The future of biological dosimetry in mass casualty radiation emergency response, personalized radiation risk estimation and space radiation protection

References

• Balajee AS, Hande MP. 2018. History and evolution of cytogenetic techniques: current and future applications in basic and clinical research. Mutat Res Genet Toxicol Environ Mutagen. 836(Pt A):3–12.
   PubMed Web of Science ®Google Scholar
• Balog RP, Bacher R, Chang P, Greenstein M, Jammalamadaka S, Javitz H, Knox SJ, Lee S, Lin H, Shaler T, Shura L, et al. 2020. Development of a biodosimeter for radiation triage using novel blood protein biomarker panels in humans and non-human primates. Int J Radiat Biol. 96(1):22–34.
   PubMed Web of Science ®Google Scholar
• Barquinero JF, Beinke C, Borràs M, Buraczewska I, Darroudi F, Gregoire E, Hristova R, Kulka U, Lindholm C, Moreno M, et al. 2017. RENEB biodosimetry intercomparison analyzing translocations by FISH. Int J Radiat Biol. 93(1):30–35.
   PubMed Web of Science ®Google Scholar
• Bezdan D, Grigorev K, Meydan C, Pelissier Vatter FA, Cioffi M, Rao V, MacKay M, Nakahira K, Burnham P, Afshinnekoo E, et al. 2020. Cell-free DNA (cfDNA) and exosome profiling from a year-long human spaceflight reveals circulating biomarkers. iScience. 23(12):10184425.
   PubMed Web of Science ®Google Scholar
• Bucher M, Endesfelder D, Roessler U, Borkhardt A, Dückers G, Kirlum HJ, Lankisch P, Oommen PT, Niehues T, Rübe CE, et al. 2021. Analysis of chromosomal aberrations and γH2A.X foci to identify radiation-sensitive ataxia-telangiectasia patients. Mutat Res Genet Toxicol Environ Mutagen. 861-862:503301.
   PubMed Web of Science ®Google Scholar
• Cruz-Garcia L, Badie C, Anbalagan S, Moquet J, Gothard L, O'Brien G, Somaiah N, Ainsbury EA. 2021. An ionising radiation-induced specific transcriptional signature of inflammation-associated genes in whole blood from radiotherapy patients: a pilot study. Radiat Oncol. 16(1):83.
   PubMed Web of Science ®Google Scholar
• Cruz-Garcia L, O'Brien G, Donovan E, Gothard L, Boyle S, Laval A, Testard I, Ponge L, Woźniak G, Miszczyk L, et al. 2018. Influence of confounding factors on radiation dose estimation using in vivo validated transcriptional biomarkers. Health Phys. 115(1):90–101.
   PubMed Web of Science ®Google Scholar
• Cruz-Garcia L, O'Brien G, Sipos B, Mayes S, Love MI, Turner DJ, Badie C. 2020. Generation of a transcriptional radiation exposure signature in human blood using long-read nanopore sequencing. Radiat Res. 193(2):143–154.
   PubMed Web of Science ®Google Scholar
• Cucinotta FA, To K, Cacao E. 2017. Predictions of space radiation fatality risk for exploration missions. Life Sci Space Res (Amst). 13:1–11.
   PubMed Web of Science ®Google Scholar
• del Rosario Pérez M, Carr Z, Rojas-Palma C, van der Meer K, Smith K, Rahola T, Muikku M, Liland A, Jaworska A, Jerstad A. 2010. A new handbook on triage, monitoring and treatment of people following malevolent use of radiation. Health Phys. 98(6):898–902.
   PubMed Web of Science ®Google Scholar
• Depuydt J, Baeyens A, Barnard S, Beinke C, Benedek A, Beukes P, Buraczewska I, Darroudi F, De Sanctis S, Dominguez I, et al. 2017. RENEB intercomparison exercises analyzing micronuclei (Cytokinesis-block Micronucleus Assay). Int J Radiat Biol. 93(1):36–47.
   PubMed Web of Science ®Google Scholar
• Durante M. 2004. Heavy ion radiobiology for hadrontherapy and space radiation protection. Radiother Oncol. 73(Suppl 20):S158–S160.
   PubMed Web of Science ®Google Scholar
• Durante M, Cucinotta F. 2011. Physical basis of radiation protection in space travel. Rev Mod Phys. 83(4):1245–1281.
   Web of Science ®Google Scholar
• Edmondson EF, Gatti DM, Ray FA, Garcia EL, Fallgren CM, Kamstock DA, Weil MM. 2020. Genomic mapping in outbred mice reveals overlap in genetic susceptibility for HZE ion- and γ-ray-induced tumors. Sci Adv. 6(16):eaax5940.
   PubMed Web of Science ®Google Scholar
• [FFMD] Final Frontier Medical Devices 2021. [accessed 2021 Apr 04]. https://space.xprize.org/prizes/tricorder/teams/final_frontier_medical_devices.
   Google Scholar
• George K, Rhone J, Beitman A, Cucinotta FA. 2013. Cytogenetic damage in the blood lymphocytes of astronauts: effects of repeat long-duration space missions. Mutat Res. 756(1-2):165–169.
   PubMed Web of Science ®Google Scholar
• Gertz ML, Chin CR, Tomoiaga D, MacKay M, Chang C, Butler D, Afshinnekoo E, Bezdan D, Schmidt MA, Mozsary C, et al. 2020. Multi-omic, single-cell, and biochemical profiles of astronauts guide pharmacological strategies for returning to gravity. Cell Rep. 33(10):108429.
   PubMed Web of Science ®Google Scholar
• Giussani A, Lopez MA, Romm H, Testa A, Ainsbury EA, Degteva M, Della Monaca S, Etherington G, Fattibene P, Güclu I, et al. 2020. Eurados review of retrospective dosimetry techniques for internal exposures to ionising radiation and their applications. Radiat Environ Biophys. 59(3):357–387.
   PubMed Web of Science ®Google Scholar
• Guiot J, Vaidyanathan A, Deprez L, Zerka F, Danthine D, Frix AN, Lambin P, Bottari F, Tsoutzidis N, Miraglio B, et al. 2021. A review in radiomics: making personalized medicine a reality via routine imaging. Med Res Rev. doi:https://doi.org/10.1002/med.21846.
   Google Scholar
• Hall J, Jeggo PA, West C, Gomolka M, Quintens R, Badie C, Laurent O, Aerts A, Anastasov N, Azimzadeh O, et al. 2017. Ionizing radiation biomarkers in epidemiological studies - An update. Mutat Res. 771:59–84.
   PubMed Web of Science ®Google Scholar
• Hamm PB, Billica RD, Johnson GS, Wear ML, Pool SL. 1998. Risk of cancer mortality among the Longitudinal Study of Astronaut Health (LSAH) participants. Aviat Space Environ Med. 69(2):142–144.
   PubMedGoogle Scholar
• Horstmann M, Durante M, Johannes C, Pieper R, Obe G. 2005. Space radiation does not induce a significant increase of intrachromosomal exchanges in astronauts' lymphocytes. Radiat Environ Biophys. 44(3):219–224.
   PubMed Web of Science ®Google Scholar
• Horvath S, Raj K. 2018. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat Rev Genet. 19(6):371–384.
   PubMed Web of Science ®Google Scholar
• [IAEA] International Atomic Energy Agency 2011. Cytogenetic dosimetry: applications in preparedness for and response to radiation Emergencies. Vienna (AT): EPR-Biodosimetry Series; [accessed 2021 mar 22]. https://www.iaea.org/publications/8735/cytogenetic-dosimetry-applications-in-preparedness-for-and-response-to-radiation-emergencies.
   Google Scholar
• Imamura K, Yada Y, Izumi Y, Morita M, Kawata A, Arisato T, Nagahashi A, Enami T, Tsukita K, Kawakami H, et al. 2021. Prediction model of amyotrophic lateral sclerosis by deep learning with patient induced pluripotent stem cells. Ann Neurol. 89(6):1226–1233.
   PubMed Web of Science ®Google Scholar
• Jandial R, Hoshide R, Waters JD, Limoli CL. 2018. Space-brain: the negative effects of space exposure on the central nervous system. Surg Neurol Int. 9:9.
   PubMedGoogle Scholar
• Jang S, Shin SG, Lee MJ, Han S, Choi CH, Kim S, Cho WS, Kim SH, Kang YR, Jo W, et al. 2021. Feasibility study on automatic interpretation of radiation dose using deep learning technique for dicentric chromosome assay. Radiat Res. 195(2):163–172.
   PubMed Web of Science ®Google Scholar
• Jaworska A, Ainsbury EA, Fattibene P, Lindholm C, Oestreicher U, Rothkamm K, Romm H, Thierens H, Trompier F, Voisin P, et al. 2015. Operational guidance for radiation emergency response organisations in Europe for using biodosimetric tools developed in EU MULTIBIODOSE project. Radiat Prot Dosimetry. 164(1-2):165–169.
   PubMed Web of Science ®Google Scholar
• Koelsche C, Schrimpf D, Stichel D, Sill M, Sahm F, Reuss DE, Blattner M, Worst B, Heilig CE, Beck K, et al. 2021. Sarcoma classification by DNA methylation profiling. Nat Commun. 12(1):498.
   PubMed Web of Science ®Google Scholar
• Kulka U, Wojcik A. 2017. Special issue: Networking in biological and EPR/OSL dosimetry: the European RENEB platform for emergency preparedness and research. Int J Radiat Biol. 93(1):1.
   PubMed Web of Science ®Google Scholar
• Kulka U, Wojcik A, Di Giorgio M, Wilkins R, Suto Y, Jang S, Quing-Jie L, Jiaxiang L, Ainsbury E, Woda C, et al. 2018. Biodosimetry and biodosimetry networks for managing radiation emergency. Radiat Prot Dosimetry. 182(1):128–138.
   PubMed Web of Science ®Google Scholar
• Lowe D, Horvath S, Raj K. 2016. Epigenetic clock analyses of cellular senescence and ageing. Oncotarget. 7(8):8524–8531.
   PubMedGoogle Scholar
• Luxton JJ, McKenna MJ, Lewis AM, Taylor LE, Jhavar SG, Swanson GP, Bailey SM. 2021. Telomere length dynamics and chromosomal instability for predicting individual radiosensitivity and risk via machine learning. J Pers Med. 11(3):188.
   PubMed Web of Science ®Google Scholar
• Marcos-Zambrano LJ, Karaduzovic-Hadziabdic K, Loncar Turukalo T, Przymus P, Trajkovik V, Aasmets O, Berland M, Gruca A, Hasic J, Hron K, et al. 2021. Applications of machine learning in human microbiome studies: a review on feature selection, biomarker identification, disease prediction and treatment. Front Microbiol. 12:634511.
   PubMed Web of Science ®Google Scholar
• May JM, Bylicky M, Chopra S, Coleman CN, Aryankalayil MJ. 2021. Long and short non-coding RNA and radiation response: a review. Transl Res. 233:162–179.
   PubMed Web of Science ®Google Scholar
• Moquet J, Barnard S, Staynova A, Lindholm C, Monteiro Gil O, Martins V, Rößler U, Vral A, Vandevoorde C, Wojewódzka M, et al. 2017. The second gamma-H2AX assay inter-comparison exercise carried out in the framework of the European biodosimetry network (RENEB). Int J Radiat Biol. 93(1):58–64.
   PubMed Web of Science ®Google Scholar
• Moquet J, Higueras M, Donovan E, Boyle S, Barnard S, Bricknell C, Sun M, Gothard L, O'Brien G, Cruz-Garcia L, et al. 2018. Dicentric dose estimates for patients undergoing radiotherapy in the RTgene study to assess blood dosimetric models and the new Bayesian method for gradient exposure. Radiat Res. 190(6):596–604.
   PubMed Web of Science ®Google Scholar
• [NIST] National Institute of Standards and Technologies, U.S. Department of Commerce 2021. NIST on a chip: Emergency Dosimetry; [accessed 2021 Apr 04]. https://www.nist.gov/noac/technology/radiation/emergency-dosimetry.
   Google Scholar
• Oestreicher U, Samaga D, Ainsbury E, Antunes AC, Baeyens A, Barrios L, Beinke C, Beukes P, Blakely WF, Cucu A, et al. 2017. RENEB intercomparisons applying the conventional Dicentric Chromosome Assay (DCA). Int J Radiat Biol. 93(1):20–29.
   PubMed Web of Science ®Google Scholar
• Onal C, Kotek A, Unal B, Arslan G, Yavuz A, Topkan E, Yavuz M. 2011. Plasma citrulline levels predict intestinal toxicity in patients treated with pelvic radiotherapy. Acta Oncol. 50(8):1167–1174.
   PubMed Web of Science ®Google Scholar
• Pannkuk EL, Fornace AJ, Jr, Laiakis EC. 2017. Metabolomic applications in radiation biodosimetry: exploring radiation effects through small molecules. Int J Radiat Biol. 93(10):1151–1176.
   PubMed Web of Science ®Google Scholar
• Patel ZS, Brunstetter TJ, Tarver WJ, Whitmire AM, Zwart SR, Smith SM, Huff JL. 2020. Red risks for a journey to the red planet: the highest priority human health risks for a mission to Mars. NPJ Microgravity. 6(1):33.
   PubMed Web of Science ®Google Scholar
• Pernot E, Hall J, Baatout S, Benotmane MA, Blanchardon E, Bouffler S, El Saghire H, Gomolka M, Guertler A, Harms-Ringdahl M, et al. 2012. Ionizing radiation biomarkers for potential use in epidemiological studies. Mutat Res. 751(2):258–286.
   PubMed Web of Science ®Google Scholar
• Port M, Majewski M, Abend M. 2019. Radiation dose is of limited clinical usefulness in persons with acute radiation syndrome. Radiat Prot Dosimetry. 186(1):126–129.
   PubMed Web of Science ®Google Scholar
• Rea ME, Gougelet RM, Nicolalde RJ, Geiling JA, Swartz HM. 2010. Proposed triage categories for large-scale radiation incidents using high-accuracy biodosimetry methods. Health Phys. 98(2):136–144.
   PubMed Web of Science ®Google Scholar
• Repin M, Pampou S, Brenner DJ, Garty G. 2020. The use of a centrifuge-free RABiT-II system for high-throughput micronucleus analysis. J Radiat Res. 61(1):68–72.
   PubMed Web of Science ®Google Scholar
• Royba E, Repin M, Balajee AS, Shuryak I, Pampou S, Karan C, Brenner DJ, Garty G. 2020. The RABiT-II DCA in the rhesus macaque model. Radiat Res. doi: https://doi.org/10.1667/RR15547.1.
   Google Scholar
• Royba E, Repin M, Pampou S, Karan C, Brenner DJ, Garty G. 2019. RABiT-II-DCA: a fully-automated dicentric chromosome assay in multiwell plates. Radiat Res. 192(3):311–323.
   PubMed Web of Science ®Google Scholar
• Sehl ME, Carroll JE, Horvath S, Bower JE. 2020. The acute effects of adjuvant radiation and chemotherapy on peripheral blood epigenetic age in early stage breast cancer patients. NPJ Breast Cancer. 6:2323.
   PubMed Web of Science ®Google Scholar
• Shirley BC, Knoll JHM, Moquet J, Ainsbury E, Pham ND, Norton F, Wilkins RC, Rogan PK. 2020. Estimating partial-body ionizing radiation exposure by automated cytogenetic biodosimetry. Int J Radiat Biol. 96(11):1492–1503.
   PubMed Web of Science ®Google Scholar
• Simon SL, Bouville A. 2016. Long-term biodosimetry redux. Radiat Prot Dosimetry. 172(1-3):244–247.
   PubMed Web of Science ®Google Scholar
• Sotnik NV, Azizova TV, Darroudi F, Ainsbury EA, Moquet JE, Fomina J, Lloyd DC, Hone PA, Edwards AA. 2015. Verification by the FISH translocation assay of historic doses to Mayak workers from external gamma radiation. Radiat Environ Biophys. 54(4):445–451.
   PubMed Web of Science ®Google Scholar
• Sproull MT, Camphausen KA, Koblentz GD. 2017. Biodosimetry: a future tool for medical management of radiological emergencies. Health Secur. 15(6):599–610.
   PubMed Web of Science ®Google Scholar
• Sridharan DM, Chien LC, Cucinotta FA, Pluth JM. 2020. Comparison of signaling profiles in the low dose range following low and high LET radiation. Life Sci Space Res (Amst). 25:28–41.
   PubMed Web of Science ®Google Scholar
• Sun M, Moquet JE, Barnard S, Lloyd DC, Rothkamm K, Ainsbury EA. 2016. Doses in Radiation Accidents Investigated by Chromosomal Aberration Analysis XXV. London (UK): PHE CRCE 025; [accessed 2021 Mar 22]. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/515260/PHE-CRCE-025.pdf.
   Google Scholar
• Swarts SG, Sidabras JW, Grinberg O, Tipikin DS, Kmiec MM, Petryakov SV, Schreiber W, Wood VA, Williams BB, Flood AB, et al. 2018. Developments in biodosimetry methods for triage with a focus on x-band electron paramagnetic resonance in vivo fingernail dosimetry. Health Phys. 115(1):140–150.
   PubMed Web of Science ®Google Scholar
• Swartz HM, Flood AB, Singh VK, Swarts SG. 2020. Scientific and logistical considerations when screening for radiation risks by using biodosimetry based on biological effects of radiation rather than dose: the need for prior measurements of homogeneity and distribution of dose. Health Phys. 119(1):72–82.
   PubMed Web of Science ®Google Scholar
• Terzoudi GI, Pantelias G, Darroudi F, Barszczewska K, Buraczewska I, Depuydt J, Georgieva D, Hadjidekova V, Hatzi VI, Karachristou I, et al. 2017. Dose assessment intercomparisons within the RENEB network using G0-lymphocyte prematurely condensed chromosomes (PCC assay). Int J Radiat Biol. 93(1):48–57.
   PubMed Web of Science ®Google Scholar
• Tichy A, Kabacik S, O’Brien G, Pejchal J, Sinkorova Z, Kmochova A, Sirak I, Malkova A, Beltran CG, Gonzalez JR, et al. 2018. The first in vivo multiparametric comparison of different radiation exposure biomarkers in human blood. PLoS One. 2313(2):e0193412.
   PubMed Web of Science ®Google Scholar
• Umakoshi M, Yamaguchi I, Hirata H, Kunugita N, Williams BB, Swartz HM, Miyake M. 2017. In vivo electron paramagnetic resonance tooth dosimetry: dependence of radiation-induced signal amplitude on the enamel thickness and surface area of ex vivo human teeth. Health Phys. 113(4):262–270.
   PubMed Web of Science ®Google Scholar
• Walsh L, Hafner L, Straube U, Ulanowski A, Fogtman A, Durante M, Weerts G, Schneider U. 2021. A bespoke health risk assessment methodology for the radiation protection of astronauts. Radiat Environ Biophys. 60(2):213–231.
   PubMed Web of Science ®Google Scholar
• Wathen LK, Eder PS, Horwith G, Wallace RL. 2020. Using biodosimetry to enhance the public health response to a nuclear incident. Int J Radiat Biol. 21:1–4.
   Web of Science ®Google Scholar
• Wojcik A, Oestreicher U, Barrios L, Vral A, Terzoudi G, Ainsbury E, Rothkamm K, Trompier F, Kulka U. 2017. The RENEB operational basis: complement of established biodosimetric assays. Int J Radiat Biol. 93(1):15–19.
   PubMed Web of Science ®Google Scholar