Modeling normal bladder injury after radiation therapy

References

• American Cancer Society. 2019. Facts and figures 2019. Atlanta (GA): American Cancer Society.
   Google Scholar
• Beleslin-Cokic BB, Cokic VP, Yu X, Weksler BB, Schechter AN, Noguchi CT. 2004. Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells. Blood. 104(7):2073–2080.
   PubMed Web of Science ®Google Scholar
• Buyyounouski MK, Choyke PL, McKenney JK, Sartor O, Sandler HM, Amin MB, Kattan MW, Lin DW. 2017. Prostate cancer – major changes in the American Joint Committee on Cancer eighth edition cancer staging manual. CA Cancer J Clin. 67(3):245–253.
   PubMed Web of Science ®Google Scholar
• Cantero-Navarro E, Fernandez-Fernandez B, Ramos AM, Rayego-Mateos S, Rodrigues-Diez RR, Sanchez-Nino MD, Sanz AB, Ruiz-Ortega M, Ortiz A. 2021. Renin-angiotensin system and inflammation update. Mol Cell Endocrinol. 529:111254.
   PubMed Web of Science ®Google Scholar
• Cao S, Wu R. 2012. Expression of angiotensin II and aldosterone in radiation-induced lung injury. Cancer Biol Med. 9(4):254–260.
   PubMedGoogle Scholar
• Cardwell CR, Mc Menamin UC, Hicks BM, Hughes C, Cantwell MM, Murray LJ. 2014. Drugs affecting the renin-angiotensin system and survival from cancer: a population based study of breast, colorectal and prostate cancer patient cohorts. BMC Med. 12(1):28.
   PubMedGoogle Scholar
• Chamie K, Williams SB, Hu JC. 2015. Population-based assessment of determining treatments for prostate cancer. JAMA Oncol. 1(1):60–67.
   PubMedGoogle Scholar
• Chen R, Suchard MA, Krumholz HM, Schuemie MJ, Shea S, Duke J, Pratt N, Reich CG, Madigan D, You SC, et al. 2021. Comparative first-line effectiveness and safety of ACE (angiotensin-converting enzyme) inhibitors and angiotensin receptor blockers: a multinational cohort study. Hypertension. 78(3):591–603.
   PubMed Web of Science ®Google Scholar
• Cohen EP, Fish BL, Moulder JE. 2016. Clinically relevant doses of enalapril mitigate multiple organ radiation injury. Radiat Res. 185(3):313–318.
   PubMed Web of Science ®Google Scholar
• Cohen EP, Irving AA, Drobyski WR, Klein JP, Passweg J, Talano JA, Juckett MB, Moulder JE. 2008. Captopril to mitigate chronic renal failure after hematopoietic stem cell transplantation: a randomized controlled trial. Int J Radiat Oncol Biol Phys. 70(5):1546–1551.
   PubMed Web of Science ®Google Scholar
• Collaboration ARBT. 2011. Effects of telmisartan, irbesartan, valsartan, candesartan, and losartan on cancers in 15 trials enrolling 138,769 individuals. J Hypertens. 29(4):623–635.
   PubMed Web of Science ®Google Scholar
• de Moor JS, Mariotto AB, Parry C, Alfano CM, Padgett L, Kent EE, Forsythe L, Scoppa S, Hachey M, Rowland JH. 2013. Cancer survivors in the United States: prevalence across the survivorship trajectory and implications for care. Cancer Epidemiol Biomarkers Prev. 22(4):561–570.
   PubMed Web of Science ®Google Scholar
• Dearnaley D, Syndikus I, Mossop H, Khoo V, Birtle A, Bloomfield D, Graham J, Kirkbride P, Logue J, Malik Z, et al. 2016. Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: 5-year outcomes of the randomised, non-inferiority, phase 3 CHHiP trial. Lancet Oncol. 17(8):1047–1060.
   PubMed Web of Science ®Google Scholar
• Diefenbach MA, Mohamed NE. 2007. Regret of treatment decision and its association with disease-specific quality of life following prostate cancer treatment. Cancer Invest. 25(6):449–457.
   PubMed Web of Science ®Google Scholar
• Donaldson SS, Moskowitz PS, Evans JW, Fajardo LF. 1984. Protection from radiation nephropathy by WR-2721. Radiat Res. 97(2):414–423.
   PubMed Web of Science ®Google Scholar
• Emami B, Lyman J, Brown A, Cola L, Goitein M, Munzenrider JE, Shank B, Solin LJ, Wesson M. 1991. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys. 21(1):109–122.
   PubMed Web of Science ®Google Scholar
• Gallagher KA, Liu ZJ, Xiao M, Chen H, Goldstein LJ, Buerk DG, Nedeau A, Thom SR, Velazquez OC. 2007. Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha. J Clin Invest. 117(5):1249–1259.
   PubMed Web of Science ®Google Scholar
• Geraci JP, Mariano MS, Jackson KL. 1993. Amelioration of radiation nephropathy in rats by dexamethasone treatment after irradiation. Radiat Res. 134(1):86–93.
   PubMed Web of Science ®Google Scholar
• Geraci JP, Sun MC, Mariano MS. 1995. Amelioration of radiation nephropathy in rats by postirradiation treatment with dexamethasone and/or captopril. Radiat Res. 143(1):58–68.
   PubMed Web of Science ®Google Scholar
• Ghosh SN, Wu Q, Mader M, Fish BL, Moulder JE, Jacobs ER, Medhora M, Molthen RC. 2009. Vascular injury after whole thoracic x-ray irradiation in the rat. Int J Radiat Oncol Biol Phys. 74(1):192–199.
   PubMed Web of Science ®Google Scholar
• Goldstein LJ, Gallagher KA, Bauer SM, Bauer RJ, Baireddy V, Liu ZJ, Buerk DG, Thom SR, Velazquez OC. 2006. Endothelial progenitor cell release into circulation is triggered by hyperoxia-induced increases in bone marrow nitric oxide. Stem Cells. 24(10):2309–2318.
   PubMed Web of Science ®Google Scholar
• Grimm J, Marks LB, Jackson A, Kavanagh BD, Xue J, Yorke E. 2021. High dose per fraction, hypofractionated treatment effects in the clinic (HyTEC): an overview. Int J Radiat Oncol Biol Phys. 110(1):1–10.
   PubMed Web of Science ®Google Scholar
• Groves AM, Paris N, Hernady E, Johnston CJ, Aljitawi O, Lee YF, Kerns SL, Marples B. 2023. Prevention of radiation-induced bladder injury: a murine study using captopril. Int J Radiat Oncol Biol Phys. 115(4):972–982.
   PubMed Web of Science ®Google Scholar
• Hernández-Presa M, Bustos C, Ortego M, Tuñon J, Renedo G, Ruiz-Ortega M, Egido J. 1997. Angiotensin-converting enzyme inhibition prevents arterial nuclear factor-kappa B activation, monocyte chemoattractant protein-1 expression, and macrophage infiltration in a rabbit model of early accelerated atherosclerosis. Circulation. 95(6):1532–1541.
   PubMed Web of Science ®Google Scholar
• Hoffman RM, Lo M, Clark JA, Albertsen PC, Barry MJ, Goodman M, Penson DF, Stanford JL, Stroup AM, Hamilton AS. 2017. Treatment decision regret among long-term survivors of localized prostate cancer: results from the prostate cancer outcomes study. J Clin Oncol. 35(20):2306–2314.
   PubMed Web of Science ®Google Scholar
• Jaal J, Dorr W. 2005. Early and long-term effects of radiation on intercellular adhesion molecule 1 (ICAM-1) expression in mouse urinary bladder endothelium. Int J Radiat Biol. 81(5):387–395.
   PubMed Web of Science ®Google Scholar
• Jaal J, Dorr W. 2006a. Radiation induced inflammatory changes in the mouse bladder: the role of cyclooxygenase-2. J Urol. 175(4):1529–1533.
   PubMed Web of Science ®Google Scholar
• Jaal J, Dorr W. 2006b. Radiation induced late damage to the barrier function of small blood vessels in mouse bladder. J Urol. 176(6):2696–2700.
   PubMed Web of Science ®Google Scholar
• Jaal J, Dorr W. 2010. Radiation effects on cellularity, proliferation and EGFR expression in mouse bladder urothelium. Radiat Res. 173(4):479–485.
   PubMed Web of Science ®Google Scholar
• Juncos LI, Carrasco Duenas S, Cornejo JC, Broglia CA, Cejas H. 1993. Long-term enalapril and hydrochlorothiazide in radiation nephritis. Nephron. 64(2):249–255.
   PubMed Web of Science ®Google Scholar
• Kerkmeijer LG, Monninkhof EM, van Oort IM, van der Poel HG, de Meerleer G, van Vulpen M. 2016. PREDICT: model for prediction of survival in localized prostate cancer. World J Urol. 34(6):789–795. eng.
   PubMed Web of Science ®Google Scholar
• Kerns SL, Amidon Morlang A, Lee SM, Peterson DR, Marples B, Zhang H, Bylund K, Rosenzweig D, Hall W, De Ruyck K. 2022. Use of angiotensin converting enzyme inhibitors is associated with reduced risk of late bladder toxicity following radiotherapy for prostate cancer. Radiother Oncol. 168:75–82.
   PubMed Web of Science ®Google Scholar
• Kerns SL, Fachal L, Dorling L, Barnett GC, Baran A, Peterson DR, Hollenberg M, Hao K, Narzo AD, Ahsen ME, et al. 2020. Radiogenomics consortium genome-wide association study meta-analysis of late toxicity after prostate cancer radiotherapy. J Nat Cancer Inst. 112(2):179–190.
   PubMedGoogle Scholar
• Kosaka T, Miyajima A, Takayama E, Kikuchi E, Nakashima J, Ohigashi T, Asano T, Sakamoto M, Okita H, Murai M, et al. 2007. Angiotensin II type 1 receptor antagonist as an angiogenic inhibitor in prostate cancer. Prostate. 67(1):41–49.
   PubMed Web of Science ®Google Scholar
• Kowaliuk J, Sarsarshahi S, Hlawatsch J, Kastsova A, Kowaliuk M, Krischak A, Kuess P, Duong L, Dorr W. 2020. Translational aspects of nuclear factor-kappa B and its modulation by thalidomide on early and late radiation sequelae in urinary bladder dysfunction. Int J Radiat Oncol Biol Phys. 107(2):377–385.
   PubMed Web of Science ®Google Scholar
• Kraft M, Oussoren Y, Stewart FA, Dörr W, Schultz-Hector S, Dorr W. 1996. Radiation-induced changes in transforming growth factor beta and collagen expression in the murine bladder wall and its correlation with bladder function. Radiat Res. 146(6):619–627.
   PubMed Web of Science ®Google Scholar
• Laskin BL, Goebel J, Davies SM, Jodele S. 2011. Small vessels, big trouble in the kidneys and beyond: hematopoietic stem cell transplantation-associated thrombotic microangiopathy. Blood. 118(6):1452–1462.
   PubMed Web of Science ®Google Scholar
• Lee S, Kerns S, Ostrer H, Rosenstein B, Deasy JO, Oh JH. 2018. Machine learning on a genome-wide association study to predict late genitourinary toxicity after prostate radiation therapy. Int J Radiat Oncol Biol Phys. 101(1):128–135.
   PubMed Web of Science ®Google Scholar
• Li EC, Heran BS, Wright JM. 2014. Angiotensin converting enzyme (ACE) inhibitors versus angiotensin receptor blockers for primary hypertension. Cochrane Database Syst Rev. 2014(8):CD009096.
   PubMedGoogle Scholar
• Marks LB, Carroll PR, Dugan TC, Anscher MS. 1995. The response of the urinary bladder, urethra, and ureter to radiation and chemotherapy. Int J Radiat Oncol Biol Phys. 31(5):1257–1280.
   PubMed Web of Science ®Google Scholar
• Martin SE, Begun EM, Samir E, Azaiza MT, Allegro S, Abdelhady M. 2019. Incidence and morbidity of radiation-induced hemorrhagic cystitis in prostate cancer. Urology. 131:190–195.
   PubMed Web of Science ®Google Scholar
• Medhora M, Gao F, Gasperetti T, Narayanan J, Khan AH, Jacobs ER, Fish BL. 2019. Delayed effects of acute radiation exposure (Deare) in juvenile and old rats: mitigation by Lisinopril. Health Phys. 116(4):529–545.
   PubMed Web of Science ®Google Scholar
• Medhora M, Gao F, Jacobs ER, Moulder JE. 2012. Radiation damage to the lung: mitigation by angiotensin-converting enzyme (ACE) inhibitors. Respirology. 17(1):66–71.
   PubMed Web of Science ®Google Scholar
• Mendenhall WM, Henderson RH, Costa JA, Hoppe BS, Dagan R, Bryant CM, Nichols RC, Williams CR, Harris SE, Mendenhall NP. 2015. Hemorrhagic radiation cystitis. Am J Clin Oncol. 38(3):331–336.
   PubMed Web of Science ®Google Scholar
• Michalski JM, Moughan J, Purdy J, Bosch W, Bruner DW, Bahary J-P, Lau H, Duclos M, Parliament M, Morton G, et al. 2018. Effect of standard vs dose-escalated radiation therapy for patients with intermediate-risk prostate cancer: the NRG oncology RTOG 0126 randomized clinical trial. JAMA Oncol. 4(6):e180039.
   PubMed Web of Science ®Google Scholar
• Molony RD, Kerns SL, Marples B, Oshodi E, Chen Y, Lee Y-F. 2023. Postradiotherapy urinary extracellular vesicle concentrations predict late bladder toxicity in prostate cancer patients. JU Open Plus 1(2):e00007.
   Google Scholar
• Morales DR, Conover MM, You SC, Pratt N, Kostka K, Duarte-Salles T, Fernandez-Bertolin S, Aragon M, DuVall SL, Lynch K, et al. 2021. Renin-angiotensin system blockers and susceptibility to COVID-19: an international, open science, cohort analysis. Lancet Digit Health. 3(2):e98–e114.
   PubMedGoogle Scholar
• Moulder JE, Fish BL, Cohen EP. 1993. Treatment of radiation nephropathy with ACE inhibitors. Int J Radiat Oncol Biol Phys. 27(1):93–99.
   PubMed Web of Science ®Google Scholar
• Moulder JE, Fish BL, Cohen EP. 1997. Noncontinuous use of angiotensin converting enzyme inhibitors in the treatment of experimental bone marrow transplant nephropathy. Bone Marrow Transplant. 19(7):729–735.
   PubMed Web of Science ®Google Scholar
• Moulder JE, Fish BL, Cohen EP. 1998. Radiation nephropathy is treatable with an angiotensin converting enzyme inhibitor or an angiotensin II type-1 (AT1) receptor antagonist. Radiother Oncol. 46(3):307–315.
   PubMed Web of Science ®Google Scholar
• Moulder JE, Robbins ME, Cohen EP, Hopewell JW, Ward WF. 1998. Pharmacologic modification of radiation-induced late normal tissue injury. Cancer Treat Res. 93:129–151.
   PubMedGoogle Scholar
• Nordal RA, Nagy A, Pintilie M, Wong CS. 2004. Hypoxia and hypoxia-inducible factor-1 target genes in central nervous system radiation injury: a role for vascular endothelial growth factor. Clin Cancer Res. 10(10):3342–3353.
   PubMed Web of Science ®Google Scholar
• Oscarsson N, Muller B, Rosen A, Lodding P, Molne J, Giglio D, Hjelle KM, Vaagbo G, Hyldegaard O, Vangedal M, et al. 2019. Radiation-induced cystitis treated with hyperbaric oxygen therapy (RICH-ART): a randomised, controlled, phase 2-3 trial. Lancet Oncol. 20(11):1602–1614.
   PubMed Web of Science ®Google Scholar
• Pascoe C, Duncan C, Lamb BW, Davis NF, Lynch TH, Murphy DG, Lawrentschuk N. 2019. Current management of radiation cystitis: a review and practical guide to clinical management. BJU Int. 123(4):585–594.
   PubMed Web of Science ®Google Scholar
• Passos-Silva DG, Brandan E, Santos RA. 2015. Angiotensins as therapeutic targets beyond heart disease. Trends Pharmacol Sci. 36(5):310–320.
   PubMed Web of Science ®Google Scholar
• Pinter M, Kwanten WJ, Jain RK. 2018. Renin-angiotensin system inhibitors to mitigate cancer treatment-related adverse events. Clin Cancer Res. 24(16):3803–3812.
   PubMed Web of Science ®Google Scholar
• Pratt MC, Lewis-Barned NJ, Walker RJ, Bailey RR, Shand BI, Livesey J. 1992. Effect of angiotensin converting enzyme inhibitors on erythropoietin concentrations in healthy volunteers. Br J Clin Pharmacol. 34(4):363–365.
   PubMed Web of Science ®Google Scholar
• Rajaganapathy BR, Janicki JJ, Levanovich P, Tyagi P, Hafron J, Chancellor MB, Krueger S, Marples B. 2015. Intravesical liposomal tacrolimus protects against radiation cystitis induced by 3-beam targeted bladder radiation. J Urol. 194(2):578–584.
   PubMed Web of Science ®Google Scholar
• Resnick MJ, Guzzo TJ, Cowan JE, Knight SJ, Carroll PR, Penson DF. 2013. Factors associated with satisfaction with prostate cancer care: results from cancer of the prostate strategic urologic research endeavor (CaPSURE). BJU Int. 111(2):213–220.
   PubMed Web of Science ®Google Scholar
• Robbins ME, Diz DI. 2006. Pathogenic role of the renin-angiotensin system in modulating radiation-induced late effects. Int J Radiat Oncol Biol Phys. 64(1):6–12.
   PubMed Web of Science ®Google Scholar
• Schieffer B, Luchtefeld M, Braun S, Hilfiker A, Hilfiker-Kleiner D, Drexler H. 2000. Role of NAD(P)H oxidase in angiotensin II-induced JAK/STAT signaling and cytokine induction. Circ Res. 87(12):1195–1201.
   PubMed Web of Science ®Google Scholar
• Sharma GP, Fish BL, Frei AC, Narayanan J, Gasperetti T, Scholler D, Pierce L, Szalewski N, Blue N, Medhora M, et al. 2022. Pharmacologic ACE-inhibition mitigates radiation-induced pneumonitis by suppressing ACE-expressing lung myeloid cells. Int J Radiat Oncol Biol Phys. 113(1):177–191.
   PubMed Web of Science ®Google Scholar
• Siegel RL, Miller KD, Fuchs HE, Jemal A. 2021. Cancer statistics, 2021. CA Cancer J Clin. 71(1):7–33.
   PubMed Web of Science ®Google Scholar
• Smit SG, Heyns CF. 2010. Management of radiation cystitis. Nat Rev Urol. 7(4):206–214.
   PubMed Web of Science ®Google Scholar
• Stewart FA. 1986. Mechanism of bladder damage and repair after treatment with radiation and cytostatic drugs. Br J Cancer Suppl. 7:280–291.
   PubMedGoogle Scholar
• Stewart FA, Lundbeck F, Oussoren Y, Luts A. 1991. Acute and late radiation damage in mouse bladder: a comparison of urination frequency and cystometry. Int J Radiat Oncol Biol Phys. 21(5):1211–1219.
   PubMed Web of Science ®Google Scholar
• Stewart FA, Oussoren Y, Luts A. 1990. Long-term recovery and reirradiation tolerance of mouse bladder. Int J Radiat Oncol Biol Phys. 18(6):1399–1406.
   PubMed Web of Science ®Google Scholar
• Stewart FA, Randhawa VS, Michael BD. 1984. Multifraction irradiation of mouse bladders. Radiother Oncol. 2(2):131–140.
   PubMed Web of Science ®Google Scholar
• Tanaka T, Minami A, Uchida J, Nakatani T. 2019. Potential of hyperbaric oxygen in urological diseases. Int J Urol. 26(9):860–867.
   PubMed Web of Science ®Google Scholar
• Te Poele JA, van Kleef EM, van der Wal AF, Dewit LG, Stewart FA. 2001. Radiation-induced glomerular thrombus formation and nephropathy are not prevented by the ADP receptor antagonist clopidogrel. Int J Radiat Oncol Biol Phys. 50(5):1332–1338.
   PubMed Web of Science ®Google Scholar
• Thor M, Apte A, Deasy JO, Karlsdottir A, Moiseenko V, Liu M, Muren LP. 2013. Dose/volume-response relations for rectal morbidity using planned and simulated motion-inclusive dose distributions. Radiother Oncol. 109(3):388–393.
   PubMed Web of Science ®Google Scholar
• Verheij M, Stewart FA, Oussoren Y, Weening JJ, Dewit L. 1995. Amelioration of radiation nephropathy by acetylsalicylic acid. Int J Radiat Biol. 67(5):587–596.
   PubMed Web of Science ®Google Scholar
• Viswanathan AN, Yorke ED, Marks LB, Eifel PJ, Shipley WU. 2010. Radiation dose-volume effects of the urinary bladder. Int J Radiat Oncol Biol Phys. 76(3 Suppl):S116–S122.
   PubMed Web of Science ®Google Scholar
• Voors AA, van Geel PP, Buikema H, Oosterga M, van Veldhuisen DJ, van Gilst WH. 2005. High angiotensin II responsiveness is associated with decreased endothelium-dependent relaxation in human arteries. J Renin Angiotensin Aldosterone Syst. 6(3):145–150.
   PubMed Web of Science ®Google Scholar
• Vujaskovic Z, Marks LB, Anscher MS. 2000. The physical parameters and molecular events associated with radiation-induced lung toxicity. Semin Radiat Oncol. 10(4):296–307.
   PubMed Web of Science ®Google Scholar
• Wang K, Mavroidis P, Royce TJ, Falchook AD, Collins SP, Sapareto S, Sheets NC, Fuller DB, El Naqa I, Yorke E, et al. 2021. Prostate stereotactic body radiation therapy: an overview of toxicity and dose response. Int J Radiat Oncol Biol Phys. 110(1):237–248.
   PubMed Web of Science ®Google Scholar
• Zhao SG, Chang SL, Spratt DE, Erho N, Yu M, Ashab HA, Alshalalfa M, Speers C, Tomlins SA, Davicioni E, et al. 2016. Development and validation of a 24-gene predictor of response to postoperative radiotherapy in prostate cancer: a matched, retrospective analysis. Lancet Oncol. 17(11):1612–1620.
   PubMed Web of Science ®Google Scholar
• Zwaans BM, Krueger S, Bartolone SN, Chancellor MB, Marples B, Lamb LE. 2016. Modeling of chronic radiation-induced cystitis in mice. Adv Radiat Oncol. 1(4):333–343.
   PubMedGoogle Scholar