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Original Article

Detection of Single-strand Breaks and Base Damage in DNA of Blood Cells from Leukaemia Patients Receiving Chemo- and Radiotherapy

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Pages 33-43 | Received 03 Sep 1991, Accepted 27 Jan 1992, Published online: 03 Jul 2009

References

  • Baker M.C., Lawler S.D., Harris H., Barret A., Powles R.L. Radiation damage in patients treated by total-body irradiation, bone-marrow grafting and cyclosporin. Radiation Research 1986; 105: 413–424
  • Birnboim H.C., Jevcak J.J. Fluorometric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation. Cancer Research 1981; 41: 1889–1892
  • Carbonell F., Ganser A., Fliedner T.M., Kubanek B. The fate of cells with chromosome aberrations after total-body irradiation and bone-marrow transplantation. Radiation Research 1983; 93: 453–460
  • Carrier W.L., Setlow R.B. Endonuclease from Micrococcus luteus which has activity toward ultraviolet-irradiated deoxyribonucleic acid: purification and properties. Journal of Bacteriology 1970; 102: 178–186
  • Cerutti P.A. Prooxidant states and tumour promotion. Science 1985; 227: 375–381
  • Chresta C.M., Crook T.M., Souhami R.L. Depletion of cellular glutathione by N,N′-bis(trans-4-hydroxy-cyclohexyl)-N′-nitrosourea as a determinant of sensitivity of K562 human leukemia cells to 4-hydroperoxycyclophosphamide. Cancer Research 1990; 50: 4067–4071
  • Chung F.L., Young R., Hecht S.S. Formation of cyclic 1,N2-propanodeoxyguanosine adducts in DNA upon reaction with acrolein or crotonaldehyde. Cancer Research 1984; 44: 990–995
  • Cosset J.M., Baume D., Pico J.L., Girinski T., Benhamou E., Briot E., Malaise E., Hayat M., Dutreix J. Single dose versus hyperfractionated total body irradiation before allogeneic bone marrow transplantation: a non-randomized comparative study of 54 patients at the Institute Gustave-Roussy. Radiotherapy and Oncology 1989; 15: 151–160
  • Crook T.R., Souhami R.L., McLean A.E.M. Cytotoxicity, DNA cross-linking, and single-strand breaks induced by activated cyclophosphamide and acrolein in human leukaemia cells. Cancer Research 1986; 46: 5029–2034
  • Deeley J.O., Moore J.L. Nuclear lysate sedimentation measurements of peripheral blood lymphocytes from radiotherapy patients. International Journal of Radiation Biology 1989; 56: 963–973
  • DeNeve W., Valeriote F., Edelstein M., Everett C., Bischoff M. In vivo DNA cross-linking by cyclophosphamide: Comparison of human chronic lymphatic leukaemia cells with mouse L1210 leukaemia and normal bone marrow cells. Cancer Research 1989; 49: 3452–3456
  • De Witte T., Hoogenhout J., De Pauw B., Holdrinet R., Janssen J., Wessels J., VanDaal W., Hustinx T., Haanen C. Depletion of donor lymphocytes by counterflow centrifugation successfully prevents acute graft versus host disease in matched allogeneic bone-marrow transplantation. Blood 1986; 67: 1302–1308
  • Erickson L.C., Ramonas L.M., Zaharko D.S., Kohn K.W. Cytotoxicity and DNA cross-linking, activity of 4-sulfidocyclophosphamides in mouse leukaemia cells in vitro. Cancer Research 1980; 40: 4216–4220
  • Fornace A.J., Jr. Measurement of M. luteus endonuclease-sensitive lesions by alkaline elution. Mutation Research 1982; 94: 263–276
  • Fornace A.J., Jr., Kinsella T.J., Dobson P.P., Mitchell J.B. Repair of ionizing radiation DNA base damage in Ataxia-Telangiectasia cells. Cancer Research 1986; 46: 1703–1706
  • Franssen C., Boekema P., De Witte T., Wessels J., Van Der Kogel A., Haanen C. DNA strand breaks in human leukocytes induced by chemotherapy and total body irradiation. Leukemia Research 1990; 14: 91–97
  • Guerro I.M., Villasante A.V., Corces V., Pellicer A. Activation of a c-K-ras oncogene by somatic mutation in mouse lymphomas induced by gamma radiation. Science 1984; 225: 1159–1162
  • Heinze B., Arnold R., Kratt E., Zick L., Fliedner T.M. Chromosome aberrations in the peripheral blood of leukaemic patients prior to and after bone marrow transplantation. European Society for Radiation Biology, book of abstracts 22nd annual meeting, Brussels, Belgium 1989; 133–133
  • Hentosh P. Induction and repair of DNA damage in γ-irradiated human lymphoblasts: Irradiation in the presence and absence of misonidazole. Radiation Research 1988; 115: 436–447
  • Jorgensen T.J., Kow Y.W., Wallage S.S., Henner W.D. Mechanisms of action of Micrococcus luteus γ-endonuclease. Biochemistry 1987; 26: 6436–6443
  • Jorgensen T.J., Furlong E.A., Henner W.D. Gamma endonuclease of Micrococcus luteus: Action on irradiated DNA. Radiation Research 1988; 114: 556–566
  • Lartigue-Mattei C., Chabard J.L., Touzet C., Chollet P., Plagne R., Petit J., Berger J.A. Pharmacokinetics of cyclophosphamide administered alone or in combination with vindesin or cisplatin in 5 patients with bronchial adenocarcinoma. Biomedical and Pharmacotherapeutics 1988; 42: 555–560
  • Little S.A., Mirkes P.E. DNA cross-linking and single-strand breaks induced by teratogenic concentrations of 4-hydroperoxycyclophosphamide and phosphoramide mustard in postimplantation embryos. Cancer Research 1987; 47: 5421–5426
  • Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • McWilliams R.S., Cross W.G., Kaplan J.G., Birnboim H.C. Rapid rejoining of DNA strand breaks in resting human lymphocytes after irradiation by low doses of 60Co-γ-rays or 14·6 MeV neutrons. Radiation Research 1983; 94: 499–507
  • Moore M.J., Hardy R.W., Thiessen J.J., Soldin S.J., Erlichman C. Rapid development of enhanced clearance after high-dose cyclophosphamide. Clinical Pharmacology and Therapeutics 1988; 44: 622–628
  • Nordenskjöld M., Söderhäll S., Moldéus P. Studies of DNA-strand breaks induced in human fibroblasts by chemical mutagens/carcinogens. Mutation Research 1979; 63: 393–400
  • Powis G., Reece P., Ahnmann D.L., Ingle J.N. Effect of body weight on the pharmacokinetics of cyclophosphamide in breast cancer patients. Cancer Chemotherapy and Pharmacology 1987; 20: 219–222
  • Raemaekers J., De Witte T., Schattenberg A., Van Der Lely N. Prevention of leukaemic relapse after transplantation with lymphocyte-depleted marrow by intensification of the conditioning regimen with a 6-day continuous infusion of anthracyclines. Bone Marrow Transplantation 1989; 4: 167–171
  • Rauscher H., Bauchinger M. Chromosome aberrations induced in patients treated with chemotherapeutic drugs and irradiation for acute lymphatic leukaemia. Human Genetics 1983; 64: 73–79
  • Schmitz N., Gödde-Salz E., Löffler H. Cytogenetic studies on recipients of allogeneic bone-marrow transplants after fractionated total-body irradiation. British Journal of Hematology 1985; 60: 239–244
  • Schutte H.H., Van der Schans G.P., Lohman P.H.M. Comparison of induction and repair of adducts and alkali-labile sites in human lymphocytes and granulocytes after exposure to ethylating agents. Mutation Research 1988; 194: 23–38
  • Skare J.A., Schrotel K.R. Alkaline elution of rat testicular DNA: detection of DNA cross-links after in vivo treatment with chemical mutagens. Mutation Research 1984; 130: 295–303
  • Smith R.A., Sysel I.A., Tibbels T.S., Cohen S.M. Implications for the formation of a-basic sites following modification of polydeoxycytidylic acid by acrolein in vitro. Cancer Letters 1988; 40: 103–109
  • Van den Akker J., Gorin N.C., Laporte J.P., Douay L., Lopez M., Taillemite J.L., Najman A., Duhamel G. Chromosome abnormalities after autologous bone-marrow transplantation with marrow treated by cyclophosphamide derivatives. The Lancet May, 1985; 1211–1212, 25
  • Van der Schans G.P., Plooy A.C.M., Berends F. Distribution of molecular weights in alkalidenatured DNA samples with randomly induced singlestrand breaks and interstrand crosslinks. Cancer Research 1984; 44: 2049–2050
  • Van der Schans G.P., Groenendijk R.H., Lohman P.H.M. Sensitive detection of single-strand breaks in DNA after in vivo exposure to ionizing radiation to evaluate the effects of protecting agents. Pharmacology and Therapeutics 1988; 39: 147–148
  • Van der Schans G.P., Van Loon A.A.W.M., Groenendijk R.H., Baan R.A. Detection of DNA-damage in cells exposed to ionizing radiation by use of anti-single-stranded DNA monoclonal antibody. International Journal of Radiation Biology 1989; 55: 747–760
  • Van Loon A.A.W.M., Groenendijk R.H., Timmerman A.J., van der Schans G.P., Lohman P.H.M., Baan R.A. Quantitative detection of DNA damage in cells after exposure to ionizing radiation by an improved immunochemical assay. Mutation Research 1991a, in press
  • Van Loon A.A.W.M., Groenendijk R.H., Van der Schans G.P., Lohman P.H.M., Baan R.A. Detection of base damage in DNA in human blood exposed to ionizing radiation at biologically relevant doses. International Journal of Radiation Research 1991b; 59: 651–660

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