Tumour Hypoxia: The Picture Has Changed in the 1990s

References

• Anderson G.R., Stoler D.L., Scarcello L.A. Normal fibroblasts responding to anoxia exhibit features of the malignant phenotype. Journal of Biological Chemistry 1989; 264: 14885–14892
   PubMed Web of Science ®Google Scholar
• Berry R.J. Population distribution in tumours and normal tissues: a guide to tissue radiosensitivity. The Biological and Clinical Basis of Radiosensitivity, M. Friedman. Charles C. Thomas, IL 1974; 141–155, In
   Google Scholar
• Brock W.A., Baker F.L., Peters L.J. Radiosensitivity of human head and neck squamous cell carcinomas in primary culture and its potential as a predictive assay of tumour radiocurability. International Journal of Radiation Biology 1989; 56: 751–760
   PubMed Web of Science ®Google Scholar
• Brown J.M. Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation. British Journal of Radiology 1979; 52: 650–656
   PubMed Web of Science ®Google Scholar
• Brown J.M. Clinical trials of radiosensitizers: what should we expect?. International Journal of Radiation Oncology, Biology and Physics 1984; 10: 425–429
   PubMed Web of Science ®Google Scholar
• Brown J.M., Koong A. Therapeutic advantage of hypoxic cells in tumors: a theoretical study. Journal of the National Cancer Institute 1991; 83: 178–185
   PubMed Web of Science ®Google Scholar
• Brown J.M., Lemmon M.J. Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors. Cancer Research 1990; 50: 7745–7749
   PubMed Web of Science ®Google Scholar
• Brown J.M., Lemmon M.J. Fractionation increases the antitumour effect of adding hypoxic cytotoxin to irradiation. Radiation Research a Twentieth Century Perspective, W.C. Dewey, M. Edington, R.J.M. Fry, E.J. Hall, G.F. Whitmore. Academic, San Diego 1992; 807–812, In
   Google Scholar
• Chaplin D.J., Olive P.L., Durand R.E. Intermittent blood flow in a murine tumor: radiobiological effects. Cancer Research 1987; 47: 597–601
   PubMed Web of Science ®Google Scholar
• Datta R., Hallahan D.E., Kharbanda S.M., Rubin E., Sherman M.L., Huberman E., Weichselbaum R.R., Kufe D.W. Involvement of reactive oxygen intermediates in the induction of c-jun gene transcription by ionizing radiation. Biochemistry 1992; 31: 8300–8306
   PubMed Web of Science ®Google Scholar
• Deacon J., Peckham M.J., Steel G.G. The radioresponsiveness of human tumours and the initial slope of the cell curvival curve. Radiotherapy and Oncology 1984; 2: 317–323
   PubMed Web of Science ®Google Scholar
• Denny W.A., Wilson W.R., Tercel M., Pullen S.M. (1993) Benzylic mustard quaternary salts, a new class of compounds capable of releasing diffusible cytotoxins on bioreduction. 8th International Conference on Chemical Modifiers of Cancer Treatment, KyotoJapan, 1993, Abs II-8.
   Google Scholar
• Dorie M.J., Brown J.M. Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin. Cancer Research 1993; 53: 4633–4636
   PubMed Web of Science ®Google Scholar
• Dorie M.J., Menke D., Brown J.M. Comparison of the enhancement of tumor responses to fractionated irradiation by SR 4233 (Tirapazamine) and by nicotinamide with carbogen. International Journal of Radiation Oncology, Biology and Physics 1993, in press
   PubMedGoogle Scholar
• Fertil B., Malaise E.P. Inherent cellular radiosensitivity as a basic concept for human tumor radiotherapy. International Journal of Radiation Oncology, Biology and Physics 1981; 7: 612–629
   Google Scholar
• Gatenby R.A., Kessler H.B., Rosenblum J.S., Coia L.R., Moldofsky P.J., Hartz W.H., Broder G.J. Oxygen distribution in squamous cell carcinoma metstases and its relationship to outcome of radiation therapy. International Journal of Radiation Oncology, Biology and Physics 1988; 14: 831–838
   PubMed Web of Science ®Google Scholar
• Giaccia A.J., Auger E.A., Koong A., Terris D., Minchinton A., Hahn G.M., Brown J.M. Activation of the heat shock transcription factor by hypoxia in normal and tumor cell lines in vivo and in vitro. International Journal of Radiation Oncology, Biology and Physics 1992; 23: 891–897
   PubMed Web of Science ®Google Scholar
• Goldberg M.A., Dunning S.P., Bunn H.F. Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science 1988; 242: 1412–1415
   PubMed Web of Science ®Google Scholar
• Graeber T., Peterson J., Tsai M., Fornace A.J., Giaccia A.J. Hypoxia and heat induce the accumulation of p53 protein in wild-type p53 and in human papillomavirus infected cells: evidence for p53 regulation by a different mechanism than that triggered by DNA. Cell 1993, (submitted).
   Google Scholar
• Grau C., Overgaard J. Effect of cancer chemotherapy on the hypoxic fraction of a solid tumor measured using a local tumor control assay. Radiotherapy and Oncology 1988; 13: 301–309
   PubMed Web of Science ®Google Scholar
• Hall E.J. The oxygen effect: pertinent or irrelevent to clinical radiotherapy. British Journal of Radiology 1967; 40: 874–875
   Google Scholar
• Heacock C.S., Sutherland R.M. Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism. British Journal of Cancer 1990; 62: 217–225
   PubMedGoogle Scholar
• Hill R.P. Sensitizers and radiation dose fractionation: results and interpretations. International Journal of Radiation Oncology, Biology and Physics 1986; 12: 1049–1054
   PubMed Web of Science ®Google Scholar
• Hockel M., Knoop C., Schlenger K., Vorndran B., Baubmann E., Mitze M., Knapstein P.G., Vaupel P. Intratumoral pO2 predicts survival in advance cancer of the uterine cervix. Radiotherapy and Oncology 1993; 26: 45–50
   PubMed Web of Science ®Google Scholar
• Hockel M., Schlenger K., Knoop C., Vaupel P. Oxygenation of carcinomas of the uterine cervix: evaluation by computerized O2 tension measurements. Cancer Research 1991; 51: 6098–6102
   PubMed Web of Science ®Google Scholar
• Kaplan H.S. Radiobiology's contribution to radiotherapy: promise or mirage? Failla Memorial Lecture. Radiation Research 1970; 43: 460–476
   PubMed Web of Science ®Google Scholar
• Kennedy K.A. Hypoxic cells as specific drug targets for chemotherapy. Anticancer Drug Design 1987; 2: 181–194
   PubMedGoogle Scholar
• Kim I.H., Brown J.M. Reoxygenation and rehypoxiation in the SCCVII mouse tumor. International Journal of Radiation Oncology, Biology and Physics 1993, in press
   Google Scholar
• Koh W.-J., Rasey J.S., Evans M.L., Grierson J.R., Lewellen T.K., Graham M.M., Krohn K.A., Griffin T.W. Imaging of hypoxia in human tumors and [F-18]Fluoromisonidazole. International Journal of Radiation Oncology, Biology and Physics 1992; 22: 199–212
   PubMed Web of Science ®Google Scholar
• Koong A., Chen E., Lee A.S., Brown J.M., Giaccia A.J. Increased cytotoxicity of chronic hypoxic cells by molecular inhibition of GR P78 induction. International Journal of Radiation Oncology, Biology and Physics 1993, in press
   Google Scholar
• Lowry C.V., Cerdan M.E., Zitomer R.S. A hypoxic consensus operator and a constitutive activation region regulate the ANB1 gene of Saccharomyces cerevisiae. Molecular and Cellular Biology 1990; 10: 5921–5926
   PubMedGoogle Scholar
• Mueller-Klieser W., Vaupel P., Manz R., Schmidseder R. Intracapillary oxyhemoglobin saturation of malignant tumors in humans. International Journal of Radiation Oncology, Biology and Physics 1981; 7: 1397–1404
   PubMedGoogle Scholar
• Murphy B.J., Laderoute K.R., Short S.M., Sutherland R.M. The identification of heme oxygenase as a major hypoxic stress protein in Chinese hamster ovary cells. British Journal of Cancer 1991; 64: 69–73
   PubMed Web of Science ®Google Scholar
• Overgaard J., Hansen H.S., Jorgensen K., Hansen M.H. Primary radiotherapy of larynx and pharynx carcinoma—an analysis of some factors influencing local control and survival. International Journal of Radiation Oncology, Biology and Physics 1986; 12: 515–521
   PubMed Web of Science ®Google Scholar
• Rofstad E.K., Wahl A., Brustad T. Radiation sensitivity in vitro of cells isolated from human tumor surgical specimens. Cancer Research 1987; 47: 106–110
   PubMed Web of Science ®Google Scholar
• Roll D.E., Murphy B.J., Laderoute K.R., Sutherland R.M., Smith H.C. Oxygen regulated 80 kDA protein and glucose regulation 78 kDa protein are identical. Molecular and Cellular Biochemistry 1991; 103: 141–148
   PubMedGoogle Scholar
• Sartorelli A.C. Therapeutic attack of hypoxic cells of solid tumors: presidential address. Cancer Research 1988; 48: 775–778
   PubMedGoogle Scholar
• Sciandra J.J., Subjeck J.R., Hughes C.S. Induction of glucose-regulated proteins during anaerobic exposure and of heat-shock proteins after reoxygenation. Proceedings of the National Academy of Sciences, USA 1984; 81: 4843–4847
   PubMed Web of Science ®Google Scholar
• Shweiki D., Itin A., Soffer D., Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992; 359: 843–845
   PubMed Web of Science ®Google Scholar
• Steel G.G., McMillan T.J., Peacock J.H. The picture has changed in the 1980s. International Journal of Radiation Biology 1989; 56: 525–537
   PubMed Web of Science ®Google Scholar
• Stratford I.J., Oneill P., Sheldon P.W., Silver A.R., Walling J.M., Adams G.E. RSU 1069, a nitroimidazole containing an aziridine group. Bioreduction greatly increases cytotoxicity under hypoxic conditions. Biochemical Pharmacology 1986; 35: 105–109
   PubMed Web of Science ®Google Scholar
• Tannock I., Guttman P. Response of Chinese hamster ovary cells to anticancer drugs under aerobic and hypoxic conditions. British Journal of Cancer 1981; 42: 245–248
   Google Scholar
• Trotter M.J., Chaplin D.J., Olive P.L. Use of a carbocyanine dye as a marker of functional vasculature in murine tumours. British Journal of Cancer 1989; 59: 706–709
   PubMedGoogle Scholar
• Vaupel P., Schlenger K., Knoop C., Hockel M. Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements. Cancer Research 1991; 51: 3316–3322
   PubMed Web of Science ®Google Scholar
• Weichselbaum R.R., Beckett M.A., Vijayakumar S., Simon M.A., Awan A.M., Nachman J., Panje W.R., Goldman M.E., Tybor A.G., Moran W.J., Vokes E.E., Ahmed-Swan S., Farhangi E. Radiobiological characterization of head and neck and sarcoma cells derived from patients prior to radiotherapy. International Journal of Radiation Oncology, Biology and Physics 1990; 19: 313–319
   PubMed Web of Science ®Google Scholar
• West C.M.L., Davidson S.E., Hunter R.D. Evaluation of surviving fraction at 2 Gy as a potential prognostic factor for the radiotherapy of carcinoma of the cervix. International Journal of Radiation Biology 1989; 56: 761–765
   PubMed Web of Science ®Google Scholar
• Zeman E.M., Brown J.M., Lemmon M.J., Hirst V.K., Lee W.W. SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells. International Journal of Radiation Oncology, Biology and Physics 1986; 12: 1239–1242
   PubMed Web of Science ®Google Scholar