corey SJ. 2015. G-CSF and GM-CSF in neutropenia. J Immunol. 195(4):1341–1349.
  • Metcalf D, Mifsud S, Di Rago L. 2005. Murine megakaryocyte progenitor cells and their susceptibility to suppression by G-CSF. Stem Cells 23(1):55–62.
  • Plett PA, Sampson CH, Chua HL, Joshi M, Booth C, Gough A, Johnson CS, Katz BP, Farese AM, Parker J, et al. 2012. Establishing a murine model of the hematopoietic syndrome of the acute radiation syndrome. Health Phys. 103(4):343–355.
  • Saito M, Takada K, Yamada T, Fujimoto J. 1996. Overexpression of granulocyte colony-stimulating factor in vivo decreases the level of polyploidization of mouse bone marrow megakaryocytes. Stem Cells 14(1):124–131.
  • Sanofi-Aventis US LLC. 2018. Leukine (sargramostim) – US prescribing information. [accessed 2019 May 3]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/103362s5237lbl.pdf
  • Shrestha RP, Horowitz J, Hollot CV, Germain MJ, Widness JA, Mock DM, Veng-Pedersen P, Chait Y. 2016. Models for the red blood cell lifespan. J Pharmacokinet Pharmacodyn. 43(3):259–274.
  • Singh VK, Newman VL, Seed TM. 2015. Colony-stimulating factors for the treatment of the hematopoietic component of the acute radiation syndrome (H-ARS): a review. Cytokine 71(1):22–37.
  • Singh VK, Seed TM. 2017. A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasures. Int J Radiat Biol. 93(9):851–869.
  • Smith TJ, Khatcheressian J, Lyman GH, Ozer H, Armitage JO, Balducci L, Bennett CL, Cantor SB, Crawford J, Cross SJ, et al. 2006. 2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline. J Clin Oncol 24(19):3187–3205.
  • US FDA. 2018. Radiological and nuclear emergency preparedness information from FDA. https://www.fda.gov/emergency-preparedness-and-response/mcm-issues/radiological-and-nuclear-emergency-preparedness-information-fda.
  • US FDA. 2019. Animal rule information. https://www.fda.gov/emergency-preparedness-and-response/mcm-regulatory-science/animal-rule-information.
  • Ushach I, Zlotnik A. 2016. Biological role of granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) on cells of the myeloid lineage. J Leukoc Biol. 100(3):481–489.
  • van den Berg S, van Wamel WJ, Snijders SV, Ouwerling B, de Vogel CP, Boelens HA, Willems RJ, Huijsdens XW, Verreck FA, Kondova I, et al. 2011. Rhesus macaques (Macaca mulatta) are natural hosts of specific Staphylococcus aureus lineages. PLoS One 6(10):e26170.
  • Waller EK. 2007. The role of sargramostim (rhGM-CSF) as immunotherapy. Oncologist. 12(Suppl. 2):22–26.
  • Waselenko JK, MacVittie TJ, Blakely WF, Pesik N, Wiley AL, Dickerson WE, Tsu H, Confer DL, Coleman CN, Seed T, et al. 2004. Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Ann Intern Med. 140(12):1037–1051.
  • Weinstock DM, Case C, Jr., Bader JL, Chao NJ, Coleman CN, Hatchett RJ, Weisdorf DJ, Confer DL. 2008. Radiologic and nuclear events: contingency planning for hematologists/oncologists. Blood 111(12):5440–5445.
  • Young BC, Wu CH, Gordon NC, Cole K, Price JR, Liu E, Sheppard AE, Perera S, Charlesworth J, Golubchik T, et al. 2017. Severe infections emerge from commensal bacteria by adaptive evolution. Elife 6:e30637.