Advances in Radioprotection through the Use of Combined Agent Regimens

References

• Ainsworth E.J. From endotoxins to newer immunomodulators: Survival-promoting effects of microbial polysaccharide complexes in irradiated animals. Pharmacology and Therapeutics 1988; 39: 223–241
   PubMed Web of Science ®Google Scholar
• Ainsworth E.J., Larsen R.M., Mitchell F.A., Taylor J.F. Survival-promoting effects of endotoxin in mice, dogs, and sheep. Radiation Protection and Sensitization, Proceedings of the Second International Symposium on Radiosensitizing and Radio-Protective Dugs, H.L. Moroson, M. Quintiliani. Taylor & Francis, London 1970; 381–388
   Google Scholar
• Blumberg A.L., Nelson D.F., Gramkowski M., Glover D., Glick J.H., Yuhas J.M., Kligerman M.M. Clinical trials of WR-2721 with radiation therapy. International Journal of Radiation Oncology, Biology, Physics 1982; 8: 561–563
   PubMed Web of Science ®Google Scholar
• Bogo V. Behavioral radioprotection. Pharmacology and Therapeutics 1988; 39: 73–78
   PubMed Web of Science ®Google Scholar
• Bogo V., Jacobs A.J., Weiss J.F. Behavioral toxicity and efficacy of WR-2721 as a radioprotectant. Radiation Research 1985; 104: 182–190
   PubMed Web of Science ®Google Scholar
• Brown D.Q., Graham W.J., MacKenzie L.J., Pittock J.W., Shaw L.M. Can WR-2721 be improved upon?. Pharmacology and Therapeutics 1988; 39: 157–168
   PubMed Web of Science ®Google Scholar
• Treatment of Radiation Injuries, D. Browne, J.F. Weiss, T.J. MacVittie, M.V. Pillai. Plenum, New York 1990, (In press)
   Google Scholar
• Chirigos M.A., Patchen M.L. Survey of newer biological response modifiers for possible use in radioprotection. Pharmacology and Therapeutics 1988; 39: 243–246
   PubMed Web of Science ®Google Scholar
• Davidson D.E., Grenan M.M., Sweeney T.R. Biological characteristics of some improved radioprotectors. Radiation Sensitizers, Their Use in the Clinical Management of Cancer, L.W. Brady. Masson, New York 1980; 309–320
   Google Scholar
• Denekamp J., Michael B.D., Rojas A., Stewart F.A. Radioprotection of mouse skin by WR-2721: the critical influence of oxygen tension. International Journal of Radiation Oncology, Biology, Physics 1982; 8: 531–534
   PubMed Web of Science ®Google Scholar
• Durum S., Oppenheim J.J., Neta R. Immunophysiological role of inter-leukin-1. Immunophysiology: Role of Cells and Cytokines in Immunity and Inflammation, J.J. Oppenheim, E. Shevach. Oxford University Press, Oxford 1989; 210–225
   Google Scholar
• Floersheim G.L., Floersheim P. Protection against ionizing radiation and synergism with thiols by zinc aspartate. British Journal of Radiology 1986; 59: 597–602
   PubMed Web of Science ®Google Scholar
• Foye W.O. Radioprotective drugs. Burger's Medicinal Chemistry, M.E. Wolff. Wiley, New York 1981; 11–45
   Google Scholar
• Glover D., Fox K.R., Weiler C., Kligerman M.M., Turrisi A., Glick J.H. Clinical trials of WR-2721 prior to alkylating agent chemotherapy and radio-therapy. Pharmacology and Therapeutics 1988; 39: 3–7
   PubMed Web of Science ®Google Scholar
• Grdina D.J., Nagy B., Hill C.K., Wells R.L., Peraino C. The radioprotector WR-1065 reduces radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in V79 cells. Carcinogenesis 1985; 6: 929–931
   PubMed Web of Science ®Google Scholar
• Hanson W.R. Radioprotection of murine intestine by WR-2721, 16,16-dimethyl prostaglandin E2 and the combination of both agents. Radiation Research 1987a; 111: 361–373
   PubMed Web of Science ®Google Scholar
• Hanson W.R. Radiation protection by exogenous arachidonic acid and several metabolites. Prostaglandin and Lipid Metabolism in Radiation Injury, T.L. Walden, H.N. Hughes. Plenum, New York 1987b; 233–243
   Google Scholar
• Hanson W.R., Ainsworth E.J. 16,16-Dimethyl prostaglandin E2 induces radioprotection in murine intestinal and hematopoietic stem cells. Radiation Research 1985; 100: 290–297
   Google Scholar
• Hanson W.R., Houseman K.A., Collins P.W. Radiation protection in vivo by prostaglandins and related compounds of the arachidonic acid cascade. Pharmacology and Therapeutics 1988; 39: 347–356
   PubMed Web of Science ®Google Scholar
• Hughes H.N., Walden T.L., Steel L.K. Radioprotective efficacy of platelet activating factor in mice. Abstracts of Papers for the 37th Annual Meeting of the Radiation Research Society, Seattle, WA, 1989; 186–186
   Google Scholar
• Jacobs A.J., Rankin W.A., Srinivasan V., Weiss J.F. Effects of vitamin E and selenium on glutathione peroxidase activity and survival of irradiated mice. Proceedings of the 7th International Congress of Radiation Research, J.J. Broerse, G.W. Barendsen, H.B. Kal, A.J. van der Kogel. Martinus Nijhoff, Amsterdam 1983; D5–D15
   Google Scholar
• Kumar K.S., Weiss J.F. Effect of metals on oxygen consumption by radioprotective thiols in vitro. Frontiers of Radiation Biology, Proceedings of the 21st Annual Meeting of the European Society for Radiation Biology, E. Riklis. VCH, Weinheim/Deerfield Beach, FL 1989, and Balaban, Rehovot/Philadelphia, (In press)
   Google Scholar
• Kumar K.S., Sancho A.M., Weiss J.F. A novel interaction of diethyldithiocarbamate with the glutathione/glutathione peroxidase system. International Journal of Radiation Oncology, Biology, Physics 1986; 12: 1463–1467
   PubMed Web of Science ®Google Scholar
• Kumar K.S., Vaishnav Y.N., Weiss J.F. Radioprotection by antioxidant enzymes and enzyme mimetics. Pharmacology and Therapeutics 1988; 39: 301–309
   PubMed Web of Science ®Google Scholar
• Landauer M.R., Davis H.D., Dominitz J.A., Weiss J.F. Dose and time relationships of the radioprotector WR-2721 on locomotor activity in mice. Pharmacology, Biochemistry and Behavior 1987; 27: 573–576
   PubMed Web of Science ®Google Scholar
• Landauer M.R., Davis H.D., Kumar K.S., Weiss J.F. Caffeine mitigates the behavioral toxicity of the radioprotector WR-3689. Abstracts of Papers for the 22nd Annual Meeting of the European Society for Radiation Biology, Brussels. 1989a; 146–146
   Google Scholar
• Landauer M.R., Walden T.L., Davis H.D. Behavioral effects of radioprotective agents in mice: combination of WR-2721 and 16, 16 dimethyl prostaglandin E2. Frontiers of Radiation Biology, Proceedings of the 21st Annual Meeting of the European Society for Radiation Biology, E. Riklis. VCH, Weinheim/Deerfield Beach, FL 1989b, and Balaban, Rehovot/Philadelphia (In press)
   Google Scholar
• Laver J., Gillio A., Abboud M., Gasparetto C., Warren D., O'Reilly R.J., Moore M.A.S. Myeloprotective effects of interleukin-1 following exposure to chemoradiotherapy. Treatment of Radiation Injuries, D. Browne, J.F. Weiss, T.J. MacVittie, M.V. Pillai. Plenum, New York 1990, (In press)
   Google Scholar
• Lehnert S. Radioprotection of mouse intestine by inhibitors of cyclic AMP phosphodiesterase. International Journal of Radiation Oncology, Biology, Physics 1979; 5: 825–833
   PubMed Web of Science ®Google Scholar
• Maisin J.R., Bacq Z.M. Toxicity. International Encyclopedia of Pharmacology and Therapeutics: Sulfur-Containing Radioprotective Agents, Z.M. Bacq. Pergamon, New York 1975; 15–39
   Google Scholar
• Maisin J.R., Kondi-Tamba A., Mattelin G. Polysaccharides induce radioprotection of murine hemopoetic stem cells and increase the LD 50/30 days. Radiation Research 1986; 105: 276–281
   PubMed Web of Science ®Google Scholar
• Maisin J.R., Mattelin G., Fridman-Manduzio A., Van der Parren J. Reduction of short- and long-term radiation lethality by mixtures of chemical protectors. Radiation Research 1968; 35: 26–44
   PubMed Web of Science ®Google Scholar
• Malick M.A., Roy R.M., Sternberg J. Effect of vitamin E on postirradiation death in mice. Experientia 1978; 34: 1216–1217
   PubMedGoogle Scholar
• Masuda A., Longo D.L., Kobayashi Y., Appella E., Oppenheim J.J., Matsushima K. Induction of mitochondrial manganese superoxide dismutase by interleukin-1. FASEB Journal 1988; 2: 3087–3091
   PubMed Web of Science ®Google Scholar
• Neta R. Role of cytokines in radioprotection. Pharmacology and Therapeutics 1988; 39: 261–266
   PubMed Web of Science ®Google Scholar
• Neta R., Kumar K.S., Weiss J.F. Enhancement of survival of irradiated mice by treatment with interleukin-1 (IL-1) alone and in combination with WR-2721. Abstracts of the 37th Annual Meeting of the Radiation Research Society, Seattle, WA, 1989; 185–185
   Google Scholar
• Neta R., Oppenheim J.J., Douches S.D. Interdependence of the radioprotective effects of human recombinant interleukin 1α, tumor necrosis factor α, granulocyte colony-stimulating factor, and murine recombinant granulocyte-macrophage colony-stimulating factor. Journal of Immunology 1988; 140: 108–111
   PubMed Web of Science ®Google Scholar
• Oppenheim J.J., Neta R., Tiberghien P., Gress R., Kenny J., Longo D. Interleukin 1 enhances survival of lethally irradiated mice treated with allogeneic bone marrow cells. Blood 1989; 74: 2257–2263
   PubMed Web of Science ®Google Scholar
• Patchen M.L., D'Alesandro M.M., Chirigos M.A., Weiss J.F. Radioprotection by biological response modifiers alone and in combination with WR-2721. Pharmacology and Therapeutics 1988; 39: 247–254
   PubMed Web of Science ®Google Scholar
• Patchen M.L., MacVittie T.J., Jackson W.E. Postirradiation glucan administration enhances the radioprotective effects of WR-2721. Radiation Research 1989; 117: 59–69
   PubMed Web of Science ®Google Scholar
• Patchen M.L., MacVittie T.J., Weiss J.F. Combined modality radioprotection: The use of glucan and selenium with WR-2721. International Journal of Radiation Oncology, Biology, Physics. 1990, (In press)
   Google Scholar
• Petkau A. Role of superoxide dismutase in modification of radiation injury. British Journal of Cancer 1987; 55(Suppl. VIII)87–95
   Google Scholar
• Purdie J.W., Inhaber E.R., Schneider H., Labelle J.L. Interaction of cultured mammalian cells with WR-2721 and its thiol WR-1065: implications for mechanisms of radioprotection. International Journal of Radiation Biology 1983; 43: 517–527
   Web of Science ®Google Scholar
• Riklis E. DNA repair as a probe of radiosensitivity and radioprotection. Radioprotectors and Anticarcinogens, O.F. Nygaard, M.G. Simic. Academic Press, New York 1983; 363–380
   Google Scholar
• Schally A.V., Paz-Bouza J.I., Schlosser J.V., Karashima T., Debeljuk L., Gandle B., Sampson M. Protective effects of analogs of luteinizing hormone-releasing hormone against X-radiation-induced damage in rats. Proceedings of the National Academy of Sciences, USA 1987; 84: 851–857
   PubMed Web of Science ®Google Scholar
• Seifter E., Rettura G., Padawer J., Stratford F., Weinzweig J., Demetrious A.A., Levenson S.M. Morbidity and mortality reduction by supplemental vitamin A or β-carotene in CBA mice given total body radiation. Journal of the National Cancer Institute 1984; 73: 1167–1177
   PubMedGoogle Scholar
• Singh A., Singh H. Time-scale and nature of radiation-biological damage: approaches to radiation protection and postirradiation therapy. Progress in Biophysics and Molecular Biology 1982; 39: 69–106
   PubMed Web of Science ®Google Scholar
• Steel L.K., Walden T.L., Hughes H.N., Jackson W.E. Protection of mice against mixed fission neutron-γ (n:γ=1:1) irradiation by WR-2721, 16,16-dimethyl PGE2, and the combination of both agents. Radiation Research 1988; 115: 605–608
   PubMed Web of Science ®Google Scholar
• Sztanyik L.B., Santha A. Synergistic effect of radioprotective substances having different mechanisms of action. Modification of Radiosensitivity of Biological Systems. International Atomic Energy Agency, Vienna 1976; 47–59
   Google Scholar
• Uma Devi P., Thomas B. Bone marrow cell protection and modification of drug toxicity by combination of protectors. Pharmacology and Therapeutics 1988; 39: 213–214
   PubMed Web of Science ®Google Scholar
• Vaishnav Y.N., Kumar K.S., Weiss J.F., Neta R. Induction of superoxide dismutase: A mechanism for radioprotection by interleukin-1 (IL-1)?. Abstracts of Papers for the 37th Annual Meeting of the Radiation Research Society, Seattle, WA, 1989; 185–185
   Google Scholar
• Walden T.L. A paradoxical role for eicosanoids: Radioprotectants and radiosensitizers. Prostaglandin and Lipid Metabolism in Radiation Injury, T.L. Walden, H.N. Hughes. Plenum, New York 1987; 263–271
   Google Scholar
• Walden T.L., Patchen M.L., MacVittie T.J. Leukotriene-induced radioprotection of hematopoietic stem cells in mice. Radiation Research 1988; 113: 338–395
   Web of Science ®Google Scholar
• Walden T.L., Patchen M., Snyder S.L. 16,16-Dimethyl prostaglandin E2 increases survival in mice following irradiation. Radiation Research 1987; 109: 440–448
   PubMed Web of Science ®Google Scholar
• Weiss J.F., Kumar K.S. Antioxidant mechanisms in radiation injury and radioprotection. Cellular Antioxidant Defense Mechanisms, C.K. Chow. CRC Press, Orlando 1988; II: 163–189
   Google Scholar
• Weiss J.F., Hoover R.L., Kumar K.S. Selenium pretreatment enhances the radioprotective effect and reduces the lethal toxicity of WR-2721. Free Radical Research Communications 1987; 3: 33–38
   PubMedGoogle Scholar
• Yuhas J.M., Proctor J.O., Smith L.M. Some pharmacologic effects of WR-2721: Their role in toxicity and radioprotection. Radiation Research 1973; 54: 222–233
   PubMed Web of Science ®Google Scholar
• Yuhas J.M., Storer J.B. Chemoprotection against three modes of radiation death in the mouse. International Journal of Radiation Biology 1969; 15: 233–237
   Web of Science ®Google Scholar