The Design and Interpretation of ‘Top-up’ Experiments to Investigate the Effects of Low Radiation Doses

References

• Alper T. Cellular Radiobiology. Cambridge University Press, Cambridge 1979, Chapter 12
   Google Scholar
• Ang K.K., van der Kogel A., van der Schueren E. Lack of evidence for increased tolerance of rat spinal cord with decreasing fraction doses below 2 Gy. International Journal of Radiation Oncology, Biology, Physics 1985; 11: 105–110
   PubMed Web of Science ®Google Scholar
• Denekamp J. Changes in the rate of repopulation during multifraction irradiation of mouse skin. British Journal of Radiology 1973; 46: 381–387
   PubMed Web of Science ®Google Scholar
• Denekamp J., Field S.B. Repair and repopulation in mouse skin during fractionated neutron and X-irradiation. European Journal of Cancer 1974; 10: 241–247
   Google Scholar
• Denekamp J., Harris S.R. The response of mouse skin to multiple small doses of radiation. Proceedings of the 6th L. H. Gray Conference, London, T. Alper. Wiley, Chichester 1975; 342–350
   Google Scholar
• Denekamp J., Joiner M.C., Maughan R.L. Neutron RBE's for mouse skin at low doses per fraction. Radiation Research 1984; 98: 317–331
   PubMed Web of Science ®Google Scholar
• Douglas B.G., Fowler J.F. The effect of multiple small doses of X-rays on skin reactions in the mouse foot and a basic interpretation. Radiation Research 1976; 66: 401–426
   PubMed Web of Science ®Google Scholar
• Field S.B., Hornsey S., Kutsutani Y. Effects of fractionated irradiation on mouse lung and a phenomenon of slow repair. British Journal of Radiology 1976; 49: 700–707
   PubMed Web of Science ®Google Scholar
• Folkard M. Determination of d(3)-Be and d(4)-Be neutron spectra using a recoil proton spectrometer. Physics in Medicine and Biology 1986; 31: 135–144
   Web of Science ®Google Scholar
• Fowler J.F. Fractionated radiation therapy after Strandqvist. Acta Radiologica Oncology 1984 a; 23: 209–216
   PubMed Web of Science ®Google Scholar
• Fowler J.F. The 1st James Kirk memorial lecture: What next in fractionated radiotherapy?. British Journal of Cancer 1984 b; 49(Suppl. VI)285–300
   Google Scholar
• Fowler J.F., Denekamp J., Delapeyre C., Harris S.R., Sheldon P.W. Skin reactions in mice after multifraction X-irradiation. International Journal of Radiation Biology 1974; 25: 213–223
   Web of Science ®Google Scholar
• Fowler J.F., Stern B.E. II, Dose-time relationships in radiotherapy and the validity of cell survival curve models. British Journal of Radiology 1963; 36: 163–173
   PubMed Web of Science ®Google Scholar
• Gray Laboratory Annual Report. Cancer Research Campaign. 1985; 31–48
   Google Scholar
• Hill S.A., Smith K.A., Denekamp J. Stromal radiosensitivity as assessed from the tumour bed assay. Abstracts of the 12th L. H. Gray Conference, ManchesterU.K., 1985
   Google Scholar
• Jirtle R.L., Michalopoulas G., McLain J.R., Crowle J. The survival of parenchymal hepatocytes exposed to ionizing radiation. Cancer Research 1981; 41: 3512–3518
   PubMed Web of Science ®Google Scholar
• Joiner M.C. The response of the mouse kidney to low doses per fraction of X-rays. Abstracts of 34th Annual Meeting of Radiation Research Society, Las Vegas, 1986, Dn-15
   Google Scholar
• Joiner M.C., Bremner J.C., Denekamp J., Maughan R.L. The interaction between X-rays and 3 MeV neutrons in the skin of the mouse foot. International Journal of Radiation Biology 1984; 46: 625–638
   Web of Science ®Google Scholar
• Joiner M.C., Denekamp J. Evidence for a constant repair capacity over 20 fractions of X-rays. International Journal of Radiation Biology 1986 a; 49: 143–150
   Google Scholar
• Joiner M.C., Denekamp J. The effect of small radiation doses on mouse skin. British Journal of Cancer 1986 b; 53(Suppl. VII)63–66
   Google Scholar
• Joiner M.C., Denekamp J., Maughan R.L. The use of top-up experiments to investigate the effect of very small doses per fraction in mouse skin. International Journal of Radiation Biology 1986; 49: 565–580
   Web of Science ®Google Scholar
• Joiner M.C., Maughan R.L., Fowler J.F., Denekamp J. The RBE for mouse skin irradiated with 3 MeV neutrons: Single and fractionated doses. Radiation Research 1983; 95: 130–141
   PubMed Web of Science ®Google Scholar
• Maughan R.L., Hall A.S., Roper M.J., Michael B.D., Fowler J.F. The use of a 4 MV Van de Graaff accelerator as a fast neutron source for radiobiology at the Gray Laboratory. Radiation Protection: 4th Symposium on Neutron Dosimetry, Neuherberg, G. Burger, H.G. Ebert. Commission of the European Communities, Luxembourg 1981; 2: 5–15, EUR 7448
   Google Scholar
• McCulloch E.A., Till J.E. The sensitivity of cells from normal mouse bone marrow to gamma radiation in vitro and in vivo. Radiation Research 1962; 16: 822–832
   PubMed Web of Science ®Google Scholar
• Parkins C.S., Fowler J.F. The linear quadratic fit for lung function after irradiation with X-rays at smaller doses per fraction than 2 Gy. British Journal of Cancer 1986; 53(Suppl. VII)320–323
   Google Scholar
• Cell Clones: Manual of Mammalian Cell Techniques, C.S. Potten, J.H. Hendry. Churchill Livingstone, Edinburgh 1985
   Google Scholar
• Stewart F.A., Soranson J.A., Alpen E.L., Williams M.V., Denekamp J. Radiation-induced renal damage: The effects of hyperfractionation. Radiation Research 1984; 98: 407–420
   PubMed Web of Science ®Google Scholar
• Terry N.H.A., Denekamp J. RBE values and repair characteristics for colorectal injury after caesium 137 gamma ray and neutron irradiation. II. Fractionation up to ten doses. British Journal of Radiology 1984; 57: 617–629
   PubMed Web of Science ®Google Scholar
• Thames H.D. Effect-independent measures of tissue responses to fractionated irradiation. International Journal of Radiation Biology 1984; 45: 1–10
   Web of Science ®Google Scholar
• Thames H.D., Rozell M.E., Tucker S.L., Ang K.K., Fisher D.R., Travis E.L. Direct analysis of quantal radiation response data. International Journal of Radiation Biology 1986; 49: 999–1009
   Web of Science ®Google Scholar
• Travis E.L., Parkins C.S., Down J.D., Fowler J.F., Maughan R.L. Is there a loss of repair capacity in mouse lungs with increasing number of dose fractions?. International Journal of Radiation Oncology, Biology, Physics 1983; 9: 691–699
   PubMedGoogle Scholar
• Tucker S.L. Tests for the fit of the linear quadratic model to radiation isoeffect data. International Journal of Radiation Oncology, Biology, Physics 1984; 10: 1933–1939
   PubMed Web of Science ®Google Scholar
• Withers H.R. The dose survival relationship for irradiation of epithelial cells of mouse skin. British Journal of Radiology 1967; 40: 187–194
   PubMed Web of Science ®Google Scholar
• Withers H.R. Responses of some normal tissues to low doses of X-radiation. Proceedings of the 6th L. H. Gray Conference, London. T. Alper. Wiley, Chichester 1975; 369–375
   Google Scholar
• Withers H.R., Elkind M.M. Microcolony survival assay for cells of mouse intestinal mucosa exposed to radiation. International Journal of Radiation Biology 1970; 17: 261–267
   Web of Science ®Google Scholar
• Withers H.R., Thames H.D., Peters L.J. A new isoeffect curve for change in dose per fraction. Radiotherapy and Oncology 1983; 1: 187–191
   PubMedGoogle Scholar