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Original Article

Nicotinamide and Carbogen: Relationship between pO2 and Radiosensitivity in Three Tumour Lines

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Pages 379-386 | Received 31 May 1993, Accepted 18 Oct 1993, Published online: 03 Jul 2009

References

  • Badib A.O., Webster J.H. Changes in tumor oxygen tension during radiation therapy. Acta Radiologica Therapy Physics Biology 1969; 8: 247–257
  • Chaplin D.J., Horsman M.R., Trotter M.J. Effect of nicotinamide on the microregional heterogeneity of oxygen delivery within a murine tumor. Journal of the National Cancer Institute 1990; 82: 672–676
  • Chaplin D.J., Peters C.E., Horsman M.R., Trotter M.J. Drug induced perturbations in tumor blood flow: therapeutic potential and possible limitations. Radiotherapy and Oncology 1991; 20: 93–101, suppl.
  • Chapman J.D. Measurement of tumor hypoxia by invasive and non invasive procedures: a review of recent clinical studies. Radiotherapy and Oncology 1991; 20: 13–19, suppl.
  • Gatenby R.A., Kessler H.B., Rosenblum J.S., Coia L.R., Moldofsky P.J., Hartz W.H., Broder G.L. Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. International Journal of Radiation Oncology, Biology and Physics 1988; 14: 831–838
  • Guichard M. Comparison of the radiobiological properties of human tumour xenografts and rodent tumours. International Journal of Radiation Biology 1989; 56: 583–586
  • Guichard M., Dertinger H., Malaise E.P. Radiosensitivity of four human tumor xenografts. Influence of hypoxia and cell-cell contract. Radiation Research 1983; 95: 602–609
  • Guichard M., Gosse C., Malaise E.P. Survival curve of a human melanoma in nude mice. Journal of the National Cancer Institute 1977b; 58: 1665–1669
  • Guichard M., Lachet B., Malaise E.P. Measurement of RBE, OER and recovery of potentially lethal damage of a 645 MeV Helium Ion Beam using EMT6 cells. Radiation Research 1977a; 71: 413–420
  • Hasegawa T., Rhee J.G., Levitt S.H., Song C.W. Increase in tumrou PO2 by perfluorochemicals and carbogen. International Journal of Radiation Oncology, Biology and Physics 1987; 13: 569–574
  • Hill R.P., Bush R.S. Dose fractionation studies with a murine sarcoma under conditions of air or carbogen (95% O2 + 5% CO2) breathing. International Journal of Radiation Oncology, Biology and Physics 1977; 2: 913–919
  • Horsman M.R., Brown J.M., Hirst V.K., Lemmon M.J., Wood P.J., Dunphy E.P., Overgaard J. Mechanism of action of the selective tumor radiosensitizer nicotinamide. International Journal of Radiation Oncology, Biology and Physics 1988; 15: 685–690
  • Horsman M.R., Chaplin D.J., Brown J.M. Radiosensitization by nicotinamide in vivo: a greater enhancement of tumor damage compared to that of normal tissues. Radiation Research 1987; 109: 479–489
  • Horsman M.R., Chaplin D.J., Brown J.M. Tumor radiosensitization by nicotinamide: a result of improved perfusion and oxygenation. Radiation Research 1989a; 118: 139–150
  • Horsman M.R., Hansen P.V., Overgaard J. Radiosensitization by nicotinamide in tumors and normal tissues: the importance of tissue oxygenation status. International Journal of Radiation Oncology, Biology and Physics 1989b; 16: 1273–1276
  • Horsman M.R., Wood P.J., Chaplin D.J., Brown J.M., Overgaard J. The potentiation of radiation damage by nicotinamide in the SCCVII tumour in vivo. Radiotherapy and Oncology 1990; 18: 49–57
  • Höckel M., Knoop C., Schlenger K., Vorndran B., Baussmann E., Mitze M., Knapstein P.G., Vaupel P. Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix. Radiotherapy and Oncology 1993; 26: 45–50
  • Inch W.R., MacCredie J.A., Sutherland R.M. Effect of duration of breathing 95% oxygen plus 5% carbon dioxide before X-irradiation on cure of C3H mammory tumor. Cancer 1970; 25: 926–931
  • Johnson R.S.R. A comparison of the effect of hyperbaric oxygen an oxygen plus 5% CO2 on tissue circulation and oxygenation. Radiology 1971; 98: 177–181
  • Kelleher D.K., Vaupel P.W. Nicotinamide exerts different acute effects on microcirculatory function and tissue oxygenation in rat tumors. International Journal of Radiation Oncology, Biology, and Physics 1993; 26: 95–102
  • Kjellen E., Joiner M.C., Collier J.M., Johns H., Rojas A. A therapeutic benefit from combining normobaric carbogen or oxygen with nicotinamide in fractionated X-ray treatments. Radiotherapy and Oncology 1991; 22: 81–91
  • Kolstad P. Intercapillary distance, oxygen tension and local recurrence in cervix cancer. Scandinavian Journal of Clinical Laboratory Investigations 1968; 106: 145–157
  • Kruuv J.A., Inch W.R., McCredie J.A. Blood flow and oxygenation of tumors in mice. I. Effects of breathing gases containing carbon dioxide at atmospheric pressure. Cancer 1967; 20: 51–59
  • Lartigau E., Le Ridant A.M., Lambin P., Weeger P., Martin L., Sigal R., Lusinchi A., Luboinski B., Eschwege F., Guichard M. Oxygenation of head and neck tumors. Cancer 1993; 71: 2319–2325
  • Lee I., Cunningham W.P., Levitt S.H. Improvement in RBC flux, acidosis and oxygenation in tumour microregions by Fluosol-DA 20%. International Journal of Radiation Biology 1991; 60: 695–705
  • Lee I., Levitt S.H., Song C.W. Radiosensitization of murine tumors by Fluosol-DA 20%. Radiation Research 1990; 122: 275–279
  • Lee I., Song C.W. The oxygenation of murine tumor isografts and human tumor xenografts by nicotinamide. Radiation Research 1992; 130: 65–71
  • Martin D.F., Kimler B.F., Evans R.G., Morantz R.A., Vats T.S. Potentiation of rat brain tumor therapy by Fluosol and carbogen. National Cancer Institute Monography 1988; 6: 119–122
  • Martin L., Lartigau E., Weeger P., Lambin P., Le Ridant A.M., Lusinchi A., Wibault P., Eschwege F., Luboinski B., Guichard M. Changes in the oxygenation of head and neck, tumors during carbogen breathing. Radiotherapy and Oncology 1993; 27: 123–130
  • Milne N., Hill R.P., Bush R.S. Factors affecting hypoxic KHT tumor cells in mice breathing O2, O2 + CO2 or hyperbaric oxygen with or without anaesthesia. Radiology 1973; 106: 663–671
  • Pappova N., Siracka E., Vacek A., Durkovsky J. Oxygen tension and prediction of the radiation response, polarographic study in human breast cancer. Neoplasma 1982; 29: 669–674
  • Rockwell S., Kelley M., Irvin C.G., Hughes C.S., Porter E., Yabuki H., Fischer J.J. Modulation of tumor oxygenation and radiosensitivity by a perfluorooctylbromide emulsion. Radiotherapy and Oncology 1991; 22: 92–98
  • Rockwell S., Moulder J.E. Hypoxic fractions of human tumors xenografted into mice: a review. International Journal of Radiation Oncology, Biology and Physics 1990; 19: 197–202
  • Siemann D.W., Hill R.P., Bush R.S. The importance of the pre-irradiation breathing times of oxygen and carbogen (5% CO2:95% O2) on the in vivo radiation response of a murine sarcoma. International Journal of Radiation Oncology, Biology and Physics 1977; 2: 903–911
  • Song C.W., Lee I., Hasegawa T., Rhee J.G., Levitt S.H. Increase in pO2 and radiosensitivity of tumors by Fluosol-Da (20%) and carbogen. Cancer Research 1987; 47: 442–446
  • Suit H.D., Marshall N., Woerner D. Oxygen, oxygen plus carbogen dioxide and radiation therapy of a mouse mammary carcinomla. Cancer 1972; 30: 1154–1158
  • Thomas C., Lartigau E., Malaise E.P., Guichard M. New high O2 carrying perfluorochemical emulsions and/or carbogen: reactions of a human tumor xenograft to irradiation. International Journal of Radiation Oncology, Biology and Physics 1989; 16: 1157–1160
  • Vaupel P., Okunieff P., Kallinowski F., Neuringer L.J. Correlation between 31P-NMR spectroscopy and tissue O2 tension measurements in a murine fibrosarcoma. Radiation Research 1989; 120: 477–493
  • Vitu-Loas L., Thomas C., Chavaudra N., Guichard M. Radiosensitivity, blood perfusion and tumour oxygenation after perflubron emulsion injection. Radiotherapy and Oncology 1993; 27: 149–155

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