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Original Article

Early Chelation Therapy for Injected Pu-238 and Am-241 in the Rat: Comparison of 3,4,3-LIHOPO, DFO-HOPO, DTPA-DX, DTPA and DFOA

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Pages 785-793 | Received 10 Dec 1992, Accepted 11 Feb 1993, Published online: 03 Jul 2009

References

  • Durbin P.W., Jeung N., Rodgers S.J., Turowski P.N., Weitl F.L., White D.L., Raymond K.N. Removal of Pu-238(IV) from mice by polycatecholate, -hydroxamate, or -hydroxypyridonate ligands. Radiation Protection Dosimetry 1989 b; 26: 351–358
  • Durbin P.W., Jones E.S., Raymond K.N., Weitl F.L. Specific sequestring agents for the actinides: 4. Removal of Pu(IV)-238 from mice by sulfonated tetrameric catechoyl amides. Radiation Research 1980; 81: 170–187
  • Durbin P.W., White D.L., Jeung N., Weitl F.L., Uhlir L.C., Jones S.E., Bruenger F.W., Raymond K.N. Specific sequestring agents for the actinides: 18. In-vivo chelation of Pu-238(IV) by 3,4,3-LICAM(C): effects of ligand methylation and pH. Health Physics 1989a; 56: 839–855
  • Guilmette R.A., Muggenburg B.A. Reducing the radiation dose from inhaled Am-241 using continuously administered DTPA therapy. International Journal of Radiation Biology 1988; 53: 261–271
  • Lagerquist C.R., Putzier E.A., Piltingsrud C.W. Bioassay and body counter results for the first 2 years following an acute plutonium exposure. Health Physics 1967; 13: 965–972
  • Seidel A., Volf V. Rapid determination of some transuranium elements in biological material by liquid scintillation counting. International Journal of Applied Radiation and Isotopes 1972; 23: 1–4
  • Stradling G.N., Gray S.A., Ellender M., Moody J.C., Hodgson A., Pearce M., Wilson I., Burgada R., Bailly T., Leroux Y.G.P., El Manouni D., Raymond K.N., Durbin P.W. The efficacies of 3,4,3-LIHOPO and DTPA for enhancing the excretion of plutonium and americium from the rat: comparison with other siderophore analogues. International Journal of Radiation Biology 1992; 62: 487–497
  • Stradling, G.N., Gray, S.A., Ellender, M., Pearce, M., Wilson, I., Moody, J.C., Hodgson, A. Removal of inhaled plutonium and americium from the rat by administration of ZnDTPA in drinking water. Human and Experimental Toxicology, in press, 1993
  • Stradling G.N., Gray S.A., Moody J.C., Hodgson A., Raymond K.N., Durbin P.W., Rodgers S.J., White D.L., Turowski P.N. The efficacy of DFO-HOPO, DTPA-DX and DTPA for enhancing the excretion of plutonium and americium from the rat. International Journal of Radiation Biology 1991; 59: 1269–1277
  • Stradling G.N., Stather J.W., Gray S.A., Moody J.C., Ellender M., Hodgson A., Volf V., Taylor D.M., Wirth P., Gaskin P.W. The efficacies of pure LICAM(C) and DTPA on the retention of plutonium-238 and americium-241 in rats after their inhalation as nitrate and intravenous injection as citrate. International Journal of Radiation Biology 1989; 56: 503–514
  • Taylor D.M., Volf V. Oral chelation treatment of injected Am-241 or Pu-239 in rats. Health Physics 1980; 38: 147–158
  • Turowski P.N., Rodgers S.J., Scarrow R.C., Raymond K.N. Ferric ion sequestring agents. 18. Two hydroxamic acid derivatives of EDTA and DTPA. Inorganic Chemistry 1988; 27: 474–481
  • Volf V. Plutonium decorporation in rats: experimental evidence and practical implications. Diagnosis and Treatment of Incorporated Radionuclides. International Atomic Energy Agency, Vienna 1976; 307–322, In
  • Volf V. Treatment of Incorporated Transuranium Elements. Technical Reports Series No. 184, International Atomic Energy Agency, Vienna 1978
  • Volf V. Chelation therapy of incorporated plutonium-238 and americium-241: comparison of LICAM(C), DTPA and DFOA in rats, hamsters and mice. International Journal of Radiation Biology 1986; 49: 449–462
  • Volf V. Optimisation and status of chelation therapy. Radiation Protection Dosimetry 1989; 26: 331–335
  • White D.L., Durbin P.W., Jeung N., Raymond K.N. Specific sequestring agents for the actinides: 16. Synthesis and initial biological testing of polydentate oxohydroxypyridine carboxylate ligands. Journal of Medicinal Chemistry 1988; 31: 11–18

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