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Original Article

Repair of DNA Single- and Double-strand Breaks in Proliferating and Quiescent Murine Tumor Cells

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Pages 253-264 | Received 19 Dec 1988, Accepted 24 Apr 1989, Published online: 03 Jul 2009

References

  • Blöcher D., Pohlit W. DNA double-strand breaks in Ehrlich ascites tumor cells at low doses of X-rays. Can cell death be attributed to double-strand breaks?. International Journal of Radiation Biology 1982; 42: 329–338
  • Blöcher D., Nusse M., Bryant P.E. Kinetics of double-strand break repair in the DNA of synchronized mammalian cells. International Journal of Radiation Biology 1983; 43: 579–584
  • Bohr V.A., Smith C.A., Okumoto D.S., Hanawalt P.C. DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene is much more efficient than in the genome overall. Cell 1985; 40: 359–369
  • Chen T.R. In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. Experimental Cell Research 1977; 104: 225–262
  • Cheng, W-Y., Ridinger, D.N., Lehman, C.M., Puryear, R.L., Dethlefsen, L.A. The physiological state as a modifier of radiation-induced cytoxicity in heterogeneous murine tumor cells growing in vitro. International Journal of Radiation Biology, in press, 1989
  • Cleaver J.E. DNA repair in human xeroderma pigmentosum group C cells involves a different distribution of damaged sites in confluent and growing cells. Nucleic Acids Research 1986; 14: 8155–8165
  • Cole A., Meyn R.E., Chen R., Corry P.M., Hittelman W. Mechanisms of cell injury. Radiation in Cancer Research, R.E. Meyn, H.R. Withers. Raven Press, New York 1980; 33–58
  • Dethlefsen L.A. In search of the quaint quiescent cell. Radiation Biology in Cancer Research, R. Meyn, H.R. Withers. Raven Press, New York 1980; 415–435
  • Dexter D.L., Calabresi P. Intraneoplastic diversity. Biochimica et Biophysica, Acta 1982; 695: 97–112
  • Dexter D.L., Kowalski H.M., Blazer B.A., Fligiel Z., Vogel R., Heppner G.H. Heterogeneity of tumor cells from a single mouse mammary tumor. Cancer Research 1978; 38: 3174–3181
  • Flick, M.B., Warters, R.L., Yasui, L.S., Krisch, R.E. Measurement of radiation induced DNA damage using gel electrophoresis or neutral filter elution shows an increased frequency of DNA strand breaks after exposure to pH9·6. Radiation Research, in press, 1989
  • Fornace A.J., Jr., Nagasawa H., Little J.B. Relationship of DNA repair to chromosome aberrations, sister-chromatid exchanges and survival during liquid-holding recovery in X-irradiated mammalian cells. Mutation Research 1980; 70: 323–336
  • Giaccia A., Weinstein R., Hu J., Stamato T.D. Cell cycle-dependent repair of double-strand breaks in a γ-ray-sensitive Chinese hamster cell. Somatic Cell and Molecular Genetics 1985; 11: 485–491
  • Goodhead D.T. Saturable repair models of radiation action in mammalian cells. Radiation Research 1985; 104: S58–S67
  • Hahn G.M., Little J.B. Plateau-phase cultures of mammalian cells: an in vitro model for human cancer. Current Topics in Radiation Research 1972; 8: 39–83
  • Humphrey R.M., Steward D.L., Sedita B.A. DNA-strand breaks and rejoining following exposure of synchronized Chinese hamster cells to ionizing radiation. Mutation Research 1968; 6: 459–465
  • Koval T.M., Kazmir E.R. DNA double-strand break repair in eukaryotic cell lines having radically different radiosensitivities. Radiation Research 1988; 113: 268–277
  • Meyn R.E., Grdina D.J., Fletcher S.E. Repair of radiation damage in vivo. Radiation Biology in Cancer Research, R. Meyn, H.R. Withers. Raven Press, New York 1980; 95–102
  • Murray D., Meyn R.E. Differential repair of τ-ray-induced DNA strand breaks by various cellular subpopulations of mouse jejunal epithelium and bone marrow in vivo. Radiation Research 1987; 109: 153–164
  • Painter R.B. The role of DNA damage and repair in cell killing induced by ionizing radiation. Radiation Biology in Cancer Research, R. Meyn, H.R. Withers. Raven Press, New York 1980; 59–68
  • Radford I.R. Evidence for a general relationship between the induced level of DNA double-strand breakage and cell-killing after X-irradiation of mammalian cells. International Journal of Radiation Biology 1986; 49: 611–620
  • Radford I.R. Effect of cell-cycle position and dose on the kinetics of DNA double-strand breakage repair in X-irradiated Chinese hamster cells. International Journal of Radiation Biology 1987; 52: 555–563
  • Resnick M.A. Similar responses to ionizing radiation of fungal and vertebrate cells and the importance of DNA double-strand breaks. Journal of Theoretical Biology 1978; 71: 339–346
  • Rydberg B., Johansen K.J. Radiation-induced DNA strand breaks and their rejoining in crypt and villous cells of the small intestine of the mouse. Radiation Research 1975; 64: 281–292
  • Sakai K., Okada S. Radiation-induced DNA damage and cellular lethality in cultured mammalian cells. Radiation Research 1984; 98: 479–490
  • Schneider E.L., Stanbridge E.J., Epstein C.J. Incorporation of 3H-uridine and 3H-uracil into RNA. Experimental Cell Research 1974; 84: 311–318
  • Spiro I.J., Kennedy K.A., Stickler R., Ling C.C. Cellular and molecular repair of X-ray-induced damage: dependence on oxygen tension and nutritional status. Radiation Research 1985; 101: 144–155
  • Sweigert S.E., Rowley R., Warters R.L., Dethlefsen L.A. Cell cycle effect on the induction of DNA double-strand breaks by X-rays. Radiation Research 1988; 116: 228–244
  • Tobias C.A., Blakely E.A., Ngo F.Q.H., Yang T.C.H. The repair-misrepair model of cell survival. Radiation Biology in Cancer Research, R.E. Meyn, H.R. Withers. Raven Press, New York 1980; 195–230
  • Tofilon P.J., Meyn R.E. Reduction in DNA repair capacity following differentiation of murine proadipocytes. Experimental Cell Research 1988; 174: 502–510
  • Wallen C.A., Higashikubo R., Dethlefsen L.A. Murine mammary carcinoma cells in vitro. I. The development of a quiescent state. Cell Tissue Kinetics 1984; 17: 65–77
  • Wallen C.A., Ridinger D.N., Dethlefsen L.A. Heterogeneity of X-ray cytotoxicity in proliferating and quiescent murine mammary carcinoma cells. Cancer Research 1985; 45: 3064–3069
  • Ward J.F., Kuo I. Strand breaks, base release, and post-irradiation changes in DNA γ-irradiated in dilute O2-saturated solution. Radiation Research 1976; 66: 485–498
  • Ward J.F., Blakely W.F., Joner E.I. Mammalian cells are not killed by DNA single-strand breaks caused by hydroxyl radicals from hydrogen peroxide. Radiation Research 1985; 103: 383–392
  • Warters R.L., Lyons B.L., Ridinger D.N., Dethlefsen L.A. DNA damage repair in quiescent murine mammary carcinoma cells in culture. Biochimica et Biophysica Acta 1985; 824: 357–364
  • Wheeler K.T., Nelson G.B. Saturation of a DNA repair process in dividing and nondividing mammalian cells. Radiation Research 1987; 109: 109–117
  • Wheeler K.T., Nelson G.B., Terrell K.E., Wallen C.A. Regulation of DNA repair kinetics in proliferative and quiescent tumor cells. International Journal of Radiation Biology 1988; 54: 245–255
  • Wilson K.M., Keng P.C. Radiation-induced DNA damage and repair in quiescent and proliferating human tumor cells in vitro. International Journal of Radiation Biology 1989; 55: 385–395
  • Wlodek D., Hittelman W.N. The relationship of DNA and chromosome damage to survival of synchronized X-irradiated L5178Y cells. II. Repair. Radiation Research 1988; 115: 566–575

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