Calculation of the initial DNA damage induced by alpha particles in comparison with protons and electrons using Geant4-DNA

References

• Agostinelli S, Allison J, Amako K, Apostolakis J, Araujo H, Arce P, Asai M, Axen D, Banerjee S, Barrand G, et al. 2003. Geant4-a simulation toolkit. Nucl Instrum Methods Phys Res A. 506(3):250–303.
   Web of Science ®Google Scholar
• Bernal MA, Bordage MC, Brown JMC, Davídková M, Delage E, El Bitar Z, Enger SA, Francis Z, Guatelli S, Ivanchenko VN, et al. 2015. Track structure modeling in liquid water: a review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit. Phys Med. 31(8):861–874.
   PubMed Web of Science ®Google Scholar
• Bordage MC, Bordes J, Edel S, Terrissol M, Franceries X, Bardiès M, Lampe N, Incerti S. 2016. Implementation of new physics models for low energy electrons in liquid water in Geant4-DNA. Phys Med. 32(12):1833–1840.
   PubMed Web of Science ®Google Scholar
• Brahme A. 2004. Recent advances in light Ion radiation therapy. Int J Radiat Oncol Biol Phys. 58(2):603–616.
   PubMed Web of Science ®Google Scholar
• Charlton D, Nikjoo H, Humm JL. 1989. Calculation of initial yields of single- and double-strand breaks in cell nuclei from electrons, protons and alpha particles. Int J Radiat Biol. 56(1):1–19.
   PubMed Web of Science ®Google Scholar
• Chris Wang CK. 2010. The progress of radiobiological models in modern radiotherapy with emphasis on the uncertainty issue. Mutat Res. 704(1–3):175–181.
   PubMed Web of Science ®Google Scholar
• de la Fuente Rosales L, Incerti S, Francis Z, Bernal M A. 2018. Accounting for radiation-induced indirect damage on DNA with the Geant4-DNA code. Phys Med. 51:108–116.
   PubMed Web of Science ®Google Scholar
• Dingfelder M. 2008. Comparisons of calculations with PARTRAC and NOREC: transport of electrons in liquid water. Radiat Res. 16:584–594.
   Google Scholar
• El Naqa I, Pater P, Seuntjens J. 2012. Monte Carlo role in radiobiological modelling of radiotherapy outcomes. Phys Med Biol. 57:75–79.
   Web of Science ®Google Scholar
• Famulari G, Pater P, Enger S. 2017. Microdosimetry calculations for monoenergetic electrons using Geant4-DNA combined with a weighted track sampling algorithm. Phys Med Biol. 62(13):5495–5508.
   PubMed Web of Science ®Google Scholar
• Fernández-Varea JM, González-Muñoz G, Galassi ME, Wiklund K, Lind BK, Ahnesjö A, Tilly N. 2012. Limitations (and merits) of PENELOPE as a track-structure code. Int J Radiat Biol. 88(1–2):66–70.
   PubMed Web of Science ®Google Scholar
• Ferrari A, Sala P, Fasso A, Ranft J. 2005. FLUKA: a multi-particle transport code. Geneva (Switzerland): CERN.
   Google Scholar
• Francis Z, Incerti S, Karamitros M, Tran HN, Villagrasa C. 2011. Stopping power and ranges of electrons, protons and alpha particles in liquid water using the Geant4-DNA package. Nucl Instrum Methods Phys Res B. 269(20):2307–2311.
   Web of Science ®Google Scholar
• Franken NAP, Hovingh S, Ten Cate R, Krawczyk P, Stap J, Hoebe R, Aten J, Barendsen GW. 2012. Relative biological effectiveness of high linear energy transfer α-particles for the induction of DNA-double-strand breaks, chromosome aberrations and reproductive cell death in SW-1573 lung tumour in SW-1573 lung tumour cells. Oncol Rep. 27(3):769–774.
   PubMed Web of Science ®Google Scholar
• Frankenberg D, Brede HJ, Schrewe UJ, Steinmetz C, Frankenberg-Schwager M, Kasten G, Pralle E, 1999. Induction of DNA double-strand breaks by 1h and 4he ions in primary human skin fibroblasts in the LET range of 8 to 124 keV/um. Radiat Res. 151(5):540–549.
   PubMed Web of Science ®Google Scholar
• Friedland W, Dingfelder M, Jacob P, Paretzke H. 2005. Calculated DNA double-strand break and fragmentation yields after irradiation with He ions. Radiat Phys Chem. 72(2–3):279–286.
   Web of Science ®Google Scholar
• Friedland W, Dingfelder M, Kundrát P, Jacob P. 2011. Track structures, DNA targets and radiation effects in the biophysical Monte Carlo simulation code PARTRAC. Mutat Res. 711(1–2):28–40.
   PubMed Web of Science ®Google Scholar
• Friedland W, Jacob P, Bernhardt P, Paretzke H G, Dingfelder M. 2003. Simulation of DNA damage after proton irradiation. Radiat Res. 159(3):401–410.
   PubMed Web of Science ®Google Scholar
• Friedland W, Schmitt E, Kundrát P, Dingfelder M, Baiocco G, Barbieri S, Ottolenghi A. 2017. Comprehensive track structure based evaluation of DNA damage by light ions from radiotherapy relevant energies down to stopping. Sci Rep. 7:45161.
   PubMed Web of Science ®Google Scholar
• Goodhead DT. 1994. Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. Int J Radiat Biol. 65(1):7–17.
   PubMed Web of Science ®Google Scholar
• Goodhead DT, Thacker J. 1977. Inactivation and mutation of cultured mammalian cells by aluminium characteristic ultrasoft X-rays I. Properties of aluminium X-rays and preliminary experiments with Chinese hamster cells. Int J Radiat Biol. 31:541–559.
   Web of Science ®Google Scholar
• Goorley T, James M, Brown F, Bull J, Durkee J, Elson J, Hendricks J, Jonns R, Forster RA, Kiedrowski B. et al. 2013. Initial MCNP6 release overview – MCNP6 version 1.0. Los Alamos (NM): Los Alamos National Library.
   Google Scholar
• ICRU. 1983. Microdosimetry. Bethesda (MD): International Commission on Radiation Units and Measurements.
   Google Scholar
• Incerti S, Ivanchenko A, Karamitros M, Mantero A, Moretto P, Tran HN, Mascialino B, Champion C, Ivanchenko VN, Bernal MA, et al. 2010. Comparison of GEANT4 very low energy cross section models with experimental data in water. Med Phys. 37(9):4692–4708.
   PubMed Web of Science ®Google Scholar
• Jenner TJ, deLara CM, O’Neill P, Stevens DL. 1993. Induction and rejoining of DNA double-strand breaks in V79-4 mammalian cells following y- and a-irradiation. Int J Radiat Biol. 64(3):265–273.
   PubMed Web of Science ®Google Scholar
• Kandaiya S, Lobachevsky PN, D’cunha G, Martin RF. 1996. DNA strand breakage by 125I decay in synthetic oligodeoxynucleotide:1. Fragment distribution and DMSO protection effect. Acta Oncol. 35(7):803–808.
   PubMed Web of Science ®Google Scholar
• Karamitros M, Luan S, Bernal MA, Allison J, Baldacchino G, Davidkova M, Francis Z, Friedland W, Ivantchenko V, Ivantchenko A, et al. 2014. Diffusion-controlled reactions modeling in Geant4-DNA. Comput Phys. 274:841–882.
   Google Scholar
• Kellerer A. 1975. Fandamental of microdosimetry. In: Kase KR, Bjarngaard BE, Attix FH, editors. The dosimetry of ionizing radiation. Cambridge (MA): Academic Press; p. 77–162.
   Google Scholar
• Kim YS, Brechbiel MW. 2012. An overview of targeted alpha therapy. Tumor Biol. 33(3):573–590.
   PubMed Web of Science ®Google Scholar
• Lampe N, Karamitros M, Breton V, Brown JMC, Sakata D, Sarramia D, Incerti S. 2018. Mechanistic DNA damage simulations in Geant4-DNA part 2: electron and proton damage in a bacterial cell. Physica Med. 48:146–155.
   PubMed Web of Science ®Google Scholar
• Martin RF, Haseltine WA. 1981. Range of radiochemical damage to DNA with decay of iodine-125. Science. 213(4510):896–898.
   PubMed Web of Science ®Google Scholar
• Meylan S, Incerti S, Karamitros M, Tang N, Bueno M, Clairand I, Villagrasa C. 2017. Simulation of early DNA damage after the irradiation of a fibroblast cell nucleus using Geant4-DNA. Sci Rep. 7(1):11923.
   PubMedGoogle Scholar
• Milligan J R, Wu CCL, Ng JYY, Aguilera JA, Ward JF. 1996. Characterization of the reaction rate coefficient of DNA with the hydroxyl radical. Radiat Res. 146(5):510–513.
   PubMed Web of Science ®Google Scholar
• Mokari M, Alamatsaz MH, Moeini H, Babaei-Brojeny AA, Taleei R. 2018. Track structure simulation of low energy electron damage to DNA using Geant4-DNA. Biomed Phys Eng Express. 4(6):065009.
   Web of Science ®Google Scholar
• Mokari M, Alamatsaz MH, Moeini H, Taleei R. 2018. A simulation approach for determining the spectrum of DNA damage induced by protons. Phys Med Biol. 63(17):175003.
   PubMed Web of Science ®Google Scholar
• Mulford DA, Scheinberg DA, Jurcic JG. 2005. The promise of targeted alpha particle therapy. J Nucl Med. 46:199S–204S.
   PubMed Web of Science ®Google Scholar
• Neary GJ, Horgan VJ, Bance DA, Stretch A. 1972. Further data on DNA strand breakage by various radiation qualities. Int J Radiat Biol. 22:527–537.
   Web of Science ®Google Scholar
• Neary GJ, Simpson-Gildemeister VEW, Peacocke AR. 1970. The influence of radiation quality and oxygen on strand breakage in dry DNA. Int J Radiat Biol. 18:25–40.
   Web of Science ®Google Scholar
• Nikjoo H, Bolton CE, Watanabe R, Terrissol M, O’Neill P, Goodhead DT. 2002. Modelling of DNA damage induced by energetic electrons (100 eV to 100 keV). Radiat Prot Dosim. 99(1):77–80.
   PubMed Web of Science ®Google Scholar
• Nikjoo H, Emfietzoglou D, Liamsuwan T, Taleei R, Liljequist D, Uehara S. 2016. Radiation track, DNA damage and response-a review. Rep Prog Phys. 79(11):116601.
   PubMed Web of Science ®Google Scholar
• Nikjoo H, Goodhead DT, Charlton DE, Paretzke HG. 1989. Energy deposition in small cylindrical targets by ultrasoft X-rays. Phys Med Biol. 34(6):691–705.
   PubMed Web of Science ®Google Scholar
• Nikjoo H, Goodhead DT, Charlton DE, Paretzke HG. 1991. Energy deposition in small cylindrical targets by monoenergetic electrons. Int J Radiat Biol. 60(5):739–756.
   PubMed Web of Science ®Google Scholar
• Nikjoo H, O’Neill P, Goodhead DT, Terrissol M. 1997. Computational modelling of low-energy electron-induced DNA damage by early physical and chemical events. Int J Radiat Biol. 71(5):467–483.
   PubMed Web of Science ®Google Scholar
• Nikjoo H, O’Neill P, Wilson WE, Goodhead DT. 2001. Computational approach for determining the spectrum of DNA damage induced by ionizing radiation. Radiat Res. 156(5):577–583.
   PubMed Web of Science ®Google Scholar
• Nikjoo H, Uehara S. 2004. Track structure studies of biological systems. In: Mozuumder A, Hatano Y, editors. Charged particle and photon interactions with matter: chemical, physiochemical, and biological consequences with applications. New York (NY): Marcel Dekker.
   Google Scholar
• Nusse M, Kramer M, Egner H J. 1987. Flow cytometric detecting of chromosome aberrations and micronuclei in irradiated mammalian cells. Abstracts of third workshop on heavy charged particles in Biology and Medicine, GSI Rep. 87:11.
   Google Scholar
• Roots R, Okada S. 1975. Estimation of life times and diffusion distances of radicals involved in x-ray-induced DNA strand breaks or killing of mammalian cells. Radiat Res. 64(2):306–320.
   PubMed Web of Science ®Google Scholar
• Sartor O, Maalouf B, Hauck C, Macklis R. 2012. Targeted use of alpha particles: current status in cancer therapeutics. J Nucl Med Radiat Ther. 3:136.
   Google Scholar
• Scholes G, Willson RL, Ebert M. 1969. Pulse radiolysis of aqueous solutions of deoxyribonucleotides and of DNA: Reaction with hydroxy-radicals. Chem Commun:17–18.
   Google Scholar
• Semenenko V, Stewart R. 2006. Fast Monte Carlo simulation of DNA damage formed by electrons and light ions. Phys Med Biol. 51(7):1693–1706.
   PubMed Web of Science ®Google Scholar
• Sgouros G. 2008. Alpha-particles for targeted therapy. Adv Drug Delivery Rev. 60(12):1402–1406.
   PubMed Web of Science ®Google Scholar
• Terrissol M. 1994. Modelling of radiation damage by 125I on a nucleosome. Int J Radiat Biol. 66(5):447–452.
   PubMed Web of Science ®Google Scholar
• Uehara S. 1986. The development of a Monte Carlo code simulating electron–photon showers and its evaluation by various transport benchmarks. Nucl Instrum Methods Phys Res B. 14(4–6):559–570.
   Web of Science ®Google Scholar
• Ward JF. 1994. The complexity of DNA damage – relevance to biological consequences. Int J Radiat Biol. 66(5):427–432.
   PubMed Web of Science ®Google Scholar
• Watanabe R, Nikjoo H. 2002. Modeling the effect of incorporated halogenated pyrimidine on radiation-induced DNA strand breaks. Int J Radiat Biol. 11:953–966.
   Google Scholar
• Wilson WE, Nikjoo H. 1999. A Monte Carlo code for positive ion track simulation. Radiat Environ Biophys. 38(2):97–104.
   PubMed Web of Science ®Google Scholar