mRNA and small RNA gene expression changes in peripheral blood to detect internal Ra-223 exposure

References

• Andrés-León E, Cases I, Alonso S, Rojas AM. 2017. Novel miRNA-mRNA interactions conserved in essential cancer pathways. Sci Rep. 7:46101.
   PubMed Web of Science ®Google Scholar
• Birchall A, Puncher M, Marsh JW, Davis K, Bailey MR, Jarvis NS, Peach AD, Dorrian MD, James AC. 2007. IMBA Professional Plus: a flexible approach to internal dosimetry. Radiat Prot Dosimetry. 125(1–4):194–197.
   PubMed Web of Science ®Google Scholar
• Blake GM, Park-Holohan SJ, Cook GJR, Fogelman I. 2001. Quantitative studies of bone with the use of 18F-fluoride and 99mTc-methylene diphosphonate. Semin Nucl Med. 31(1):28–49.
   PubMed Web of Science ®Google Scholar
• Boldt S, Knops K, Kriehuber R, Wolkenhauer O. 2012. A frequency-based gene selection method to identify robust biomarkers for radiation dose prediction. Int J Radiat Biol. 88(3):267–276.
   PubMed Web of Science ®Google Scholar
• Carrasquillo JA, O'Donoghue JA, Pandit-Taskar N, Humm JL, Rathkopf DE, Slovin SF, Williamson MJ, Lacuna K, Aksnes A-K, Larson SM, et al. 2013. Phase i pharmacokinetic and biodistribution study with escalating doses of 223Ra-dichloride in men with castration-resistant metastatic prostate cancer. Eur J Nucl Med Mol Imaging. 40(9):1384–1393.
   PubMed Web of Science ®Google Scholar
• Chaudhry MA. 2008. Biomarkers for human radiation exposure. J Biomed Sci. 15(5):557–563.
   PubMed Web of Science ®Google Scholar
• Chittenden SJ, Hindorf C, Parker CC, Lewington VJ, Pratt BE, Johnson B, Flux GD. 2015. A phase 1, open-label study of the biodistribution, pharmacokinetics, and dosimetry of 223Ra-dichloride in patients with hormone-refractory prostate cancer and skeletal metastases. J Nucl Med. 56(9):1304–1309.
   PubMed Web of Science ®Google Scholar
• Confer D, Chao N, Case C. 2018. Are we prepared for nuclear terrorism? N Engl J Med. 378(25):2447–2450.
   PubMed Web of Science ®Google Scholar
• Eichholz GG. 2005. The radiological accident in Cochabamba. Vienna: International Atomic Energy Agency.
   Google Scholar
• Ghandhi SA, Sima C, Weber WM, Melo DR, Rudqvist N, Morton SR, Turner HC, Amundson SA. 2020. Dose and dose-rate effects in a mouse model of internal exposure to 137Cs. part 1: global transcriptomic responses in blood. Radiat Res. 2020:41.
   Google Scholar
• Ghandhi SA, Weber W, Melo D, Doyle-Eisele M, Chowdhury M, Guilmette R, Amundson SA. 2015. Effect of 90Sr internal emitter on gene expression in mouse blood. BMC Genomics. 16(1):74.
   PubMed Web of Science ®Google Scholar
• Giussani A, Lopez MA, Romm H, Testa A, Ainsbury EA, Degteva M, Della Monaca S, Etherington G, Fattibene P, Güclu I, et al. 2020. Eurados review of retrospective dosimetry techniques for internal exposures to ionising radiation and their applications. Radiat Environ Biophys. 59(3):357–387.
   PubMed Web of Science ®Google Scholar
• Guo H, Ingolia NT, Weissman JS, Bartel DP. 2010. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature. 466(7308):835–840.
   PubMed Web of Science ®Google Scholar
• Hall EJ, Giaccia AJ. 2012. Radiobiology for the radiologist: Seventh edition. Alphen aan den Rijn, Netherlands: Wolters Kluwer.
   Google Scholar
• Harrison J, Fell T, Leggett R, Lloyd D, Puncher M, Youngman M. 2017. The polonium-210 poisoning of Mr Alexander Litvinenko. J Radiol Prot. 37(1):266–278.
   PubMed Web of Science ®Google Scholar
• Harrison J, Phipps A, Stather J. 2004. Guest editorial: last report in series on public doses. Ann ICRP. 34(3–4):1–27.
   Google Scholar
• Hindorf C, Chittenden S, Aksnes AK, Parker C, Flux GD. 2012. Quantitative imaging of 223Ra-chloride (Alpharadin) for targeted alpha-emitting radionuclide therapy of bone metastases. Nucl Med Commun. 33(7):726–732.
   PubMed Web of Science ®Google Scholar
• IAEA. 2004. Strengthening control over radioactive sources in authorized use and regaining control over orphan sources, IAEA-TECDOC-1388 [Internet]. (February):108; [accessed 2021 Oct 29]. http://www-pub.iaea.org/MTCD/publications/PDF/te_1388_web.pdf.
   Google Scholar
• Information FP. 2013. XOFIGO (radium Ra 223 dichloride) – prescription – Bayerhealthcare.com.: 1–14.
   Google Scholar
• International Atomic Energy Agency. 2005. Categorization of radioactive sources. IAEA Saf Stand Ser [Internet]. No. RS-G-1(July):70; [accessed 2021 Oct 29]. http://www-pub.iaea.org/MTCD/publications/PDF/Pub1227_web.pdf.
   Google Scholar
• Jacobs AR, Guyon T, Headley V, Nair M, Ricketts W, Gray G, Wong JYC, Chao N, Terbrueggen R. 2020. Role of a high throughput biodosimetry test in treatment prioritization after a nuclear incident. Int J Radiat Biol. 96(1):57–66.
   PubMed Web of Science ®Google Scholar
• Jefferson RD, Goans RE, Blain PG, Thomas SHL. 2009. Diagnosis and treatment of polonium poisoning Polonium poisoning. Clin Toxicol. 47(5):379–392.
   Web of Science ®Google Scholar
• Kabacik S, MacKay A, Tamber N, Manning G, Finnon P, Paillier F, Ashworth A, Bouffler S, Badie C. 2011. Gene expression following ionising radiation: identification of biomarkers for dose estimation and prediction of individual response. Int J Radiat Biol. 87(2):115–129.
   PubMed Web of Science ®Google Scholar
• Karlsruhe K. 1979. Meßtechniken bei der Inkorporationsüberwachung auf Tritium und Kohlenstoff-14. (November).
   Google Scholar
• Lassmann M, Eberlein U. 2018. Targeted alpha-particle therapy: imaging, dosimetry, and radiation protection. Ann ICRP. 47(3–4):187–195.
   PubMedGoogle Scholar
• Lassmann M, Nosske D. 2013. Dosimetry of 223Ra-chloride: dose to normal organs and tissues. Eur J Nucl Med Mol Imaging. 40(2):207–212.
   PubMed Web of Science ®Google Scholar
• Manning G, Kabacik S, Finnon P, Bouffler S, Badie C. 2013. High and low dose responses of transcriptional biomarkers in ex vivo X-irradiated human blood. Int J Radiat Biol. 89(7):512–522.
   PubMed Web of Science ®Google Scholar
• Meadows SK, Dressman HK, Daher P, Himburg H, Russell JL, Doan P, Chao NJ, Lucas J, Nevins JR, Chute JP. 2010. Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles. PLoS One. 5(7):e11535.
   PubMed Web of Science ®Google Scholar
• Meadows SK, Dressman HK, Muramoto GG, Himburg H, Salter A, Wei ZZ, Ginsburg G, Chao NJ, Nevins JR, Chute JP. 2008. Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. PLoS One. 3(5):12.
   Google Scholar
• Miederer M, Thomas C, Beck J, Hampel C, Krieger C, Baqué PE, Helisch A, Schreckenberger M. 2015. Hämatopoetische toxizität von radium-223 bei patienten mit hoher ossärer tumorlast. NuklearMedizin. 54(5):197–203.
   PubMedGoogle Scholar
• Miller KL. 2012. NCRP Report No. 166, population monitoring and radionuclide decorporation following a radiological or nuclear incident. Health Phys. 102(1):100.
   Google Scholar
• O’Brien G, Cruz-Garcia L, Majewski M, Grepl J, Abend M, Port M, Tichý A, Sirak I, Malkova A, Donovan E, et al. 2018. FDXR is a biomarker of radiation exposure in vivo. Sci Rep. 8(1):43.
   PubMed Web of Science ®Google Scholar
• Ostheim P, Haupt J, Schüle S, Herodin F, Valente M, Drouet M, Majewski M, Port M, Abend M. 2020. Differentiating total- or partial-body irradiation in baboons using mRNA expression patterns: a proof of concept. Radiat Res. 194(5):476–484.
   PubMed Web of Science ®Google Scholar
• Paul S, Amundson SA. 2008. Development of gene expression signatures for practical radiation biodosimetry. Int J Radiat Oncol Biol Phys. 71(4):1236–1244.
   PubMed Web of Science ®Google Scholar
• Paul S, Barker CA, Turner HC, McLane A, Wolden SL, Amundson SA. 2011. Prediction of in vivo radiation dose status in radiotherapy patients using ex vivo and in vivo gene expression signatures. Radiat Res. 175(3):257–265.
   PubMed Web of Science ®Google Scholar
• Port M, Herodin F, Valente M, Drouet M, Lamkowski A, Majewski M, Abend M. 2016. First generation gene expression signature for early prediction of late occurring hematological acute radiation syndrome in baboons. Radiat Res. 186(1):39–54.
   PubMed Web of Science ®Google Scholar
• Port M, Hérodin F, Valente M, Drouet M, Lamkowski A, Majewski M, Abend M. 2017. Gene expression signature for early prediction of late occurring pancytopenia in irradiated baboons. Ann Hematol. 96(5):859–870.
   PubMed Web of Science ®Google Scholar
• Port M, Herodin F, Valente M, Drouet M, Ullmann R, Doucha-Senf S, Lamkowski A, Majewski M, Abend M. 2016. MicroRNA expression for early prediction of late occurring hematologic acute radiation syndrome in baboons. PLoS One. 11(11):e0165307.
   PubMed Web of Science ®Google Scholar
• Port M, Hérodin F, Valente M, Drouet M, Ullmann R, Majewski M, Abend M. 2017. Pre-exposure gene expression in baboons with and without pancytopenia after radiation exposure. Int J Mol Sci. 18(3):541.
   Web of Science ®Google Scholar
• Port M, Majewski M, Herodin F, Valente M, Drouet M, Forcheron F, Tichy A, Sirak I, Zavrelova A, Malkova A, et al. 2018. Validating baboon ex vivo and in vivo radiation-related gene expression with corresponding human data. Radiat Res. 189(4):389–398.
   PubMed Web of Science ®Google Scholar
• Port M, Ostheim P, Majewski M, Voss T, Haupt J, Lamkowski A, Abend M. 2019. Rapid high-throughput diagnostic triage after a mass radiation exposure event using early gene expression changes. Radiat Res. 192(2):208–218.
   PubMed Web of Science ®Google Scholar
• Rosoff H, Von Winterfeldt D. 2007. A risk and economic analysis of dirty bomb attacks on the ports of Los Angeles and Long Beach. Risk Anal. 27(3):533–546.
   PubMed Web of Science ®Google Scholar
• Rothkamm K, Beinke C, Romm H, Badie C, Balagurunathan Y, Barnard S, Bernard N, Boulay-Greene H, Brengues M, De Amicis A, et al. 2013. Comparison of established and emerging biodosimetry assays. Radiat Res. 180(2):111–119.
   PubMed Web of Science ®Google Scholar
• Rump A, Becker B, Eder S, Lamkowski A, Abend M, Port M. 2018. Medical management of victims contaminated with radionuclides after a “dirty bomb” attack. Mil Med Res. 5(1):27.
   PubMed Web of Science ®Google Scholar
• Rump A, Stricklin D, Lamkowski A, Eder S, Abend M, Port M. 2016. The Impact of Time on Decorporation Efficacy after a “dirty Bomb” Attack Studied by Simulation. Drug Res. 66(11):607–613.
   Google Scholar
• Rump A, Stricklin D, Lamkowski A, Eder S, Abend M, Port M. 2017. The incorporation of radionuclides after wounding by a “Dirty Bomb”: the impact of time for decorporation efficacy and a model for cases of disseminated fragmentation wounds. Adv Wound Care. 6(1):1–9.
   Web of Science ®Google Scholar
• Shuryak I, Ghandhi SA, Turner HC, Weber W, Melo D, Amundson SA, Brenner DJ. 2020. Dose and dose-rate effects in a mouse model of internal exposure from 137Cs. Part 2: integration of Gamma-H2AX and gene expression biomarkers for retrospective radiation biodosimetry. Radiat Res. 2020:42.1.
   Google Scholar
• Taylor GA, Carolina S. 2000. The evolution of internal dosimetry bioassay methods at the savannah river site in-vitro bioassay. Environ Sci. (800):253–264.
   Google Scholar
• De Vincentis G, Gerritsen W, Gschwend JE, Hacker M, Lewington V, O’Sullivan JM, Oya M, Pacilio M, Parker C, Shore N, et al. 2019. Advances in targeted alpha therapy for prostate cancer. Ann Oncol. 30(11):1728–1739.
   PubMed Web of Science ®Google Scholar