Radiation responses of cancer and normal cells to split dose fractions with uniform and grid fields: increasing the therapeutic ratio

References

• Arcangeli G, Mauro F, Morelli D, Nervi C. 1979. Multiple daily fractionation in radiotherapy: biological rationale and preliminary clinical experiences. Eur J Cancer. 15(9):1077–1083.
   PubMed Web of Science ®Google Scholar
• Claridge Mackonis E, Hammond L, Esteves AIS, Suchowerska N. 2018. Radiation dosimetry in cell biology: comparison of calculated and measured absorbed dose for a range of culture vessels and clinical beam qualities. Int J Radiat Biol. 94(2):150–156.
   PubMed Web of Science ®Google Scholar
• Claridge Mackonis E, Suchowerska N, Naseri P, McKenzie DR. 2012. Optimisation of exposure conditions for in vitro radiobiology experiments. Australas Phys Eng Sci Med. 35(2):151–157.
   PubMed Web of Science ®Google Scholar
• Dal Bello R, Becher T, Fuss MC, Krämer M, Seco J. 2020. Proposal of a chemical mechanism for mini-beam and micro-beam efficacy. Front Phys. 8:452.
   Web of Science ®Google Scholar
• Desai S, Kobayashi A, Konishi T, Oikawa M, Pandey BN. 2014. Damaging and protective bystander cross-talk between human lung cancer and normal cells after proton microbeam irradiation. Mutat Res. 763–764:39–44.
   PubMed Web of Science ®Google Scholar
• Diffenderfer ES, Verginadis II, Kim MM, Shoniyozov K, Velalopoulou A, Goia D, Putt M, Hagan S, Avery S, Teo K, et al. 2020. Design, implementation, and in vivo validation of a novel proton FLASH radiation therapy system. Int J Radiat Oncol Biol Phys. 106(2):440–448.
   PubMed Web of Science ®Google Scholar
• Ebert MA, Suchowerska N, Jackson MA, McKenzie DR. 2010. A mathematical framework for separating the direct and bystander components of cellular radiation response. Acta Oncol. 49(8):1334–1343.
   PubMed Web of Science ®Google Scholar
• Elkind MM, Sutton H. 1959. X-ray damage and recovery in mammalian cells in culture. Nature. 184:1293–1295.
   PubMed Web of Science ®Google Scholar
• Favaudon V, Caplier L, Monceau V, Pouzoulet F, Sayarath M, Fouillade C, Poupon MF, Brito I, Hupé P, Bourhis J, et al. 2014. Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice. Sci Transl Med. 6(245):245ra293.
   Web of Science ®Google Scholar
• Filippovich IV, Sorokina NI, Robillard N, Lisbona A, Chatal J-F. 1998. Radiation-induced apoptosis in human tumor cell lines: adaptive response and split-dose effect. Int J Cancer. 77(1):76–81.
   PubMed Web of Science ®Google Scholar
• Franken NA, Rodermond HM, Stap J, Haveman J, van Bree C. 2006. Clonogenic assay of cells in vitro. Nat Protoc. 1(5):2315–2319.
   PubMed Web of Science ®Google Scholar
• Griffin RJ, Prise KM, McMahon SJ, Zhang X, Penagaricano J, Butterworth KT. 2020. History and current perspectives on the biological effects of high-dose spatial fractionation and high dose-rate approaches: GRID, microbeam & FLASH radiotherapy. Br J Radiol. 93(1113):20200217.
   PubMed Web of Science ®Google Scholar
• Hall Eric J. 1994. Radiobiology for the radiologist. Hyperthermia., 4th edition. Philadelphia (PA): JB Lippincott Company.
   Google Scholar
• Kench PL, Rogers L, Esteves A, Gorjiara T, Mackonis EC, Morrell S, McKenzie DR, Suchowerska N. 2020. Imaging prior to radiotherapy impacts in-vitro survival. Phys Imaging Radiat Oncol. 16:138–143.
   PubMedGoogle Scholar
• Lee CT, Dong Y, Li T, Freedman S, Anaokar J, Galloway TJ, Hallman MA, Weiss SE, Hayes SB, Price RA, et al. 2018. Local control and toxicity of external beam reirradiation with a pulsed low-dose-rate technique. Int J Radiat Oncol Biol Phys. 100(4):959–964.
   PubMed Web of Science ®Google Scholar
• Lin PS, Wu A. 2005. Not all 2 Gray radiation prescriptions are equivalent: cytotoxic effect depends on delivery sequences of partial fractionated doses. Int J Radiat Oncol Biol Phys. 63(2):536–544.
   PubMed Web of Science ®Google Scholar
• Ling CC, Guo M, Chen CH, Deloherey T. 1995. Radiation-induced apoptosis: effects of cell age and dose fractionation. Cancer Res. 55(22):5207–5212.
   PubMed Web of Science ®Google Scholar
• Mackonis EC, Suchowerska N, Zhang M, Ebert M, McKenzie DR, Jackson M. 2007. Cellular response to modulated radiation fields. Phys Med Biol. 52(18):5469–5482.
   PubMed Web of Science ®Google Scholar
• McIlwrath AJ, Vasey PA, Ross GM, Brown R. 1994. Cell cycle arrests and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity. Cancer Res. 54(14):3718–3722.
   PubMed Web of Science ®Google Scholar
• Montay-Gruel P, Petersson K, Jaccard M, Boivin G, Germond JF, Petit B, Doenlen R, Favaudon V, Bochud F, Bailat C, et al. 2017. Irradiation in a flash: unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s. Radiother Oncol. 124(3):365–369.
   PubMed Web of Science ®Google Scholar
• Mothersill C, Seymour C. 2001. Radiation-induced bystander effects: past history and future directions. Radiat Res. 155(6):759–767.2.0.CO;2]
   PubMed Web of Science ®Google Scholar
• Peng V, Suchowerska N, Esteves ADS, Rogers L, Claridge Mackonis E, Toohey J, McKenzie DR. 2018. Models for the bystander effect in gradient radiation fields: range and signalling type. J Theor Biol. 455:16–25.
   PubMed Web of Science ®Google Scholar
• Peng V, Suchowerska N, Rogers L, Claridge Mackonis E, Oakes S, McKenzie DR. 2017. Grid therapy using high definition multileaf collimators: realizing benefits of the bystander effect. Acta Oncol. 56(8):1048–1059.
   PubMed Web of Science ®Google Scholar
• Potter MD, Suchowerska N, Rizvi S, McKenzie DR. 2011. Hidden stressors in the clonogenic assay used in radiobiology experiments. Australas Phys Eng Sci Med. 34(3):345–350.
   PubMed Web of Science ®Google Scholar
• Prezado Y, Jouvion G, Guardiola C, Gonzalez W, Juchaux M, Bergs J, Nauraye C, Labiod D, De Marzi L, Pouzoulet F, et al. 2019. Tumor control in RG2 glioma-bearing rats: a comparison between proton minibeam therapy and standard proton therapy. Int J Radiat Oncol Biol Phys. 104(2):266–271.
   PubMed Web of Science ®Google Scholar
• Prise KM, O'Sullivan JM. 2009. Radiation-induced bystander signalling in cancer therapy. Nat Rev Cancer. 9(5):351–360.
   PubMed Web of Science ®Google Scholar
• Rogers LJ, Suchowerska N, Ralston A, Napper A, McKenzie DR. 2015. Imaging dose affects in vitro survival following subsequent therapeutic irradiation. Biomed Phys Eng Express. 1(4):45016.
   Google Scholar
• Trainor C, Butterworth KT, McGarry CK, McMahon SJ, O'Sullivan JM, Hounsell AR, Prise KM. 2012. DNA damage responses following exposure to modulated radiation fields. PLOS One. 7(8):e43326.
   PubMed Web of Science ®Google Scholar
• Wright MD, Romanelli P, Bravin A, Le Duc G, Brauer-Krisch E, Requardt H, Bartzsch S, Hlushchuk R, Laissue J-A, Djonov V. 2021. Non-conventional ultra-high dose rate (FLASH) microbeam radiotherapy provides superior normal tissue sparing in rat lung compared to non-conventional ultra-high dose rate (FLASH) radiotherapy. Cureus. 13(11).
   Google Scholar
• Zorov DB, Filburn CR, Klotz LO, Zweier JL, Sollott SJ. 2000. Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes. J Exp Med. 192(7):1001–1014.
   PubMed Web of Science ®Google Scholar