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International Journal of Radiation Biology Volume 97, 2021 - Issue sup1: Medical Counter Measure Development for Radiation
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Original Articles

Characterization of the hemorrhagic syndrome in the New Zealand white rabbit model following total body irradiation

Isabel L. Jacksona Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USACorrespondence[email protected]
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Ganga Gurunga Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USAView further author information
,
Emmanuel Ayompea Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USAView further author information
,
Elena-Rose Fowna Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USAView further author information
,
Sarah Trieslera Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USAView further author information
,
Buddha Malia Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USAView further author information
,
Andrea Casildoa Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USAView further author information
,
Allison Gibbsa Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USAView further author information
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Yannick Poiriera Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USAORCID Iconhttps://orcid.org/0000-0002-6548-8321View further author information
ORCID Icon,
Eric P. Cohenb Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USAView further author information
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Diana Newmana Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USAView further author information
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Zeljko Vujaskovica Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USAView further author information
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Pages S32-S44 | Received 23 Jun 2019, Accepted 30 Sep 2019, Published online: 16 Oct 2020

References

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  • Cronkite EP, Halpern B, Jackson DP, Le RG. 1950. A study of the hemorrhagic state in dogs after a lethal dose of two million volt X-rays. J Lab Clin Med. 36(5):814.
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  • Jackson IL, Gurung G, Poirier Y, Gopalakrishnan M, Cohen EP, Shea Donohue T, Cohen MJ, Newman D, Vujaskovic Z. 2019. A New Zealand White rabbit model of thrombocytopenia and coagulopathy following total body irradiation across the dose range to induce the hematopoietic-subsyndrome of acute radiation syndrome. Rev Int J Radiat Biol. 1–36. DOI:https://doi.org/10.1080/09553002.2019.1668981
  • Liebow AA, Warren S. 1947. Injuries produced by the atomic bomb: observations on human beings at Hiroshima and Nagasaki. Am J Pathol. 23(5):888–891.
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  • Moroni M, Elliott TB, Deutz NE, Olsen CH, Owens R, Christensen C, Lombardini ED, Whitnall MH. 2014. Accelerated hematopoietic syndrome after radiation doses bridging hematopoietic (H-ARS) and gastrointestinal (GI-ARS) acute radiation syndrome: early hematological changes and systemic inflammatory response syndrome in minipig. Int J Radiat Biol. 90(5):363–372.
  • Moroni M, Ngudiankama BF, Christensen C, Olsen CH, Owens R, Lombardini ED, Holt RK, Whitnall MH. 2013. The Gottingen minipig is a model of the hematopoietic acute radiation syndrome: G-colony stimulating factor stimulates hematopoiesis and enhances survival from lethal total-body γ-irradiation. Int J Radiat Oncol Biol Phys. 86(5):986–992.
  • Poirier Y, Prado C, Prado K, Draeger E, Jackson IL, Vujaskovic Z. 2019. Use of CT simulation and 3-D radiation therapy treatment planning system to develop and validate a total-body irradiation technique for the New Zealand White rabbit Manuscript under review at International Journal Radiation Biology.(BARDA RadNuc Special Issue).
  • Stohlman F, Jr., Brecher G, Schneiderman M, Cronkite EP. 1957. The hemolytic effect of ionizing radiations and its relationship to the hemorrhagic phase of radiation injury. Blood. 12(12):1061–1085.

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