6
Views
13
CrossRef citations to date
0
Altmetric
Original Article

Fission-neutron-induced Expression of a Tumour-associated Antigen in Human Cell Hybrids (HeLa × Skin Fibroblast): Evidence for Increased Expression at Low Dose Rate

, , &
Pages 673-680 | Received 19 Jan 1990, Accepted 23 Apr 1990, Published online: 03 Jul 2009

References

  • Balcer-Kubiczek E.K., Harrison G.H., Zeman G.H., Mattson P.J., Kunska A. Lack of inverse dose-rate effect on fission neutron induced transformation of C3H10T½ cells. International Journal of Radiation Biology 1988; 54: 531–536
  • Barendsen G.W. Do fast neutrons at low dose-rate enhance cell transformation in vitro? A basic problem of microdosimetry and interpretation. International Journal of Radiation Biology 1985; 47: 731–734
  • Belli M., Cherubini R., Finotto S., Moschini G., Sapora O., Simone G., Tabocchini M.A. RBE-LET relationship for the survival of V79 cells irradiated with low-energy protons. International Journal of Radiation Biology 1989; 55: 93–104
  • Borek C. X-ray-induced in vitro neoplastic transformation of human diploid cells. Nature 1980; 238: 776–778
  • Borek C. Cellular and molecular mechanisms in malignant transformation of diploid rodent and human cells by radiation. Carcfinogenesis—a Comprehensive Survey, Vol 9: Mammalian-cell Transformation: Mechanisms of Carcinogenesis and Assays for Carcinogens, J.C. Barrett, R.W. Tennant. Raven Press, New York 1985; 365–370
  • Burch P.R., Chesters M.S. Neoplastic transformation of cells in vitro at low and high dose-rates of fission neutrons: an interpretation. International Journal of Radiation Biology 1986; 49: 495–500
  • Elkind M.M., Hill C.K. Radiobiological issues in the anomalous enhanced effect of low-dose-rate fission-spectrum neutrons: reply to letter to the editor by G. W. Barendsen. International Journal of Radiation Biology 1985; 48: 139–144
  • Elkind M.M., Hill C.K. Biophysical models for the role of intracellular repair in the anomalous enhancement of neoplastic transformation by low doses of fission-spectrum neutrons at low dose-rate. Reply to the letter to the Editor by P. R. J. Burch and M. S. Chesters. International Journal of Radiation Biology 1986A
  • Elkind M.M., Hill C.K. Age dependent variations in cellular susceptibility to neoplastic transformation. Reply to the letter to the Editor by H. H. Rossi and A. M. Vellere. International Journal of Radiation Biology 1986B; 50: 1117–1122
  • Han A., Elkind M.M. Transformation of mouse C3H/10T½ cells by single and fractionated doses of X-rays and fission-spectrum neutrons. Cancer Research 1979; 39: 123–130
  • Hieber L., Ponsel G., Roos H., Fenn S., Fromke E., Kellerer A.M. Absence of a dose-rate effect in the transformation of C3H10T½ cells by α-particles. International Journal of Radiation Biology 1987; 52: 859–869
  • Hill C.K., Han A., Elkind M.M. Fission-spectrum neutrons at a low dose-rate enhance neoplastic transformation in the linear, low-dose region (0–10cGy). International Journal of Radiation Biology 1984; 46: 11–15
  • Hill C.K., Buonaguro F.M., Myers C.P., Han A., Elkind M.M. Fission-spectrum neutrons at reduced dose-rates enhance neoplastic transformation. Nature 1982; 298: 67–69
  • Hill C.K., Carnes B.A., Han A., Elkind M.M. Neoplastic transformation is enhanced by multiple low doses of fission-spectrum neutrons. Radiation Research 1985; 102: 404–410
  • Jones C.A., Sedita B.A., Hill C.K., Elkind M.M. Influence of dose-rate on the transformation of Syrian hamster embryo cells by rission-spectrum neutrons. Low Dose Radiation—Biological Bases and Risk Assessment, K.F. Baverstock, J.W. Strather. Taylor & Francis, London 1989; 539–546
  • Keppel G. Design and Analysis—A Researcher's Handbook2nd edn. Prentice-Hall, New Jersey 1982
  • Kronenberg A., Little J.B. Mutagenic properties of low doses of X-rays, fast neutrons and selected heavy ions in human cells. Low Dose Radiation—Biological Bases of Risk Assessment, K.F. Baverstock, J.W. Strather. Taylor & Francis, London 1989; 554–559
  • Kubota N., Jones C.A., Hill C.K. (1987) The influence of low dose rate irradiations with neutrons on mutation induction in Chinese hamster cells and human diploid fibroblasts. Abstract in Proceedings of the 8th International Congress of Radiation Research, Edinburgh, July, 1987. Taylor & Francis, London
  • Marshall I., Williamson F.S. Microdosimetric spectra measurements of JANUS-neutrons. Radiation Protection Dosimetry 1985; 13: 111–115
  • Miller R.C., Brenner D.J., Geard C.R., Komatsu K., Marino S.A., Hall E.J. Oncogenic transformation by fractionated doses of neutrons. Radiation Research 1988; 114: 589–598
  • Miller R.C., Geard C.R., Brenner D.J., Komatsu K., Marino S.A., Hall E.J. Neutron-energy-dependent oncogenic transformation of C3H10T½ mouse cells. Radiation Research 1989; 117: 114–127
  • Redpath J.L. Radiation-induced neoplastic transformation of human cell hybrids. Anticarcinogenesis and Radiation Protection, P. Cerutti, O. Nygaard, M.G. Simic. New York, New York 1987; 335–340
  • Redpath J.L., Sun C., Colman M., Stanbridge E.J. Neoplastic transformation of human hybrid cells by gamma-irradiation: a quantitative assay. Radiation Research 1987; 110: 468–472
  • Redpath J.L., Sun C., Mendonca M., Colman M., Stanbridge E.J. The application of a human hybrid cell system to studies of radiation-induced cell transformation: quantitative, cellular and molecular aspects. Cell Transformation and Radiation-Induced Cancer, K.H. Chadwick, C. Scymour, B. Barnhart. Adam Hilger, Bristol and New York 1989; 85–90
  • Rossi H.J., Kellerer A.M. The dose-rate dependence of oncogenic transformation by neutrons may be due to variation of response during the cell cycle. International Journal of Radiation Biology 1986; 50: 353–361
  • Stanbridge E.J. Suppression of malignancy in human cells. Nature 1976; 260: 17–20
  • Stanbridge E.J., Wilkinson J. Dissociation of anchorage independence from tumorigenicity in human cell hybrids. Somatic Cell Genetics 1980; 7: 699–712
  • Sun C., Redpath J.L. Application of a freeze-thaw technique to studies of radiation-induced cell transformation. International Journal of Radiation Biology 1988; 54: 825–827
  • Sun C., Redpath J.L., Colman M., Stanbridge E.J. Further studies of the radiation-induced expression of a tumor specific antigen in human cell hybrids. Radiation Research 1988; 114: 84–93
  • Thomson J.F., Williamson F.S., Grahn D., Ainsworth E.J. Life shortening in mice exposed to fission neutrons and gamma-rays. II. Duration of life and long-term fractionated exposures. Radiation Research 1981; 86: 573–579
  • Ullrich R.L. Tumor induction in BALB/c mice after fractionated or protracted exposure to fission-spectrum neutrons. Radiation Research 1984; 97: 587–597
  • Ullrich R.L., Storer J.B. Life shortening and tumor induction after low doses of fission neutrons. Radiation Research 1981; 87: 454–454, (abstr.).
  • Vogel H.H., Jr., Dickson H.W. Mammary neoplasia following acute and protracted irradiation with fission neutrons and 60cobalt gamma-rays. Radiation Research 1981; 87: 453–454, (abstr.).
  • Williamson F.S., Frigerio N.A. Proceedings of the First Symposium on Neutron Dosimetry in Biological and Medical Researc. Neuherberg, Munich 1972; 743–743, In
  • Yang T.C., Cruise L.M., Mei M., Tobias C.A. Dose protraction studies with low- and high-LET radiations on neoplastic cell transformation in vitro. Advances in Space Research 1986; 6: 137–147

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.