25
Views
26
CrossRef citations to date
0
Altmetric
Original Article

Radiation-induced DNA Damage and Repair in Radiosensitive and Radioresistant Human Tumour Cells Measured by Field Inversion Gel Electrophoresis

, &
Pages 703-713 | Received 29 Jun 1992, Accepted 16 Nov 1992, Published online: 03 Jul 2009

References

  • Begg A.C., Hofland I. Cell kinetic analysis of mixed populations using three-color fluorescence flow cytometry. Cytometry 1991; 12: 445–454
  • Blöcher D., Pohlit W. DNA double strand breaks in Ehrlich ascites tumor cells at low doses of X-rays. II. Can cell death be attributed to DNA double strand breaks?. International Journal of Radiation Biology 1982; 46: 57–65
  • Bryant P.E. Enzymatic restriction of mammalian cell DNA using Pvull and Bam HI: evidence for the double strand break origin of the chromosomal aberrations. International Journal of Radiation Biology 1984; 46: 57–65
  • Frankenberg D., Frankenberg-Schwager M., Blöcher D., Harbich R. Evidence for DNA double strand breaks as the critical lesions in yeast cells irradiated with sparsely or densely ionizing radiation under oxic or anoxic conditions. Radiation Research 1981; 88: 524–532
  • Garwood D.P., Thompson L.L., Dewey W.C. Use of used field gel electrophoresis to measure X-ray induced double-strand breaks in DNA substituted with BrdU. Radiation Research 1991; 128: 210–215
  • Giaccia A., Weinstein R., Hu J., Stamato T.D. Cell cycle dependent repair of double strand DNA breaks in a gamma-ray-sensitive Chinese Hamster cell. Somatic Cellular and Molecular Genetics 1985; 11: 485–491
  • Iliakis G.E., Metzger L., Denko N., Stamato T.D. Detection of DNA double strand breaks in synchronous cultures of CHO cells by means of asymmetric field inversion gel electrophoresis. International Journal of Radiation Biology 1991; 59: 321–341
  • Iliakis G.E., Metzger L., Muschel R.J., McKenna W.G. Induction and repair of DNA double strand breaks in radiation resistant cells obtained by transformation of primary rat embryo cells with the oncogenes H-ras and v-myc. Cancer Research 1991; 50: 6575–6579
  • Iliakis G.E., Okayasu R. Radiosensitivity throughout the cell cycle and repair of potentially lethal damage and DNA double strand breaks in an X-ray sensitive CHO mutant. International Journal of Radiation Biology 1990; 57: 1195–1211
  • Jeggo P.A., Kemp L.M. X-ray sensitive mutants of the Chinese hamster ovary cell line. Isolation and cross-sensitivity to other DNA damaging agents. Mutation Research 1983; 112: 313–327
  • Kelland L.R., Edwards S.M., Steel G.G. Induction and rejoining of DNA double strand breaks in human cervix carcinoma cell lines of differing radiosensitivity. Radiation Research 1988; 116: 526–538
  • McKenna W.G., Weiss M.C., Endlich B., Ling C.C., Bakanauskas V.J., Kelsten M.L., Muschel R.J. Synergistic effect of the v-myc oncogene with H-ras on radioresistance. Cancer Research 1990; 50: 97–102
  • Lehman A.R. The cellular and molecular responses of ataxia-telangiectasia cells to DNA damage. Ataxia-Telangiectasia, B.A. Bridges, D.G. Harndsen. Wiley, New York 1982; 83–101, In
  • Natarajan A.T., Obe A.T. Molecular mechanisms involved in the production of chromosomal aberrations: III. Restriction endonucleases. Chromasoma (Berlin) 1984; 90: 120–127
  • Painter R.B., Young B.R. Radiosensitivity in ataxia-telangiectasia: a new explanation. Proceedings of the National Academy of Science, USA 1980; 77: 7315–7317
  • Radford I. The level of induced DNA double strand breakage correlates with cell killing after irradiation. International Journal of Radiation Biology 1985; 48: 45–54
  • Schwartz J.L., Mustafi R., Beckett M.A., Czyzewski E.A., Farhangi E., Grdina D.J., Rotmensch J., Weischselbaum R.R. Radiation-induced DNA double strand break frequencies in human squamous cell carcinoma cell lines of different radiosensitivities. International Journal of Radiation Biology 1991; 59: 1341–1352
  • Schwartz J.L., Mustafi R., Beckett M.A., Weichselbaum R.R. Prediction of the radiosensitivity of human squamous cell carcinoma cells using DNA filter elution. Radiation Research 1990; 123: 1–6
  • Schwartz J.L., Rotmensch J., Giovanazzi S.M., Cohen M.B., Weichselbaum R.R. Faster repair of DNA double strand breaks in radioresistant human tumor cells. International Journal of Radiation Oncology Biology Physics 1988; 15: 907–912
  • Schwartz J.L., Vaughan T.M. Association among DNA/Chromosome break rejoining rates, chromatin structure alterations, and radiation sensitivity in human tumor cell lines. Cancer Research 1989; 49: 5054–5057
  • Stamato T.D., Denko N. Asymmetric field inversion gel electrophoresis: a new method for detecting DNA double strand breaks in mammalian cells. Radiation Research 1990; 121: 228–244
  • Thierry D., Rigaud O., Duranton I., Moustacchi E., Magdelenat H. Quantitative measurement of DNA strand breaks and repair in gamma-irradiated human leukocytes from normal and ataxia telangiectasia donors. Radiation Research 1985; 102: 347–358
  • Ueno A.M., Goldin E.M., Cox A.B., Lett J.T. Deficient repair and degradation of DNA in X-irradiated L5178Y R/S cells: cell-cycle and temperature dependence. Radiation Research 1979; 79: 377–389
  • Warters R.L., Lyons B.W. Detection of ionizing radiation induced DNA double strand breaks by filter elution is affected by nuclear chromatin structure. Radiation Research 1990; 124: 309–316
  • Weichselbaum R.R., Beckett M.A. The maximum recovery potential of human tumor cells may predict the clinical outcome in radiotherapy. International Journal of Radiation Oncology Biology Physics 1987; 13: 709–713
  • Weichselbaum R.R., Beckett M.A., Vijayakumar S., Simon M.A., Awan A.M., Nachman J., Ranje W.R., Goldman M.E., Tybor A.G., Morgan W.J., Vokes E.E., Ahmed-Swan S., Fahrangi E. Radiobiological characterization of head and neck sarcoma cells derived from patients prior to radiotherapy. International Journal of Radiation Oncology Biology Physics 1990; 19: 313–319
  • Weichselbaum R.R., Dahlberg W., Beckett M.A., Karrison T., Miller D., Clark J., Ervin T.J. Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients. Proceedings of the National Academy of Science, USA 1986; 83: 2684–2688
  • West C.M.L., Davidson S.E., Hendry J.H., Hunter R.D. Prediction of cervical carcinoma response to radiotherapy. Lancet 1991; 338: 818–818
  • Williams G.T. Programmed cell death; apoptosis and oncogenesis. Cell 1991; 65: 1097–1098
  • Wlodek D., Hittelman W.N. The repair of double strand DNA breaks correlates with radiosensitivity of L5178 Y-S and L5179 Y-R cells. Radiation Research 1987; 112: 146–155

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.