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Original Articles

Single high dose irradiation induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cells through the Ras/Raf/MEK/ERK pathways

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Pages 740-747 | Received 25 Feb 2018, Accepted 29 Oct 2019, Published online: 10 Feb 2020

References

  • Andolino DL, Johnson CS, Maluccio M, Kwo P, Tector AJ, Zook J, Johnstone PA, Cardenes HR. 2011. Stereotactic body radiation for primary hepatocellular carcinoma. Int J Radiat Oncol Biol Phys. 81(4):e447–e453.
  • Asati V, Mahapatra DK, Bharti SK. 2016. PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathwaysinhibitors as anticancer agents: Structural and pharmacological perspectives. Eur J Med Chem. 109:314–341.
  • Bujold A, Massey CA, Kim JJ, Brierley J, Cho C, Wong RK, Dinniwell RE, Kassam Z, Ringash J, Cummings B, et al. 2013. Sequential phase I and II trials of stereotactic body radiotherapy for locally advanced hepatocellular carcinoma. JCO. 31(13):1631–1639.
  • Cheng AL, Kang YK, Chen Z, Tsao CJ, Qin S, Kim JS, Luo R, Feng J, Ye S, Yang TS, et al. 2009. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 10(1):25–34.
  • Cheng JC, Wu JK, Huang CM, Huang DY, Cheng SH, Lin YM, Jian JJ, Yang PS, Chuang VP, Huang AT. 2002. Radiation-induced liver disease after radiation for hepatocellular carcinoma: Clinical manifestation and dosi-metric description. Radiother Oncol. 63(1):41–45.
  • Ciccarelli C, Vulcano F, Milazzo L, Gravina GL, Marampon F, Macioce G, Giampaolo A, Tombolini V, Di Paolo V, Hassan HJ, et al. 2016. Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population. Mol Cancer. 15(1):16–26897742.
  • Gollob JA, Wilhelm S, Carter C, Kelley SL. 2006. Role of Raf kinase in cancer: Therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway. Semin Oncol. 33(4):392–406.
  • Hoffmann K, Shibo L, Xiao Z, Longerich T, Büchler MW, Schemmer P. 2011. Correlation of gene expression of ATP-binding cassette protein and tyrosine kinase signaling pathway in patients with hepatocellular carcinoma. Anticancer Res. 31(11):3883–3890.
  • Jackman M, Lindon C, Nigg EA, Pines J. 2003. Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat Cell Biol. 5(2):143–148.
  • Jacob J, Nguyen F, Deutsch E, Mornex F. 2014. Stereotactic body radiation therapy in the management of liver tumours. Cancer Radiother. 18(5-6):486–494.
  • Jang WI, Kim MS, Bae SH, Cho CK, Yoo HJ, Seo YS, Kang JK, Kim SY, Lee DH, Han CJ, et al. 2013. High-dose stereotactic body radiation correlates increased local control and overall survival in patients with inoperable hepatocellular carcinoma. Radiat Oncol. 8(1):250.
  • Lee DH, Park KI, Park HS, Kang SR, Nagappan A, Kim JA, Kim EH, Lee WS, Hah YS, Chung HJ, et al. 2012. Flavonoids isolated from Korea citrus aurantium L. induce G2/M phase arrest and apoptosis in human gastric cancer AGS cells. Evid Based Complement Alternat Med. 2012:515901.
  • Liu L, Cao Y, Chen C, Zhang X, Mc Nabola A, Wilkie D, Wilhelm S, Lynch M, Carter C. 2006. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res. 66(24):11851–11858.
  • Maingon P, Nouhaud É, Mornex F, Créhange G. 2014. Stereotactic body radiation therapy for liver tumours. Cancer/Radiothérapie. 18(4):313–319.
  • Marampon F, Gravina GL, Popov VM, Scarsella L, Festuccia C, La Verghetta ME, Parente S, Cerasani M, Bruera G, Ficorella C, et al. 2014. Close correlation between MEK/ERK and Aurora-B signaling pathways in sustaining tumorigenic potential and radioresistance of gynecological cancer cell lines. Int J Oncol. 44(1):285–294.
  • Park HJ, Griffin RJ, Hui S, Levitt SH, Song CW. 2012. Radiation-induced vascular damage in tumors: Implications of vascular damage in ablative hypofractionated radiation (SBRT and SRS). Radiat Res. 177(3):311–327.
  • Scorsetti M, Comito T, Cozzi L, Clerici E, Tozzi A, Franzese C, Navarria P, Fogliata A, Tomatis S, D’Agostino G, et al. 2015. The challenge of inoperable hepatocellular carcinoma (HCC): Results of a single-institutional experience on stereotactic body radiation therapy (SBRT). J Cancer Res Clin Oncol. 141(7):1301–1309.
  • Stark GR, Taylor WR. 2006. Control of the G2/M transition. Mol Biotechnol. 32(3):227–248.
  • Tangutur AD, Kumar D, Krishna KV, Kantevari S. 2017. Microtubule targeting agents as cancer chemotherapeutics: An overview of molecular hybrids as stabilizing and destabilizing agents. Curr Top Med Chem. 17(22):2523–2537.
  • Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. 2015. Global cancer statistics. CA Cancer J Clin. 65(2):87–108.
  • Wang Y, Nie H, Zhao X, Qin Y, Gong X. 2016. Bicyclol induces cell cycle arrest and autophagy in HepG2 human hepatocellular carcinoma cells through the PI3K/AKT and Ras/Raf/MEK/ERK pathways. BMC Cancer. 16(1):742–27654866.
  • Xu L, Wang L, Wen Z, Wu L, Jiang Y, Yang L, Xiao L, Xie Y, Ma M, Zhu W, et al. 2016. Caveolin-1 is a checkpoint regulator in hypoxia-induced astrocyte apoptosis via Ras/Raf/ERK pathway. Am J Physiol Cell Physiol. 310(11):C903–910.
  • Yamada H, Abe T, Li SA, Tago S, Huang P, Watanabe M, Ikeda S, Ogo N, Asai A, Takei K. 2014. N′-[4-(dipropylamino) benzylidene]-2-hydroxybenzohydrazide is a dynamin GTPase inhibitor that suppresses cancer cell migration and invasion by inhibiting actin polymerization. Biochem Bioph Res C. 443(2):511–517.
  • Yang S, Liu G. 2017. Targeting the Ras/Raf/MEK/ERK pathway in hepatocellular carcinoma. Oncol Lett. 13(3):1041–1047.

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