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Original Article

Effects of the Perfluorochemical Emulsion FMIQ on the Radiation Response of EMT6 Tumours

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Pages 833-839 | Received 23 Sep 1991, Accepted 10 Jan 1992, Published online: 03 Jul 2009

References

  • Biro G.P., Blais P. Perfluorocarbon blood substitutes. CRC Critical Reviews in Oncology/Hematology 1987; 6: 311–374
  • Dowling, S., Fisher, J.J., Rockwell, S. Fluosol and hyperbaric oxygen as an adjunct to radiotherapy in the treatment of malignant gliomas: a pilot study. Biomaterials Artificial Cells and Immobilization Biotechnology, In press, 1992
  • Evans R.G., Kimler B.F., Morantz R.A., Vats T.S., Gemer L.S., Liston V., Lowe N. A phase I/II study of the use of Fluosol® as an adjuvant to radiation therapy in the treatment of primary high-grade brain tumors. International Journal of Radiation Oncology, Biology and Physics 1990; 19: 415–420
  • Fischer J.J., Rockwell S., Martin D.F. Perfluorochemicals and hypberbaric oxygen in radiotherapy. International Journal of Radiation Oncology, Biology and Physics 1986; 12: 95–102
  • Fowler J.F. La Ronde: radiation sciences and medical radiology. Radiotherapy and Oncology 1983; 1: 1–22
  • Guichard M. The use of fluorocarbon emulsions in cancer radiotherapy. Radiotherapy and Oncology 1991; 20: 59–64
  • Lartigau E., Thomas C., Le Blanc M., Riess J., Long D., Long C., Malaise E.P., Guichard M. New high O2 carrying perfluorochemical emulsions: toxicity, radiosensitivity of GM-CFC and development of metastases in mice. International Journal of Radiation Oncology, Biology and Physics 1989; 16: 1153–1156
  • Lee I., Cunningham W.P., Levitt S.H. Improvement in RBC flux, acidosis, and oxygenation in the tumour microregions by Fluosol-DA 20%. International Journal of Radiation Biology 1991; 60: 695–705
  • Lustig R., McIntosh-Lowe N., Rose C., Haas J., Krasnow S., Spaulding M., Prosnitz I. Phase I/II study of Fluosol-DA and 100% oxygen as an adjuvant to radiation in the treatment of advanced squamous cell tumors of the head and neck. International Journal of Radiation Oncology, Biology and Physics 1989; 16: 1587–1593
  • Martin D.F., Porter E.A., Fischer J.J., Rockwell S. Effect of a perfluorochemical emulsion on the radiation response of BA1112 rhabdomyosarcomas. Radiation Research 1987; 112: 45–53
  • Mason K.A., Withers H.R., Steckel R.J. Acute effects of a perfluorochemical oxygen carrier on the normal tissues of the mouse. Radiation Research 1985; 104: 387–394
  • Mitsuno T., Ohyanagi H., Yokoyama K., Suyama T. Recent studies of perfluorochemical (PFC) emulsion as an oxygen carrier in Japan. Biomaterials, Artificial Cells, Artificial Organs 1988; 16: 365–373
  • Morton J.D., Porter E., Yabuki H., Nath R., Rockwell S. Effects of a perfluorochemical emulsion on the response of BA1112 rat rhabdomyosarcomas to continuous low dose rate irradiation. Radiation Research 1990; 124: 178–182
  • Moulder J.E., Fish B.L. Intermittent use of a perfluorochemical emulsion (Fluosol-DA 20%) and carbogen breathing with fractionated irradiation. International Journal of Radiation Oncology, Biology and Physics 1988; 15: 1193–1196
  • Moulder J.E., Rockwell S. Hypoxic fractions of solid tumors: Experimental techniques, methods of analysis, and a survey of existing data. International Journal of Radiation Oncology, Biology and Physics 1984; 10: 695–712
  • Moulder J.E., Rockwell S. Tumor hypoxia: Its impact on cancer therapy. Cancer Metastasis Review 1987; 5: 313–341
  • Riess J.G. Reassessment of criteria for the selection of perfluorochemicals for second-generation blood substitutes: analysis of structure/property relationships. Artificial Organs 1984; 8: 44–56
  • Riess J.G., Le Blanc M. Solubility and transport phenomena in perfluorochemicals relevant to blood substitution and biomedical applications. Pure and Applied Chemistry 1982; 54: 2383–2406
  • Riess J.G., Arlen C., Greiner J., Le Blanc M., Manfredi A., Pace S., Varescon C., Zarif L. Design, synthesis and evaluation of fluorocarbons and surfactants for in vivo applications new perfluoroalkylated polyhydroxylated surfactants. Biomaterials, Artificial Cells, Artificial Organs 1988; 16: 421–430
  • Rockwell S. In vivo-in vitro tumor systems: new models for studying the response of tumors to therapy. Laboratory Animal Sciences 1977; 27: 831–851
  • Rockwell S. Use of a perfluorochemical emulsion to improve oxygenation in a solid tumor. International Journal of Radiation Oncology, Biology and Physics 1985; 11: 97–103
  • Rockwell S. Tumor radiation response and tumor oxygenation in aging mice. Experimental Gerontology 1989a; 24: 37–48
  • Rockwell S. Emulsions d'agents perfluores et radiotherapie: revue des etudes precliniques. Cancer Communication 1989b; 3: 97–114
  • Rockwell S., Schultz R.J. Failure of 5-thio-d-glucose to alter cell survival in irradiated or unirradiated EMT6 tumors. Radiation Research 1984; 100: 527–535
  • Rockwell S., Irvin C.G., Kelley M. Preclinical studies of a perfluorochemical emulsion as an adjunct to radiotherapy. International Journal of Radiation Oncology, Biology and Physics 1988; 15: 913–920
  • Rockwell S., Irvin C.G., Kelley M., Hughes C.S., Yabuki H., Porter E., Fischer J.J. Effects of hyperbaric oxygen and a perfluorooctylbromide emulsion on the radiation responses of tumors and normal tissues in rodents. International Journal of Radiation Oncology, Biology and Physics 1991a; 22: 87–93
  • Rockwell S., Kelley M., Irvin C.G., Hughes C.S., Yabuki H., Porter E., Fischer J.J. Modulation of tumor oxygenation and radiosensitivity by a perfluorooctylbromide emulsion. Radiotherapy and Oncology 1991b; 22: 92–98
  • Rockwell S., Mate T.P., Irvin C.G., Nierenburg M. Reactions of tumors and normal tissues in mice to irradiation in the presence and absence of a perfluorochemical emulsion. International Journal of Radiation Oncology, Biology and Physics 1986; 12: 1315–1318
  • Song C.W., Lee I., Hasegawa T., Rhee J.G., Levitt S.H. Increase in pO2 and radiosensitivity of tumors by Fluosol-DA 20% and carbogen. Cancer Research 1987; 47: 442–446
  • Sostman H.D., Rockwell S., Sylvia A.L., Madwed D., Cofer G., Charles H.C., Negro-Vilar R., Moore D. Evaluation of BA1112 rhabdomyosarcoma oxygenation with microelectrodes, optical spectrophotometry, radiosensitivity, and magnetic resonanace spectroscopy. Magnetic Resonance in Medicine 1991; 20: 253–267
  • Suyama, T., Yokoyama, K., Naito, R. Development of a perfluorochemical whole blood substitute (Fluosol-DA 20%)—An overview of clinical studies with 185 patients. The Red Cell, G.S. Brewer, et al. Liss, New York 1981; 609–626, In
  • Teicher B.A., Herman T.S., Jones S.M. Optimization of perfluorochemical levels with radiation therapy in mice. Cancer Research 1989; 49: 2693–2697
  • Teicher B.A., Herman T.S., Jones S.M. Influence of scheduling, dose, and volume of administration of a perfluorochemical emulsion on tumor response to radiation therapy. International Journal of Radiation Oncology, Biology and Physics 1990; 19: 945–951
  • Teicher B.A., Rose C.M. Perfluorochemical emulsions can increase tumor radiosensitivity. Science 1984; 223: 934–936
  • Thomas C., Lartigau E., Malaise E.P., Guichard M. New high O2 carrying perfluorochemical emulsions and/or carbogen: reactions of a human tumor xenograft to irradiation. International Journal of Radiation Oncology, Biology and Physics 1989; 16: 1157–1160
  • Thomas C., Riess J., Guichard M. Influence of the 100% w/v perfluorooctylbromide (PFOB) emulsion dose on tumour radiosensitivity. International Journal of Radiation Biology 1991; 59: 433–445
  • Tsuda Y., Yamanouchi K., Okamoto H., Yokoyama K., Heldebrant C. Intravascular behavior of a perfluorochemical emulsion. Journal of Pharmacobiodynamics 1990; 13: 165–171

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