Radiosensitization by Misonidazole, Pimonidazole and Azomycin and Intracellular Uptake in Human Tumour Cell Lines

References

• Adams G.E., Clarke E.D., Flockhart I.R., Jacobs R.S., Sehmi D.S., Stratford I.J., Wardman P., Watts M.E., Parrick J., Wallace R.G., Smithen C.E. Structure-activity relationships in the development of hypoxic cell radiosensitizers. I. Sensitization efficiency. International Journal of Radiation Biology 1979; 35: 133–150
   Web of Science ®Google Scholar
• Adams G.E., Flockhart I.R., Smithen C.E., Stratford I.J., Wardman P., Watts M.E. Electron-affinic sensitization. VII. A correlation between structures, one-electron reduction potentials, and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers. Radiation Research 1976; 67: 9–20
   PubMed Web of Science ®Google Scholar
• Brown D.M., Parker E., Brown J.M. Structure-activity relationships of 1-substituted 2-nitroimidazoles: effect of partition coefficient and side-chain hydroxyl groups on radiosensitization in vitro. Radiation Research 1982; 90: 98–108
   PubMed Web of Science ®Google Scholar
• Brown J.M. Clinical trials of radiosensitizers: what should we expect?. International Journal of Radiation Oncology, Biology, Physics 1984; 10: 425–429
   PubMed Web of Science ®Google Scholar
• Brown J.M., Yu N.Y. Radiosensitization of hypoxic cells in vivo by SR 2508 at low radiation doses: a preliminary report. International Journal of Radiation Oncology, Biology, Physics 1984; 10: 1207–1212
   PubMed Web of Science ®Google Scholar
• Chapman J.D., Gillespie C.J., Reuvers A.P., Dugle D.L. The inactivation of Chinese hamster cells by X Rays: the effects of chemical modifiers on single- and double-events. Radiation Research 1975; 64: 365–375
   PubMed Web of Science ®Google Scholar
• Chapman J.D., Reuvers A.P., Borsa J. Effectiveness of nitrofuran derivatives in sensitizing hypoxic mammalian cells to X rays. British Journal of Radiology 1973; 46: 623–630
   PubMed Web of Science ®Google Scholar
• De Duve C., De Barsy T., Poole B., Trouet A., Tulkens P., Van Hoof F. Lysosomotropic agents. Biochemical Pharmacology 1974; 23: 2495–2531
   PubMed Web of Science ®Google Scholar
• Dennis M.F., Stratford M.F.L., Wardman P., Watts M.E. Cellular uptake of misonidazole and analogues with acidic or basic functions. International Journal of Radiation Biology 1985; 47: 629–643
   Web of Science ®Google Scholar
• Drewinko B., Romsdahl M.M., Yang L.-Y., Ahearn M.J., Trujillo J.M. Establishment of a human carcinoembryonic antigen-producing colon adenocarcinoma cell line. Cancer Research 1976; 36: 467–475
   PubMed Web of Science ®Google Scholar
• Drewinko B., Yang L.-Y., Romsdahl M.M. Radiation response of cultured human carcinoembryonic antigen-producing colon adenocarcinoma cells. International Journal of Radiation Oncology, Biology, Physics 1977; 2: 1109–1114
   PubMed Web of Science ®Google Scholar
• Ellman G.L. Tissue sulfhydryl groups. Archives of Biochemistry and Biophysics 1959; 82: 70–77
   PubMed Web of Science ®Google Scholar
• Fertil B., Malaise E.-P. Inherent cellular radiosensitivity as a basic concept for human tumor radiotherapy. International Journal of Radiation Oncology, Biology, Physics 1981; 7: 621–629
   PubMed Web of Science ®Google Scholar
• Grdina D.J., Thames H.D., Milas L. Tumour sensitizing effect by misonidazole in a clinically relevant radiation dose range. International Journal of Radiation Oncology, Biology, Physics 1984; 10: 379–383
   PubMed Web of Science ®Google Scholar
• Hodgkiss R.J., Middleton R.W. Effects of glutathione depletion using buthionine sulphoximine on the cytotoxicity of nitroaromatic compounds in mammalian cells in vitro. Biochemical Pharmacology 1985; 34: 2175–2178
   PubMed Web of Science ®Google Scholar
• Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with Folin-phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
   PubMed Web of Science ®Google Scholar
• Millar B.C., Jinks S. Studies on the relationship between the radiation resistance and glutathione content of human and rodent cells after treatment with dexamethasone in vitro. International Journal of Radiation Biology 1985; 47: 539–552
   Web of Science ®Google Scholar
• Minchinton A.I., Rojas A., Smith K.A., Soranson J., Shrieve D.C., Jones N.R., Bremner J. Glutathione depletion in tissues after administration of buthionine sulphoximine. International Journal of Radiation, Oncology, Biology, Physics 1984; 10: 1261–1264
   PubMed Web of Science ®Google Scholar
• Mitchell J.B., Russo A. The role of glutathione in radiation and drug induced cytotoxicity. British Journal of Cancer 1987; 55(Suppl. VIII)96–104
   Google Scholar
• Mitchell J.B., Phillips T.L., DeGraff W., Carmichael J., Rajpal R.K., Russo A. The relationship of SR-2508 sensitizer enhancement ratio to cellular glutathione levels in human tumor cell lines. International Journal of Radiation Oncology, Biology, Physics 1986; 12: 1143–1146
   PubMed Web of Science ®Google Scholar
• Morstyn G., Russo A., Carney D.N., Karawya E., Wilson S.H., Mitchell J.B. Heterogeneity in the radiation survival curves and biochemical properties of human lung cancer cell lines. Journal of the National Cancer Institute 1984; 73: 801–806
   PubMedGoogle Scholar
• Palcic B., Faddegon B., Skarsgard L.D. The effect of misonidzole as a hypoxic radiosensitizer at low dose. Radiation Research 1984; 100: 340–347
   PubMed Web of Science ®Google Scholar
• Phillips T.L., Mitchell J.B., DeGraff W., Russo A., Glatstein E. Variation in sensitizing efficiency for SR 2508 in human cells dependent on glutathione content. International Journal of Radiation Oncology, Biology, Physics 1986; 12: 1627–1635
   PubMed Web of Science ®Google Scholar
• Rasheed S., Nelson-Rees W.A., Toth E.M., Arnstein P., Gardner M.B. Characterization of a newly derived human sarcoma cell line (HT-1080). Cancer 1974; 33: 1027–1033
   PubMed Web of Science ®Google Scholar
• Smithen C.E., Clarke E.D., Dale J.A., Jacobs R.S., Wardman P., Watts M.E., Woodcock M. Novel (nitro-1-imidazolyl)-alkanolamines as potential radiosensitizers with improved therapeutic properties. Radiation Sensitizers: Their Use in the Clinical Management of Cancer, L.W. Brady. Masson, New York 1980; 22–32
   Google Scholar
• Stratford I.J. Cellular radiosensitization: principles and methods of study. Radiosensitizers of Hypoxic Cells, A. Breccia, C. Rimondi, G.E. Adams. Elsevier, Amsterdam 1979; 109–128
   Google Scholar
• Stratford M.R.L., Dennis M.F., Watts M.E., Watfa R.R. Efficient radiosensitization by weak acids and bases not predicted by intracellular uptake. Radiation Research, Proceedings of the 8th International Congress of Radiation Research, Edinburgh, July 1987, Vol. 1, E.M. Fielden, J.F. Fowler, J.H. Hendry, D. Scott. Taylor and Francis, London 1987; 117–117
   Google Scholar
• Stratford M.R.L., Dennis M.F., Watts M.E., Watfa R.R. Radiosensitizer-DNA interactions. British Journal of Radiology 1988; 61: 860–862
   PubMed Web of Science ®Google Scholar
• Stratford M.R.L., Dennis M.F., Watts M.E., Watfa R.R., Woodcock M. Radiosensitizer-DNA interactions in relation to intracellular uptake. International Journal of Radiation Oncology, Biology, Physics 1989; 16: 1007–1010
   PubMed Web of Science ®Google Scholar
• Wardman P., Dennis M.F., White J. Fluorescent probes for intracellular concentrations of drugs. International Journal of Radiation Oncology, Biology, Physics 1989; 16: 935–938
   PubMed Web of Science ®Google Scholar
• Watts M.E., Jones N.R. The effect of extracellular pH on radiosensitization by misonidazole and acidic or basic analogues. International Journal of Radiation Biology 1985; 47: 645–653
   Web of Science ®Google Scholar
• Watts M.E., Anderson R.F., Jacobs R.S., Patel K.B., Wardman P., Woodcock M., Smithen C.E., Moazzam M., Parrick J., Wallace R.G. Radiation Sensitizers: Their Use in the Clinical Management of Cancer, L.W. Brady. Masson, New York 1980; 175–185
   Google Scholar
• Watts M.E., Dennis M.F., Jones N.R., Stratford M.R.L. A comparison of the intracellular uptake and radiosensitization efficiency in different media of unchanrged 2-nitroimidazoles of varying lipophilicity. International Journal of Radiation Biology 1987; 52: 359–370
   Web of Science ®Google Scholar
• Watts M.E., Hodgkiss R.J., Jones N.R., Fowler J.F. Radiosensitization of Chinese hamster cells by oxygen and misonidazole at low X-ray doses. International Journal of Radiation Biology 1986; 50: 1009–1021
   Web of Science ®Google Scholar