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Original Articles

Modulating the dose-rate differently affects the responsiveness of human epithelial prostate- and mesenchymal rhabdomyosarcoma-cancer cell line to radiation

, , ORCID Icon, , , , , , , , , , , , , , , , , , , & show all
Pages 823-835 | Received 20 Sep 2019, Accepted 07 Feb 2020, Published online: 23 Mar 2020

References

  • Ayers D, Baron B, Hunter T. 2015. miRNA influences in NRF2 pathway interactions within cancer models. J Nucleic Acids. 2015:143636.
  • Baskar R, Lee KA, Yeo R, Yeoh KW. 2012. Cancer and radiation therapy: current advances and future directions. Int J Med Sci. 3:193–199.
  • Biau J, Chautard E, Verrelle P, Dutreix M. 2019. Altering DNA repair to improve radiation therapy: specific and multiple pathway targeting. Front Oncol. 9:1009.
  • Bjørkøy G, Lamark T, Pankiv S, Øvervatn A, Brech A, Johansen T. 2009. Monitoring autophagic degradation of p62/SQSTM1. Meth Enzymol. 452:181–197.
  • Cheleschi S, De Palma A, Pascarelli NA, Giordano N, Galeazzi M, Tenti S, Fioravanti A. 2017. Could oxidative stress regulate the expression of MicroRNA-146a and MicroRNA-34a in human osteoarthritic chondrocyte cultures? Int J Mol Sci. 18:12.
  • Cheleschi S, Giordano N, Volpi N, Tenti S, Gallo I, Di Meglio M, Giannotti S, Fioravanti A. 2018. A complex relationship between visfatin and resistin and microRNA: an in vitro study on human chondrocyte cultures. Int J Mol Sci. 19:12.
  • Ciccarelli C, Di Rocco A, Gravina GL, Mauro A, Festuccia C, Del Fattore A, Berardinelli P, De Felice F, Musio D, Bouché M, et al. 2018. Disruption of MEK/ERK/c-Myc signaling radiosensitizes prostate cancer cells in vitro and in vivo. J Cancer Res Clin Oncol. 144:1685–1699.
  • Ciccarelli C, Vulcano F, Milazzo L, Gravina GL, Marampon F, Macioce G, Giampaolo A, Tombolini V, Di Paolo V, Hassan HJ, et al. 2016. Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population. Mol Cancer. 20:15–16.
  • Ciccarese F, Ciminale V. 2017. Escaping death: mitochondrial redox homeostasis in cancer cells. Front Oncol. 7:117.
  • Coelho D, Holl V, Weltin D, Lacornerie T, Magnenet P, Dufour P, Bischoff P. 2000. Caspase-3-like activity determines the type of cell death following ionizing radiation in MOLT-4 human leukaemia cells. Br J Cancer. 83:642–649.
  • Cortese F, Klokov D, Osipov A, Stefaniak J, Moskalev A, Schastnaya J, Cantor C, Aliper A, Mamoshina P, Ushakov I, et al. 2018. Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization. Oncotarget. 18:14692–14722.
  • da Silva-Diz V, Lorenzo-Sanz L, Bernat-Peguera A, Lopez-Cerda M, Muñoz P. 2018. Cancer cell plasticity: impact on tumor progression and therapy response. Semin Cancer Biol. 53:48–58.
  • De Palma A, Cheleschi S, Pascarelli NA, Tenti S, Galeazzi M, Fioravanti A. 2017. Do MicroRNAs have a key epigenetic role in osteoarthritis and in mechanotransduction? Clin Exp Rheumatol. 35:518–526.
  • Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O. 1995. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA. 92:9363–9367.
  • Durante M, Bräuer-Krisch E, Hill M. 2018. Faster and safer? FLASH ultra-high dose rate in radiotherapy. Br J Radiol. 91:20170628.
  • Eriksson D, Stigbrand T. 2010. Radiation-induced cell death mechanisms. Tumor Biol. 31:363–372.
  • Gravina GL, Festuccia C, Popov VM, Di Rocco A, Colapietro A, Sanità P, Monache SD, Musio D, De Felice F, Di Cesare E, et al. 2016. c-Myc sustains transformed phenotype and promotes radioresistance of embryonal rhabdomyosarcoma cell lines. Radiat Res. 185:411–422.
  • Gravina GL, Mancini A, Marampon F, Colapietro A, Delle Monache S, Sferra R, Vitale F, Richardson PJ, Patient L, Burbidge S, et al. 2017. The brain-penetrating CXCR4 antagonist, PRX177561, increases the antitumor effects of bevacizumab and sunitinib in preclinical models of human glioblastoma. J Hematol Oncol. 10:5.
  • Gravina GL, Mancini A, Ranieri G, Di Pasquale B, Marampon F, Di Clemente L, Ricevuto E, Festuccia C. 2013. Phenotypic characterization of human prostatic stromal cells in primary cultures derived from human tissue samples. Int J Oncol. 42:2116–2122.
  • Gravina GL, Marampon F, Sherris D, Vittorini F, Di Cesare E, Tombolini V, Lenzi A, Jannini EA, Festuccia C. 2014. Torc1/Torc2 inhibitor, Palomid 529, enhances radiation response modulating CRM1-mediated survivin function and delaying DNA repair in prostate cancer models. Prostate. 74:852–868.
  • Guo Y, Li P, Gao L, Zhang J, Yang Z, Bledsoe G, Chang E, Chao L, Chao J. 2017. Kallistatin reduces vascular senescence and aging by regulating microRNA-34a-SIRT1 pathway. Aging Cell. 16:837–846.
  • Hahnfeldt P, Hlatky L. 1996. Resensitization due to redistribution of cells in the phases of the cell cycle during arbitrary radiation protocols. Radiat Res. 145:134–143.
  • Hall EJ. 1972. Radiation dose-rate: a factor of importance in radiobiology and radiotherapy. Br J Radiol. 45:81–97.
  • Hufnagl A, Herr L, Friedrich T, Durante M, Taucher-Scholz G, Scholz M. 2015. The link between cell-cycle dependent radiosensitivity and repair pathways: a model based on the local, sister-chromatid conformation dependent switch between NHEJ and HR. DNA Repair (Amst). 27:28–39.
  • Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. 2000. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. Embo J. 19:5720–5728.
  • Kuo LJ, Yang LX. 2008. Gamma-H2AX – a novel biomarker for DNA double-strand breaks. In Vivo. 22:305–309.
  • Ling CC, Gerweck LE, Zaider M, Yorke E. 2010. Dose-rate effects in external beam radiotherapy redux. Radiother Oncol. 95:261–268.
  • Marampon F, Codenotti S, Megiorni F, Del Fattore A, Camero S, Gravina GL, Festuccia C, Musio D, De Felice F, Nardone V, et al. 2019. NRF2 orchestrates the redox regulation induced by radiation therapy, sustaining embryonal and alveolar rhabdomyosarcoma cells radioresistance. J Cancer Res Clin Oncol. 145:881–893.
  • Marampon F, Gravina GL, Di Rocco A, Bonfili P, Di Staso M, Fardella C, Polidoro L, Ciccarelli C, Festuccia C, Popov VM, et al. 2011. MEK/ERK inhibitor U0126 increases the radiosensitivity of rhabdomyosarcoma cells in vitro and in vivo by downregulating growth and DNA repair signals. Mol Cancer Ther. 10:159–168.
  • Marampon F, Gravina GL, Festuccia C, Popov VM, Colapietro EA, Sanità P, Musio D, De Felice F, Lenzi A, Jannini EA, et al. 2016. Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SirT1 axis. J Endocrinol Invest. 39:411–422.
  • Marampon F, Gravina GL, Ju X, Vetuschi A, Sferra R, Casimiro MC, Pompili S, Festuccia C, Colapietro A, Gaudio E, et al. 2016. Cyclin D1 silencing suppresses tumorigenicity, impairs DNA double strand break repair and thus radiosensitizes androgen-independent prostate cancer cells to DNA damage. Oncotarget. 7:64526.
  • Marampon F, Gravina GL, Popov VM, Scarsella L, Festuccia C, La Verghetta ME, Parente S, Cerasani M, Bruera G, Ficorella C, et al. 2014. Close correlation between MEK/ERK and Aurora-B signaling pathways in sustaining tumorigenic potential and radioresistance of gynecological cancer cell lines. Int J Oncol. 44:285–294.
  • Matsuya Y, McMahon SJ, Tsutsumi K, Sasaki K, Okuyama G, Yoshii Y, Mori R, Oikawa J, Prise KM, Date H. 2018. Investigation of dose-rate effects and cell-cycle distribution under protracted exposure to ionizing radiation for various dose-rates. Sci Rep. 8:8287.
  • Morgan MA, Lawrence TS. 2015. Molecular pathways: overcoming radiation resistance by targeting DNA damage response pathways. Clin Cancer Res. 13:2898–2904.
  • Nguyen T, Nioi P, Pickett CB. 2009. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem. 284:13291–13295.
  • Ou J, Kou L, Liang L, Tang C. 2017. MiR-375 attenuates injury of cerebral ischemia/reperfusion via targetting Ctgf. Biosci Rep. 22:37.
  • Qu X, Wang N, Cheng W, Xue Y, Chen W, Qi M. 2019. MicroRNA-146a protects against intracerebral hemorrhage by inhibiting inflammation and oxidative stress. Exp Ther Med. 18:3920–3928.
  • Rodgers K, McVey M. 2016. Error-prone repair of DNA double-strand breaks. J Cell Physiol. 231:15–24.
  • Rojo de la Vega M, Chapman E, Zhang DD. 2018. NRF2 and the hallmarks of cancer. Cancer Cell. 34:21–43.
  • Sishc BJ, Davis AJ. 2017. The role of the core non-homologous end joining factors in carcinogenesis and cancer. Cancers (Basel). 9:81.
  • Srinivas US, Tan BWQ, Vellayappan BA, Jeyasekharan AD. 2018. ROS and the DNA damage response in cancer. Redox Biol. 21:101084.
  • Steel GG, Deacon JM, Duchesne GM, Horwich A, Kelland LR, Peacock JH. 1987. The dose-rate effect in human tumour cells. Radiother Oncol. 4:299–310.
  • Sun W, Zhao L, Song X, Zhang J, Xing Y, Liu N, Yan Y, Li Z, Lu Y, Wu J, et al. 2017. MicroRNA-210 modulates the cellular energy metabolism shift during H2O2-induced oxidative stress by repressing ISCU in H9c2 cardiomyocytes. Cell Physiol Biochem. 43:383–394.
  • Sutera P, Clump DA, Kalash R, D'Ambrosio D, Mihai A, Wang H, Petro DP, Burton SA, Heron DE. 2019. Initial results of a multicenter phase 2 trial of stereotactic ablative radiation therapy for oligometastatic cancer. Int J Radiat Oncol Biol Phys. 103:116–122.
  • Tabasso AFS, Jones DJL, Jones GDD, Macip S. 2019. Radiotherapy-induced senescence and its effects on responses to treatment. Clin Oncol (R Coll Radiol). 31:283–289.
  • Tang Q, Len Q, Liu Z, Wang W. 2018. Overexpression of miR-22 attenuates oxidative stress injury in diabetic cardiomyopathy via Sirt 1. Cardiovasc Ther. 36:e12318.
  • Terashima S, Hosokawa Y, Tsuruga E, Mariya Y, Nakamura T. 2017. Impact of time interval and dose rate on cell survival following low-dose fractionated exposures. J Radiat Res. 58:782–790.
  • Wang W, Zheng Y, Wang M, Yan M, Jiang J, Li Z. 2019. Exosomes derived miR-126 attenuates oxidative stress and apoptosis from ischemia and reperfusion injury by targeting ERRFI1. Gene. 690:75–80.
  • Williams JR, Zhang Y, Zhou H, Gridley DS, Koch CJ, Slater JM, Little JB. 2008. Overview of radiosensitivity of human tumor cells to low-dose-rate irradiation. Int J Radiat Oncol Biol Phys. 72:909–917.
  • Zimmermann M, Meyer N. 2011. Annexin V/7-AAD staining in keratinocytes. Methods Mol Biol. 740:57–63.

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