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Original Article

The Effect of the Radioprotector WR-2721 and WR-1065 on Mitochondrial Lipid Peroxidation

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Pages 467-478 | Received 06 Jun 1989, Accepted 04 Oct 1989, Published online: 03 Jul 2009

References

  • Bernath P., Singer T.P. Succinate dehydrogenase. Methods in Enzymology, S. Colowick, N.O. Kaplan. Academic Press, New York 1962; V: 597–614
  • Biaglow J.E., Varnes M.E., Astor M., Mitchell J., Russo A. Intracellular thiols: involvement in drug metabolism and radiation responses. Radioprotectors and Anticarcinogens, O.F. Nygaard, M.G. Simic. Academic Press, New York 1983; 203–236
  • Bindoli A. Lipid peroxidation in mitochondria. Free Radical Biology and Medicine 1988; 5: 247–261
  • Brigelius R. Mixed disulfide: biological functions and increase in oxidative stress. Oxidative Stress, H. Sies. Academic Press, London 1985; 243–272
  • Buege J.A., Aust S.D. Microsomal lipid peroxidation. Methods in Enzymology, S. Fleischer, L. Packer. Academic Press, New York 1978; LII: 302–310
  • Chance B., Sies H., Boveris A. Hydroperoxide metabolism in mammalian organs. Physiological Reviews 1979; 59: 527–605
  • Cleland W.W., Thompson V.W., Barden R.E. Isocitrate dehydrogenase (TPN-specific) from pig heart. Methods in Enzymology, J.M. Lowenstein. Academic Press, New York 1969; XIII: 30–33
  • Durand R.E. Radioprotection by WR-2721 in vitro at low oxygen tensions: implications for its mechanism of action. British Journal of Cancer 1983; 47: 387–392
  • Ellman G.L. Tissue sulfhydryl groups. Archives of Biochemistry 1959; 82: 70–77
  • Fiske H.G., Subba-Row Y. The colorimetric determination of phosphorus. Journal of Biological Chemistry 1925; 66: 375–400
  • Flohé J. Glutathione peroxidase brought into focus. Free Radicals in Biology, W.A. Pryor. Academic Press, New York 1982; V: 223–254
  • Forman H.J., Boveris A. Superoxide radical and hydrogen peroxide in mitochondria. Free radicals in Biology, W.A. Pryor. Academic Press, New York 1982; V: 65–90
  • Gornall A.G., Bardawill C.J., David M.M. Determination of serum proteins by means of the biuret method. Journal of Biological Chemistry 1949; 177: 751–766
  • Green R.C., Little C., O'Brien P.J. The inactivation of isocitrate dehydrogenase by a lipid peroxide. Archives of Biochemistry and Biophysics 1971; 142: 598–605
  • Heath R.L., Tappel A.L. A new sensitive assay for the measurement of hydroperoxides. Analytical Biochemistry 1976; 76: 184–191
  • Jocelyn P.C. Some properties of mitochondrial glutathione. Biochimica et Biophysica Acta 1975; 369: 427–436
  • Katki A.G., Myers C.E. Membrane-bound glutathione peroxidase-like activity in mitochondria. Biochemical and Biophysical Research Communications 1980; 96: 85–91
  • Kergonou J.F., Braquet M., Rocquet G. Influence of whole body irradiation upon rat liver mitochondrial fractions. Radiation Research 1981; 88: 377–384
  • Knizer S.A., Jacobs A.J., Lyon R.C., Swenberg C.E. In vivo dephosphorylation of WR-2721 monitored by 31P NMR spectroscopy. Journal of Pharmacology and Experimental Therapeutics 1986; 236: 37–40
  • Kunimoto M., Inoue K., Nojima S. Effect of ferrous ion and ascorbate-induced lipid peroxidation on liposomal membranes. Biochimica et Biophysica Acta 1981; 646: 169–178
  • Purdie J.W., Inhaber R.E., Schneider R., Labelle L. Interaction of cultured mammalian cells with WR-2721 and its thiol, WR-1065: implication for mechanisms of radioprotection. International Journal of Radiation Biology 1983; 43: 517–527
  • Raleigh J.A., Kremers W., Gaboury B. Dose-rate and oxygen effects in models of lipid membranes: linoleic acids. International Journal of Radiation Biology 1977; 31: 203–213
  • Rasey J.S., Nelson N.J., Mahler P., Anderson K., Krohn K.A., Menard T. Radioprotection of normal tissues against gamma rays and cyclotron neutrons with WR-2721: LD50 studies and 35S-WR2721 biodistribution. Radiation Research 1984; 97: 598–607
  • Rónai É., Tretter L., Szabados Gy., Horváth I. The inhibitory effect of succinate on radiation-enhanced mitochondrial lipid peroxidation. International Journal of Radiation Biology 1987; 51: 611–617
  • Soper J.W., Pedersen P.L. Isolation of oligomycin-sensitive ATPase complex from rat liver mitochondria. Methods in Enzymology, S. Fleischer, L. Packer. Academic Press, New York 1979; LV: 328–333
  • Steel L., Jacobs A., Giambaressi L.I., Jackson W.E. Protection of mice against fission neutron irradiation by WR-2721 or WR-151327. Radiation Research 1987; 109: 469–478
  • Szabados Gy., Andó A., Tretter L., Horváth I. The effect of succinate on mitochondrial lipid peroxidation. Journal of Bioenergetics and Biomembranes 1987; 19: 21–30
  • Takahashi I., Nagai T., Miyaishi K., Maehara Y., Niibe H. Clinical study of the radioprotective effects of amifostine (YM-08310, WR-2721) on chronic radiation injury. International Journal of Radiation Oncology, Biology, Physics 1986; 12: 935–938
  • Takayanagi R., Takeshige K., Minakami S. NADH- and NADPH-dependent lipid peroxidation in bovine heart submitochondrial particles. Biochemical Journal 1980; 192: 853–860
  • Tashildar H.I., Biaglow J.E., Kligerman M.M., Varnes M.E. Factors influencing the oxidation of the radioprotector WR-1065. Radiation Research 1988; 113: 243–251
  • Tien M., Bucher J.R., Aust S.D. Thiol-dependent lipid peroxidation. Biochemical and Biophysical Research Communications 1982; 107: 279–285
  • Utley J.F., Seaver B.A., Newton G.L., Fahey R.C. Pharmacokinetics of WR-1065 in mouse tissue following treatment with WR-2721. International Journal of Radiation Oncology, Biology, Physics 1984; 10: 1525–1528
  • Williams C.H., Kamin H. Microsomal triphosphopyridine nucleotidecytochrome c reductase of liver. Journal of Biological Chemistry 1962; 237: 587–592
  • Yukawa O., Nakazawa T. Radiation-induced lipid peroxidation and membrane-bound enzymes in liver microsomes. International Journal of Radiation Biology 1980; 37: 621–631
  • Yukawa O., Miyahara M., Shiraishi N., Nakazawa T. Radiation-induced damage to mitochondrial D-B-hydroxybutyrate dehydrogenase and lipid peroxidation. International Journal of Radiation Biology 1985; 48: 107–115

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