Vaccination with gamma radiation-attenuated Toxoplasma gondii protects against ovarian infiltration in mice-bearing Ehrlich ascites carcinoma

References

• Agrawal SS, Sharma P. 2017. Anticancer activity of cyclophosphamide nanoparticles against Ehrlich ascites carcinoma cells bearing Swiss Albino mice. Int J Pharmapharm Res. 9(3):244–265.
   Google Scholar
• Amin M, Hafez EN. 2015. Effect of vaccination with irradiated tachyzoites on histopathological changes and DNA damage in hepatocytes of experimental toxoplasmosis. Arab J Nucl Sci Appl. 48 (4):237–245.
   Google Scholar
• Apte SS, Parks WC. 2015. Metalloproteinases: a parade of functions in matrix biology and an outlook for the future. Matrix Biol. 44–46:1–6.
   PubMed Web of Science ®Google Scholar
• Bahgat AE, El-Naggar MI, Badr OM. 2015. Evaluation of antitumor activity of sodium hypochlorite. Int J Pharmacol. 11(5):513–517.
   Google Scholar
• Baird JR, Byrne KT, Lizotte PH, Toraya-Brown S, Scarlett UK, Alexander MP, Sheen MR, Fox BA, Bzik DJ, Bosenberg M, et al. 2013a. Immune-mediated regression of established B16F10 melanoma by intratumoral injection of attenuated Toxoplasma gondii protects against rechallenge. J Immunol. 190(1):469–478.
   PubMed Web of Science ®Google Scholar
• Baird JR, Fox BA, Sanders KL, Lizotte PH, Cubillos-Ruiz JR, Scarlett UK, Rutkowski MR, Conejo-Garcia JR, Fiering S, Bzik DJ. 2013b. Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment. Cancer Res. 73(13):3842–3851.
   PubMed Web of Science ®Google Scholar
• Bala A, Kar B, Haldar PK, Mazumder UK, Bera S. 2010. Evaluation of anticancer activity of Cleome gynandra on Ehrlich’s ascites carcinoma treated mice. J Ethnopharmacol. 129(1):131–134.
   PubMed Web of Science ®Google Scholar
• Cabrales LB, Ciria HC, Bruzon RP, Quevedo MS, Aldana RH, De Oca LM, Salas MF, Pena OG. 2001. Electrochemical treatment of mouse Ehrlich tumor with direct electrical current. Bioelectromagnatics. 22(5):316–322.
   PubMed Web of Science ®Google Scholar
• Chomczynski P. 1993. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. BioTechniques. 15(3):532–537.
   PubMed Web of Science ®Google Scholar
• Coussens LM, Fingleton B, Matrisian LM. 2002. Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science. 295(5564):2387–2392.
   PubMed Web of Science ®Google Scholar
• Da Costa A, Zorgi EN, Do Nascimento N, Galisteo AJ, De Andrade HF. 2018. Gamma irradiation of Toxoplasma gondii protein extract improve immune response and protection in mice models. Biomed Pharmather. 106:599–604.
   PubMed Web of Science ®Google Scholar
• Darani HY, Yousefi M. 2012. Parasites and cancers: parasite antigens as possible targets for cancer immunotherapy. Future Oncol. 8(12):1529–1535.
   PubMed Web of Science ®Google Scholar
• Denkers EY, Bzik DJ, Fox BA, Butcher BA. 2012. An inside job: hacking into Janus kinase/signal transducer and activator of transcription signaling cascades by the intracellular protozoan Toxoplasma gondii. Infect Immun. 80(2):476–482.
   PubMed Web of Science ®Google Scholar
• Deways WD. 1982. Pathophysiological of cancer cachexia: current understanding and areas for future research. Cancer Res. 42:721s–726s.
   PubMed Web of Science ®Google Scholar
• Drury RA, Wallington EA. 1980. Carlton’s histological technique. 4th ed. New York: Oxford University Press.
   Google Scholar
• Dupont CD, Christian DA, Selleck EM, Pepper M, Leney-Greene M, Harms Pritchard G, et al. 2014. Parasite fate and involvement of infected cells in the induction of CD4+ and CD8+ T cell responses to Toxoplasma gondii. PLoS Pathog. 10:e1004047.
   PubMed Web of Science ®Google Scholar
• El Gawish MAM, Moawad MAF, Mahmoud N. 2001. Trial to use irradiated cysts as a vaccine against Toxoplasma gondii infection in rats. Arab J Nucl Sci Appl. 34(2):223–228.
   Google Scholar
• Fox BA, Bzik DJ. 2010. Avirulent uracil auxotrophs based on disruption of orotidine-5′-monophosphate decarboxylase elicit protective immunity to Toxoplasma gondii. Infect Immun. 78(9):3744–3752.
   PubMed Web of Science ®Google Scholar
• Fox BA, Sanders KL, Chen C, Bzik DJ. 2013. Targeting tumors with nonreplicating Toxoplasma gondii uracil auxotroph vaccines. Trends Parasitol. 29(9):431–437.
   PubMed Web of Science ®Google Scholar
• Guo J, Cai J, Zhang Y, Zhu Y, Yang P, Wang Z. 2017. Establishment of two ovarian cancer orthotopic xenograft mouse models for in vivo imaging: a comparative study. Int J Oncol. 51(4):1199–1208.
   PubMed Web of Science ®Google Scholar
• Gurzu S, Ciortea D, Munteanu T, Kezdi-Zaharia I, Jung I. 2013. Mesenchymal-to-endothelial transition in Kaposi sarcoma: a histogenetic hypothesis based on a case series and literature review. PLoS One. 8(8):e71530.
   PubMed Web of Science ®Google Scholar
• Hiramoto RM, Anders J, Galisreo JH, Heitor F, Andrade JR. 1999. Effects of cobalt 60 ionizing radiation on the metabolism and infectivity of a parasitic protozoa, Toxoplasma gondii. Proceedings of the General Congress on Nuclear Energy; Aug 31–Sep 3; Belo Horizonte, MG, Brazil.
   Google Scholar
• Hiramoto RM, Galisteo J, Nascimento J, Andrade J. 2002. 200 Gy sterilised Toxoplasma gondii tachyzoites maintain metabolic functions and mammalian cell invasion, eliciting cellular immunity and cytokine response similar to natural infection in mice. Vaccine. 20(16):2072–2081.
   PubMed Web of Science ®Google Scholar
• Jagetia GC, Venkatesha AK. 2005. Enhancement of radiation effect by Aphanamixis polystachya in mice transplanted with Ehrlich ascites carcinoma. Biol Pharm Bull. 28(1):69–77.
   PubMed Web of Science ®Google Scholar
• Jiang L, Malpica A, Deavers MT, Guo M, Villa L, Nuovo G, Merino MJ, Silva EG. 2010. Endometrial endometrioid adenocarcinoma of the uterine corpus involving the cervix: some cases probably represent independent primaries. Int J Gynecol Pathol. 29 (2):146–156.
   PubMed Web of Science ®Google Scholar
• Kamat AA, Fletcher M, Gruman LM, Mueller P, Lopez A, Landen CN Jr, Han L, Gershenson DM, Sood AK. 2006. The clinical relevance of stromal matrix metalloproteinase expression in ovarian cancer. Clin Cancer Res. 12(6):1707–1714.
   PubMed Web of Science ®Google Scholar
• Khan IA, Hwang S, Moretto M. 2019. Toxoplasma gondii: CD8 T cells cry for CD4 help. Front Cell Infect Microbiol. 9:136.
   PubMed Web of Science ®Google Scholar
• Kim J, Jung S, Kim S, Kim TY, Shin D, Lee J, Lee Y. 2007. Inhibition of Lewis lung carcinoma growth by Toxoplasma gondii through induction of Th1 immune responses and inhibition of angiogenesis. J Korean Med Sci. 22(Suppl):S38–S46.
   PubMedGoogle Scholar
• Komita H, Zhao X, Katakam AK, Kumar P, Kawabe M, Okada H, Braughler JM, Storkus WJ. 2009. Conditional interleukin-12 gene therapy promotes safe and effective antitumor immunity. Cancer Gene Ther. 16(12):883–891.
   PubMed Web of Science ®Google Scholar
• Laidlaw BJ, Craft JE, Kaech SM. 2016. The multifaceted role of CD4 (+) T cells in CD8 (+) T cell memory. Nat Rev Immunol. 16 (2):102–111.
   PubMed Web of Science ®Google Scholar
• Liu CY, Lin HH, Tang MJ, Wang YK. 2015. Vimentin contributes to epithelial-mesenchymal transition cancer cell mechanics by mediating cytoskeletal organization and focal adhesion maturation. Oncotarget. 6(18):15966–15983.
   PubMedGoogle Scholar
• Matsushita H, Vesely MD, Koboldt DC, Rickert CG, Uppaluri R, Magrini VJ, Arthur CD, White JM, Chen YS, Shea LK, et al. 2012. Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting. Nature. 482(7385):400–404.
   PubMed Web of Science ®Google Scholar
• Moawad MA, Amin MM, Hafez EN. 2016. Vaccination with irradiated tachyzoites show better therapeutic effect than some plants or drugs on toxoplasmosis. Pak J Zool. 48(1):241–248.
   Web of Science ®Google Scholar
• Mohamad F, Shakibapour M, Sharafi SM, Andalib AR, Tolouel S, Darani HY. 2019. Anti-Toxoplasma gondii antibodies attach to mouse cancer cell lines but not normal mouse lymphocytes. Biomed Rep. 10:183–188.
   PubMed Web of Science ®Google Scholar
• Mohammad SR, Mohammad BA, Yun HC, Jin CY. 2017. Anticancer activity and antioxidant potential of Aponogetonundulatus against Ehrlich ascites carcinoma cells in Swiss albino mice. Oncol Lett. 14(3):3169–3176.
   PubMed Web of Science ®Google Scholar
• Niveditha SR, Bajaj P. 2003. Vimentin expression in breast carcinomas. Indian J Pathol Microbiol. 46(4):579–584.
   PubMedGoogle Scholar
• Pfaffl MW. 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29:2002–2007.
   Web of Science ®Google Scholar
• Salem FS, Bad MO, Neamat-Allah AN. 2011. Biochemical and pathological studies on the effects of levamisole and chlorambucil on Ehrlich ascites carcinoma bearing mice. Vet Italiana. 47(1):89–95.
   PubMed Web of Science ®Google Scholar
• Sanders KL, Fox BA, Bzik DJ. 2016. Attenuated Toxoplasma gondii therapy of disseminated pancreatic cancer generates long-lasting immunity to pancreatic cancer. Oncoimmunol. 5(4):e1104447.
   PubMed Web of Science ®Google Scholar
• Schreiber RD, Old LJ, Smyth MJ. 2011. Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science. 331(6024):1565–1570.
   PubMed Web of Science ®Google Scholar
• Sehgal S, Goyal1 P, Agarwal R, Singh S, Kumar A, Gupta R, Kumar V, Agrawa D. 2013. Differences in the angiogenesis of benign and malignant ovarian surface epithelial tumors demonstrated by microvessel density and immunohistochemistry. J Interdiscipl Histopathol. 1(3):145–152.
   Google Scholar
• Shankaran V, Ikeda H, Bruce AT, White JM, Swanson PE, Old LJ, Schreiber RD. 2001. IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature. 410(6832):1107–1111.
   PubMed Web of Science ®Google Scholar
• Sibley LD. 2004. Intracellular parasite invasion strategies. Science. 304(5668):248–253.
   PubMed Web of Science ®Google Scholar
• Ulakoglu G, Altun S. 2004. The effects of epirubicin on proliferation and DNA synthesis of Ehrlich ascites carcinoma cells in vitro and in vivo. Biologia. 59(6):727–734.
   Web of Science ®Google Scholar
• Wang L, Jin X, Lin D, Liu Z, Zhang X, Lu Y, Liu Y, Wang M, Yang M, Li J, et al. 2013. Clinicopathologic significance of claudin-6, occludin, and matrix metalloproteinases-2 expression in ovarian carcinoma. Diagn Pathol. 8:190–198.
   PubMed Web of Science ®Google Scholar
• Xiaohua W, Haili L, Lin KLL, Weiping W, Baoen S. 2002. Activated matrix metalloproteinase-2—a potential marker of prognosis for epithelial ovarian cancer. Gynecol Oncol. 84(1):126–134.
   PubMed Web of Science ®Google Scholar
• Zaidi MR, Merlino G. 2011. The two faces of interferon-gamma in cancer. Lin Cancer Res. 17(19):6118–6124.
   Google Scholar
• Zhang Y, Tang H, Cai J, Zhang T, Guo J, Feng D, Wang Z. 2011. Ovarian cancer-associated fibroblasts contribute to epithelial ovarian carcinoma metastasis by promoting angiogenesis, lymphangiogenesis and tumor cell invasion. Cancer Lett. 303(1):47–55.
   PubMed Web of Science ®Google Scholar