A comparative study of genotoxicity endpoints for women exposed to different levels of indoor radon concentrations

References

• Abbotts R, Wilson DM. III. 2017. Coordination of DNA single strand break repair. Free Radic Biol Med. 107:228–244.
   PubMed Web of Science ®Google Scholar
• Ali YF, Cucinotta FA, Ning-Ang L, Zhou G. 2020. Cancer risk of low dose ionizing radiation. Front Phys. 8:1–9.
   Web of Science ®Google Scholar
• Belmans N, Gilles L, Vermeesen R, Virag P, Hedesiu M, Salmon B, Baatout S, Lucas S, Lambrichts I, Jacobs R, et al. 2020. Quantification of DNA double strand breaks and oxidation response in children and adults undergoing dental CBCT scan. Sci Rep. 10(1):2113.
   PubMed Web of Science ®Google Scholar
• Belmans N, Gilles L, Virag P, Hedesiu M, Salmon B, Baatout S, Lucas S, Jacobs R, Lambrichts I, Moreels M. 2019. Method validation to assess in vivo cellular and subcellular changes in buccal mucosa cells and saliva following CBCT examinations. Dentomaxillofac Radiol. 48(6):20180428.
   PubMed Web of Science ®Google Scholar
• Chalmers A, Johnston P, Woodcock M, Joiner M, Marples B. 2004. PARP-1, PARP-2, and the cellular response to low doses of ionizing radiation. Int J Radiat Oncol Biol Phys. 58(2):410–419.
   PubMed Web of Science ®Google Scholar
• Cheng GH, Wu N, Jiang DF, Zhao HG, Zhang Q, Wang JF, Gong SL. 2010. Increased levels of p53 and PARP-1 in EL-4 cells probably related with the immune adaptive response induced by low dose ionizing radiation in vitro. Biomed Environ Sci. 23(6):487–495.
   PubMed Web of Science ®Google Scholar
• Cinelli G, Tollefsen T, Bossew P, Gruber V, Bogucarskis K, De Felice L, De Cort M. 2019. Digital version of the European Atlas of natural radiation. J Environ Radioact. 196:240–252.
   PubMed Web of Science ®Google Scholar
• Collins AR, Dobson VL, Dušinská M, Kennedy G, Štětina R. 1997. The comet assay: what can it really tell us? Mutat Res – Fundam Mol Mech Mutagen. 375(2):183–193.
   PubMed Web of Science ®Google Scholar
• Cosma C, Cucoş Dinu A, Dicu T. 2013. Preliminary results regarding the first map of residential radon in some regions in Romania. Radiat Prot Dosimetry. 155(3):343–350.
   PubMed Web of Science ®Google Scholar
• Cosma C, Cucoş A, Papp B, Begy R, Dicu T, Moldovan M, Truţă LA, Niţă DC, Burghele B-D, Suciu L, et al. 2013. Radon and remediation measures near Bǎiţa-Ştei old uranium mine (Romania). Acta Geophys. 61(4):859–875.
   Web of Science ®Google Scholar
• Cucoş (Dinu) A, Cosma C, Dicu T, Begy R, Moldovan M, Papp B, Niţă D, Burghele B, Sainz C. 2012. Thorough investigations on indoor radon in Bǎiţa radon-prone area (Romania). Sci Total Environ. 431:78–83.
   PubMed Web of Science ®Google Scholar
• Cucoş (Dinu) A, Papp B, Dicu T, Moldovan M, Burghele DB, Moraru IT, Tenţer A, Cosma C. 2017. Residential, soil and water radon surveys in north-western part of Romania. J Environ Radioact. 166(Pt 2):412–416.
   PubMed Web of Science ®Google Scholar
• D’Errico M, Calcagnile A, Iavarone I, Sera F, Baliva G, Chinni LM, Corona R, Pasquini P, Dogliotti E. 1999. Factors that influence the DNA repair capacity of normal and skin cancer-affected individuals. Cancer Epidemiol Biomarkers Prev. 8(6):553–559.
   PubMed Web of Science ®Google Scholar
• Dicu T, Burghele BD, Cucoș A, Mishra R, Sapra BK. 2019. Assessment of annual effective dose from exposure to natural radioactivity sources in a case-control study in Bihor County. Romania. Radiat Prot Dosimetry. 185(1):7–16.
   PubMed Web of Science ®Google Scholar
• Druzhinin VG, Sinitsky MY, Larionov AV, Volobaev VP, Minina VI, Golovina TA. 2015. Assessing the level of chromosome aberrations in peripheral blood lymphocytes in long-term resident children under conditions of high exposure to radon and its decay products. Mutagenesis. 30(5):677–683.
   PubMed Web of Science ®Google Scholar
• Dusinska M, Collins AR. 2008. The comet assay in human biomonitoring: gene-environment interactions. Mutagenesis. 23(3):191–205.
   PubMed Web of Science ®Google Scholar
• El-Zein RA, Monroy CM, Cortes A, Spitz MR, Greisinger A, Etzel CJ. 2010. Rapid method for determination of DNA repair capacity in human peripheral blood lymphocytes amongst smokers. BMC Cancer. 10:439.
   PubMed Web of Science ®Google Scholar
• EPA and DHHS (Environmental Protection Agency and Department of Health and Human Services). 1986. A citizen’s guide to Radon. OPA-86-004. Washington (DC): Environmental Protection Agency.
   Google Scholar
• Euratom. 2014. Council Directive 2013/59/Euratom of 5 December 2013 laying down basic safety standards for protection against the dangers arising from exposure to ionizing radiation, and repealing Directives 89/618/Euratom, 90/641/Euratom, 96/29/Euratom, 97/43/Euratom a. Official J Eur Union. 57(L13):1–73.
   Google Scholar
• Fenech M. 2000. The in vitro micronucleus technique. Mutat Res – Fundam Mol Mech Mutagen. 455(1–2):81–95.
   PubMed Web of Science ®Google Scholar
• Fisher AEO, Hochegger H, Takeda S, Caldecott KW. 2007. Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-Ribose) glycohydrolase. Mol Cell Biol. 27(15):5597–5605.
   PubMed Web of Science ®Google Scholar
• Fitzmaurice G, Laird N, Ware J. 2011. Applied longitudinal analysis. 2nd ed. Hoboken (NJ): John Wiley & Sons.
   Google Scholar
• Fracasso ME, Doria D, Franceschetti P, Perbellini L, Romeo L. 2006. DNA damage and repair capacity by comet assay in lymphocytes of white-collar active smokers and passive smokers (non- and ex-smokers) at workplace. Toxicol Lett. 167(2):131–141.
   PubMed Web of Science ®Google Scholar
• Gajski G, Gerić M, Živković Semren T, Tariba Lovaković B, Oreščanin V, Pizent A. 2020. Application of the comet assay for the evaluation of DNA damage from frozen human whole blood samples: implications for human biomonitoring. Toxicol Lett. 319:58–65.
   PubMed Web of Science ®Google Scholar
• Gerić M, Janušić R, Šarčević B, Garaj-Vrhovac V. 2015. A case-control study of genotoxicity endpoints in patients with papillary thyroid cancer. Mutat Res – Genet Toxicol Environ Mutagen. 784–785:47–50.
   PubMed Web of Science ®Google Scholar
• Hastak K, Bhutra S, Parry R, Ford JM. 2017. Poly (ADP-ribose) polymerase inhibitor, an effective radiosensitizer in lung and pancreatic cancers. Oncotarget. 8(16):26344–26355.
   PubMedGoogle Scholar
• He JL, Chen WL, Jin LF, Jin HY. 2000. Comparative evaluation of the in vitro micronucleus test and the comet assay for the detection of genotoxic effects of X-ray radiation. Mutat Res – Genet Toxicol Environ Mutagen. 469(2):223–231.
   PubMed Web of Science ®Google Scholar
• Hellman B, Friis L, Vaghef H, Edling C. 1999. Alkaline single cell gel electrophoresis and human biomonitoring for genotoxicity: a study on subjects with residential exposure to radon. Mutat Res – Genet Toxicol Environ Mutagen. 442(2):121–132.
   Web of Science ®Google Scholar
• Hennequin C, Quero L, Favaudon V. 2008. Determinants and predictive factors of tumour radiosensitivity. Cancer Radiother. 12(1):3–13.
   PubMed Web of Science ®Google Scholar
• Heylmann D, Ponath V, Kindler T, Kaina B. 2021. Comparison of DNA repair and radiosensitivity of different blood cell populations. Sci Rep. 11(1):2478.
   PubMed Web of Science ®Google Scholar
• HG 526. 2018. HG Nr. 526/2018. National Radon Action Plan Published in the Official Gazette of Romania, [WWW Document]. Off. Gaz. Rom (No. 645/25.VII.2018).
   Google Scholar
• Karuppasamy CV, Ramachandran EN, Kumar VA, Kumar PRV, Koya PKM, Jaikrishan G, Das B. 2016. Peripheral blood lymphocyte micronucleus frequencies in men from areas of Kerala, India, with high vs normal levels of natural background ionizing radiation. Mutat Res – Genet Toxicol Environ Mutagen. 800–801:40–45.
   PubMed Web of Science ®Google Scholar
• Katarkar A, Mukherjee S, Khan MH, Ray JG, Chaudhuri K. 2014. Comparative evaluation of genotoxicity by micronucleus assay in the buccal mucosa over comet assay in peripheral blood in oral precancer and cancer patients. Mutagenesis. 29(5):325–334.
   PubMed Web of Science ®Google Scholar
• Kazimirova A, Baranokova M, Staruchova M, Drlickova M, Volkovova K, Dusinska M. 2019. Titanium dioxide nanoparticles tested for genotoxicity with the comet and micronucleus assays in vitro, ex vivo and in vivo. Mutat Res Genet Toxicol Environ Mutagen. 843:57–65.
   PubMed Web of Science ®Google Scholar
• Kumar PRV, Seshadri M, Jaikrishan G, Das B. 2015. Effect of chronic low dose natural radiation in human peripheral blood mononuclear cells: evaluation of DNA damage and repair using the alkaline comet assay. Mutat Res. 775:59–65.
   PubMed Web of Science ®Google Scholar
• Ladeira C, Viegas S, Carolino E, Gomes M, Brito M. 2015. Correlation between the genotoxicity endpoints measured by two different genotoxicity assays: comet assay and CBMN assay. Front Genet. 6. https://www.researchgate.net/publication/279058986_Correlation_between_the_genotoxicity_endpoints_measured_by_two_different_genotoxicity_assays_comet_assay_and_CBMN_assay
   Google Scholar
• Liu Q, Gheorghiu L, Drumm M, Clayman R, Eidelman A, Wszolek MF, Olumi A, Feldman A, Wang M, Marcar L, et al. 2018. PARP-1 inhibition with or without ionizing radiation confers reactive oxygen species-mediated cytotoxicity preferentially to cancer cells with mutant TP53. Oncogene. 37(21):2793–2805.
   PubMed Web of Science ®Google Scholar
• Lord CJ, Ashworth A. 2012. The DNA damage response and cancer therapy. Nature. 481(7381):287–294.
   PubMed Web of Science ®Google Scholar
• Marnett LJ. 2000. Oxyradicals and DNA damage. Carcinogenesis. 21(3):361–370.
   PubMed Web of Science ®Google Scholar
• Masoomi JR, Mohammadi S, Amini M, Ghiassi-Nejad M. 2006. High background radiation areas of Ramsar in Iran: evaluation of DNA damage by alkaline single cell gel electrophoresis (SCGE). J Environ Radioact. 86(2):176–186.
   PubMed Web of Science ®Google Scholar
• Meenakshi C, Mohankumar MN. 2013. Synergistic effect of radon in blood cells of smokers – an in vitro study. Mutat Res – Genet Toxicol Environ Mutagen. 757(1):79–82.
   PubMed Web of Science ®Google Scholar
• Meenakshi C, Sivasubramanian K, Venkatraman B. 2017. Nucleoplasmic bridges as a biomarker of DNA damage exposed to radon. Mutat Res – Genet Toxicol Environ Mutagen. 814:22–28.
   PubMed Web of Science ®Google Scholar
• Mohammadi S, Taghavi-Dehaghani M, Gharaati MR, Masoomi R, Ghiassi-Nejad M. 2006. Adaptive response of blood lymphocytes of inhabitants residing in high background radiation areas of Ramsar-micronuclei, apoptosis and comet assays. JRR. 47(3/4):279–285.
   PubMed Web of Science ®Google Scholar
• Moore S, Stanley FKT, Goodarzi AA. 2014. The repair of environmentally relevant DNA double strand breaks caused by high linear energy transfer irradiation-no simple task. DNA Repair. 17:64–73.
   PubMed Web of Science ®Google Scholar
• Nie JH, Chen ZH, Liu X, Wu YW, Li JX, Cao Y, Hei TK, Tong J. 2012. Oxidative damage in various tissues of rats exposed to radon. J Toxicol Environ Health A. 75(12):694–699.
   PubMed Web of Science ®Google Scholar
• Nitta M, Kozono D, Kennedy R, Stommel J, Ng K, Zinn PO, Kushwaha D, Kesari S, Inda M-d-M, Wykosky J, et al. 2010. Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy. PLoS One. 5(5):e10767.
   PubMed Web of Science ®Google Scholar
• Oestreicher U, Braselmann H, Stephan G. 2004. Cytogenetic analyses in peripheral lymphocytes of persons living in houses with increased levels of indoor radon concentrations. Cytogenet Genome Res. 104(1–4):232–236.
   PubMed Web of Science ®Google Scholar
• Peng C, DuPre N, VoPham T, Heng YJ, Baker GM, Rubadue CA, Glass K, Sonawane A, Zeleznik O, Kraft P, et al. 2020. Low dose environmental radon exposure and breast tumor gene expression. BMC Cancer. 20(1):695..
   PubMed Web of Science ®Google Scholar
• Popp W, Plappert U, Müller WU, Rehn B, Schneider J, Braun A, Bauer PC, Vahrenholz C, Presek P, Brauksiepe A, et al. 2000. Biomarkers of genetic damage and inflammation in blood and bronchoalveolar lavage fluid among former German uranium miners: a pilot study. Radiat Environ Biophys. 39(4):275–282.
   PubMed Web of Science ®Google Scholar
• Salazar A, Ojeda B, Dueñas M, Fernández F, Failde I. 2016. Simple generalized estimating equations (GEEs) and weighted generalized estimating equations (WGEEs) in longitudinal studies with dropouts: guidelines and implementation in R. Stat Med. 35(19):3424–3448.
   PubMed Web of Science ®Google Scholar
• Sankaranarayanan K. 1991. Ionizing radiation and genetic risks I. Epidemiological, population genetic, biochemical and molecular aspects of Mendelian diseases. Mutat Res Genet Toxicol. 258(1):3–49.
   PubMed Web of Science ®Google Scholar
• Sato I, Sasaki J, Satoh H, Natsuhori M, Murata T, Okada K. 2020. Assessments of DNA damage and radiation exposure dose in cattle living in the contaminated area caused by the Fukushima nuclear accident. Bull Environ Contam Toxicol. 105(3):496–501.
   PubMed Web of Science ®Google Scholar
• Sethi TK, El-Ghamry MN, Kloecker GH. 2012. Radon and lung cancer. Clin Adv Hematol Oncol. 10(3):157–164.
   PubMedGoogle Scholar
• Sinitsky MY, Druzhinin VG. 2014. The application of the cytokinesis-block micronucleus assay on peripheral blood lymphocytes for the assessment of genome damage in long-term residents of areas with high radon concentration. J Radiat Res. 55(1):61–66.
   PubMed Web of Science ®Google Scholar
• Sperati A, Abeni DD, Tagesson C, Forastiere F, Miceli M, Axelson O. 1999. Exposure to indoor background radiation and urinary concentrations of 8-hydroxydeoxyguanosine, a marker of oxidative DNA damage. Environ Health Perspect. 107(3):213–215.
   PubMed Web of Science ®Google Scholar
• Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, Miyamae Y, Rojas E, Ryu JC, Sasaki YF. 2000. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen. 35(3):206–221.
   PubMed Web of Science ®Google Scholar
• UNSCEAR. 2006. ANNEX E Sources-to-effects assessment for radon in homes and workplaces. United Nations Sci Comm Eff at Radiat 2006 Report, Vol. II.
   Google Scholar
• Virag P, Brie I, Postescu I, Perde-Schrepler M, Fischer-Fodor E, Soritau O, Irimie A, Cernea V. 2009. Comparative study of two evaluation methods for the genotoxic effects of environmental heavy metals on normal cells. Toxicol Ind Health. 25(4–5):253–258.
   PubMed Web of Science ®Google Scholar
• Vral A, Fenech M, Thierens H. 2011. The micronucleus assay as a biological dosimeter of in vivo ionising radiation exposure. Mutagenesis. 26(1):11–17.
   PubMed Web of Science ®Google Scholar
• Walczak K, Olszewski J, Domeradzka-Gajda K, Politański P, Zmyślony M, Kowalczyk K, Stępnik M. 2019. Micronuclei frequency in peripheral blood lymphocytes and levels of anti-p53 autoantibodies in serum of residents of Kowary city regions (Poland) with elevated indoor concentrations of radon. Mutat Res Genet Toxicol Environ Mutagen. 838:67–75.
   PubMed Web of Science ®Google Scholar
• Wang X, Tu W, Chen D, Fu J, Wang J, Shao C, Zhang J. 2019. Autophagy suppresses radiation damage by activating PARP-1 and attenuating reactive oxygen species in hepatoma cells. Int J Radiat Biol. 95(8):1051–1057.
   PubMed Web of Science ®Google Scholar
• Xanthoudakis S, Curran T. 1996. Redox regulation of Ap-1. In: Snyder R, editor. Biological reactive intermediates V. Advances in experimental medicine and biology. Vol 387, 69–75. Boston (MA): Springer. https://doi.org/https://doi.org/10.1007/978-1-4757-9480-9_10.
   Google Scholar
• Yanxiao G, Mei T, Gang G, Xiaochun W, Jianxiang L. 2019. Changes of 8-OHdG and TrxR in the residents who bathe in radon hot springs. Dose-Response. 17(1):155932581882097.
   Web of Science ®Google Scholar