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Original Article

Study of Dose-rate and Split-dose Effects on the in Vitro Micronucleus Yield in Human Lymphocytes Exposed to X-rays

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Pages 777-784 | Received 06 Aug 1991, Accepted 13 Nov 1991, Published online: 03 Jul 2009

References

  • Almassy Z., Krepinsky A.B., Blanco A., Koteles G.J. The present state and perspectives of micronucleus assay in radiation protection. Applied Radiation Isotopes 1987; 38: 241–249
  • Brewen J.G., Luippold H.E. Radiation induced human chromosome aberrations: in vitro dose rate studies. Mutation Research 1971; 12: 305–314
  • Countryman P.I., Heddle J.A. The production of micronuclei from chromosome aberrations in iradiated cultures of human lymphocytes. Mutation Research 1976; 41: 321–332
  • Curtis S.B. Lethal and potentially lethal lesions induced by radiation: a unified repair model. Radiation Research 1986; 106: 252–270
  • Edwards A.A., Lloyd D.C., Purrot R.J. Radiation induced chromosome aberrations and the Possion distribution. Radiation and Environmental Biophysics 1979; 16: 89–100
  • Fabry L., Coton C. Study on the repair of the radio induced lesions involved in the formation of chromosomal aberrations in Go human lymphocytes after exposure to gamma rays and fast neutrons. Mutation Research 1985; 149: 475–483
  • Fenech M., Morley A.A. Measurement of micronuclei in lymphocytes. Mutation Research 1985; 147: 29–36
  • Fenech M., Morley A.A. Cytokinesis-block micronucleus method in human lymphocytes: effect of in vivo aging and low dose X-iradiation. Mutation Research 1986; 161: 193–198
  • Holmberg M. On the time course of interactions between DNA breaks in the production of a radiation induced chromosome exchange aberration. Mutation Research 1990; 232: 267–272
  • Huber R., Streng S., Bauchinger M. The suitability of the human lymphocyte micronucleus assay system for biological dosimetry. Mutation Research 1983; 111: 185–193
  • Illiakis G. Workshop: lesions and processes underlying PLD repair in eucaryotes. Submitted to Radiation Research, A Twentieth-Century Perspective, J.D. Chapman, W.C. Dewey, G.F. Whitmore. Ninth International Congress of Radiation Research, Toronto July, 1991; II
  • Kormos C., Koteles G.J. Micronuclei in X-irradiated lymphocytes. Mutation Research 1988; 199: 31–35
  • Liniecky J., Bajerska A., Andryszek C. Chromosomal aberrations in human lymphocytes irradiated in vitro from donors (males and females) of varying age. International Journal of Radiation Biology 1971; 19: 349–360
  • Littlefield L.G., Sayer A.M., Frome E.L. Comparisons of dose-response parameters for radiation induced acentric fragments and micronuclei observed in cytokinesis arrested lymphocytes. Mutagenesis 1989; 4: 265–270
  • Lloyd D.C., Edwards A.A., Prosser J.S. Chromosome aberrations induced in human lymphocytes by in vitro acute X and gamma radiation. Radiation Protection Dosimetry 1986; 15: 83–88
  • Lloyd D.C., Purrott R.J., Dolphin G.W., Bolton D., Edwards A.A., Corp. M.J. The relationship between chromosome aberrations and low-LET radiation dose to human lymphocytes. International Journal of Radiation Biology 1975; 28: 75–90
  • Masunaga S., Ono K., Wandl E.O., Fushiki M., Abe M. Use of the MN assay for the selective detection of radiosensitivity in BUdR-unincorporated cells after pulse-labeling of exponentially growing tumour cells. International Journal of Radiation Biology 1990; 58: 303–311
  • Mayer P.J., Bradley M.O., Nichols W.W. Incomplete rejoining of DNA double-strand breaks in unstimulated normal human lymphocytes. Mutation Research 1986; 166: 275–285
  • Mayer P.J., Lange C.S., Bradley M.O., Nichols W.W. Age-dependent decline in rejoining of X-ray induced DNA dsb in normal human lymphocytes. Mutation Research 1989; 219: 95–100
  • Natarajan A.T., Darroudi F., Mullenders L.H.F., Meijers M. The nature and repair of DNA lesions that lead to chromosomal aberrations induced by ionizing radiations. Mutation Research 1986; 160: 231–236
  • Neary G.J. Chromosome aberrations and the theory of RBE. 1. General considerations. International Journal of Radiation Biology 1965; 9: 477–503
  • Peacock J.H., Burnet N.G. Radiosensitivity of normal cells measured using the MN assay. International Journal of Radiation Biology. September, 1991; 23–23, Workshop report, 2nd L. H. Gray workshop, Submitted
  • Pincu M., Bass D., Norman A. An improved micronuclear assay in lymphocytes. Mutation Research 1984; 139: 61–65
  • Prempree T., Merz T. Radiation sensitivity and repair time: the repair time of chromosome breaks produced during the different stages of the cell cycle. Mutation Research 1969; 7: 441–451
  • Prosser J.S., Moquet J.E., Lloyd D.C., Edwards A.A. Radiation induction of micronuclei in human lymphocytes. Mutation Research 1988; 199: 37–45
  • Purrott R.J., Reeder E. The effect of changes in dose rate on the yield of chromosome aberrations in human lymphocytes exposed to gamma radiation. Mutation Research 1976; 35: 437–444
  • Ramalho A., Sunjevaric I., Natarajan A.T. Use of the frequencies of micronuclei as quantitative indicators of X-ray-induced chromosomal aberrations in human peripheral blood lymphocytes: comparison of two methods. Mutation Research 1988; 207: 141–146
  • Savage J.R.K. Sites of radiation induced chromosome exchanges. Current Topics on Radiation Research 1970; 6: 129–194
  • Savage J.R.K. A comment on the quantitative relationship between micronuclei and chromosomal aberrations. Mutation Research 1988a; 207: 33–36
  • Savage J.R.K. Some comments on the relationship between chromosomal aberrations and MN. Clinical Cytogenetics Bulletin 1988b; 2: 32–34
  • Savage J.R.K. Acentric chromosomal fragments and MN: the time-displacement factor. Mutation Research 1989; 225: 171–173
  • Schmid E., Bauchinger M., Mergenthaler W. Analysis of the time relationship for the interaction of X-ray induced primary breaks in the formation of dicentric chromosomes. International Journal of Radiation Biology 1976; 30: 339–346
  • Scott D., Sharpe H.B.A., Batchelor A.L., Evans H.J., Papworth D.G. Radiation-induced chromosome damage in human peripheral blood lymphocytes in vitro. II. RBE and dose rate studies with 60Co gamma and X-rays. Mutation Research 1970; 9: 225–237
  • Seuntjens J., Thierens H., van der Plaetsen A., Segaert O. Conversion factor f for X-ray beam qualities, specified by peak tube potential and HVL value. Physics in Medicine and Biology 1987; 32: 595–603
  • Stefanescu D.T., Teodorescu M., Popescu H.I., Brucher J. Lack of recovery from radiation induced chromosome damage in G0 human lymphocytes. Experimental Cell Research 1972; 71: 156–160
  • Streffer C. Determination of MN in human tumours: predictive assay for radiosensitivity. International Journal of Radiation Biology. September, 1991; 21–21, Workshop report, 2nd L. H. Gray workshop, Submitted
  • Thierens, H., Vral, A., de Ridder, L. Biological dosimetry using the micronucleus assay for lymphocytes: interindividual differences in dose-response. Health Physics, In press, 1991
  • Thomson E.J., Perry P.E. The identification of micronucleated chromosomes: a possible assay for aneuploidy. Mutagenesis 1988; 3: 415–418
  • Virsik R.P., Harder D. Recovery kinetics of radiation induced chromosome aberrations in human G0 lymphocytes. Radiation Environmental Biophysics 1980; 18: 221–238
  • Virsik R.P., Harder D. Statistical intrpretation of the overdispersed distribution of radiation induced dicentric chromosome aberrations at high LET. Radiation Research 1981; 85: 13–23
  • Wandl E.O., Ono K., Kain R., Herbsthofer T., Hienert G., Hobarth K. Linear correlation between surviving fraction and the MN frequency. International Journal of Radiation Biology 1989; 56: 771–775
  • Wolff S. The repair of X-ray induced chromosome aberrations in stimulated and unstimulated human lymphocytes. Mutation Research 1972; 15: 435–444

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