The role of small GTPase Rac1 in ionizing radiation-induced testicular damage

References

• Abdel-Magied N, Abdel Fattah SM, Elkady AA. 2019. Differential effect of Taraxacum officinale L. (dandelion) root extract on hepatic and testicular tissues of rats exposed to ionizing radiation. Mol Biol Rep. 46(5):4893–4907.
   PubMed Web of Science ®Google Scholar
• Ash P. 1980. The influence of radiation on fertility in man. Br J Radiol. 53(628):271–278.
   PubMed Web of Science ®Google Scholar
• Boehm JE, Chaika OV, Lewis RE. 1999. Rac-dependent anti-apoptotic signaling by the insulin receptor cytoplasmic domain. J Biol Chem. 274(40):28632–28636.
   PubMed Web of Science ®Google Scholar
• De Felice F, Marchetti C, Marampon F, Cascialli G, Muzii L, Tombolini V. 2019. Radiation effects on male fertility. Andrology. 7(1):2–7.
   PubMed Web of Science ®Google Scholar
• El-Mesallamy HO, Gawish RA, Sallam AM, Fahmy HA, Nada AS. 2018. Ferulic acid protects against radiation-induced testicular damage in male rats: impact on SIRT1 and PARP1. Environ Sci Pollut Res Int. 25(7):6218–6227.
   PubMed Web of Science ®Google Scholar
• Freeman EA, Jani P, Millette CE. 2002. Expression and potential function of Rho family small G proteins in cells of the mammalian seminiferous epithelium. Cell Commun Adhes. 9(4):189–204.
   PubMed Web of Science ®Google Scholar
• Gong EJ, Shin IS, Son TG, Yang K, Heo K, Kim JS. 2014. Low-dose-rate radiation exposure leads to testicular damage with decreases in DNMT1 and HDAC1 in the murine testis. J Radiat Res. 55(1):54–60.
   PubMed Web of Science ®Google Scholar
• Guerci AM, Dulout FN, Grillo CA, Seoane AI. 2005. Differential response of two cell lines sequentially irradiated with low X-ray doses. Int J Radiat Biol. 81(5):367–372.
   PubMed Web of Science ®Google Scholar
• Hatzi VI, Laskaratou DA, Mavragani IV, Nikitaki Z, Mangelis A, Panayiotidis MI, Pantelias GE, Terzoudi GI, Georgakilas AG. 2015. Non-targeted radiation effects in vivo: a critical glance of the future in radiobiology. Cancer Lett. 356(1):34–42.
   PubMed Web of Science ®Google Scholar
• Hein AL, Post CM, Sheinin YM, Lakshmanan I, Natarajan A, Enke CA, Batra SK, Ouellette MM, Yan Y. 2016. RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment. Oncogene. 35(49):6319–6329.
   PubMed Web of Science ®Google Scholar
• Kadhim M, Salomaa S, Wright E, Hildebrandt G, Belyakov OV, Prise KM, Little MP. 2013. Non-targeted effects of ionising radiation-implications for low dose risk. Mutat Res. 752(2):84–98.
   PubMed Web of Science ®Google Scholar
• Kaya C, Baseskioglu AB, Yigitaslan S, Ozatik FY, Ozatik O, Uslu S. 2019. The therapeutic potential of amifostine on cyclophosphamide-induced testicular dysfunction in rats: an experimental study. Int J Reprod Biomed. 17(4):245–252.
   PubMed Web of Science ®Google Scholar
• Liu Z, Cao K, Liao Z, Chen Y, Lei X, Wei Q, Liu C, Sun X, Yang Y, Cai J, et al. 2020. Monophosphoryl lipid A alleviated radiation-induced testicular injury through TLR4-dependent exosomes. J Cell Mol Med. 24(7):3917–3930.
   PubMed Web of Science ®Google Scholar
• Ma Y, Jia X. 2018. Polydatin alleviates radiation-induced testes injury by scavenging ROS and inhibiting apoptosis pathways. Med Sci Monit. 24:8993–9000.
   PubMed Web of Science ®Google Scholar
• McBride WH, Schaue D. 2020. Radiation-induced tissue damage and response. J Pathol. 250(5):647–655.
   PubMed Web of Science ®Google Scholar
• Ozbilgin K, Karaca F, Turan A, Kose C, Vatansever S, Ozcakir T. 2015. The higher heparin-binding epidermal growth factor (HB-EGF) in missed abortion. Taiwan J Obstet Gynecol. 54(1):13–18.
   PubMed Web of Science ®Google Scholar
• Panganiban RA, Snow AL, Day RM. 2013. Mechanisms of radiation toxicity in transformed and non-transformed cells. Int J Mol Sci. 14(8):15931–15958.
   PubMed Web of Science ®Google Scholar
• Paul C, Robaire B. 2013. Impaired function of the blood-testis barrier during aging is preceded by a decline in cell adhesion proteins and GTPases. PLoS One. 8(12):e84354.
   PubMed Web of Science ®Google Scholar
• Pervaiz S, Cao J, Chao OS, Chin YY, Clement MV. 2001. Activation of the RacGTPase inhibits apoptosis in human tumor cells. Oncogene. 20(43):6263–6268.
   PubMed Web of Science ®Google Scholar
• Pouget JP, Georgakilas AG, Ravanat JL. 2018. Targeted and off-target (Bystander and Abscopal) effects of radiation therapy: redox mechanisms and risk/benefit analysis. Antioxid Redox Signal. 29(15):1447–1487.
   PubMed Web of Science ®Google Scholar
• Said RS, Mohamed HA, Kamal MM. 2019. Coenzyme Q10 mitigates ionizing radiationinduced testicular damage in rats through inhibition of oxidative stress and mitochondria mediated apoptotic cell death. Toxicol Appl Pharmacol. 383:114780.
   PubMed Web of Science ®Google Scholar
• Shaban NZ, Ahmed Zahran AM, El-Rashidy FH, Abdo Kodous AS. 2017. Protective role of hesperidin against gamma-radiation-induced oxidative stress and apoptosis in rat testis. J Biol Res. 24:5.
   Web of Science ®Google Scholar
• Shimura N, Kojima S. 2018. The lowest radiation dose having molecular changes in the living body. Dose-Response. 16(2):155932581877732.
   Web of Science ®Google Scholar
• Sisakht M, Darabian M, Mahmoodzadeh A, Bazi A, Shafiee SM, Mokarram P, Khoshdel Z. 2020. The role of radiation induced oxidative stress as a regulator of radio-adaptive responses. Int J Radiat Biol. 2020:1–16.
   Google Scholar
• Stewart FA, Akleyev AV, Hauer-Jensen M, Hendry JH, Kleiman NJ, Macvittie TJ, Aleman BM, Edgar AB, Mabuchi K, Muirhead CR, Shore RE, et al. 2012. ICRP publication 118: ICRP statement on tissue reactions and early and late effects of radiation in normal tissues and organs–threshold doses for tissue reactions in a radiation protection context. Ann Icrp. 41(1–2):1–322.
   PubMedGoogle Scholar
• Sylow L, Kleinert M, Pehmoller C, Prats C, Chiu TT, Klip A, Richter EA, Jensen TE. 2014. Akt and Rac1 signaling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance. Cell Signal. 26(2):323–331.
   PubMed Web of Science ®Google Scholar
• Takai Y, Sasaki T, Matozaki T. 2001. Small GTP-binding proteins. Physiol Rev. 81(1):153–208.
   PubMed Web of Science ®Google Scholar
• Wang A, Wang L, Lu X, Wang Y, Chen X, Shi Z, Li P, He C, Zhang S, Gao Y, et al. 2020. A Chinese herbal prescription Yiqi Jiedu decoction attenuates irradiation induced testis injury in mice. Biomed Pharmacother. 123:109804.
   PubMed Web of Science ®Google Scholar
• Yi J, Chen C, Liu X, Kang Q, Hao L, Huang J, Lu J. 2020. Radioprotection of EGCG based on immunoregulatory effect and antioxidant activity against 60Coγ radiation-induced injury in mice. Food Chem Toxicol. 135:111051.
   PubMed Web of Science ®Google Scholar
• Zhang L, Huang B, Tang H, Ye X, Yao Y, Gong P, Tang H. 2020. Amifostine inhibited the differentiation of RAW264.7 cells into osteoclasts by reducing the production of ROS under 2 Gy radiation. J Cell Biochem. 121(1):497–507.
   PubMed Web of Science ®Google Scholar