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Original Article

Reduction of Intracellular Glutathione Content and Radiosensitivity

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Pages 155-165 | Received 15 Aug 1985, Accepted 16 Dec 1985, Published online: 03 Jul 2009

References

  • Alexander P., Charlesby A. Physico-chemical methods of protection against ionizing radiations. Radiobiology Symposium. Butterworth, London 1954; 49–58
  • Alper T., Howard-Flanders P. Role of oxygen in modifying the radiosensitivity of E. coli B. Nature 1956; 178: 978–979
  • Astor M.B. Radiobiological studies with a series of human cell lines of varying glutathione content. British Journal of Radiology 1984; 57: 717–722
  • Astor M.B., Hall E.J., Biaglow J.E., Hartog B. Effects of D,L-buthionine-S,R-sulfoximine on cellular thiol levels and the oxygen effect in Chinese hamster V79 cells. International Journal of Radiation, Oncology, Biology, Physics 1984; 10: 1239–1242
  • Biaglow J.E., Clark E.P., Epp E.R., Morse-Guadio M., Varnes M.A., Mitchell J.B. Nonprotein thiols and the radiation response of A549 human lung carcinoma cells. International Journal of Radiation Biology 1983 a; 44: 486–495
  • Biaglow J.E., Varnes M.E., Clark E.P., Epp E.R. The role of thiols in cellular response to radiation and drugs. Radiation Research 1983b; 95: 437–455
  • Bradley M.O., Kohn K.W. X-ray induced double strand break production and repair in mammalian cells as measured by neutral elution. Nucleic Acids Research 1979; 7: 793–804
  • Bump E.A., Yu N.Y., Brown J.M. Radiosensitization of hypoxic tumor cells by depletion of intracellular glutathione. Science 1982; 217: 544–545
  • Chapman J.D., Reuvers A.P., Borsa J., Greenstock C.L. Chemical radioprotection and radiosensitization of mammalian cells growing in vitro. Radiation Research 1973; 56: 219–306
  • Chapman J.D., Sturrock J., Borig J.W., Crookall J.O. Factors affecting the oxygen tension around cells growing in plastic petri dishes. International Journal of Radiation Biology 1970; 17: 305–328
  • Clark E.P., Epp E.R., Biaglow J.E., Morse-Gaudio M., Zachgo E. Glutathione depletion, radiosensitization and misonidazole potentiation in hypoxic Chinese hamster ovary cells by buthionine sulfoximine. Radiation Research 1984; 98: 370–380
  • Deschavanne P.J., Midander J., Edgren M., Larsson A., Malaise E.P., Révész L. Oxygen enhancement of radiation induced lethality is greatly reduced in glutathione deficient human fibroblasts. Biomedicine 1981; 35: 35–37
  • Deschavanne P.J., Chavaudra N., Debieu D., Malaise E.P. Reduced PLD repair ability in glutathione synthetase deficient human fibroblasts after u.v. irradiation. International Journal of Radiation Biology 1984; 46: 375–382
  • Edgren M., Larsson A., Nilsson K., Révész L., Scott O.C.A. Lack of oxygen effect in glutathione-deficient human cells in culture. International Journal of Radiation Biology 1980; 37: 299–306
  • Edgren M., Révész L., Larsson A. Induction and repair of single-strand DNA breaks after u.v. irradiation of human fibroblasts deficient in glutathione. International Journal of Radiation Biology 1981; 40: 355–363
  • Evans J.W., Taylor Y.C., Brown J.M. The role of glutathione and DNA strand break repair in determining the shoulder of the radiation survival curve. British Journal of Cancer 1984; 49(VI)49–53
  • Griffith O.W. Depletion of glutathione by inhibition of biosynthesis. Methods of Enzymology, W.B. Jacoby. Academic Press, New York 1981; 77: 59–63
  • Griffith O.W., Meister A. Potent and specific inhibition of gluthathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). Journal of Biological Chemistry 1979; 254: 7558–7560
  • Jocelyn P.C. Biochemistry of the SH Group. Academic Press, London 1972
  • Koch C.J., Painter R.B. The effect of extreme hypoxia on the repair of DNA single-strand breaks in mammalian cells. Radiation Research 1975; 64: 256–269
  • Lowry O.H., Rosenbrough N.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Martin P.M., Blakeby E.A., Tobias C.A. Post-irradiation effects of diamide on cell survival. Radiation Research 1981; 87: 463–463
  • Meister A. Selective modification of glutathione metabolism. Science 1983; 220: 472–477
  • Mitchell J.B., Russo A., Biaglow J.E., McPherson S. Cellular glutathione depletion by diethyl maleate or buthionine sulfoximine: No effect of glutathione depletion on the oxygen enhancement ratio. Radiation Research 1983; 96: 422–428
  • Morse M.L., Dahl R.H. Cellular glutathione is a key to the oxygen effect in radiation damage. Nature 1978; 271: 660–662
  • Plummer J.L., Smith B.R., Sies H., Bend J.H. Chemical depletion of glutathione in vivo. Methods of Enzymology, W.B. Jacoby. Academic Press, New York 1981; 77: 50–58
  • Reeve J., Kuhlenkamp J., Kaplowitz N. Estimation of glutathione in rat liver by reversed phase high performance liquid chromatography: separation from cysteine and 7-glutamylcysteine. Journal of Chromatography 1980; 194: 424–428
  • Révész L., Edgren M. Glutathione-dependent yield and repair of single-strand DNA breaks in irradiated cells. British Journal of Cancer 1984; 49(VI)55–60
  • Russo A., Mitchell J.B., Finkelstein E., DeGraff W.G., Spiro I.J., Gamson J. The effects of cellular glutathione elevation on the oxygen enhancement ratio. Radiation Research 1985; 103: 232–239
  • Schans G.P., van der, Centen H.B., Lohman P.H.M. DNA lesions induced by ionizing radiation. Progress in Mutation Research 1982; 4: 285–299
  • Schans G.P., van der, Vos O., Roos-Verheij W.S.D., Lohman P.H.M. The influence of oxygen on the induction of radiation damage in DNA in mammalian cells after sensitization by intracellular glutathione depletion. International Journal of Radiation Biology 1986, in the press
  • Shiloh Y., Schans G.P., van der, Lohman P.H.M., Becker Y. Induction and repair of DNA damage in normal and ataxiatelangiectasic skin fibroblasts treated with neocarzinostatin. Carcinogenesis 1983; 4: 917–921
  • Shrieve D.C., Denekamp J., Minchinton A.I. Effects of glutathione depletion by buthionine sulfoximine on radiosensitization by oxygen and misonidazole in vitro. Radiation Research 1985; 102: 282–292
  • Varnes M.E., Biaglow J.E., Roizin-Towle L., Hall E.J. Depletion of intracellular GSH and NPSH by buthionine sulfoximine and diethyl maleate: factors that influence enhancement of aerobic response. International Journal of Radiation, Oncology, Biology, Physics 1984; 10: 1229–1233
  • Vos O., Grant G.A., Budke L. Radiosensitization of mammalian cells by diamide. International Journal of Radiation Biology 1976; 29: 513–522
  • Vos O., van der Schans G.P., Roos-Verheij W.S.D. Effects of BSO and DEM on thiol-level and radiosensitivity in HeLa cells. International Journal of Radiation, Oncology, Biology, Physics 1984; 10: 1249–1253

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