50
Views
28
CrossRef citations to date
0
Altmetric
Original Article

Reducing the Radiation Dose from Inhaled Americium-241 Using Continuously Administered DTPA Therapy

&
Pages 261-271 | Received 29 May 1987, Accepted 19 Sep 1987, Published online: 03 Jul 2009

References

  • Bhattacharyya M.H., Peterson D.P. DTPA-induced excretion of plutonium into dog bile. Argonne National Laboratory Division of Biological and Medical Research Annual Report 1978, M.W. Rosenthal, 1978; 35–36, (Document No. ANL-79-90)
  • Bhattacharyya M.H., Peterson D.P. Action of DTPA on hepatic plutonium. III. Evidence for a direct chelation mechanism for DTPA-induced excretion of monomeric plutonium in rat bile. Radiation Research 1979; 80: 108–115
  • Cohen N., Losasso T., Wrenn M.E. Metabolism of americium-241 in man: an unusual case of internal contamination of a child and his father. Science 1979; 206: 64–66
  • Durbin P. Metabolism and biological effects of the transplutonium elements. Uranium, Plutonium, Transplutonium Elements, Volume 36 of Handbook of Experimental Pharmacology. Springer-Verlag, New York 1973; 739–896
  • Durbin P., Schmidt C.T. Part V: Implications for metabolic modeling. Health Physics 1985; 49: 623–661
  • Fry F.A. Long-term retention of americium-241 following accidental inhalation. Health Physics 1976; 31: 13–20
  • Gemenetzis E., Volf V. DTPA treatment schedules for decorporation of 239Pu from simulated wounds. Health Physics 1977; 32: 489–492
  • Gillett N.A., Hahn F.F., Mewhinney J.A., Muggenburg B.A. Osteosarcoma following single inhalation exposure to americium-241 in beagle dogs. Radiation Research 1985; 104: 83–93
  • Guilmette R.A., Bay A.S. Radioassay of americium or curium in biological material by isooctyl acid phosphate solvent extraction and α liquid scintillation counting. Analytical Chemistry 1981; 53: 2351–2354
  • Guilmette R.A., Muggenburg B.A. Reduction of Cm translocation from lung by constant infusion of DTPA after inhalation of Cm2O3 by rats. Health Physics 1985; 48: 487–493
  • Guilmette R.A., Moretti E.S., Lindenbaum A. Toward an optimal DTPA therapy for decorporation of actinides: time-dose relationships for plutonium in the dog. I. Radiation Research 1979; 78: 415–428
  • Guilmette R.A., Diel J.H., Muggenburg B.A., Mewhinney J.A., Boecker B.B., McClellan R.O. Biokinetics of inhaled 239PuO2 in the beagle dog: effect of aerosol particle size. International Journal of Radiation Biology 1984; 45: 563–581
  • Heid K.R., Breitenstein B.D., Palmer H.E., McMurray B.J., Wald N. The 1976 Hanford americium accident. The Medical Basis for Radiation Accident Preparedness, K.F. Hübner, S.A. Fry. Elsevier North Holland, New York 1980; 345–355
  • International Commission on Radiological Protection. The Metabolism of Plutonium and Related Elements. A Report of a Task Group of Committee 2 of the International Commission on Radiological Protection. Pergamon Press, Oxford 1986; 16, ICRP Publication 48, Annals of the ICRP, 2/3
  • Jackman W.S., Lougheed W., Marliss E.B., Zinman B., Albisser A.M. For insulin infusion: a miniature precision peristaltic pump and silicone rubber reservoir. Diabetes Care 1980; 3: 322–331
  • Lloyd R.D., Taylor G.N., Mays C.W., McFarland S.S., Atherton D.R. DTPA Therapy of 241Am from a simulated wound site. Health Physics 1975; 29: 808–811
  • Lloyd R.D., Mays C.W., McFarland S.S., Taylor G.N., Atherton D.R. A comparison of Ca-DTPA and Zn-DTPA for chelating 241Am in beagles. Health Physics 1976; 31: 281–284
  • Lokich J., Bothe A., Fine N., Perri J. Phase I study of protracted venous infusion of 5-fluorouracil. Cancer 1981; 48: 2565–2568
  • Mewhinney J.A., Griffith W.C. Models of Am metabolism in beagles and humans. Health Physics 1982; 42: 629–644
  • Mewhinney J.A., Griffith W.C., Muggenburg B.A. The influence of aerosol size on retention and translocation of 241Am following inhalation of 241AmO2 by beagles. Health Physics 1982; 42: 611–627
  • Muggenburg B.A., Mewhinney J.A. Removal of inhaled 241Am oxide particles of various sizes from beagle dogs using lung lavage and chelation treatment. Health Physics 1981; 41: 123–133
  • Piomelli S., Graziano J., Karpatkin M., Dudell G.G., Hart D., Helgartner M., Khanna K., Valdez-Cruz L.M., Vora S. Chelation therapy, transfusional requirement, and iron balance in young thalassemic patients. Fourth Cooley's Anemia Symposium, Annals of the New York Academy of Sciences, W.F. Anderson, A. Banks, E.C. Zaino, 1980; 344: 409–417
  • Plass T., Ohnuma T., Bruckner H., Chamberlain K., Mars T., Holland J.F. Portable infusion pumps in ambulatory cancer chemotherapy. Cancer 1982; 50: 27–31
  • Sanders C.L., Mahaffey J.A. Inhalation carcinogenesis of high-fired 241AmO2 in rats. Radiation Research 1983; 94: 66–80
  • Stather J.W., Smith H., Bailey M.R., Birchall A., Bulman R.A., Crawley F.E.H. The retention of 14C-DTPA in human volunteers after inhalation or intravenous injection. Health Physics 1983; 44: 45–52
  • Stevens E., Rosoff B., Weiner M., Spender H. Metabolism of the chelating agent diethylene-triamine pentaacetic acid. Proceedings of the Society for Experimental Biology and Medicine 1962; 111: 235–238
  • Stradling G.N., Stather J.W., Sumner S.A., Moody J.C., Strong J.C. Decorporation of inhaled americium-241 dioxide and nitrate from hamsters using ZnDTPA and Puchel. Health Physics 1984; 46: 1296–1300
  • Taylor D.M., Volf V. Oral chelation treatment of injected 241Am or 239Pu in rats. Health Physics 1980; 38: 147–158
  • Taylor G.N., Williams J.L., Roberts L., Atherton D.R., Shabestari L. Increased toxicity of Na3CaDTP when given by protracted administration. Health Physics 1974; 27: 285–288
  • Taylor G.N., Lloyd R.D., Boseman J.J., Atherton D.R., Mays C.W. Removal of plutonium from beagles using Ca-DTPA and Zn-DTPA: Effect of initial DTPA injection. Health Physics 1978; 35: 201–210
  • Volf V. Treatment of Incorporated Transuranium Elements. IAEA Technical Report Series No. 184, IAEA, Vienna 1978
  • United States Department of Energy. Spent Fuel and Radioactive Waste Inventories. 1985, Department of Energy Document No. DOE/RW-0006.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.