Direct ionizing radiation and bystander effect in mouse mesenchymal stem cells

References

• Aparicio T, Baer R, Gautier J. 2014. DNA double-strand break repair pathway choice and cancer. DNA Repair (Amst). 19:169–175.
   PubMed Web of Science ®Google Scholar
• Archer S. 1993. Measurement of nitric oxide in biological models. FASEB J. 7(2):349–360.
   PubMed Web of Science ®Google Scholar
• Autsavapromporn N, Kobayashi A, Liu C, Jaikang C, Tengku Ahmad TA, Oikawa M, Konishi T. 2022. Hypoxia and proton microbeam: role of gap junction intercellular communication in inducing bystander responses on human lung cancer cells and normal cells. Radiat Res. 197(2):122–130.
   PubMed Web of Science ®Google Scholar
• Barcellos-Hoff MH, Ravani SA. 2000. Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. Cancer Res. 60:1254–1260.
   PubMed Web of Science ®Google Scholar
• Bianco P, Riminucci M, Gronthos S, Robey PG. 2001. Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells. 19(3):180–192.
   PubMed Web of Science ®Google Scholar
• Branzei D, Foiani M. 2008. Regulation of DNA repair throughout the cell cycle. Nat Rev Mol Cell Biol. 9(4):297–308.
   PubMed Web of Science ®Google Scholar
• Chen JH, Hales CN, Ozanne SE. 2007. DNA damage, cellular senescence and organismal ageing: causal or correlative? Nucleic Acids Res. 35(22):7417–7428.
   PubMed Web of Science ®Google Scholar
• Chen MF, Lin CT, Chen WC, Yang CT, Chen CC, Liao SK, Liu JM, Lu CH, Lee KD. 2006. The sensitivity of human mesenchymal stem cells to ionizing radiation. Int J Radiat Oncol Biol Phys. 66(1):244–253.
   PubMed Web of Science ®Google Scholar
• Clancy S. 2008. DNA damage & repair: mechanisms for maintaining DNA integrity. Nat Educ. 1:103.
   Google Scholar
• D'Andrea FP. 2012. Intrinsic radiation resistance of mesenchymal cancer stem cells and implications for treatment response in a murine sarcoma model. Dan Med J. 59:B4388.
   PubMed Web of Science ®Google Scholar
• D'Andrea FP, Horsman MR, Kassem M, Overgaard J, Safwat A. 2012. Tumourigenicity and radiation resistance of mesenchymal stem cells. Acta Oncol. 51(5):669–679.
   PubMed Web of Science ®Google Scholar
• DeSimone JN, Dolezalova H, Redpath JL, Stanbridge EJ. 2000. Prolonged cell cycle arrest in irradiated human diploid skin fibroblasts: the role of nutrient deprivation. Radiat Res. 153(2):131–143.
   PubMed Web of Science ®Google Scholar
• Dickey JS, Zemp FJ, Altamirano A, Sedelnikova OA, Bonner WM, Kovalchuk O. 2011. H2AX phosphorylation in response to DNA double-strand break formation during bystander signalling: effect of microRNA knockdown. Radiat Prot Dosimetry. 143(2-4):264–269.
   PubMed Web of Science ®Google Scholar
• Fenech M. 2000. The in vitro micronucleus technique. Mutat Res. 455(1-2):81–95.
   PubMed Web of Science ®Google Scholar
• Fenech M, Kirsch-Volders M, Natarajan AT, Surralles J, Crott JW, Parry J, Norppa H, Eastmond DA, Tucker JD, Thomas P. 2011. Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells. Mutagenesis. 26(1):125–132.
   PubMed Web of Science ®Google Scholar
• Hall EJ. 2003. The bystander effect. Health Phys. 85(1):31–35.
   PubMed Web of Science ®Google Scholar
• Hall EJ, Giaccia AJ. 2012. Radiobiology for the Radiologist. PA, USA: Lippincott Williams & Wilkins. 7th ed. Chapter 3. Cell Survival Curves; p. 30–46.
   Google Scholar
• Herberg S, Kondrikova G, Hussein KA, Periyasamy-Thandavan S, Johnson MH, Elsalanty ME, Shi X, Hamrick MW, Isales CM, Hill WD. 2014. Total body irradiation is permissive for mesenchymal stem cell-mediated new bone formation following local transplantation. Tissue Eng Part A. 20(23-24):3212–3227.
   PubMed Web of Science ®Google Scholar
• Hu MS, Borrelli MR, Lorenz HP, Longaker MT, Wan DC. 2018. Mesenchymal stromal cells and cutaneous wound healing: a comprehensive review of the background, role, and therapeutic potential. Stem Cells Int. 2018:6901983.
   PubMed Web of Science ®Google Scholar
• Huang RX, Zhou PK. 2020. DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer. Signal Transduct Target Ther. 5(1):60.
   PubMed Web of Science ®Google Scholar
• Huhn D, Bolck HA, Sartori AA. 2013. Targeting DNA double-strand break signalling and repair: recent advances in cancer therapy. Swiss Med Wkly. 143:w13837.
   PubMed Web of Science ®Google Scholar
• Jäkel O. 2014. Light-ion radiation therapy planning. In: Brahme A, editor. Comprehensive Biomedical Physics. Oxford: Elsevier; p. 487–504.
   Google Scholar
• Kalinina NI, Sysoeva VY, Rubina KA, Parfenova YV, Tkachuk VA. 2011. Mesenchymal stem cells in tissue growth and repair. Acta Naturae. 3(4):30–37.
   PubMed Web of Science ®Google Scholar
• Kang MA, So EY, Simons AL, Spitz DR, Ouchi T. 2012. DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway. Cell Death Dis. 3:e249.
   PubMed Web of Science ®Google Scholar
• Kohl V, Fabarius A, Drews O, Bierbaum M, Jawhar A, Darwich A, Weiss C, Flach J, Brendel S, Kleiner H, et al. 2021. Genotoxic bystander signals from irradiated human mesenchymal stromal cells mainly localize in the 10-100 kDa fraction of conditioned medium. Cells. 10(4):827.
   PubMed Web of Science ®Google Scholar
• Leach JK, Van Tuyle G, Lin PS, Schmidt-Ullrich R, Mikkelsen RB. 2001. Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen/nitrogen. Cancer Res. 61(10):3894–3901.
   PubMed Web of Science ®Google Scholar
• Marin A, Martin M, Linan O, Alvarenga F, Lopez M, Fernandez L, Büchser D, Cerezo L. 2015. Bystander effects and radiotherapy. Rep Pract Oncol Radiother. 20(1):12–21.
   PubMedGoogle Scholar
• Marion NW, Mao JJ. 2006. Mesenchymal stem cells and tissue engineering. Methods Enzymol. 420:339–361.
   PubMed Web of Science ®Google Scholar
• Memmott RM, Dennis PA. 2009. Akt-dependent and -independent mechanisms of mTOR regulation in cancer. Cell Signal. 21(5):656–664.
   PubMed Web of Science ®Google Scholar
• Mladenov E, Magin S, Soni A, Iliakis G. 2013. DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy. Front Oncol. 3:113.
   PubMedGoogle Scholar
• Mothersill C, Seymour CB. 2004. Radiation-induced bystander effects-implications for cancer. Nat Rev Cancer. 4(2):158–164.
   PubMed Web of Science ®Google Scholar
• Murphy JB, Liu JH, Sturm E. 1922. STUDIES ON X-Ray EFFECTS: IX. THE ACTION OF SERUM FROM X-RAYED ANIMALS ON LYMPHOID CELLS IN VITRO. J Exp Med. 35(3):373–384.
   PubMedGoogle Scholar
• Nakamura AJ, Rao VA, Pommier Y, Bonner WM. 2010. The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks. Cell Cycle. 9(2):389–397.
   PubMed Web of Science ®Google Scholar
• Nelson G, Buhmann M, von Zglinicki T. 2009. DNA damage foci in mitosis are devoid of 53BP1. Cell Cycle. 8(20):3379–3383.
   PubMed Web of Science ®Google Scholar
• NIH. 2020. Signal Transduction and Targeted Therapy Volume 5: NIH – National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/types/radiation-therapy.
   Google Scholar
• Nogueira-Pedro A, Makiyama EN, Segreto HRC, Fock RA. 2021. The role of low-dose radiation in association with TNF-α on immunomodulatory properties of mesenchymal stem cells. Stem Cell Rev Rep. 17(3):968–980.
   PubMed Web of Science ®Google Scholar
• Paredes-Gamero EJ, Franca JP, Moraes AA, Aguilar MO, Oshiro ME, Ferreira AT. 2004. Problems caused by high concentration of ATP on activation of the P2X7 receptor in bone marrow cells loaded with the Ca2+ fluorophore fura-2. J Fluoresc. 14(6):711–722.
   PubMed Web of Science ®Google Scholar
• Pittenger MF, Discher DE, Peault BM, Phinney DG, Hare JM, Caplan AI. 2019. Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regen Med. 4:22.
   PubMed Web of Science ®Google Scholar
• Prise KM, O'Sullivan JM. 2009. Radiation-induced bystander signalling in cancer therapy. Nat Rev Cancer. 9(5):351–360.
   PubMed Web of Science ®Google Scholar
• Pucci B, Kasten M, Giordano A. 2000. Cell cycle and apoptosis. Neoplasia. 2(4):291–299.
   PubMed Web of Science ®Google Scholar
• Redon CE, Nakamura AJ, Zhang YW, Ji JJ, Bonner WM, Kinders RJ, Parchment RE, Doroshow JH, Pommier Y. 2010. Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers. Clin Cancer Res. 16(18):4532–4542.
   PubMed Web of Science ®Google Scholar
• Schmitt CA. 2007. Cellular senescence and cancer treatment. Biochim Biophys Acta. 1775(1):5–20.
   PubMed Web of Science ®Google Scholar
• Schmitt E, Paquet C, Beauchemin M, Bertrand R. 2007. DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis. J Zhejiang Univ Sci B. 8(6):377–397.
   PubMedGoogle Scholar
• Shen H, Yu H, Liang PH, Cheng H, XuFeng R, Yuan Y, Zhang P, Smith CA, Cheng T. 2012. An acute negative bystander effect of γ-irradiated recipients on transplanted hematopoietic stem cells. Blood. 119(15):3629–3637.
   PubMed Web of Science ®Google Scholar
• Singh K, Matsuyama S, Drazba JA, Almasan A. 2012. Autophagy-dependent senescence in response to DNA damage and chronic apoptotic stress. Autophagy. 8(2):236–251.
   PubMed Web of Science ®Google Scholar
• Siva S, MacManus MP, Martin RF, Martin OA. 2015. Abscopal effects of radiation therapy: a clinical review for the radiobiologist. Cancer Lett. 356(1):82–90.
   PubMed Web of Science ®Google Scholar
• Thomas P, Umegaki K, Fenech M. 2003. Nucleoplasmic bridges are a sensitive measure of chromosome rearrangement in the cytokinesis-block micronucleus assay. Mutagenesis. 18(2):187–194.
   PubMed Web of Science ®Google Scholar
• Wakatsuki M, Magpayo N, Kawamura H, Held KD. 2012. Differential bystander signaling between radioresistant chondrosarcoma cells and fibroblasts after x-ray, proton, iron ion and carbon ion exposures. Int J Radiat Oncol Biol Phys. 84(1):e103–e108.
   PubMed Web of Science ®Google Scholar
• Williams MV, Denekamp J, Fowler JF. 1985. A review of alpha/beta ratios for experimental tumors: implications for clinical studies of altered fractionation. Int J Radiat Oncol Biol Phys. 11(1):87–96.
   PubMed Web of Science ®Google Scholar
• Wouters B, Begg A. 2011. Irradiation-induced damage and the DNA damage response. In: Joiner M, Kogel AVD, editors. Basic Clinical Radiobiology. 4th ed. London: Hodder Arnold; p. 11–26.
   Google Scholar
• Yang H, Asaad N, Held KD. 2005. Medium-mediated intercellular communication is involved in bystander responses of X-ray-irradiated normal human fibroblasts. Oncogene. 24(12):2096–2103.
   PubMed Web of Science ®Google Scholar
• Ye B. 2010. Ca2+ oscillations and its transporters in mesenchymal stem cells. Physiol Res. 59(3):323–329.
   PubMed Web of Science ®Google Scholar
• Yoshino H, Kashiwakura I. 2017. Involvement of reactive oxygen species in ionizing radiation-induced upregulation of cell surface Toll-like receptor 2 and 4 expression in human monocytic cells. J Radiat Res. 58(5):626–635.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Guo J, Qi Y, Shao Q, Liang J. 2014. The prevention of radiation-induced DNA damage and apoptosis in human intestinal epithelial cells by salvianic acid A. J Radiat Res Appl Sci. 7:274–285.
   Google Scholar