Application of the Constant Exposure Time Technique to Transformation Experiments with Fission Neutrons: Failure to Demonstrate Dose-rate Dependence

References

• AAPM. Protocol for neutron beam dosimetry. American Association of Physicists in Medicine, American Institute of Physics, New York 1980, Report No. 7
   Google Scholar
• Akaike H. An information criterion. Mathematical Science 1976; 1: 5–9
   Google Scholar
• Balcer-Kubiczek E.K., Harrison G.H. Lack of dose-rate modification (0·0049 versus 0·12 Gy/min) of fission-neutron-induced neoplastic transformation in C3H/10T½ cells. International Journal of Radiation Biology 1991a; 59: 1017–1026
   PubMed Web of Science ®Google Scholar
• Balcer-Kubiczek E.K., Harrison G.H. Neoplastic transformation of C3H/10T½ cells following exposure to 120-Hz modulated 2·45-GHz microwaves and phorbol ester tumor promoter. Radiation Research 1991b; 126: 65–71
   PubMed Web of Science ®Google Scholar
• Balcer-Kubiczek E.K., Harrison G.H. ‘Inter silvas Academi quaerere verum’: reply to Letter to the Editor by M. M. Elkind. International Journal of Radiation Biology 1991c; 59: 1477–1482
   Web of Science ®Google Scholar
• Balcer-Kubiczek E.K., Harrison G.H. AFRRI-neutron transformation results viz. current models (Poster P-24-9). 40th Annual Meeting of the Radiation Research Society, Salt Lake City, UTUSA, March, 1992
   Google Scholar
• Balcer-Kubiczek E.K., Harrison G.H., Hei T.K. Neutron dose-rate experiments at the AFRRI nuclear reactor. Radiation Research 1991; 128: S65–S70
   PubMedGoogle Scholar
• Balcer-Kubiczek E.K., Harrison G.H., Thompson B.W. Repair time for oncogenic transformation in C3H/10T½ cells subjected to protracted X-irradiation. International Journal of Radiation Biology 1987; 51: 219–226
   Web of Science ®Google Scholar
• Balcer-Kubiczek E.K., Harrison G.H., Zeman G.H., Mattson P.J., Kunska A. Lack of inverse dose-rate effect on fission neutron induced transformation of C3H/10T½ cells. International Journal of Radiation Biology 1988; 54: 531–536
   PubMed Web of Science ®Google Scholar
• Balcer-Kubiczek E.K., Hill C.K., Harrison G.H., Blakely W.F. Effects of WR-1065 and WR-151326 on survival and neoplastic transformation in C3H/10T½ cells exposed to TRIGA or JANUS fission neutrons. International Journal of Radiation Biology 1993; 63: 37–46
   PubMed Web of Science ®Google Scholar
• Bettega D., Calzolari G., Noris Chiorda G., Tallone-Lombardi L. Transformation of C3H/10T½ cells with 4·3 MeV α particles at low doses: effects of single and fractionated doses. Radiation Research 1992; 131: 66–71
   PubMedGoogle Scholar
• Borek C., Hall E.J. Effect of split doses of X-rays on neoplastic transformation of single cells. Nature 1974; 252: 499–501
   PubMedGoogle Scholar
• Brenner D.J., Hall E.J. Inverse dose-rate effect for oncogenic transformation by neutrons and charged particles: a plausible interpretation consistent with published data. International Journal of Radiation Biology 1990; 58: 745–758
   PubMed Web of Science ®Google Scholar
• Brenner D.J., Hall E.J. Commentary 2 to Cox and Little: Radiation-induced oncogenic transformation: the interplay between dose, dose protraction, and radiation quality. Advances in Radiation Biology 1992; 16: 167–179
   PubMedGoogle Scholar
• Burch P.R.J., Chesters M.E. Neoplastic transformation of cells in vitro at low and high dose rates of fission neutrons: an interpretationn. International Journal of Radiation Biology 1986; 49: 495–500
   Web of Science ®Google Scholar
• Cao J., Wells R.L., Elkind M.M. Enhanced sensitivity to neoplastic transformation by 137Cs γ-rays of cells in the G2/M-phase age interval. International Journal of Radiation Biology 1992; 62: 191–199
   PubMed Web of Science ®Google Scholar
• Goggle J.E. Lung tumour induction in mice after X-rays and neutrons. International Journal of Radiation Biology 1988; 53: 585–598
   Google Scholar
• Dennis J.A., Dennis L.A. Neutron dose relationships at low doses. Radiation and Environmental Biophysics 1988; 27: 91–101
   PubMed Web of Science ®Google Scholar
• Dixon W.J., Massey F.J. Introduction to Statistical Analysis. McGraw-Hill, New York 1957, chapter 11.
   Google Scholar
• Elkind M.M. Enhanced transformation due to protracted exposures of fission-spectrum neutrons: a biophysical model. International Journal of Radiation Biology 1991; 59: 1471–1476
   Google Scholar
• Goodhead D.T., Belli M., Mill A.J., Bance D.A., Allen L.A., Hall S.C., Ianzani F., Simone G., Stevens D.L., Stretch A., Tabocchini M.A., Wilkinson R.E. Direct comparison between protons and alpha-particles of the same LET. I. Irradiation methods and inactivation of asynchronous V79, HeLa and C3H/10T½ cells. International Journal of Radiation Biology 1992; 61: 611–624
   PubMed Web of Science ®Google Scholar
• Goodman L.J. A practical guide to ionization chamber dosimetry at the AFRRI reactor. AFRRI Contract Report CR85-1. Armed Forces Radiobiology Research Institute, Bethesda, MD 1985
   Google Scholar
• Hall E.J. Weiss Lecture: The dose rate factor in radiation biology. International Journal of Radiation Biology 1991; 59: 595–610
   PubMed Web of Science ®Google Scholar
• Hall E.J., Miller R.C. The how and the why in in vitro oncogenic transformation. Radiation Research 1981; 87: 208–223
   PubMed Web of Science ®Google Scholar
• Han A., Elkind M.M. Transformation of mouse C3H/10T½ cells by single and fractionated doses of X-rays and fission spectrum neutrons. Cancer Research 1979; 39: 123–130
   PubMed Web of Science ®Google Scholar
• Harrison G.H., Balcer-Kubiczek E.K. Ambiguity of the Brenner-Hall model. International Journal of Radiation Biology 1992; 61: 139–142
   PubMed Web of Science ®Google Scholar
• Hieber L., Ponsel G., Roos H., Fenn S., Fromke E., Kellerer A.M. Absence of a dose rate effect in the transformation of C3H/10T½ cells by α-particles. International Journal of Radiation Biology 1987; 52: 859–869
   Web of Science ®Google Scholar
• Hill C.K., Buonoguro F.M., Myers C.P., Han A., Elkind M.M. Fission-spectrum neutrons at. Nature 1982; 298: 67–68
   PubMed Web of Science ®Google Scholar
• Hill C.K., Han A., Elkind M.M. Fission-spectrum neutrons at low dose rate enhance neoplastic transformation in the linear, low dose region (0–10cGy). International Journal of Radiation Biology 1984; 46: 11–14
   Web of Science ®Google Scholar
• Hill C.K., Zhu L. Energy and dose-rate dependence of neoplastic transformation and mutations induced in mammalian cells by fast neutrons. Radiation Research 1991; 124: S48–S52
   Google Scholar
• IARC/NCI/EPA Working Group. Cellular and molecular mechanisms of cell transformation and standardization of transformation assays of established cell lines for prediction of carcinogenic chemicals: overview and recommended protocols. Cancer Research 1985; 45: 2395–2399
   Web of Science ®Google Scholar
• ICRU. Neutron dosimetry for biology and medicine. Report No. 26, International Commission on Radiation Units and Measurements, Washington, DC 1976
   Google Scholar
• Kellerer A.M., Rossi H.H. The theory of dual radiation action. Current Topics in Radiation Research Quarterly 1972; 8: 85–158
   Google Scholar
• Kleinbaum D.G., Kupper L.L., Muller K.E. Applied Regression Analysis and Other Multivariate Methods. PWS-Kent, Boston 1988
   Google Scholar
• Komatsu K., Sawada S., Takeoka S., Kodama S., Okumura Y. Dose-rate effects of neutrons and gamma rays on the induction of mutation and oncogenic transformation in plateau-phase mouse m5S cells. International Journal of Radiation Biology 1993; 52: 859–869
   Google Scholar
• Little J.B. Quantitative studies of radiation transformation with A31-11 mouse BALB3/3T3 cell line. Cancer Research 1979; 39: 1474–1480
   PubMed Web of Science ®Google Scholar
• Miller R.C., Hall E.J. X-ray dose fractionation and oncogenic transformation in cultured mouse embryo cells. Nature 1978; 272: 58–60
   PubMed Web of Science ®Google Scholar
• Miller R.C., Brenner D.J., Randers-Pehrson G., Marino S.A., Hall E.J. The effects of the temporal distribution of dose on oncogenic transformation by neutrons and charged particles of intermediate LET. Radiation Research 1990; 124: S62–S68
   PubMed Web of Science ®Google Scholar
• Miller R.C., Hall E.J. Oncogenic transformation of C3H/10T½ cells by acute and protracted exposures to monoenergetic neutrons. Radiation Research 1991; 128: S60–S64
   PubMedGoogle Scholar
• Miller R.C., Randers-Pehrson G., Hieber L., Marino S.A., Richards M., Hill E.J. The inverse dose-rate effect for oncogenic transformation is dependent on linear energy transfer. Radiation Research 1993; 133: 360–364
   PubMed Web of Science ®Google Scholar
• Moore M.L., Elsasser S. The TRIGA Reactor Facility at the Armed Forces Radiobiology Research Institute: a simplified technical desctription. AFRRI Technical Report TR86-1, Armed Forces Radiobiology Research Institute, Bethesda, MD 1986
   Google Scholar
• Oftedal P. A theoretical study of mutant yield and cell killing after treatment of heterogeneous cell populations. Hereditas 1968; 60: 177–210
   PubMed Web of Science ®Google Scholar
• Pazzaglia S., Priset L., Saran A., Robessi S., Coppola M., Di Majo V., Broerse J.J., Zotelief H., Covelli V. (1993) Neutron-induced neoplastic transformation of C3H/10T½ cells (Poster 17). International Symposium on Molecular Mechanisms of Radiation and Carcinogen-induced Cell Transformation, Mackinac Island, MIUSA, September, 19–23
   Google Scholar
• Peixoto J.L. Incorrect F-formulas in regression analysis. American Statistician 1993; 47: 194–197
   Google Scholar
• Redpath J.L., Sun C., Blackely W.F. Effect of fission-neutron dose rate on the induction of a tumor-associated antigen in human cell hybrids (HeLa × skin fibroblasts). Radiation Research 1991; 128: S71–S74
   PubMed Web of Science ®Google Scholar
• Reznikoff C.A., Bertrham J.S., Brankow D.W., Heidelberger C. Quantitative and qualitative studies of chemical transformation of cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of cell division. Cancer Research 1973b; 33: 3239–3249
   PubMed Web of Science ®Google Scholar
• Reznikoff C.A., Brankow D.W., Heidelberger C. Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of cell division. Cancer Research 1973a; 33: 3231–3238
   PubMed Web of Science ®Google Scholar
• Rossi H.H. Consideration on the time factor in radiobiology. Radiation and Environmental Biophysics 1981; 18: 1–9
   Google Scholar
• Rossi H.H., Kellerer A.M. The dose-rate dependence of oncogenic transformation by neutrons may be due to variation of response during the cell cycle. International Journal of Radiation Biology 1986; 50: 353–361
   Web of Science ®Google Scholar
• Saran A., Pazzaglia S., Pariset L., Rebessi S., Coppola M., Di Majo V., Covelli V. (1993) Cell-cycle dependence of C3H/10T½ cell transformation by fissionspectrum neutrons and X-rays (Poster P-17-4). 41st Annual Meeting of the Radiation Research Society, Dallas, TXUSA, March, 20–25
   Google Scholar
• Saran A., Pazzaglia S., Coppola M., Rebessi S., Di Majo V., Garavini M., Covelli V. Absence of dose-fractionation effect on neoplastic transformation induced by fission-spectrum neutrons in C3H/10T½ cells. Radiation Research 1991; 126: 343–348
   PubMedGoogle Scholar
• Sykes C.E., Watt D.E. Interpretation of the increase in the frequency of neoplastic transformations observed for some ionising radiations at low dose rates. International Journal of Radiation Biology 1989; 55: 925–942
   PubMed Web of Science ®Google Scholar
• Tauchi H., Nakamura N., Sawada S. Cell cycle dependence for the induction of 6-thioquanine-resistant mutations: G2/M-stage is distinctively sensitive to 252Cf neutrons but not to 60Co γ-rays. International Journal of Radiation Biology 1993; 63: 475–481
   PubMed Web of Science ®Google Scholar
• Ullrich R.L. Tumor induction in BALB/c mice after fractionated or protracted exposures to fission-spectrum neutrons. Radiation Research 1984; 97: 587–597
   PubMed Web of Science ®Google Scholar
• Verbinski V.V., Ferlick K., Cassapakis C.C., Daxon E., Hagan W.K. Radiation field characterization for the AFRRI TRIGA reactor. Report No. 5793F-1, Defense Nuclear Agency, Washington, DC 1981a; 1
   Google Scholar
• Verbinski V.V., Ferlick K., Cassapakis C.C., Daxon E., Hagan W.K. Calculation of the neutron and gamma-ray environment in and around for the AFRRI TRIGA reactor. Report No. 5793F-2, Defense Nuclear Agency, Washington, DC 1981b; 2
   Google Scholar
• Watt D.E. Comment on mechanism of radiation effects with special reference to transformation. Letter to Editor. International Journal of Radiation Biology 1992; 61: 263–267
   PubMed Web of Science ®Google Scholar
• Zeman G.H., Dooley M., Eagleson D.M., Goodman L., Schwartz R.B., Eisenhauer C.M., McDonald J.C. Intercomparison of neutron dosimetry techniques at the AFRRI TRIGA reactor. Radiation Protection Dosimetry 1988; 23: 317–320
   Web of Science ®Google Scholar