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Original Articles

Autophagy regulates X-ray radiation-induced premature senescence through STAT3-Beclin1-p62 pathway in lung adenocarcinoma cells

, , , , , , & show all
Pages 1432-1441 | Received 10 Sep 2021, Accepted 14 Mar 2022, Published online: 15 Apr 2022

References

  • Amaravadi R, Kimmelman AC, White E. 2016. Recent insights into the function of autophagy in cancer. Genes Dev. 30(17):1913–1930.
  • Cao Y, Klionsky DJ. 2007. Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein. Cell Res. 17(10):839–849.
  • Chang SH, Minai-Tehrani A, Shin JY, Park S, Kim JE, Yu KN, Hong SH, Hong CM, Lee KH, Beck GR, Jr, et al. 2012. Beclin1-induced autophagy abrogates radioresistance of lung cancer cells by suppressing osteopontin. J Radiat Res. 53(3):422–432.
  • Chen C, Deng M, Sun Q, Loughran P, Billiar TR, Scott MJ. 2014. Lipopolysaccharide stimulates p62-dependent autophagy-like aggregate clearance in hepatocytes. Biomed Res Int. 2014:267350.
  • Chen Z, Cao K, Xia Y, Li Y, Hou Y, Wang L, Li L, Chang L, Li W. 2019. Cellular senescence in ionizing radiation. Oncol Rep. 42(3):883–894.
  • Cho KA, Ryu SJ, Oh YS, Park JH, Lee JW, Kim H-P, Kim KT, Jang IS, Park SC. 2004. Morphological adjustment of senescent cells by modulating caveolin-1 status. J Biol Chem. 279(40):42270–42278.
  • Chun-Yan D, Qing-Jie L, Jiang-Bin F, Mei T, Xue L, Shuang L, Gao L. 2019. Study on the role of STAT3 in premature senescence of lung adenocarcinoma induced by the irradiation of high energy X-ray. China Med Equipment. 16:121–142.
  • Coppé JP, Patil CK, Rodier F, Sun Y, Muñoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J. 2008. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 6(12):2853–2868.
  • D’Arcy MS. 2019. Cell death: a review of the major forms of apoptosis, necrosis and autophagy. Cell Biol Int. 43(6):582–592.
  • Falck J, Coates J, Jackson SP. 2005. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature. 434(7033):605–611.
  • Fekadu J, Rami A. 2016. Beclin-1 deficiency alters autophagosome formation, lysosome biogenesis and enhances neuronal vulnerability of HT22 hippocampal cells. Mol Neurobiol. 53(8):5500–5509.
  • Gao L, Li F-S, Chen X-H, Liu Q-W, Feng J-B, Liu Q-J, Su X. 2014. Radiation induces phosphorylation of STAT3 in a dose- and time-dependent manner. Asian Pac J Cancer Prev. 15(15):6161–6164.
  • Gewirtz DA. 2014. Autophagy and senescence in cancer therapy. J Cell Physiol. 229:6–9.
  • Gloria S, Abigail C, Jingwen H, Yitong Z, Alexa S, Lula H, Nikolay P, Farshad F, Seok HH. 2020. SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence. Autophagy. 16:1092–1110.
  • Hanning JE, Saini HK, Murray MJ, Caffarel MM, van Dongen S, Ward D, Barker EM, Scarpini CG, Groves IJ, Stanley MA, et al. 2013. Depletion of HPV16 early genes induces autophagy and senescence in a cervical carcinogenesis model, regardless of viral physical state. J Pathol. 231(3):354–366.
  • Herbst RS, Morgensztern D, Boshoff C. 2018. The biology and management of non-small cell lung cancer. Nature. 553(7689):446–454.
  • Imielinski M, Cha S, Rejtar T, Richardson EA, Karger BL, Sgroi DC. 2012. Integrated proteomic, transcriptomic, and biological network analysis of breast carcinoma reveals molecular features of tumorigenesis and clinical relapse. Mol Cell Proteomics. 11(6):M111.014910.
  • Kang C, Elledge SJ. 2016. How autophagy both activates and inhibits cellular senescence. Autophagy. 12(5):898–899.
  • Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ. 2015. The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science. 349(6255):aaa5612.
  • Katsuragi Y, Ichimura Y, Komatsu M. 2015. p62/SQSTM1 functions as a signaling hub and an autophagy adaptor. Febs J. 282(24):4672–4678.
  • Kurz DJ, Decary S, Hong Y, Erusalimsky JD. 2000. Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells. J Cell Sci. 113(20):3613–3622.
  • Lee BY, Han JA, Im JS, Morrone A, Johung K, Goodwin EC, Kleijer WJ, DiMaio D, Hwang ES. 2006. Senescence-associated beta-galactosidase is lysosomal beta-galactosidase. Aging Cell. 5(2):187–195.
  • Lee JH, Paull TT. 2005. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science. 308(5721):551–554.
  • Lee JY, Yu KR, Lee BC, Kang I, Kim JJ, Jung EJ, Kim HS, Seo Y, Choi SW, Kang KS. 2018. GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging. Exp Mol Med. 50(5):1–12.
  • Lee M, Lee JS. 2014. The roles of tumor cell senescence in anticancer therapy. BMB Reports. 47(2):51–59.
  • Li-Ping M, Chun-Yan D, Mei T, Qing-Jie L, Ling G. 2021. Study on the regulatory relationship of STAT3 and Cav-1 in the premature senescence of X-ray-induced lung adenocarcinoma A 549 cells. China Med Equipment. 18:1–5.
  • Menolfi D, Zha Z. 2020. ATM, ATR and DNA-PKcs kinases-the lessons from the mouse models: inhibition = deletion. Cell Biosci. 10:8.
  • Mongiardi MP, Radice G, Piras M, Stagni V, Pacioni S, Re A, Putti S, Ferrè F, Farsetti A, Pallini R, et al. 2019. Axitinib exposure triggers endothelial cells senescence through ROS accumulation and ATM activation. Oncogene. 38(27):5413–5424.
  • Nasim F, Sabath BF, Eapen GA. 2019. Lung cancer. Med Clin North Am. 103(3):463–473.
  • Rajendran P, Alzahrani AM, Hanieh HN, Kumar SA, Ben Ammar R, Rengarajan T, Alhoot MA. 2019. Autophagy and senescence: A new insight in selected human diseases. J Cell Physiol. 234(12):21485–21492.
  • Rubinsztein D, Marino G, Kroemer G. 2011. Autophagy and aging. Cell. 146(5):682–695.
  • Yorimitsu T, Klionsky DJ. 2005. Autophagy: molecular machinery for self-eating. Cell Death Differ. 12(S2):1542–1552.
  • You L, Wang Z, Li H, Shou J, Jing Z, Xie J, Sui X, Pan H, Han W. 2015. The role of STAT3 in autophagy. Autophagy. 11(5):729–739.

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