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Original Article

Dual-function Radiation Sensitizers and Bioreductive Drugs: Factors Affecting Cellular Uptake and Sensitizing Efficiency in Analogues of RSU 1069

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Pages 641-649 | Received 10 Jul 1987, Accepted 23 Nov 1987, Published online: 03 Jul 2009

References

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  • Adams G.E., Ahmed I., Sheldon P.W., Stratford I.J. RSU 1069, a 2-nitroimidazole containing an alkylating group: High efficiency as a radio- and chemosensitizer in vitro and in vivo. International Journal of Radiation Oncology, Biology and Physics 1984b; 10: 1653–1656
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  • Adams G.E., Flockhart I.R., Smithen C.E., Stratford I.J., Wardman P., Watts M.E. Electron-affinic sensitization, VII. A correlation between structure, one-electron reduction potentials and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers. Radiation Research 1976; 67: 9–20
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  • Smithen C.E., Clarke E.D., Dale J.A., Jacobs R.S., Wardman P., Watts M.E., Woodcock M. Novel (nitro-1-imidazolyl)-alkanolamines as potential radiosensitizers with improved therapeutic properties. Radiation Sensitizers: their use in the clinical management of cancer, L.W. Brady. Masson, New York 1980; 22–32
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  • Wardman P. Molecular structure and biological activity of hypoxic cell radiosensitizers and hypoxia specific cytotoxins. Advanced Topics on Radiosensitizers of Hypoxic Cells, A. Breccia, C. Rimondi, G.E. Adams. NATO Advanced Study Institutes Series A43, Plenum, New York 1982; 49–76
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