23
Views
43
CrossRef citations to date
0
Altmetric
Original Article

Genetic and Cellular Features of Ataxia Telangiectasia

, , &
Pages 65-70 | Received 23 Aug 1993, Accepted 23 Sep 1993, Published online: 03 Jul 2009

References

  • Cox R. A cellular description of the repair defect in ataxia telangiectasia. Ataxia Telangiectasia: A Cellular and Molecular Link Between Cancer, Neuropathology and Immune Deficiency, B.A. Bridges, D.G. Harnden. Wiley, Chichester 1982; 141–153, In
  • Cox R., Debenham P.G., Masson W.K., Webb M.B.T. Ataxia telangiectasia: a human mutation giving high frequency misrepair of DNA double-stranded scissions. Molecular Biology in Medicine 1986; 3: 229–244
  • Gatti R.A., Berkel I., Boder E., Braedt G., Charmley P., Concannon P., Ersoy F., Foroud T., Jaspers N.G.J., Lange K., Lathrop G.M., Leppert M., Nakamura Y., O'Connell P., Paterson M., Salser W., Sanal O., Silver J., Sparkes R.S., Susi E., Weeks D.E., Wei S., White R., Yoder F. Localisation of an ataxia telangiectasia gene to chromosome 11q22–23. Nature 1988; 336: 577–580
  • Hernandez D., McConville C.M., Stacey M., Woods C.G., Brown M.M., Shutt P., Rysiecki G., Taylor A.M.R. A family showing no evidence of linkage between the ataxia telangiectasia gene and chromosome 11q22–23. Journal of Medical Genetics 1993; 30: 145–150
  • Hickman J.A. Apoptosis induced by anticancer drugs. Cancer and Metastasis Reviews 1992; 11: 121–139
  • Kapp L.N., Painter R.B., Yu L.-C., van Loon N., Richard C.W., James M.R., Cox D.R., Murnane J.P. Cloning of a candidate gene for ataxia telangiectasia group D. American Journal of Human Genetics 1992; 51: 45–54
  • Kuo M.T., Hsu T.C. Bleomycin causes release of nucleosomes from chromatin and chromosomes. Nature 1978; 271: 83–84
  • Lange E., Gatti R.A., Sobel E., Concannon P., Lange K. How many ataxia telangiectasia genes?. Ataxia Telangiectasia, R.A. Gatti, R.B. Painter. Springer-Verlag, Heidelberg 1993, (in press)
  • Lehmann A.R., Stevens S. The response of ataxia telangiectasia cells to bleomycin. Nucleic Acids Research 1979; 6: 1953–1960
  • Lipkowitz S., Stern M.-H., Kirsch I.R. Hybrid T cell receptor genes formed by interlocus recombination in normal and ataxia telangiectasia lymphocytes. Journal of Experimental Medicine 1990; 172: 409–418
  • Meyn M.S. High spontaneous intrachromosomal recombination rates in ataxia telangiectasia. Science 1993; 260: 1327–1330
  • McCarthy N.J., Smith C.A., Williams G.T. Apoptosis in the development of the immune system: growth factors, clonal selection and bcl 2. Cancer and Metastasis Reviews 1992; 11: 157–178
  • McConville C.M., Byrd P.J., Ambrose H.J., Stankovic T., Ziv Y., Bar-Shira A., Vanagaite L., Rotman G., Shiloh Y., Gillett G.T., Riley J.H., Taylor A.M.R. Paired STSs amplified from radiation hybrids and from associated YACs, identify highly polymorphic loci flanking the ataxia telangiectasia locus on chromosome 11q22–23. Human and Molecular Genetics 1993; 2: 969–974
  • Painter R.B. Structural changes in chromatin as the basis for radiosensitivity in ataxia telangiectasia. Cytogeneity and Cell Genetics 1982; 33: 139–144
  • Painter R.B., Young B.R. Radiosensitivity in ataxia telangiectasia: a new explanation. Proceedings of the National Academy of Sciences, USA 1980; 77: 7315–7317
  • Pandita T.K., Hittelman W.N. Initial chromosome damage but not DNA damage is greater in ataxia telangiectasia cells. Radiation Research 1992; 130: 94–103
  • Shiloh Y., Tabor E., Becker Y. The response of ataxia telangiectasia homozygous and heterozygous skin fibroblasts to neocarzinostatin. Carcinogenesis 1982; 3: 815–820
  • Shiloh Y., Tabor E., Becker Y. Abnormal response of ataxia telangiectasia cells to agents that break the deoxyribose moiety of DNA via a targeted free radical mechanism. Carcinogenesis 1983; 4: 1317–1322
  • Shiloh Y., Tabor E., Becker Y. Cells from patients with ataxia telangiectasia are abnormally sensitive to the cytotoxic effect of a tumour promoter, phorbol-12-myristate-13-acetate. Mutation Research 1985; 149: 283–286
  • Sedgwick R.P., Boder E. Ataxia Telangiectasia. Handbook of Clinical Neurology. Hereditary Neuropathies and Spinocerebellar Atrophies, J.M.B.V. de Jong. Elsevier, Amsterdam 1991; 16: 347–423, In
  • Taylor A.M.R., Flude E., Garner C.M., Campbell J.B., Edwards M.J. Effects of the DNA strand cleaving antitumour agent streptonigrin on ataxia telangiectasia cells. Cancer Research 1983; 43: 2700–2703
  • Taylor A.M.R., Flude E., Laher B., Stacey M., McKay E., Watt J., Green S.H., Harding A.E. Variant forms of ataxia telangiectasia. Journal of Medical Genetics 1987; 24: 669–677
  • Taylor A.M.R., Rosney C.M., Campbell J.B. Unusual sensitivity of ataxia telangiectasia cells to bleomycin. Cancer Research 1979; 39: 1046–1050
  • Thacker J., Chalk J., Ganesh A., North P. A mechanism for deletion formation in DNA by human cell extracts; the involvement of short sequence repeats. Nucleic Acids Research 1992; 20: 6183–6188
  • Wyllie A.H. Apoptosis and the regulation of cell numbers in normal and neoplastic tissues; an overview. Cancer and Metastasis Reviews 1992; 11: 95–103
  • Yamada T., Ohyama H. Radiation-induced interphase death of rat thymocytes is internally programmed (apoptosis). International Journal of Radiation Biology 1988; 53: 65–75

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.