9
Views
4
CrossRef citations to date
0
Altmetric
Original Article

Effect of Cellular Glutathione Content on the Induction of DNA Double Strand Breaks by 25 MeV Electrons

, &
Pages 185-190 | Received 16 Dec 1986, Accepted 22 Mar 1987, Published online: 03 Jul 2009

References

  • Alexander P., Charlesby A. (1955) Physico-chemical methods of protection against ionizing radiation. Radiobiology Symposium, Liege, 1954, Z.M. Bacq, P. Alexander. Butterworth, London, 49–57
  • Alper T. The modification of damage caused by primary ionization of biological targets. Radiation Research 1956; 5: 573–586
  • Alper T., Howard-Flanders P. The role of oxygen in modifying the radiosensitivity of E. coli B. Nature 1956; 178: 978–979
  • Barendsen G.W., Gaiser J.F. Cell transformation in vitro by neutrons of different energies: Implications for mechanisms. Radiation Protection Dosimetry 1985; 13: 145–148
  • Biaglow J.E., Varnes M.E., Clark E.P., Epp E.R. Symposium: Thiols. The role of thiols in cellular response to radiation and drugs. Radiation Research 1983; 95: 437–455
  • Boveri T. Zur Frage der Entstehung maligner Tumoren. J. Fischer, Jena 1914
  • Bryant P.E. Enzymatic restriction of mammalian cell DNA using Pvu II and Bam H1: Evidence for the double-strand break origin of chromosomal aberrations. International Journal of Radiation Biology 1984; 46: 57–65
  • Bump E.A., Yu N.Y., Brown J.M. Radiosensitization of hypoxic tumour cells by depletion of intracellular glutathione. Science 1982; 217: 544–545
  • Cairns J. The origin of human cancer. Nature 1981; 289: 353–357
  • Carrano A.V. Chromosome aberrations and radiation-induced cell death. Mutation Research 1973; 17: 341–366
  • Clark E.P., Epp E.R., Morse-Goudio M. The role of glutathione in the aerobic radioresponse. I. Sensitization and recovery in the absence of intracellular glutathione. Radiation Research 1986; 108: 238–250
  • Debieu D., Deschavanne P.J., Midander J., Larsson A., Malaise E.P. Survival curves of glutathione synthetase deficient human fibroblasts: correlation between radiosensitivity in hypoxia and glutathione synthetase activity. International Journal of Radiation Biology 1985; 48: 525–543
  • Dewey W.C., Furman S.C., Miller H.H. Comparison of lethality and chromosomal damage induced by X-rays in synchronised Chinese hamster cells in vitro. Radiation Research 1970; 43: 561–581
  • Edgren M., Revesz L. Glutathione requirement for the rejoining of radiation-induced DNA breaks in misonidazole-treated cells. International Journal of Radiation Biology 1985; 48: 207–212
  • Edgren M., Revesz L., Larsson A. Induction and repair of single-strand DNA breaks after X-irradiation of human fibroblasts deficient in glutathione. International Journal of Radiation Biology 1981; 40: 355–363
  • Frankenberg D., Frankenberg-Schwager M., Blöcher D., Harbich R. Evidence for DNA double-strand breaks as the critical lesions in yeast cells irradiated with sparsely or densely ionizing radiation under oxic or anoxic conditions. Radiation Research 1981; 88: 524–532
  • Frankenberg D., Goodhead D.T., Frankenberg-Schwager M., Harbich R., Bance D.A., Wilkinson R.E. Effectiveness of 1·5 keV aluminium K and 0·3 KeV carbon K characteristic X-rays at inducing DNA double-strand breaks in yeast cells. International Journal of Radiation Biology 1986 a; 50: 727–741
  • Frankenberg D., Kistler M., Eckardt F. Influence of endogenous glutathione content on the induction and repair of DNA double-strand breaks. International Journal of Radiation Biology 1986 b; 49: 698–698
  • Fuchs J.A., Warnes H.R. Isolation of an Escherichia coli mutant deficient in glutathione synthesis. Journal of Bacteriology 1975; 124: 140–148
  • Graevsky E.Y., Konstantinova M.M., Nekrasova I.V., Solokova O.M., Tarasenko A.G. Increase in the content of endogenous sulphydryl compounds as the mechanism of radio-protective action. Nature 1966; 212: 475–477
  • Griffith O.W., Meister A. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (s-n-butyl homocysteine sulfoximine). Journal of Biological Chemistry 1979; 254: 7558–7560
  • Grote S.J. Radiation-induced lethality and genetic damage in mammalian cells. University of London. 1971, Thesis
  • Held K.D., Harrop H.A., Michael B.D. Reaction kinetics of sulphydryl-containing compounds and oxygen with irradiated transforming DNA. Radiation Research 1982; 91: 304–304, (Abstract)
  • Ho K.Y. Induction of DNA double-strand breaks by X-rays in a radio-sensitive strain of the yeast Saccharomyces cerevisiae. Mutation Research 1975; 30: 327–334
  • Howard-Flanders P., Levin J., Theriot L. Reaction of DNA radicals with sulphydryl compounds in X-irradiated bacteriophage systems. Radiation Research 1963; 18: 593–606
  • Howard-Flanders P., Moore D. The time interval after pulsed irradiation within which injury to the bacteria can be modified by dissolved oxygen. Radiation Research 1958; 9: 422–437
  • Johansen I., Howard-Flanders P. Macromolecular repair and free radical scavenging in the protection of bacteria against X-rays. Radiation Research 1965; 24: 184–200
  • Joshi G.P., Nelson W., Revell S.H., Shaw C.A. X-ray-induced chromosome damage in live mammalian cells and improved measurement of its effect on their colony-forming ability. International Journal of Radiation Biology 1982; 41: 161–181
  • Kistler M. Untersuchungen zur Kontrolle von Glutathion in der Hefe Saccharomyces cerevisiae: Isolierung und Charakterisierung von Glutathion-Defektmutanten. University of Munich. 1986, Thesis
  • Kistler M., Summer K.-H., Eckardt F. Isolation of glutathione-deficient mutants of the yeast Saccharomyces cerevisiae. Mutation Research 1986; 173: 117–120
  • Klein G. The role of gene damage and genetic transposition in carcinogenesis. Nature 1981; 294: 313–318
  • Koch C.F. Competition between radiation protectors and radiation sensitizers in mammalian cells. Radioprotectors and Anticarcinogens, O.F. Nygaard, H.G. Simic. Academic Press, New York 1983; 275–296
  • Luchnik A.N., Glaser V.M., Shestakov S.V. Repair of DNA double-strand breaks requires two homogenous DNA duplexes. Molecular Biology Reports 1977; 3: 437–442
  • Malaise E.P. Reduced oxygen enhancement of radiosensitivity of glutathione-deficient fibroblasts as demonstrated by their clonogenic survival. Radiation Research 1983; 95: 486–494
  • Meister A. Glutathione metabolism and transport. Radioprotectors and Anticarcinogens, O.F. Nygaard, M. Simic. Academic Press, New York 1983; 121–126
  • Midander J. Oxygen enhancement ratios for glutathione-deficient human fibroblasts determined from the frequency of radiation induced micro nuclei. International Journal of Radiation Biology 1982; 42: 195–198
  • Mitchell F.B., Russo A., Biaglow J.E., McPherson S. Cellular glutathione depletion by diethyl maleate or buthione sulfoximine: no effect of glutathione depletion on the oxygen enhancement ratio. Radiation Research 1983; 96: 422–428
  • Morse H.L., Dale R.H. Cellular glutathione is a key to the oxygen effect in radiation damage. Nature 1978; 271: 660–662
  • Natarajan A.T., Obe G. Molecular mechanisms involved in the production of chromosomal aberrations. I. Utilization of neurospora endonuclease for the study of aberration production in G2 stage of the cell cycle. Mutation Research 1978; 52: 137–149
  • Natarajan A.T., Obe G. Molecular mechanisms involved in the production of chromosomal aberrations. III. Restriction endonuclease. Chromosoma 1984; 90: 120–127
  • Natarajan A.T., Obe G., Van Zeeland A.A., Palitti F., Meijers M., Verdegaal-Immerzeel E.A.M. Molecular mechanisms involved in the production of chromosomal aberrations. II Utilization of Neurospora endonuclease for the study of aberration production by X-rays in G1 and G2 stages of the cell cycle. Mutation Research 1980; 69: 293–305
  • Resnick M.A., Martin P. Repair of double-strand breaks in the nuclear DNA of Saccharomyces cerevisiae and its genetic control. Molecular and General Genetics 1976; 143: 119–129
  • Revesz L., Bergstrand M., Modig H. Intrinsic non-protein sulphydryl levels and cellular radiosensitivity. Nature 1963; 198: 1275–1277
  • Van de Schans G.P., Vos O., Roos-Verheiz W.S.D., Lohman P.H.M. The influence of oxygen on the induction of radiation damage in DNA in mammalian cells after sensitization by intracellular glutathione depletion. International Journal of Radiation Biology 1986; 50: 453–465
  • Varnes M.E., Biaglow J.E., Koch C.J., Hall E.J. Depletion of non-protein thiols of hypoxic cells by misonidazole and metronidazole. Radiation Sensitizers, L. Brady. Masson, New York 1980; 121–126
  • Wendel A. Glutathione perioxidase. Methods in Enzymology 1981; 77: 325–333

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.