Radiation adverse outcome pathways (AOPs) are on the horizon: advancing radiation protection through an international Horizon-Style exercise

References

• Ankley GT, Bennett RS, Erickson RJ, Hoff DJ, Hornung MW, Johnson RD, Mount DR, Nichols JW, Russom CL, Schmieder PK, et al. 2010. Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment. Environ Toxicol Chem. 29(3):730–741.
   PubMed Web of Science ®Google Scholar
• Azimzadeh O, Moertl S, Ramadan R, Baselet B, Laiakis EC, Sebastian S, Beaton D, Hartikainen JM, Kaiser Jc, Beheshti A. 2022. Application of radiation omics in the development of adverse outcome pathway networks: an example of radiation-induced cardiovascular disease. Int J Radiat Biol. 98(12):in press.
   Web of Science ®Google Scholar
• Beyer J, Petersen K, Song Y, Ruus A, Grung M, Bakke T, Tollefsen KE. 2014. Environmental risk assessment of combined effects in aquatic ecotoxicology: a discussion paper. Mar Environ Res. 96:81–91.
   PubMed Web of Science ®Google Scholar
• Boxall ABA, Rudd MA, Brooks BW, Caldwell DJ, Choi K, Hickmann S, Innes E, Ostapyk K, Staveley JP, Verslycke T, et al. 2012. Pharmaceuticals and personal care products in the environment: what are the big questions? Environ Health Perspect. 120(9):1221–1229.
   PubMed Web of Science ®Google Scholar
• Chauhan V, Beaton D, Hamada N, Wilkins R, Burtt J, Leblanc J, Cool D, Garnier-Laplace J, Laurier D, Le Y, et al. 2022. Adverse outcome pathway: a path toward better data consolidation and global co-ordination of radiation research. Int J Radiat Biol. 98(12):in press.
   Web of Science ®Google Scholar
• Chauhan V, Hamada N, Garnier-Laplace J, Laurier D, Beaton D, Tollefsen KE, Locke PA. 2022. Establishing a communication and engagement strategy to facilitate the adoption of the adverse outcome pathways in radiation research and regulation. Int J Radiat Biol. 98(12):in press.
   Web of Science ®Google Scholar
• Chauhan V, Hamada N, Monceau V, Ebrahimian T, Adam N, Wilkins RC, Sebastian S, Patel ZS, Huff JL, Simonetto C, et al. 2021. Expert consultation is vital for adverse outcome pathway development: a case example of cardiovascular effects of ionizing radiation. Int J Radiat Biol. 97(11):1516–1525.
   PubMed Web of Science ®Google Scholar
• Chauhan V, Leblanc J, Sadi B, Burtt J, Sauvé K, Lane R, Randhawa K, Wilkins R, Quayle D. 2021. COHERE – strengthening cooperation within the Canadian government on radiation research. Int J Radiat Biol. 97(9):1153–1165.
   PubMed Web of Science ®Google Scholar
• Chauhan V, Sherman S, Said Z, Yauk CL, Stainforth R. 2021. A case example of a radiation-relevant adverse outcome pathway to lung cancer. Int J Radiat Biol. 97(1):68–84.
   PubMed Web of Science ®Google Scholar
• Chauhan V, Stricklin D, Cool D. 2021. The integration of the adverse outcome pathway framework to radiation risk assessment. Int J Radiat Biol. 97(1):60–67.
   PubMed Web of Science ®Google Scholar
• Chauhan V, Villeneuve D, Cool D. 2021. Collaborative efforts are needed among the scientific community to advance the adverse outcome pathway concept in areas of radiation risk assessment. Int J Radiat Biol. 97(6):815–823.
   PubMed Web of Science ®Google Scholar
• Chauhan V, Wilkins RC, Beaton D, Sachana M, Delrue N, Yauk C, O'Brien J, Marchetti F, Halappanavar S, Boyd M, et al. 2021. Bringing together scientific disciplines for collaborative undertakings: a vision for advancing the adverse outcome pathway framework. Int J Radiat Biol. 97(4):431–441.
   PubMed Web of Science ®Google Scholar
• Dillman DA, Smyth JD, Christian LM. 2009. Internet, mail, and mixed-mode surveys: the tailored design method. 3rd ed. Hoboken (NJ): John Wiley & Sons.
   Google Scholar
• EPRI. 2021. Electric Power Research Institute (EPRI), The International Dose Effect Alliance (IDEA) Virtual Workshop – November 2021. https://www.epri.com/research/programs/061197/events/F87E2EBE-CDC8-415F-9279-F322E6E54326.
   Google Scholar
• EURAMED 2021. European Alliance for Medical Radiation Protection Research (EURAMED), 5th European Radiation Protection Week (ERPW). https://www.euramed.eu/wp-content/uploads/2021/10/5th-European-Radiation-Protection-Week_draft-programme.pdf.
   Google Scholar
• Fairbrother A, Muir D, Solomon KR, Ankley GT, Rudd MA, Boxall ABA, Apell JN, Armbrust KL, Blalock BJ, Bowman SR, et al. 2019. Toward sustainable environmental quality: priority research questions for North America. Environ Toxicol Chem. 38(8):1606–1624.
   PubMed Web of Science ®Google Scholar
• Fleishman E, Blockstein DE, Hall JA, Mascia MB, Rudd MA, Scott JM, Sutherland WJ, Bartuska AM, Brown AG, Christen CA, et al. 2011. Top 40 priorities for science to inform US conservation and management policy. BioScience. 61(4):290–300.
   Web of Science ®Google Scholar
• Furnham A, Boo HC. 2011. A literature review of the anchoring effect. J Socio Econ. 40(1):35–42.
   Google Scholar
• Hecker M, LaLone CA. 2019. Adverse outcome pathways: moving from a scientific concept to an internationally accepted framework. Environ Toxicol Chem. 38(6):1152–1163.
   PubMed Web of Science ®Google Scholar
• ICRP. 2021. The Internation Commission on Radiological Protection (ICRP) Digital Workshop – The Future of Radiological Protection. https://www.icrp.org/page.asp?id=526.
   Google Scholar
• IRPA. 2022. International Radiation Protection Association (IRPA), 6th European Congress on Radiation Protection. https://static.akcongress.com/downloads/irpa/irpa2022.-boa.pdf.
   Google Scholar
• ISoRED 2021. Webinar on the Canadian Organization on Health Effects from Radiation Exposure (COHERE) @ the International Society of Radiation Epidemiology and Dosimetry (ISoRED). https://www.youtube.com/watch?v=CJ-18slrPRg.
   Google Scholar
• Jaylet T, et al. 2022. Development of an adverse outcome pathway for radiation-induced microcephaly via expert consultation and machine learning. Int J Radiat Biol. 98(12):in press.
   PubMed Web of Science ®Google Scholar
• Klokov D, Applegate K, Badie C, Brede DA, Dekkers F, Karabulutoglu M, Le Y, Rutten E, Lumniczky K, Gomolka M. 2022. International expert group collaboration for developing an adverse outcome pathway to radiation-induced leukaemia. Int J Radiat Biol. 98(12):in press.
   Web of Science ®Google Scholar
• Kozbenko T, Adam N, Lai V, Sandhu S, Kuan J, Flores D, Appleby M, Parker H, Hocking R, Tsaioun K, et al. 2022. Deploying elements of scoping review methods for adverse outcome pathway development: a space travel case example. Int J Radiat Biol. 98(in this issue). https://doi.org/10.1080/09553002.2022.2110306.
   Google Scholar
• LaLone CA, Ankley GT, Belanger SE, Embry MR, Hodges G, Knapen D, Munn S, Perkins EJ, Rudd MA, Villeneuve DL, et al. 2017. Advancing the adverse outcome pathway framework — an international horizon scanning approach. Environ Toxicol Chem. 36(6):1411–1421.
   PubMed Web of Science ®Google Scholar
• Lopez BE, Magliocca NR, Crooks AT. 2019. Challenges and opportunities of social media data for socio-environmental systems research. Land. 8(7):107.
   Web of Science ®Google Scholar
• Moe SJ, Wolf R, Xie L, Landis WG, Kotamaki N, Tollefsen KE. 2021. Quantification of an adverse outcome pathway network by Bayesian regression and Bayesian network modeling. Integr Environ Assess Manag. 17(1):147–164.
   PubMed Web of Science ®Google Scholar
• NCRP. 2020. Approaches for integrating information from radiation biology and epidemiology to enhance low-dose health risk assessment. NCRP Report No. 186, National Council on Radiation Protection and Measurements, 2020.
   Google Scholar
• OECD 2016. Guidance document for the use of adverse outcome pathways in developing Integrated Approaches to Testing and Assessment (IATA). Series on Testing and Assessment, No. 260, ENV/JM/MONO. 67, OECD Environment, Health and Safety Publications 2016, Organisation for Economic Co-operation and Development, Paris, France.
   Google Scholar
• OECD. 2021. Guidance document for the scientific review of adverse outcome pathways. Series on Testing and Assessment, No. 344. Series on Adverse Outcome Pathways, No. 20. ENV/CBC/MONO. 22, Organisation of Economic Co-operation and Development, Paris, France.
   Google Scholar
• Perkins EJ, Ashauer R, Burgoon L, Conolly R, Landesmann B, Mackay C, Murphy CA, Pollesch N, Wheeler JR, Zupanic A, et al. 2019. Building and applying quantitative adverse outcome pathway models for chemical hazard and risk assessment. Environ Toxicol Chem. 38(9):1850–1865.
   PubMed Web of Science ®Google Scholar
• RADRES. 2021. Advancing the Adverse Outcome Pathway Approach in Radiation Research through Global Coordination, Radiation Research Society (RADRES) workshop. https://www.youtube.com/watch?v=-xFIA1YqdRs.
   Google Scholar
• Rudd MA, Ankley GT, Boxall ABA, Brooks BW. 2014. International scientists’ priorities for research on pharmaceutical and personal care products in the environment. Integr Environ Assess Manag. 10(4):576–587.
   PubMed Web of Science ®Google Scholar
• Rudd MA, Fleishman E. 2014. Policymakers’ and scientists’ ranks of research priorities for resource-management policy. BioScience. 64(3):219–228.
   Web of Science ®Google Scholar
• Rudd MA. 2014. Scientists’ perspectives on global ocean research priorities. Front Mar Sci. 1:36.
   Web of Science ®Google Scholar
• Salbu B, Teien HC, Lind OC, Tollefsen KE. 2019. Why is the multiple stressor concept of relevance to radioecology? Int J Radiat Biol. 95(7):1015–1024.
   PubMed Web of Science ®Google Scholar
• Sawtooth Software. 2009. The CBC/HB system for Hierarchical Bayes estimation Version 5.0 Technical Paper. Sequim (WA): Sawtooth Software, Inc. http://www.sawtoothsoftware.com/download/techpap/hbtech.pdf.
   Google Scholar
• Song Y, Xie L, Lee Y, Tollefsen KE. 2020. De novo development of a quantitative adverse outcome pathway (qAOP) network for ultraviolet B (UVB) radiation using targeted laboratory tests and automated data mining. Environ Sci Technol. 54(20):13147–13156.
   PubMed Web of Science ®Google Scholar
• Sutherland WJ, Fleishman E, Mascia MB, Pretty J, Rudd MA. 2011. Methods for collaboratively identifying research priorities and emerging issues in science and policy. Methods Ecol Evol. 2(3):238–247.
   Web of Science ®Google Scholar
• Sutherland WJ, Woodroof HJ. 2009. The need for environmental horizon scanning. Trends Ecol Evol. 24(10):523–527.
   PubMed Web of Science ®Google Scholar
• Tanabe S, Beaton D, Chauhan V, Choi I, Danielsen P, Delrue N, Esterhuizen M, Filipovska J, FitzGerald R, Fritsche E, et al. 2022. Report of the 1st and 2nd mystery of reactive oxygen species conferences. ALTEX. 39(2):336–338.
   Google Scholar
• Tanabe S, O'Brien J, Tollefsen KE, Kim Y-J, Chauhan V, Yauk C, Huliganga E, Rudel RA, Kay JE, Helm JS, et al. 2022. Reactive oxygen species in the adverse outcome pathway framework: towards creation of harmonized consensus key events. Front Toxicol. 4:887135.
   Google Scholar
• Tollefsen KE, Alonzo F, Beresford NA, Brede DA, Dufourcq-Sekatcheff E, Gilbin R, Horemans N, Hurem S, Laloi P, Maremonti E, et al. 2022. Adverse outcome pathways (AOPs) for radiation-induced reproductive effects in environmental species: state of science and identification of a consensus AOP network. Int J Rad Biol. 98(12):in press.
   Web of Science ®Google Scholar
• Van den Brink PJ, Boxall ABA, Maltby L, Brooks BW, Rudd MA, Backhaus T, Spurgeon D, Verougstraete V, Ajao C, Ankley GT, et al. 2018. Toward sustainable environmental quality: priority research questions for Europe. Environ Toxicol Chem. 37(9):2281–2295.
   PubMed Web of Science ®Google Scholar
• Yu J, Tu W, Payne A, Rudyk C, Cuadros Sanchez S, Khilji S, Kumarathasan P, Subedi S, Haley B, Wong A, et al. 2022. Adverse outcome pathways and linkages to transcriptomic effects relevant to ionizing radiation injury. Int J Radiat Biol. 1–13. doi: 10.1080/09553002.2022.2110313.
   Google Scholar