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Original Articles

Poly (ADP-ribose) polymerase inhibitors sensitize cancer cells to hypofractionated radiotherapy through altered selection of DNA double-strand break repair pathways

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Pages 1222-1234 | Received 21 Aug 2020, Accepted 02 Dec 2021, Published online: 04 Jan 2022

References

  • Albert JM, Cao C, Kim KW, Willey CD, Geng L, Xiao D, Wang H, Sandler A, Johnson DH, Colevas AD, et al. 2007. Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. Clin Cancer Res. 13(10):3033–3042.
  • Audebert M, Salles B, Calsou P. 2004. Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining. J Biol Chem. 279(53):55117–55126.
  • Audebert M, Salles B, Calsou P. 2008. Effect of double-strand break DNA sequence on the PARP-1 NHEJ pathway. Biochem Biophys Res Commun. 369(3):982–988.
  • Bang A, Bezjak A. 2019. Stereotactic body radiotherapy for centrally located stage I non-small cell lung cancer. Transl Lung Cancer Res. 8(1):58–69.
  • Barreto-Andrade JC, Efimova EV, Mauceri HJ, Beckett MA, Sutton HG, Darga TE, Vokes EE, Posner MC, Kron SJ, Weichselbaum RR. 2011. Response of human prostate cancer cells and tumors to combining PARP inhibition with ionizing radiation. Mol Cancer Ther. 10(7):1185–1193.
  • Ben-Hur E, Utsumi H, Elkind MM. 1984. Inhibitors of poly (ADP-ribose) synthesis enhance radiation response by differentially affecting repair of potentially lethal versus sublethal damage. Br J Cancer Suppl. 6:39–42.
  • Bhargava R, Onyango DO, Stark JM. 2016. Regulation of single-strand annealing and its role in genome maintenance. Trends Genet. 32(9):566–575.
  • Claybon A, Karia B, Bruce C, Bishop AJR. 2010. PARP1 suppresses homologous recombination events in mice in vivo. Nucleic Acids Res. 38(21):7538–7545.
  • Farmer H, McCabe N, Lord CJ, Tutt ANJ, Johnson DA, Richardson TB, Santarosa M, Dillon KJ, Hickson I, Knights C, et al. 2005. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature. 434(7035):917–921.
  • He X, Tan C, Wang F, Wang Y, Zhou R, Cui D, You W, Zhao H, Ren J, Feng B. 2016. Knock-in of large reporter genes in human cells via CRISPR/Cas9-induced homology-dependent and independent DNA repair. Nucleic Acids Res. 44(9):e85.
  • Hochegger H, Dejsuphong D, Fukushima T, Morrison C, Sonoda E, Schreiber V, Zhao GY, Saberi A, Masutani M, Adachi N, et al. 2006. Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells. Embo J. 25(6):1305–1314.
  • Jingu K, Matsushita H, Yamamoto T, Umezawa R, Ishikawa Y, Takahashi N, Katagiri Y, Takeda K, Kadoya N. 2018. Stereotactic radiotherapy for pulmonary oligometastases from colorectal cancer: a systematic review and meta-analysis. Technol Cancer Res Treat. 17:153303381879493.
  • Li B, Navarro S, Kasahara N, Comai L. 2004. Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1. J Biol Chem. 279(14):13659–13667.
  • Lieber MR. 2010. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem. 79(1):181–211.
  • Löser DA, Shibata A, Shibata AK, Woodbine LJ, Jeggo PA, Chalmers AJ. 2010. Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair. Mol Cancer Ther. 9(6):1775–1787.
  • Ma W, Halweg CJ, Menendez D, Resnick MA. 2012. Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. Proc Natl Acad Sci USA. 109(17):6590–6595.
  • Murai J, Huang S.-y N, Das BB, Renaud A, Zhang Y, Doroshow JH, Ji J, Takeda S, Pommier Y. 2012. Trapping of PARP1 and PARP2 by clinical PARP inhibitors. Cancer Res. 72(21):5588–5599.
  • Nile DL, Rae C, Hyndman IJ, Gaze MN, Mairs RJ. 2016. An evaluation in vitro of PARP-1 inhibitors, rucaparib and olaparib, as radiosensitisers for the treatment of neuroblastoma. BMC Cancer. 16(1):621.
  • Noël G, Giocanti N, Fernet M, Mégnin F, Favaudon V. 2003. Poly(ADP-ribose) polymerase (PARP-1) is not involved in DNA double-strand break recovery. BMC Cell Biol. 4:7.
  • Noël G, Godon C, Fernet M, Giocanti N, Mégnin-Chanet F, Favaudon V. 2006. Radiosensitization by the poly(ADP-ribose) polymerase inhibitor 4-amino-1,8-naphthalimide is specific of the S phase of the cell cycle and involves arrest of DNA synthesis. Mol Cancer Ther. 5(3):564–574.
  • Oikawa A, Tohda H, Kanai M, Miwa M, Sugimura T. 1980. Inhibitors of poly(adenosine diphosphate ribose) polymerase induce sister chromatid exchanges. Biochem Biophys Res Commun. 97(4):1311–1316.
  • Ottaviani D, LeCain M, Sheer D. 2014. The role of microhomology in genomic structural variation. Trends Genet. 30(3):85–94.
  • Patel K, Kay R, Rowell L. 2006. Comparing proportional hazards and accelerated failure time models: an application in influenza. Pharm Stat. 5(3):213–224.
  • Schultz N, Lopez E, Saleh-Gohari N, Helleday T. 2003. Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination. Nucleic Acids Res. 31(17):4959–4964.
  • Senra JM, Telfer BA, Cherry KE, McCrudden CM, Hirst DG, O'Connor MJ, Wedge SR, Stratford IJ. 2011. Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft. Mol Cancer Ther. 10(10):1949–1958.
  • Seo Y, Tamari K, Yoshioka Y, Isohashi F, Suzuki O, Hayashi K, Takahashi Y, Baek S, Otani K, Ogawa K. 2016. Characterization of in vitro radiosensitization in mammalian cells using biomathematical modelling: implications for hypofractionated radiotherapy with a combined modality approach. Br J Radiol. 89(1062):20150724.
  • Sizemore ST, Mohammad R, Sizemore GM, Nowsheen S, Yu H, Ostrowski MC, Chakravarti A, Xia F. 2018. Synthetic Lethality of PARP inhibition and ionizing radiation is p53-dependent. Mol Cancer Res. 16(7):1092–1102.
  • Thraves P, Mossman KL, Brennan T, Dritschilo A. 1985. Radiosensitization of human fibroblasts by 3-aminobenzamide: an inhibitor of poly(ADP-ribosylation). Radiat Res. 104(2 Pt 1):119–127.
  • Veuger SJ, Richardson CJ, Smith GCM, Durkacz BW, Smith GCM, Durkacz BW. 2003. Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1. Cancer Res. 63(18):6008–6015.
  • Wang M, Wu W, Wu W, Rosidi B, Zhang L, Wang H, Iliakis G. 2006. PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res. 34(21):6170–6182.

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