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Original Article

2-Deoxy-d-glucose Inhibits Rejoining of Radiation-induced DNA Double-strand Breaks in Yeast

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Pages 185-190 | Received 22 Feb 1991, Accepted 24 Jun 1991, Published online: 03 Jul 2009

References

  • Bender M.A., Griggs H.G., Bedford J.S. Mechanisms of chromosomal aberration production. III. Chemicals and ionizing radiation. Mutation Research 1974; 23: 197–212
  • Blöcher D., Pohlit W. DNA double strand breaks in Ehrlich ascites tumor cells at low doses of X-rays, II. Can all death be attributed to double strand breaks?. International Journal of Radiation Biology 1982; 42: 329–338
  • Brendel M., Fäth F.W. Isolation and characterization of mutants of Saccharomyces cerevisiae auxotrophic for 5′-dTMP. Zeitschrift für Naturforschung 1974; 29c: 733–738
  • Bryant P.E. Enzymatic restriction of mammalian cell DNA using Pvu II and Bam H1: evidence for the double-strand break origin of chromosomal aberrations. International Journal of Radiation Biology 1984; 46: 57–65
  • Dewey W.C., Furman S.C., Miller H.H. Comparison of lethality and chromosomal damages induced by X-rays in synchronized Chinese hamster cells in vitro. Radiation Research 1970; 43: 561–581
  • Dugle D.L., Gillespie C.J., Chapman J.D. DNA strand breaks, repair and survival in x-irradiated mammalian cells. Proceedings of the National Academy of Sciences, USA 1976; 73: 809–812
  • Dwarakanath B.S., Jain V.K. Energy linked modifications of the radiation reponse in a human cerebral glioma cell line. International Journal of Radiation Oncology, Biology and Physics 1989; 17: 1033–1040
  • Dwarakanath B.S., Jain V.K. Effects of gamma-rays and glucose analogs on the energy metabolism of a cell line derived from human cerebral glioma. Indian Journal of Biochemistry and Biophysics 1991; 28: 203–209
  • Frankenberg D. A ferrous sulphate dosemeter independent of photon energy in the range from 25 MeV up to 50 MeV. Physics in Medicine and Biology 1969; 14: 597–605
  • Frankenberg D., Frankenberg-Schwager M., Blöcher D., Harbich R. Evidence for DNA double-strand breaks as the critical lesions in yeast cells irradiated with sparsely or densely ionizing radiation under oxic or anoxic conditions. Radiation Research 1981; 88: 524–532
  • Frankenberg-Schwager M., Frankenberg D., Blöcher D., Adamczyk C. The influence of oxygen on the survival and yield of DNA double-strand breaks in irradiated yeast cells. International Journal of Radiation Biology 1979; 36: 261–270
  • Frankenberg-Schwager M., Frankenberg D., Blöcher D., Adamczyk C. Repair of DNA double-strand breaks in irradiated yeast cells under nongrowth conditions. Radiation Research 1980; 82: 498–510
  • Frankenberg-Schwager M., Frankenberg D., Harbich R. Potentially lethal damage, sublethal damage and DNA double-strand breaks. Radiation Protection Dosimetry 1985; 13: 171–174
  • Frankenberg-Schwager M., Frankenberg D., Harbich R. Potentially lethal damage repair is due to the difference of DNA double-strand break repair under immediate and delayed plating conditions. Radiation Research 1987; 111: 192–200
  • Frankenberg-Schwager M., Frankenberg D., Harbich R., Adamczyk C. A comparative study of rejoining of DNA double-strand breaks in yeast irradiated with 3·5 MeV α-particles or with 30 MeV electrons. International Journal of Radiation Biology 1990; 57: 1151–1168
  • Gupta I., Jain V.K., Mishra R.K. Studies on the effects of 2-deoxy-d-glucose on glucose uptake and glycolysis in respiratory-deficient yeast cells. Indian Journal of Experimental Biology 1981; 19: 231–237
  • Heredia C.F., De La Fuente G., Sols A. Metabolic studies with 2-deoxyhexoses. I. Mechanisms of inhibition of growth and fermentation in baker's yeast. Biochimica et Biophysica Acta 1964; 86: 216–223
  • Ho K.S.Y. Indication of DNA double-strand breaks by X-rays in a radiosensitive strain of the yeast Saccharomyces cerevisiae. Mutation Research 1975; 30: 327–334
  • Holahan P.K., Knizner S.A., Gabriel C.M., Swenberg C.E. Alterations in phosphate metabolism during cellular recovery of radiation damage in yeast. International Journal of Radiation Biology 1988; 54: 545–562
  • Holmsen H., Setkowski C.A., James D.H. Effects of antimycin and 2-deoxy-d-glucose on adenine nucleotides in human platelets. Biochemical Journal 1974; 144: 385–396
  • Jain V.K., Pohlit W. Influence of energy metabolism on the repair of X-ray damage in living cells. I. Effect of respiratory inhibitors and glucose on the liquid holding reactivation in yeast. Biophysik 1972; 8: 254–263
  • Jain V.K., Pohlit W., Purohit S.C. Influence of energy metabolism on the repair of X-ray damage in living cells. II. Effect of 2-deoxy-d-glucose on the liquid-holding reactivation in yeast. Biophysik 1973; 10: 137–142
  • Jain V.K., Biswas R.K., Chandra P. Effect of 2-deoxy-d-glucose on the liquid holding reactivation of yeast cells photodamaged by psoralen. Radiation and Environmental Biophysics 1976; 13: 75–77
  • Jain V.K., Höltz G.W., Pohlit W., Purohit S.C. Inhibition of unscheduled DNA synthesis and repair of potentially lethal X-ray damage by 2-deoxy-d-glucose in yeast. International Journal of Radiation Biology 1977a; 32: 175–180
  • Jain V.K., Purohit S.C., Pohlit W. Optimization of cancer therapy: I. Inhibition of repair of X-ray-induced potentially lethal damage by 2-deoxy-d-glucose in Ehrlich ascites tumour cells. Indian Journal of Experimental Biology 1977b; 15: 711–713
  • Jain V.K., Gupta I., Lata K. Energetics of cellular repair processes in a respiratory-deficient mutant in yeast. Radiation Research 1982; 92: 463–473
  • Jain V.K., Kalia V.K., Sharma R., Maharajan V., Menon M. Effects of 2-deoxy-d-glucose on glycolysis, proliferation kinetics and radiation response of human cancer cells. International Journal of Radiation Oncology, Biology and Physics 1985; 11: 943–950
  • Matsumoto S.S., Raivio K.O., Seegmiller J.E. Adenine nucleotide degradation during energy depletion in human lymphoblasts. Journal of Biological Chemistry 1979; 254: 8956–8962
  • Natarajan A.T., Obe G., von Zeeland A.A., Palitti F., Meijers M., Verdegaal-Immerzell E.A.M. Molecular mechanisms involved in the production of chromosomal aberrations. II. Utilization of Neurospora endonuclease for the study of aberration production by X-rays in G1 and G2 stages of the cell cycle. Mutation Research 1980; 69: 293–305
  • Resnick M.A. The repair of double-strand breaks in DNA: a model involving recombination. Journal of Theoretical Biology 1976; 59: 97–106
  • Resnick M.A., Martin P. The repair of double-strand breaks in the nuclear DNA of Saccharomyces cerevisiae and its genetic control. Molecular and General Genetics 1976; 143: 119–129
  • Thacker J. The nature of mutants induced by ionizing radiation in cultured hamster cells. III. Molecular characterization of HPRT deficient mutants induced by γ-rays or α-particles showing that the majority have deletion of all or part of hprt gene. Mutation Research 1986; 160: 267–275
  • Verma A., Sharma R., Jain V.K. Energetics of DNA repair in UV irradiated peripheral blood leukocytes from chronic myeloid leukemia patients. Photochemistry and Photobiology 1982; 36: 627–632
  • Wick A.N., Drury D.R., Nakada H.I., Wolfe J.B. Localization of the primary metabolic block produced by 2-deoxy-d-glucose. Journal of Biological Chemistry 1957; 224: 963–969
  • Woodward G.E. 2-deoxy-d-glucose an inhibitor in the aerobic glucose metabolism of yeast. Journal of the Franklin Institute 1952; 254: 553–555

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