Effects of WR-1065 and WR-151326 on Survival and Neoplastic Transformation in C3H/10T½ Cells Exposed to TRIGA or JANUS Fission Neutrons

References

• Afzal S.M.J., Ainsworth E.J. Radioprotection of mouse colony forming units-spleen against heavy-charged particle damage by WR2721. Radiation Research 1987; 109: 118–126
   PubMed Web of Science ®Google Scholar
• Aguilera J.A., Newton G.L., Fahey R.C., Ward J.F. Thiol uptake by Chinese hamster cells and aerobic radioprotection as a function of the net charge on the thiol. Radiation Research 1992; 130: 194–204
   PubMed Web of Science ®Google Scholar
• Balcer-Kubiczek E.K., Harrison G.H. Oncogenic transformation of C3H/10T½ cells by X-rays, fastfission neutrons, and cyclotron-produced neutrons. International Journal of Radiation Biology 1983; 44: 377–386
   Web of Science ®Google Scholar
• Balcer-Kubiczek E.K., Harrison G.H. ‘Inter silvas Academi quarere verum’: reply to Letter to the Editor by M. M. Elkind. International Journal of Radiation Biology 1991; 59: 1477–1482
   Web of Science ®Google Scholar
• Balcer-Kubiczek E.K., Harrison G.H., Thompson B.W. Repair time for oncogenic transformation in C3H/10T½ cells subjected to protracted X-irradiation. International Journal of Radiation Biology 1987; 51: 219–226
   Web of Science ®Google Scholar
• Balcer-Kubiczek E.K., Harrison G.H., Zeman G.H., Mattson P.J., Kunska A. Lack of inverse dose-rate effect on fission neutron induced transformation of C3H/10T½ cells. International Journal of Radiation Biology 1988; 54: 531–536
   PubMed Web of Science ®Google Scholar
• Balcer-Kubiczek E.K., Harrison G.H., Hei T.K. Neutron dose-rate experiments at the AFRRI nuclear reactor. Radiation Research 1991; 128: S65–S70
   PubMedGoogle Scholar
• Biaglow J.E., Issels R.W., Gerweck L.E., Varnes M.E., Jacobson B., Mitchell J.B., Russo A. Factors influencing the oxidation of cysteamine and other thiols: implication fo. hyperthermic sensitization and radiation protection. Radiation Research 1984; 100: 298–312
   PubMed Web of Science ®Google Scholar
• Calabro-Jones P.M., Aquilera J.A., Ward J.F., Smoluk G.D., Fahey R.C. Uptake of WR-2721 derivatives by cells in culture: identification of the transported form of the drug. Cancer Research 1988; 48: 3634–3640
   PubMed Web of Science ®Google Scholar
• Carnes B.A., Grdina D.J. In vivo protection by the aminothiol WR-2721 against neutron-induced carcinogenesis. International Journal of Radiation Biology 1992; 61: 567–576
   PubMed Web of Science ®Google Scholar
• Corn B.W., Liber H.L., Little J.B. Differential effects of radical scavengers on X-ray-induced mutation and cytotoxicity in human cells. Radiation Research 1987; 109: 100–108
   PubMed Web of Science ®Google Scholar
• Dennis M.F., Stratford M.R.L., Wardman P., Watfa R.R. Increase in intracellular cysteine after exposure to dithiothreitol: implications in radiobiology. International Journal of Radiation Biology 1989; 56: 877–883
   PubMed Web of Science ®Google Scholar
• Ellman G.L. Tissue sulfhydryl groups. Archives of Biochemistry and Biophysics 1959; 82: 70–77
   PubMed Web of Science ®Google Scholar
• Grdina D.J., Sigdestad C.P. Radiation protectors: the unexpected benefits. Drug Metabolism Reviews 1989; 20: 13–42
   PubMed Web of Science ®Google Scholar
• Grdina D.J., Peraino C., Carnes B.A., Hill C.K. Protective effect of S-2-(3-aminopropylamino) ethyl phosphorothioic acid against induction of altered hepatocyte foci in rats treated once with gamma radiation within one day after birth. Cancer Research 1985a; 45: 5379–5381
   PubMed Web of Science ®Google Scholar
• Grdina D.J., Nagy B., Hill C.K., Wells R.L., Peraino C. The radioprotector WR1065 reduces radiation-induced mutations at the hypoxanthine phosphoribosyl transferase locus in V79 cells. Carcinogenesis 1985b; 6: 929–931
   PubMed Web of Science ®Google Scholar
• Grdina D.J., Sigdestad C.P., Carnes B.A. Protection by WR1065 and WR151326 against fissionneutron induced mutation at the hgprt locus in V79 cells. Radiation Research 1989a; 117: 500–510
   PubMed Web of Science ®Google Scholar
• Grdina D.J., Nagy B., Hill C.K., Sigdestad C.P. Protection against radiation-induced mutagenesis in V79 cells by 2-[(aminopropyl)-amino]ethanethiol under conditions of acute hypoxia. Radiation Research 1989b; 117: 251–258
   PubMedGoogle Scholar
• Grdina D.J., Wright B.J., Carnes B.A. Protection by WR-151327 against late-effects damage from fission-spectrum neutrons. Radiation Research 1991; 128: S124–S127
   Google Scholar
• Han A., Elkind M.M. Transformation of mouse C3H/10T½ cells and single and fractionated doses of X-rays and fission-spectrum neutrons. Cancer Research 1979; 39: 123–130
   PubMed Web of Science ®Google Scholar
• Harrison G.H., Balcer-Kubiczek E.K. The oxygen enhancement ratio for d(80)+(Be+Ta) and d(80)+(Ta+Be) neutrons. Radiation Research 1980; 83: 90–98
   PubMedGoogle Scholar
• Held K.D., Melder D. Toxicity of the sulfhydrylcontaining radioprotector dithiothreitol. Radiation Research 1987; 112: 544–554
   PubMedGoogle Scholar
• Hendry J.H. The slower cellular recovery after higher-LET irradiations, including focuses on the quality of DNA breaks. Radiation Research 1991; 128: S114–S116
   Google Scholar
• Hieber L., Ponsel G., Roos H., Fenn S., Fromke E., Kellerer A.M. Absence of a dose rate effect in the transformation of C3H/10T½ cells by α-particles. International Journal of Radiation Biology 1987; 52: 859–869
   Web of Science ®Google Scholar
• Hill C.K., Buonoguro F.M., Myers C.P., Han A., Elkind M.M. Fission-spectrum neutrons at reduced dose rate enhance neoplastic transformation. Nature 1982; 298: 67–68
   PubMed Web of Science ®Google Scholar
• Hill C.K., Nagy B., Peraino C., Grdina D.J. 2-(Aminopropyl(ethanethiol (WR-1065) is anti-neoplastic and anti-mutagenic when given during 60Co gammaray irradiation. Carcinogenesis 1986; 7: 665–668
   PubMed Web of Science ®Google Scholar
• IARC/NCI/EPA Working Group. Cellular and molecular mechanisms of cell transformation and standardization of transformation assays of established cell lines for prediction of carcinogenic chemicals: overview and recommended protocols. Cancer Research 1985; 45: 2395–2399
   Web of Science ®Google Scholar
• Livesy J.C., Reed D.J. Chemical protection against ionizing radiation. Advances in Radiation Biology 1987; 13: 285–341
   Google Scholar
• Maisin J.R., Mattelin G., Lambiet-Collier M. Chemical protection against the long-term effects of a single whole-body exposure of mice to ionizing radiation. II. Cause of death. Radiation Research 1978; 74: 415–435
   PubMed Web of Science ®Google Scholar
• Marshall I.R., Wiliamson F.S. Microdosimetric spectra measurements of JANUS neutrons. Radiation Protection Dosimetry 1985; 13: 111–113
   Web of Science ®Google Scholar
• Marquardt H., Sapozink M.D., Zedeck M.S. Inhibition by cysteamine-HCl on oncogenesis induced by DMBA without affecting toxicity. Cancer Research 1974; 34: 3387–3390
   PubMed Web of Science ®Google Scholar
• Masuda K. Survival of synchronized L cells irradiated with 14 MeV neutrons. International Journal of Radiation Biology 1971; 20: 85–86
   Google Scholar
• Milas L., Hunter N., Stephens C.L., Peters L.J. Inhibition of radiation carcinogenesis by S-2-(3-aminopropyl-amino) ethyl phosphorothoic acid. Cancer Research 1984; 44: 5567–5569
   PubMed Web of Science ®Google Scholar
• Mori T., Watanabe M., Horikawa M., Nikaido P., Kimura H., Aoyama T., Sugahara T. WR-2721, its derivative and their radioprotective effects on mammalian cells in culture. International Journal Radiation Biology 1983; 44: 41–53
   Web of Science ®Google Scholar
• Murray D., Prager A., Vanankeren S.C., Altschuler E.M., Kerr M.S., Terry N.H.A., Milas L. Comparative effect of the thiols dithiothreitol, cysteamine and WR-151326 on survival and on the induction of DNA damage in cultured Chinese hamster ovary cells exposed to gamma radiation. International Journal of Radiation Biology 1990; 58: 71–91
   PubMed Web of Science ®Google Scholar
• Nagasawa H., Robertson J., Little J.B. Introduction of chromosomal aberrations and sister chromatid exchanges by alpha particles in density-inhibited cultures of 10T½ and 3T3 cells. International Journal of Radiation Biology 1990; 57: 735–744
   Google Scholar
• Nagy B., Grdina D.J. Protective effects of 2-[(amino-propyl) amino]ethanethiol against bleomycin and nitrogen mustard-induced mutagenicity in V79 cells. International Journal of Radiation Oncology, Biology and Physics 1986; 12: 1475–1478
   PubMed Web of Science ®Google Scholar
• Nagy B., Dale P.J., Grdina D.J. Protection against cis-diamine-di-chloroplatinum (ii) cytotoxicity and mutagenicity in V79 cells by free radical scavenger 2-[(aminopropyl) amino]-ethane-thiol. Cancer Research 1986; 46: 1132–1135
   PubMed Web of Science ®Google Scholar
• Nassi-Calo L., Mello-Filho A.C., Meneghini R. o-Phenanthroline protects mammalian cells from hydrogen peroxide-induced gene mutation and morphological transformation. Carcinogenesis 1989; 10: 1055–1057
   PubMed Web of Science ®Google Scholar
• Patt H.M., Tyree E.B., Straube R.L., Smith D.E. Cysteine protection against X-irradiation. Science 1949; 110: 213–214
   PubMed Web of Science ®Google Scholar
• Pike M.C., Alper T. A method for determining dose-modification factors. British Journal of Radiology 1964; 37: 458–462
   PubMed Web of Science ®Google Scholar
• Reznikoff C.A., Brankow D.W., Heidelberger C. Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to post-confluence inhibition of cell division. Cancer Research 1973a; 33: 3231–3238
   PubMed Web of Science ®Google Scholar
• Reznikoff C.A., Bertram J.S., Brankow D.W., Heidelberger C. Quantitative and qualitative studies of chemical transformation of cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of cell division. Cancer Research 1973b; 33: 3239–3249
   PubMed Web of Science ®Google Scholar
• Schwartz J.L., Giovanazzi S.M., Karrison T., Jones C., Grdina D.J. 2-[(Aminopropyl)amino]-ethanethiol-mediated reductions in 60Co gamma-ray and fission-spectrum neutron-induced chromosome damage in V79 cells. Radiation Research 1988; 113: 145–154
   PubMed Web of Science ®Google Scholar
• Sigdestad C.P., Grdina D.J., Connor A.M., Hanson W.R. A comparison of radioprotection from three neutron sources and 60Co by WR-2721 and WR-151327. Radiation Research 1986; 106: 224–233
   PubMed Web of Science ®Google Scholar
• Smoluk G.D., Fahey R.C., Calabro-Jones P.M., Aguilera J.A., Ward J.F. Radioprotection of cells in vitro by WR-2721 and derivatives: form of the drug responsible for protection. Cancer Research 1988; 48: 3641–3647
   PubMed Web of Science ®Google Scholar
• Steel L.K., Jacobs A.J., Giambarresi L.J., Jackson W.E., III. Protection of mice against fission neutron irradiation by WR-2721 or WR-151327. Radiation Research 1987; 109: 469–478
   PubMed Web of Science ®Google Scholar
• Suzuki S., Ngo F.Q.H., Koumoundourous I., Tourdot K.R., Roberts W.K. Survival responses and potentially lethal damage repair of normal 10T½ and its transformed TCL15 cells after irradiation with 43-MeV proton-produced neutrons. Acta Oncologica 1988; 27: 281–287
   PubMed Web of Science ®Google Scholar
• Suzuki Y., Lyall V., Biber T.U.L., Ford G.D. A modified technique for the measurement of sulfhydryl groups oxidized by reactive oxygen intermediates. Free Radical Biology and Medicine 1990; 9: 479–484
   PubMed Web of Science ®Google Scholar
• Terasima T., Yusukawa M., Kimura M. Neoplastic transformation of plateau-phase mouse 10T½ cells following single and fractionated doses of X-rays. Radiation Research 1985; 102: 367–377
   PubMedGoogle Scholar
• Van Ankeren S.C., Milas L., Murray D. Protection of cultured Chinese hamster cells by the aminothiol WR-255591 from the lethal and DNA-damaging effects of fast neutrons. International Journal of Radiation Oncology, Biology and Physics 1989; 16: 1205–1208
   PubMedGoogle Scholar
• Zeman G.H., Dooley M., Eagleson D.M., Goodman L., Schwartz R.B., Eisenhauer C.M., McDonald J.C. Intercomparison of neutron dosimetry techniques at the AFRRI TRIGA reactor. Radiation Protection Dosimetry 1988; 23: 317–320
   Web of Science ®Google Scholar