4
Views
2
CrossRef citations to date
0
Altmetric
Original Article

Hypoxia-specific Inhibition of Recovery from Radiation Damage by a Novel 2-nitroimidazole with a Theophylline Side Chain

, &
Pages 797-803 | Received 24 Jun 1991, Accepted 11 Dec 1991, Published online: 03 Jul 2009

References

  • Adams G.E., Dische S., Fowler J.F., Thomlinson R.H. Hypoxic cell sensitisers in radiotherapy. Lancet. January, 1976; 186–188
  • Begg A.C., Hodgkiss R.J., Middleton R.W., McNally N.J., Stratford M.R.L., Terry N.H.A. Fluorescent markers for hypoxic cells: a comparison of two compounds on three cell lines in vitro. British Journal of Radiology 1985; 58: 645–654
  • Brown D.M., Dionett C., Brown J.M. Inhibition of X-ray-induced potentially lethal damage (PLD) repair in aerobic plateau-phase Chinese hamster cells by misonidazole. Radiation Research 1984; 97: 162–170
  • Brown J.M. Keynote address: Hypoxic cell radiosensitizers: where next?. International Journal of Radiation Oncology, Biology and Physics 1989; 16: 987–993
  • Busse P.M., Bose S.K., Jones R.W., Tolmach L.J. The action of caffeine on X-irradiated HeLa cells. III. Enhancement of X-ray-induced killing during G2 arrest. Radiation Research 1978; 76: 292–307
  • Chaplin D.J., Durand R.E., Olive P.L. Acute hypoxia in tumours: Implications for modifiers of radiation effects. International Journal of Radiation Oncology, Biology and Physics 1986; 12: 1279–1282
  • Chaplin D.J., Olive P.L., Durand R.E. Intermittent blood flow in a murine tumour: radiobiological effects. Cancer Research 1987; 47: 597–601
  • Coleman C.N., Wasserman T.H., Urtusan R.C., Halsey J., Noll L., Hancock S., Phillips T.L. Final report of the phase I trial of the hypoxic cell radiosensitizer SR 2508 (Etanidazole) radiation therapy oncology group 83-03. International Journal of Radiation Oncology, Biology and Physics 1990; 18: 389–393
  • Dische S. Chemical sensitizers for hypoxic cells: A decade of experience in clinical radiotherapy. Radiotherapy and Oncology 1985; 3: 91–115
  • Dische S., Saunders M.I., Flockhart I.R., Lee M.E., Anderson P. Misonidazole—a drug for trial in radiotherapy and oncology. International Journal of Radiation Oncology, Biology and Physics 1979; 5: 851–860
  • Hall E.J., Biaglow J. Ro-07-0582 as a radiosensitizer and cytotoxic agent. International Journal of Radiation Oncology, Biology and Physics 1977; 2: 521–530
  • Hall E.J., Miller R., Astor M., Rini F. The nitroimidazoles as radiosensitizers and cytotoxic agents. British Journal of Cancer 1978; 37(III)120–123
  • Hall E.J., Astor M., Osmak R., Shapiro P., August L. A comparison of two nitroimidazoles and a dihydroquinoline as radiosensitizers and cytotoxic agents. International Journal of Radiation Oncology, Biology and Physics 1979; 5: 1781–1786
  • Hodgkiss R.J., Jones G., Long A., Parrick J., Stratford M.R.L., Wilson G.D. Flow cytometric evaluation of hypoxic cells in solid experimental tumours using fluorescence immunodetection. British Journal of Cancer 1991; 63: 119–125
  • Hodgkiss R.J., Middleton R.W. Enhancement of misonidazole radiosensitization by an inhibitor of glutathione biosynthesis. International Journal of Radiation Biology 1983; 43: 179–183
  • Hodgkiss R.J., Middleton R.W. Effects of glutathione depletion using buthionine sulphoximine on the cytotoxicity of nitroaromatic compounds in mammalian cells in vitro. Biochemical Pharmacology 1985; 34: 2175–2178
  • Hodgkiss R.J., Stratford M.R.L. Competitive dose-modification between ascorbate and misonidazole in mammalian cells: effects of thiol depletion. International Journal of Radiation Biology 1988; 54: 601–610
  • Labanowska J., Beetham K.L., Tolmach L.J. Caffeine-induced modulation of the lethal action of X-rays on Chinese hamster V79 cells. Radiation Research 1988; 115: 176–186
  • Long A., Parrick J., Hodgkiss R.J. An efficient procedure for the 1-alkylation of 2-nitroimidazoles and the synthesis of a probe for hypoxia in solid tumours. Synthesis 1991; 9: 709–714
  • Musk S.R.R., Steel G.G. Override of the radiation-induced mitotic block in human tumour cells by methylxanthines and its relationship to the potentiation of cytotoxicity. International Journal of Radiation Biology 1990; 57: 1105–1112
  • Palcic B., Skarsgard L.D. Reduced oxygen enhancement ratio at low doses of ionizing radiation. Radiation Research 1984; 100: 328–339
  • Palcic B., Brosing J.W., Skarsgard L.D. Survival measurements at low doses: oxygen enhancement ratio. British Journal of Cancer 1982; 46: 980–984
  • Palcic B., Faddegon B., Skarsgard L.D. The effect of misonidazole as a hypoxic radiosensitizer at low dose. Radiation Research 1984; 100: 340–347
  • Skarsgard L.D., Harrison I., Durand R.E., Palcic B. Radiosensitization of hypoxic cells at low doses. International Journal of Radiation Oncology, Biology and Physics 1986; 12: 1075–1078
  • Trotter M.J., Chaplin D.J., Durand R.E., Olive P.E. The use of fluorescent probes to identify regions of transient perfusion in murine tumours. International Journal of Radiation Oncology, Biology and Physics 1989; 16: 931–934
  • Waldren C.A., Rasko I. Caffeine enhancement of X-ray killing in cultured human and rodent cells. Radiation Research 1978; 73: 95–110
  • Watts M.E., Woodcock M. Radiosensitization of Chinese hamster cells by pimonidazole (Ro 03-8799) at low X-ray doses. British Journal of Radiology 1991; 64: 971–974
  • Watts M.E., Hodgkiss R.J., Jones N.R., Fowler J.F. Radiosensitization of Chinese hamster cells by oxygen and misonidazole at low X-ray doses. International Journal of Radiation Biology 1986; 50: 1009–1021
  • Wong Y.W., Whitmore G.F., Gulyas S. Studies on the toxicity and radiosensitizing ability of misonidazole under conditions of prolonged incubation. Radiation Research 1978; 75: 541–555

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.