14
Views
26
CrossRef citations to date
0
Altmetric
Original Article

Molecular Determinants of Radiosensitivity in Mammalian Cells

&
Pages 49-55 | Received 26 Jul 1993, Accepted 15 Sep 1993, Published online: 03 Jul 2009

References

  • Alaoui-Jamali M.A., Batist G., Lehnert S. Radiation-induced damage to DNA in drug- and radiation-resistant sublines of a human breast cancer cell line. Radiation Research 1992; 129: 37–42
  • Bedford J.S. Sublethal damage, potentially lethal damage, and chromosomal aberrations in mammalian cells exposed to ionizing radiation. International Journal of Radiation Oncology, Biology and Physics 1991; 21: 1457–1469
  • Blöcher D., Sigut D., Hannan M.A. Fibroblasts from ataxia-telangiectasia (AT) and AT heterozygotes show an enhanced level of residual DNA double-strand breaks after low dose-rate gamma-irradiation as assayed by pulsed field gel electrophoresis. International Journal of Radiation Biology 1991; 60: 791–802
  • Burnet N.G., Nyman J., Turesson I., Wurm R., Yarnold J.R., Peacock J.H. Prediction of normaltissue tolerance to radiotherapy from in vitro cellular radiation sensitivity. Lancet 1992; 339: 1570–1571
  • Carmichael J., Park J.G., Degraff W.G., Gamson J., Gazdar A.F., Mitchell J.B. Radiation sensitivity and study of glutathione and related enzymes in human colorectal cancer cell lines. European Journal of Cancer and Clinical Oncology 1988; 24: 1219–1224
  • Cheong N., Wang Y., Jackson M., Iliakis G. Radiation-sensitive irs mutants rejoin DNA double-strand breaks with efficiency similar to that of parental V79 cells but show altered response to radiation-induced G2 delay. Mutation Research 1992; 274: 111–122
  • Chiu S.-M., Friedman L.R., Oleinick N.L. Formation and repair of DNA-protein crosslinks in newly replicated DNA. Radiation Research 1989; 120: 545–551
  • Chiu S.-M., Oleinick N.L. The sensitivity of active and inactive chromatin to ionizing radiation-induced DNA strand breakage. International Journal of Radiation Biology 1982; 41: 71–77
  • Chiu S., Oleinick N.L., Friedman L.R., Stambrook P.J. Hypersensitivity of DNA in transcriptionally active chromatin to ionizing radiation. Biochimica et Biophysica Acta 1982; 699: 15–21
  • Cornforth M.N., Bedford J.S. On the nature of a defect in cells from individuals with ataxia-telangiectasia. Science 1985; 227: 1589–1591
  • Cornforth M.N., Bedford J.S. A quantitative comparison of potentially lethal damage repair and the rejoining of interphase chromosome breaks in low passage normal human fibroblasts. Radiation Research 1987; 111: 385–405
  • Debenham P.G., Webb M.B.T., Stretch A., Thacker J. Examination of vectors with two dominant, selectable genes for DNA repair and mutation studies in mammalian cells. Mutation Research 1988; 199: 145–158
  • Evans H.H., Mencl J., Horng M.F., Ricanati M., Sanchez C., Hozier J. Locus specificity in the mutability of L5178Y mouse lymphoma cells: the role of multi locus lesions. Proceedings of the National Academy of Sciences 1986; 83: 4379–4383
  • Frankenberg D., Frankenberg-Schwager M., Harbich R. Interpretation of the shape of survival curves in terms of induction and repair/misrepair of DNA double-strand breaks. British Journal of Cancer 1984; 49(Suppl. VI)233–238
  • Green A., Pager A., Stout P.M., Murray D. Relationships between DNA damage and the survival of radiosensitive mutant Chinese hamster cell lines exposed to gamma-radiation. Part 1: intrinsic radiosensitivity. International Journal of Radiation Biology 1992; 61: 465–472
  • Hendrickson E.A., Qin X., Bump E.A., Schatz D.A., Oettinger M., Weaver D.T. A link between double-strand break-realted repair and V(D)J recombination: the SCID mutation. Proceedings of the National Academy of Sciences 1991; 88: 4061–4065
  • Hutchinson F. On the measurement of DNA double-strand breaks by neutral elution. Radiation Research 1989; 120: 182–186
  • Iliakis G. The role of DNA double-strand breaks in ionizing radiation-induced killing of eukaryotic cells. Bioessays 1991; 13: 641–648
  • Jayanth R.V., Hittelman W.N. 9-β-d-Arainofuranosyl-2-fluoroadenine (F-Ara-A) inhibits both the fast and slow components of chromosome repair. Radiation Research: A Twentieth-Century Perspective, J.D. Chapman, W.C. Dewey, G.F. Whitmore. Academic, San Diego 1991; 1: 411–411, In
  • Kastan M.B., Onyekwere O., Sidransky D., Vogelstein B., Craig R.W. Participation of p53 protein in the cellular response to DNA damage. Cancer Research 1991; 51: 6304–6311
  • Kelland L.R., Edwards S.M., Steel G.G. Induction and rejoining of DNA double-strand breaks in human cervix carcinoma cell lines of differing radiosensitivity. Radiation Research 1988; 116: 526–538
  • Kemp L.M., Sedgwick S.G., Jeggo P.A. X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining. Mutation Research 1984; 132: 189–196
  • Ljungman M., Nyberg S., Nygren J., Erikson M., Ahnstrom G. DNA-bound proteins contribute much more than soluble intracellular compounds to the intrinsic protection against radiation-induced DNA strand breaks in human cells. Radiation Research 1991; 127: 171–176
  • McKenna W.G., Iliakis G., Weiss M.C., Bernhard E.J., Muschel R.J. Increased G2 delay in radioresistant cells obtained by transformation of primary rate embryo cells with the oncogenes H-ras and v-myc. Radiation Research 1991; 125: 283–287
  • McMillan T.J., Cassoni A.M., Edwards S., Holmes A., Peacock J.H. The relationship of DNA double-strand break induction to radiosensitivity in human tumour cell lines. International Journal of Radiation Biology 1990; 58: 427–438
  • Milner A.E., Gordon D.J., Turner B.M., Vaughan A.T.M. A correlation between DNA-nuclear matrix binding and relative radiosensitivity in two human squamous cell carcinoma cell lines. International Journal of Radiation Biology 1993; 63: 13–20
  • North P., Ganesh G., Thacker J. The rejoining of double-strand breaks in DNA by human cell extracts. Nucleic Acids Research 1990; 18: 6205–6210
  • Okayasu R., Blöcher D., Iliakis G. Variation through the cell cycle in the dose-response of DNA neutral filter elution in X-irradiated synchronous CHO-cells. International Journal of Radiation Biology 1988; 53: 729–747
  • Olive P.L. DNA organization affects cellular radiosensitivity and detection of initial DNA strand breaks. International Journal of Radiation Biology 1992; 62: 389–396
  • Pandita T.K., Hittelman W.N. The contribution of DNA and chromosome repair deficiencies to the radiosensitivity of ataxia-telangiectasia. Radiation Research 1992; 131: 214–223
  • Powell S., McMillan T.J. Clonal variation of DNA repair in a human glioma cell line. Radiotherapy and Oncology 1991; 21: 225–232
  • Powell S.N., Whitaker S.J., Edwards S.M., McMillan T.J. A DNA repair defect in a radiation-sensitive clone of a human bladder carcinoma cell line. British Journal of Cancer 1992; 65: 798–802
  • Powell S., Whitaker S., Peacock J., McMillan T.J. Ataxia-telangiectasia: an investigation of the repair defect in the cell line AT5BIVA by plasmid reconstitution. Mutation Research 1993; 294: 9–20
  • Prise K.M., Davies S., Michael B.D. Cell killing and DNA damage in Chinese hamster V79 cells treated with hydrogen peroxide. International Journal of Radiation Biology 1989; 55: 583–592
  • Radford I.R. The level of induced DNA double-strand breakage correlates with cell killing after X-irradiation. International Journal of Radiation Biology 1990; 48: 45–54
  • Revell S.H. Relationships between chromosome damage and cell death. Radiation-Induced Chromosome Damage in Man. Alan R. Liss, New York 1983; 215–233, anonymous editor
  • Ruiz de Almodovar J.M., Bush C., Peacock J.H., Steel G.G., Whitaker S.J., McMillan T.J. Dose-rate effect for DNA damage induced by ionising radiation in human tumor cells. Radiation Research 1993, in press
  • Schwartz J.L., Rotmensch J., Giovanazzi S.M., Cohen M.B., Weich-Selbaum R.R. Faster repair of DNA double-strand breaks in radioresistant human tumour cells. International Journal of Radiation Oncology, Biology and Physics 1988; 15: 907–912
  • Schwartz J.L., Mustafi R., Beckett M.A., Gzyzewski E.A., Farhangi E., Grdina D.J., Rotmensch J., Weichselbaum R.R. Radiation-induced DNA double-strand break frequencies in human squamous cell carcinoma cell lines of different radiation sensitivities. International Journal of Radiation Biology 1991; 59: 1314–1352
  • Smith P.J. Relationship between a chromatin anomaly in ataxia telangiectasia cells and enhanced sensitivity to DNA damage. Carcinogenesis 1984; 5: 1345–1350
  • Steel G.G. The ESTRO Breur lecture. Cellular sensitivity to low dose-rate irradiation focuses the problem of tumour radioresistance. Radiotherapy and Oncology 1991; 20: 71–83
  • Swift M., Reitnauer P., Morrell D., Chase C. Breast and other cancers in families with ataxia-telangiectasia. New England Journal of Medicine 1987; 316: 1289–1294
  • Taylor Y.C., Duncan P.G., Zhang X., Wright W.D. Differences in the DNA supercoiling response of irradiated cell lines from ataxia-telangiectasia versus unaffected individuals. International Journal of Radiation Biology 1991; 59: 359–371
  • Thacker J., Ganesh A.N. DNA-break repair, radioresistance of DNA synthesis, and camptothecin sensitivity in the radiosensitive irs mutants: comparison to ataxia-telangiectasia cells. Mutation Research 1990; 235: 49–58
  • Ward J.F. Biochemistry of DNA lesions. Radiation Research 1985; 104: s103–s111
  • Ward J.F. DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation and repairability. Progress in Nucleic Acids and Molecular Biology 1988; 35: 95–125
  • Ward J.F. The yield of DNA double-strand breaks produced intracellularly by ionizing radiation: a review. International Journal of Radiation Biology 1990; 57: 1141–1150
  • Warters R.L., Lyons B.W. Detection of ionizing radiation-induced DNA double-strand breaks by filter elution is affected by nuclear chromatin structure. Radiation Research 1990; 124: 309–316
  • West C.M.L., Davidson S.E., Hendry J.H., Hunter R.D. Prediction of cervical carcinoma response to radiotherapy. Lancet 1991; 338: 818–818
  • Wheeler K.T., Wierowski J.V. DNA repair kinetics in irradiated undifferentiated and terminally differentiated cells. Radiation and Environmental Biophysics 1983; 22: 3–19
  • Whitaker S.J., McMillan T.J. Oxygen effect for DNA double-strand break induction determined by pulsed-field gel electrophoresis. International Journal of Radiation Biology 1992a; 61: 29–41
  • Whitaker S.J., McMillan T.J. Pulsed-field gel electrophoresis in the measurement of DNA double-strand break repair in xrs-6 and CHO cell lines: DNA degradation under some conditions interferes with the assessment of double-strand break rejoining. Radiation Research 1992b; 130: 389–392

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.