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Original Articles

Establishment and validation of surface model for biodosimetry based on γ-H2AX foci detection

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all
Pages 1-10 | Received 05 Jul 2021, Accepted 15 Oct 2021, Published online: 17 Nov 2021

References

  • Abend M, Azizova T, Müller K, Dörr H, Senf S, Kreppel H, Rusinova G, Glazkova I, Vyazovskaya N, Schmidl D, et al. 2014. Gene expression analysis in mayak workers with prolonged occupational radiation exposure. Health Phys. 106(6):664–676.
  • Ainsbury EA, Al-Hafidh J, Bajinskis A, Barnard S, Barquinero JF, Beinke C, De Gelder V, Gregoire E, Jaworska A, Lindholm C, et al. 2014. Inter- and intra-laboratory comparison of a multibiodosimetric approach to triage in a simulated, large scale radiation emergency. Int J Radiat Biol. 90(2):193–202.
  • Ainsbury EA, Bakhanova E, Barquinero JF, Brai M, Chumak V, Correcher V, Darroudi F, Fattibene P, Gruel G, Guclu I, et al. 2011. Review of retrospective dosimetry techniques for external ionising radiation exposures. Radiat Prot Dosimetry. 147(4):573–592.
  • Andrievski A, Wilkins RC. 2009. The response of gamma-H2AX in human lymphocytes and lymphocytes subsets measured in whole blood cultures. Int J Radiat Biol. 85(4):369–376.
  • Barnard S, Ainsbury EA, Al-Hafidh J, Hadjidekova V, Hristova R, Lindholm C, Monteiro Gil O, Moquet J, Moreno M, Rößler U, et al. 2015. The first gamma-H2AX biodosimetry intercomparison exercise of the developing European biodosimetry network RENEB. Radiat Prot Dosimetry. 164(3):265–270.
  • Basheerudeen SAS, Kanagaraj K, Jose MT, Ozhimuthu A, Paneerselvam S, Pattan S, Joseph S, Raavi V, Perumal V. 2017. Entrance surface dose and induced DNA damage in blood lymphocytes of patients exposed to low-dose and low-dose-rate X-irradiation during diagnostic and therapeutic interventional radiology procedures. Mutat Res. 818:1–6.
  • Beels L, Werbrouck J, Thierens H. 2010. Dose response and repair kinetics of gamma-H2AX foci induced by in vitro irradiation of whole blood and T-lymphocytes with X- and gamma-radiation. Int J Radiat Biol. 86(9):760–768.
  • Borràs M, Armengol G, De Cabo M, Barquinero JF, Barrios L. 2015. Comparison of methods to quantify histone H2AX phosphorylation and its usefulness for prediction of radiosensitivity. Int J Radiat Biol. 91(12):915–924.
  • Chaurasia RK, Bhat NN, Gaur N, Shirsath KB, Desai UN, Sapra BK. 2021. Establishment and multiparametric-cytogenetic validation of 60Co-gamma-ray induced, phospho-gamma-H2AX calibration curve for rapid biodosimetry and triage management during radiological emergencies. Mutat Res Genet Toxicol Environ Mutagen. 866:503354.
  • Chilimoniuk J, Gosiewska A, Słowik J, Weiss R, Deckert PM, Rödiger S, Burdukiewicz M. 2021. Countfitter: efficient selection of count distributions to assess DNA damage. Ann Transl Med. 9(7):528–528.
  • Ding D, Zhang Y, Wang J, Wang X, Fan D, He L, Zhang X, Gao Y, Li Q, Chen H. 2016. γ-H2AX/53BP1/pKAP-1 foci and their linear tracks induced by in vitro exposure to radon and its progeny in human peripheral blood lymphocytes. Sci Rep. 6:38295.
  • Durdik M, Kosik P, Gursky J, Vokalova L, Markova E, Belyaev I. 2015. Imaging flow cytometry as a sensitive tool to detect low-dose-induced DNA damage by analyzing 53BP1 and γH2AX foci in human lymphocytes. Cytometry A. 87(12):1070–1078.
  • Einbeck J, Ainsbury EA, Sales R, Barnard S, Kaestle F, Higueras M. 2018. A statistical framework for radiation dose estimation with uncertainty quantification from the γ-H2AX assay. PLoS One. 13(11):e0207464.
  • Errington A, Einbeck J, Cumming J, Rössler U, Endesfelder D. 2021. The effect of data aggregation on dispersion estimates in count data models. Int J Biostat. DOI:https://doi.org/10.1515/ijb-2020-0079.
  • Garty G, Bigelow AW, Repin M, Turner HC, Bian D, Balajee AS, Lyulko OV, Taveras M, Yao YL, Brenner DJ. 2015. An automated imaging system for radiation biodosimetry. Microsc Res Tech. 78(7):587–598.
  • Grégoire E, Roy L, Buard V, Delbos M, Durand V, Martin-Bodiot C, Voisin P, Sorokine-Durm I, Vaurijoux A, Voisin P, et al. 2018. Twenty years of FISH-based translocation analysis for retrospective ionizing radiation biodosimetry. Int J Radiat Biol. 94(3):248–258.
  • Gruel G, Grégoire E, Lecas S, Martin C, Roch-Lefevre S, Vaurijoux A, Voisin P, Voisin P, Barquinero JF. 2013. Biological dosimetry by automated dicentric scoring in a simulated emergency. Radiat Res. 179(5):557–569.
  • Hamasaki K, Imai K, Nakachi K, Takahashi N, Kodama Y, Kusunoki Y. 2007. Short-term culture and gammaH2AX flow cytometry determine differences in individual radiosensitivity in human peripheral T lymphocytes. Environ Mol Mutagen. 48(1):38–47.
  • Horn S, Barnard S, Rothkamm K. 2011. Gamma-H2AX-based dose estimation for whole and partial body radiation exposure. PLoS One. 6(9):e25113.
  • IAEA 2000. Absorbed Dose Determination in External Beam Radiotherapy. Vienna, Austria: International Atomic Energy.
  • IAEA 2011. Cytogenetic Dosimetry: Applications in Preparedness for and Response to Radiation Emergencies. Vienna, Austria: International Atomic Energy.
  • Ismail IH, Wadhra TI, Hammarsten O. 2007. An optimized method for detecting gamma-H2AX in blood cells reveals a significant interindividual variation in the gamma-H2AX response among humans. Nucleic Acids Res. 35(5):e36.
  • Ivashkevich A, Redon CE, Nakamura AJ, Martin RF, Martin OA. 2012. Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research. Cancer Lett. 327(1–2):123–133.
  • Kato TA, Nagasawa H, Weil MM, Little JB, Bedford JS. 2006. Levels of gamma-H2AX foci after low-dose-rate irradiation reveal a DNA DSB rejoining defect in cells from human ATM heterozygotes in two at families and in another apparently normal individual. Radiat Res. 166(3):443–453.
  • Kulka U, Abend M, Ainsbury E, Badie C, Barquinero JF, Barrios L, Beinke C, Bortolin E, Cucu A, De Amicis A, et al. 2017. RENEB - running the European network of biological dosimetry and physical retrospective dosimetry. Int J Radiat Biol. 93(1):2–14.
  • Leatherbarrow EL, Harper JV, Cucinotta FA, O'Neill P. 2006. Induction and quantification of gamma-H2AX foci following low and high LET-irradiation. Int J Radiat Biol. 82(2):111–118.
  • Lee Y, Wang Q, Shuryak I, Brenner DJ, Turner HC. 2019. Development of a high-throughput γ-H2AX assay based on imaging flow cytometry. Radiat Oncol. 14(1):150.
  • Lisowska H, Wegierek-Ciuk A, Banasik-Nowak A, Braziewicz J, Wojewodzka M, Wojcik A, Lankoff A. 2013. The dose-response relationship for dicentric chromosomes and γ-H2AX foci in human peripheral blood lymphocytes: Influence of temperature during exposure and intra- and inter-individual variability of donors. Int J Radiat Biol. 89(3):191–199.
  • Lloyd-Smith JO. 2007. Maximum likelihood estimation of the negative binomial dispersion parameter for highly overdispersed data, with applications to infectious diseases. PLoS One. 2(2):e180.
  • Löbrich M, Rief N, Kühne M, Heckmann M, Fleckenstein J, Rübe C, Uder M. 2005. In vivo formation and repair of DNA double-strand breaks after computed tomography examinations. Proc Natl Acad Sci USA. 102(25):8984–8989.
  • Löbrich M, Shibata A, Beucher A, Fisher A, Ensminger M, Goodarzi AA, Barton O, Jeggo PA. 2010. gammaH2AX foci analysis for monitoring DNA double-strand break repair: Strengths, limitations and optimization. Cell Cycle. 9(4):662–669.
  • Mandina T, Roch-Lefvre SH, Voisin P, González JE, Lamadrid AI, Romero I, García O, Voisin P, Roy L. 2011. Dose-response relationship of γ-H2AX foci induction in human lymphocytes after X-rays exposure. Radiat Meas. 46(9):997–999.
  • Manning G, Kabacik S, Finnon P, Bouffler S, Badie C. 2013. High and low dose responses of transcriptional biomarkers in ex vivo X-irradiated human blood. Int J Radiat Biol. 89(7):512–522.
  • Martin OA, Ivashkevich A, Choo S, Woodbine L, Jeggo PA, Martin RF, Lobachevsky P. 2013. Statistical analysis of kinetics, distribution and co-localisation of DNA repair foci in irradiated cells: Cell cycle effect and implications for prediction of radiosensitivity. DNA Repair (Amst). 12(10):844–855.
  • Moquet J, Barnard S, Staynova A, Lindholm C, Monteiro Gil O, Martins V, Rößler U, Vral A, Vandevoorde C, Wojewódzka M, et al. 2017. The second gamma-H2AX assay inter-comparison exercise carried out in the framework of the European biodosimetry network (RENEB). Int J Radiat Biol. 93(1):58–64.
  • Parris CN, Adam Zahir S, Al-Ali H, Bourton EC, Plowman C, Plowman PN. 2015. Enhanced γ-H2AX DNA damage foci detection using multimagnification and extended depth of field in imaging flow cytometry. Cytometry A. 87(8):717–723.
  • Pujol M, Barrios L, Puig P, Caballín MR, Barquinero JF. 2016. A new model for biological dose assessment in cases of heterogeneous exposures to ionizing radiation. Radiat Res. 185(2):151–162.
  • R Core Team. 2020. R: A language and environment for statistical computing. Vienna, Austria.
  • Redon CE, Dickey JS, Bonner WM, Sedelnikova OA. 2009. γ-H2AX as a biomarker of DNA damage induced by ionizing radiation in human peripheral blood lymphocytes and artificial skin. Adv Space Res. 43(8):1171–1178.
  • Roch-Lefèvre S, Mandina T, Voisin P, Gaëtan G, Mesa JEG, Valente M, Bonnesoeur P, García O, Voisin P, Roy L. 2010. Quantification of gamma-H2AX foci in human lymphocytes: A method for biological dosimetry after ionizing radiation exposure. Radiat Res. 174(2):185–194.
  • Rogakou EP, Boon C, Redon C, Bonner WM. 1999. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol. 146(5):905–915.
  • Romm H, Ainsbury E, Barnard S, Barrios L, Barquinero JF, Beinke C, Deperas M, Gregoire E, Koivistoinen A, Lindholm C, et al. 2013. Automatic scoring of dicentric chromosomes as a tool in large scale radiation accidents. Mutat Res. 756(1-2):174–183.
  • Rothkamm K, Balroop S, Shekhdar J, Fernie P, Goh V. 2007. Leukocyte DNA damage after multi-detector row CT: A quantitative biomarker of low-level radiation exposure. Radiology. 242(1):244–251.
  • Rothkamm K, Löbrich M. 2003. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc Natl Acad Sci USA. 100(9):5057–5062.
  • Rothkamm K, Horn S, Scherthan H, Rössler U, De Amicis A, Barnard S, Kulka U, Lista F, Meineke V, Braselmann H, et al. 2013. Laboratory intercomparison on the γ-H2AX foci assay. Radiat Res. 180(2):149–155.
  • Rothkamm K, Barnard S, Ainsbury EA, Al-Hafidh J, Barquinero JF, Lindholm C, Moquet J, Perälä M, Roch-Lefèvre S, Scherthan H, et al. 2013. Manual versus automated γ-H2AX foci analysis across five European laboratories: Can this assay be used for rapid biodosimetry in a large scale radiation accident? Mutat Res. 756(1-2):170–173.
  • Rübe CE, Grudzenski S, Kühne M, Dong X, Rief N, Löbrich M, Rübe C. 2008. DNA double-strand break repair of blood lymphocytes and normal tissues analysed in a preclinical mouse model: Implications for radiosensitivity testing. Clin Cancer Res. 14(20):6546–6555.
  • Subramanian U, O'Brien B, McNamara M, Romanyukha L, Bolduc DL, Olsen C, Blakely WF. 2020. Automated dicentric aberration scoring for triage dose assessment: 60CO gamma ray dose-response at different dose rates. Health Phys. 119(1):52–58.
  • Zahnreich S, Ebersberger A, Kaina B, Schmidberger H. 2015. Biodosimetry based on γ-H2AX quantification and cytogenetics after partial- and total-body irradiation during fractionated radiotherapy. Radiat Res. 183(4):432–446.

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